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Search results 1 to 100 out of 262 for Ptpn1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5770 | PTPN1
Type: gene
Organism: human
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Gene
508658 | PTPN1
Type: gene
Organism: cattle
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Gene
395688 | PTPN1
Type: gene
Organism: chicken
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Gene
30081 | ptpn1
Type: gene
Organism: zebrafish
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Gene
702016 | PTPN1
Type: gene
Organism: macaque, rhesus
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Gene
549875 | ptpn1
Type: gene
Organism: frog, western clawed
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Gene
24697 | Ptpn1
Type: gene
Organism: rat
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Gene
477263 | PTPN1
Type: gene
Organism: dog, domestic
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Gene
469970 | PTPN1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:97805 | Ptpn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28111468 | J:241885
First Author: Jobe F
Year: 2017
Journal: Leukemia
Title: Deletion of Ptpn1 induces myeloproliferative neoplasm.
Volume: 31
Issue: 5
Pages: 1229-1234
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Publication
25083988 | J:215768
First Author: Chiappini F
Year: 2014
Journal: J Clin Invest
Title: Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice.
Volume: 124
Issue: 9
Pages: 3781-92
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Publication
36462232 | J:332986
 
First Author: Han D
Year: 2022
Journal: Redox Biol
Title: Small extracellular vesicles from Ptpn1-deficient macrophages alleviate intestinal inflammation by reprogramming macrophage polarization via lactadherin enrichment.
Volume: 58
Pages: 102558
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Publication
31474996 | J:296768
 
First Author: Xu X
Year: 2019
Journal: Front Immunol
Title: Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages.
Volume: 10
Pages: 1930
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Publication
27020859 | J:231906
First Author: Labbé DP
Year: 2016
Journal: Cancer Res
Title: PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers.
Volume: 76
Issue: 11
Pages: 3130-5
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Publication
23639442 | J:197143
First Author: Lanahan A
Year: 2013
Journal: Dev Cell
Title: The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis.
Volume: 25
Issue: 2
Pages: 156-68
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Publication
31299613 | J:290932
 
First Author: García-Ruiz I
Year: 2019
Journal: Redox Biol
Title: Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.
Volume: 26
Pages: 101263
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Publication
26214522 | J:225802
First Author: Krishnan N
Year: 2015
Journal: J Clin Invest
Title: PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
Volume: 125
Issue: 8
Pages: 3163-77
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Protein Coding Gene
MGP_CAROLIEiJ_G0024713 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026886 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026857 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027342 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026095 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026614 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026737 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025832 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026155 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025633 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1378268 | J:1347
First Author: Miyasaka H
Year: 1992
Journal: Biochem Biophys Res Commun
Title: The cDNA cloning, nucleotide sequence and expression of an intracellular protein tyrosine phosphatase from mouse testis.
Volume: 185
Issue: 3
Pages: 818-25
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Publication
10066179 | J:53437
First Author: Elchebly M
Year: 1999
Journal: Science
Title: Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
Volume: 283
Issue: 5407
Pages: 1544-8
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Publication
34794959 | J:321646
First Author: Wiede F
Year: 2022
Journal: Cancer Discov
Title: PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity.
Volume: 12
Issue: 3
Pages: 752-773
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Publication
16845389 | J:111969
First Author: Bence KK
Year: 2006
Journal: Nat Med
Title: Neuronal PTP1B regulates body weight, adiposity and leptin action.
Volume: 12
Issue: 8
Pages: 917-24
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Publication
19528236 | J:151519
First Author: Xue B
Year: 2009
Journal: Mol Cell Biol
Title: Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Volume: 29
Issue: 16
Pages: 4563-73
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Publication
24951831 | J:213558
First Author: Kumagai T
Year: 2014
Journal: Am J Pathol
Title: Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria.
Volume: 184
Issue: 8
Pages: 2211-24
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Publication
36075234 | J:334601
First Author: Gogiraju R
Year: 2022
Journal: Thromb Haemost
Title: Protein Tyrosine Phosphatase 1B Deficiency in Vascular Smooth Muscle Cells Promotes Perivascular Fibrosis following Arterial Injury.
Volume: 122
Issue: 10
Pages: 1814-1826
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Publication
17347513 | J:120339
First Author: Bentires-Alj M
Year: 2007
Journal: Cancer Res
Title: Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer.
Volume: 67
Issue: 6
Pages: 2420-4
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Publication
24203758 | J:220653
First Author: Rajala RV
Year: 2013
Journal: Protein Cell
Title: Neuroprotective role of protein tyrosine phosphatase-1B in rod photoreceptor neurons.
Volume: 4
Issue: 12
Pages: 890-2
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Publication
17259984 | J:120342
First Author: Julien SG
Year: 2007
Journal: Nat Genet
Title: Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.
Volume: 39
Issue: 3
Pages: 338-46
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Publication
32769011 | J:317129
 
