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Search results 1 to 100 out of 689 for Ptpn11

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
key_1584468 | Ptpn11
Type: gene
Organism: Not Specified
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Gene
5781 | PTPN11
Type: gene
Organism: human
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Gene
549586 | ptpn11
Type: gene
Organism: frog, western clawed
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Gene
25622 | Ptpn11
Type: gene
Organism: rat
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Gene
477488 | PTPN11
Type: gene
Organism: dog, domestic
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Gene
748225 | PTPN11
Type: gene
Organism: chimpanzee
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Gene
533590 | PTPN11
Type: gene
Organism: cattle
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Gene
395815 | PTPN11
Type: gene
Organism: chicken
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Gene
712044 | PTPN11
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
344593 | PTPN11P1
Type: gene
Organism: human
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Gene
391771 | PTPN11P4
Type: gene
Organism: human
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Gene
442113 | PTPN11P5
Type: gene
Organism: human
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Gene
442263 | PTPN11P3
Type: gene
Organism: human
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Gene
100421822 | PTPN11P2
Type: gene
Organism: human
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Publication
25289670 | J:222457
First Author: Usenko T
Year: 2014
Journal: PLoS One
Title: Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.
Volume: 9
Issue: 10
Pages: e109682
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Publication
28463680 | J:257090
   
First Author: Griger J
Year: 2017
Journal: Elife
Title: Loss of Ptpn11 (Shp2) drives satellite cells into quiescence.
Volume: 6
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Publication
18640765 | J:142002
First Author: Yang Z
Year: 2008
Journal: Exp Hematol
Title: Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.
Volume: 36
Issue: 10
Pages: 1285-96
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Publication
22058153 | J:181656
First Author: Schramm C
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.
Volume: 302
Issue: 1
Pages: H231-43
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Publication
21398220 | J:173832
First Author: Chan G
Year: 2011
Journal: Blood
Title: Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Volume: 117
Issue: 16
Pages: 4253-61
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Publication
27783593 | J:239412
First Author: Dong L
Year: 2016
Journal: Nature
Title: Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
Volume: 539
Issue: 7628
Pages: 304-308
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Publication
23863940 | J:204745
First Author: Yang W
Year: 2013
Journal: Nature
Title: Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Volume: 499
Issue: 7459
Pages: 491-5
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Publication
21339643 | J:172033
First Author: Marin TM
Year: 2011
Journal: J Clin Invest
Title: Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.
Volume: 121
Issue: 3
Pages: 1026-43
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Publication
19179468 | J:148430
First Author: Chan G
Year: 2009
Journal: Blood
Title: Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.
Volume: 113
Issue: 18
Pages: 4414-24
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Publication
26755576 | J:229927
First Author: Liu X
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies.
Volume: 113
Issue: 4
Pages: 984-9
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Publication
19251646 | J:147154
First Author: Araki T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation.
Volume: 106
Issue: 12
Pages: 4736-41
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Publication
36194675 | J:333063
First Author: Ventura PMO
Year: 2022
Journal: EMBO Rep
Title: Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Volume: 23
Issue: 11
Pages: e55399
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Publication
15273746 | J:91609
First Author: Araki T
Year: 2004
Journal: Nat Med
Title: Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation.
Volume: 10
Issue: 8
Pages: 849-57
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Publication
27840422 | J:241807
First Author: Liu W
Year: 2017
Journal: Leukemia
Title: Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Volume: 31
Issue: 6
Pages: 1415-1422
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Publication
23675459 | J:202176
First Author: Xu D
Year: 2013
Journal: PLoS One
Title: Activating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorder.
Volume: 8
Issue: 5
Pages: e63152
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Publication
19509418 | J:153461
First Author: Zhang W
Year: 2009
Journal: J Biol Chem
Title: Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.
Volume: 284
Issue: 33
Pages: 22353-63
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Publication
25650089 | J:221972
First Author: Chen L
Year: 2015
Journal: Leukemia
Title: Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.
Volume: 29
Issue: 6
Pages: 1290-300
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Publication
20651068 | J:166477
First Author: Xu D
Year: 2010
Journal: Blood
Title: A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Volume: 116
Issue: 18
Pages: 3611-21
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Publication
21930766 | J:177285
First Author: Xu D
Year: 2011
Journal: J Exp Med
Title: Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.
Volume: 208
Issue: 10
Pages: 1977-88
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Publication
19528235 | J:151520
First Author: Yang Z
Year: 2009
Journal: Mol Cell Biol
Title: Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants.
Volume: 29
Issue: 16
Pages: 4376-93
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Publication
28975680 | J:249974
First Author: Tarnawsky SP
Year: 2017
Journal: Dev Dyn
Title: Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.
Volume: 246
Issue: 12
Pages: 1001-1014
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Publication
23884424 | J:203541
First Author: Zheng H
Year: 2013
Journal: J Biol Chem
Title: Induction of a tumor-associated activating mutation in protein tyrosine phosphatase Ptpn11 (Shp2) enhances mitochondrial metabolism, leading to oxidative stress and senescence.
Volume: 288
Issue: 36
Pages: 25727-38
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Publication
18316486 | J:148445
First Author: Kontaridis MI
Year: 2008
Journal: Circulation
Title: Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
Volume: 117
Issue: 11
Pages: 1423-35
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Publication
30355677 | J:271155
First Author: Hill KS
Year: 2019
Journal: Mol Cancer Res
Title: PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas.
Volume: 17
Issue: 2
Pages: 583-593
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Protein
Q05C78
Organism: Mus musculus/domesticus
Length: 276  
Fragment?: true
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Publication
24865967 | J:223678
First Author: Paardekooper Overman J
Year: 2014
Journal: Mol Cell Biol
Title: PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice.
Volume: 34
Issue: 15
Pages: 2874-89
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Publication
25359717 | J:237450
First Author: Edwards MA
Year: 2015
Journal: J Appl Physiol (1985)
Title: The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration.
Volume: 118
Issue