First Author: Hsu MF
Year: 2020
Journal: Redox Biol
Title: Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice.
Volume: 36
Pages: 101658
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Publication
17724080 | J:129081
First Author: Delibegovic M
Year: 2007
Journal: Mol Cell Biol
Title: Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.
Volume: 27
Issue: 21
Pages: 7727-34
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Publication
27461362 | J:235287
First Author: Bettaieb A
Year: 2016
Journal: Am J Pathol
Title: Pancreatic Protein Tyrosine Phosphatase 1B Deficiency Exacerbates Acute Pancreatitis in Mice.
Volume: 186
Issue: 8
Pages: 2043-2054
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Publication
24956127 | J:217005
First Author: Liu S
Year: 2014
Journal: Endocrinology
Title: Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function.
Volume: 155
Issue: 9
Pages: 3329-38
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Publication
19074988 | J:146928
First Author: Delibegovic M
Year: 2009
Journal: Diabetes
Title: Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress.
Volume: 58
Issue: 3
Pages: 590-9
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Publication
21605081 | J:177894
First Author: Agouni A
Year: 2011
Journal: Biochem J
Title: Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress.
Volume: 438
Issue: 2
Pages: 369-78
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Publication
25056348 | J:214222
First Author: Nezvitsky L
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B.
Volume: 307
Issue: 5
Pages: F634-47
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Publication
22156494 | J:181125
First Author: Berdnikovs S
Year: 2012
Journal: J Immunol
Title: PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo.
Volume: 188
Issue: 2
Pages: 874-84
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Publication
23588220 | J:203575
 
First Author: Pendleton JC
Year: 2013
Journal: Exp Neurol
Title: Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ.
Volume: 247
Pages: 113-21
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Publication
22446161 | J:185734
First Author: Gomez E
Year: 2012
Journal: J Mol Cell Cardiol
Title: Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B.
Volume: 52
Issue: 6
Pages: 1257-64
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Publication
19797268 | J:259474
First Author: Gomez MA
Year: 2009
Journal: Sci Signal
Title: Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Volume: 2
Issue: 90
Pages: ra58
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Publication
16234234 | J:105784
First Author: Sangwan V
Year: 2006
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure.
Volume: 281
Issue: 1
Pages: 221-8
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Publication
19687357 | J:167111
First Author: Belin de Chantemèle EJ
Year: 2009
Journal: Circulation
Title: Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function.
Volume: 120
Issue: 9
Pages: 753-63
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Publication
27105736 | J:232203
First Author: Yue L
Year: 2016
Journal: Am J Pathol
Title: Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection.
Volume: 186
Issue: 5
Pages: 1234-44
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Publication
29569957 | J:264690
First Author: Besnier M
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: Protein tyrosine phosphatase 1B inactivation limits aging-associated heart failure in mice.
Volume: 314
Issue: 6
Pages: H1279-H1288
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Publication
16477024 | J:107314
First Author: Heinonen KM
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.
Volume: 103
Issue: 8
Pages: 2776-81
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Publication
31532798 | J:279962
First Author: Yue L
Year: 2019
Journal: PLoS One
Title: PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils.
Volume: 14
Issue: 9
Pages: e0222753
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Publication
27207947 | J:253367
First Author: Gogiraju R
Year: 2016
Journal: Cardiovasc Res
Title: Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice.
Volume: 111
Issue: 3
Pages: 204-16
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Publication
10891488 | J:63236
First Author: Klaman LD
Year: 2000
Journal: Mol Cell Biol
Title: Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Volume: 20
Issue: 15
Pages: 5479-89
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Publication
28479249 | J:251529
First Author: Sugiyama M
Year: 2017
Journal: Biochem Biophys Res Commun
Title: PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.
Volume: 488
Issue: 1
Pages: 116-121
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Publication
23154416 | J:191078
First Author: Milani ES
Year: 2013
Journal: Development
Title: Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.
Volume: 140
Issue: 1
Pages: 117-25
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Publication
15699041 | J:224820
First Author: Haj FG
Year: 2005
Journal: J Biol Chem
Title: Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.
Volume: 280
Issue: 15
Pages: 15038-46
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Publication
22221695 | J:216116
First Author: González-Rodríguez A
Year: 2012
Journal: Aging Cell
Title: Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.
Volume: 11
Issue: 2
Pages: 284-96
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Publication
36272468 | J:331662
 
First Author: Ferreira V
Year: 2022
Journal: Metabolism
Title: Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight.
Volume: 137
Pages: 155335
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Publication
29126873 | J:262802
 
First Author: González-Rodríguez Á
Year: 2018
Journal: Mol Metab
Title: Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.
Volume: 7
Pages: 132-146
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Publication
31217339 | J:276447
 
First Author: Figueiredo H
Year: 2019
Journal: Sci Transl Med
Title: Targeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes.
Volume: 11
Issue: 497
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Publication
24587334 | J:214467
First Author: Fernandez-Ruiz R
Year: 2014
Journal: PLoS One
Title: Protein tyrosine phosphatase-1B modulates pancreatic β-cell mass.
Volume: 9
Issue: 2
Pages: e90344
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Publication
21406170 | J:169922
First Author: Revuelta-Cervantes J
Year: 2011
Journal: Am J Pathol
Title: Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.
Volume: 178
Issue: 4
Pages: 1591-604
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Publication
17259385 | J:121942
First Author: Nieto-Vazquez I
Year: 2007
Journal: Diabetes
Title: Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance.
Volume: 56
Issue: 2
Pages: 404-13
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Publication
23951017 | J:204928
First Author: Zhang J
Year: 2013
Journal: PLoS One
Title: Protein tyrosine phosphatase 1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells.
Volume: 8
Issue: 8
Pages: e70828
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Publication
24760754 | J:216631
First Author: Besnier M
Year: 2014
Journal: FASEB J
Title: Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B-deficient mice.
Volume: 28
Issue: 8
Pages: 3351-61
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Publication
17068137 | J:129555
First Author: Gonzalez-Rodriguez A
Year: 2007
Journal: Endocrinology
Title: Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.
Volume: 148
Issue: 2
Pages: 594-608
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Publication
28941626 | J:255890
First Author: Wang S
Year: 2017
Journal: Biochim Biophys Acta
Title: Deletion of protein tyrosine phosphatase 1B obliterates endoplasmic reticulum stress-induced myocardial dysfunction through regulation of autophagy.
Volume: 1863
Issue: 12
Pages: 3060-3074
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Publication
15465829 | J:217999
First Author: Gu F
Year: 2004
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress.
Volume: 279
Issue: 48
Pages: 49689-93
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Publication
11137300 | J:66545
First Author: Forsell PA
Year: 2000
Journal: Gene
Title: Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes.
Volume: 260
Issue: 1-2
Pages: 145-53
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Publication
12424235 | J:81368
First Author: Haj FG
Year: 2003
Journal: J Biol Chem
Title: Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatase-1B.
Volume: 278
Issue: 2
Pages: 739-44
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Publication
15737620 | J:96374
First Author: Xu J
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.
Volume: 329
Issue: 2
Pages: 538-43
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Publication
16522684 | J:106995
First Author: Hernández MV
Year: 2006
Journal: J Cell Sci
Title: ER-bound PTP1B is targeted to newly forming cell-matrix adhesions.
Volume: 119
Issue: Pt 7
Pages: 1233-43
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Publication
17238862 | J:118608
First Author: Tiganis T
Year: 2007
Journal: Biochem J
Title: Protein tyrosine phosphatase function: the substrate perspective.
Volume: 402
Issue: 1
Pages: 1-15
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Publication
17448901 | J:121595
First Author: Gracanin M
Year: 2007
Journal: Free Radic Biol Med
Title: Inhibition of protein tyrosine phosphatases by amino acid, peptide, and protein hydroperoxides: potential modulation of cell signaling by protein oxidation products.
Volume: 42
Issue: 10
Pages: 1543-51
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Publication
18571728 | J:137670
First Author: Xu H
Year: 2008
Journal: Mol Immunol
Title: Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
Volume: 45
Issue: 13
Pages: 3545-52
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Publication
18451337 | J:149016
First Author: Nakamura Y
Year: 2008
Journal: Circ Res
Title: Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells.
Volume: 102
Issue: 10
Pages: 1182-91
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Publication
21305007 | J:169542
First Author: Matsuo K
Year: 2011
Journal: PLoS One
Title: Regulation of brown fat adipogenesis by protein tyrosine phosphatase 1B.
Volume: 6
Issue: 1
Pages: e16446
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Publication
23085227 | J:190687
First Author: Takada M
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Pyrroloquinoline quinone, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves impaired glucose tolerance in diabetic KK-A(y) mice.
Volume: 428
Issue: 2
Pages: 315-20
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Publication
22266903 | J:197311
First Author: Yip SC
Year: 2012
Journal: J Cell Sci
Title: Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin.
Volume: 125
Issue: Pt 2
Pages: 310-6
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Publication
24120971 | J:205343
 
First Author: Taheripak G
Year: 2013
Journal: Free Radic Biol Med
Title: Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells.
Volume: 65
Pages: 1435-46
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Publication
26523876 | J:318365
 
First Author: Bruder-Nascimento T
Year: 2015
Journal: Pharmacol Res
Title: Deletion of protein tyrosine phosphatase 1b in proopiomelanocortin neurons reduces neurogenic control of blood pressure and protects mice from leptin- and sympatho-mediated hypertension.
Volume: 102
Pages: 235-44
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GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697421
Stage: TS21
Assay Id: MGI:5287015
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286923
Stage: TS23
Assay Id: MGI:5287015
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286926
Stage: TS26
Assay Id: MGI:5287015
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286927
Stage: TS27
Assay Id: MGI:5287015
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286928
Stage: TS28
Assay Id: MGI:5287015
Age: postnatal day 4
Specimen Label: P4
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5286913
Assay Type: Western blot
Annotation Date: 2011-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286928
Stage: TS28
Assay Id: MGI:5287015
Age: postnatal day 8
Specimen Label: P8
Detected: true
Specimen Num: 6
•
•
•
•
•




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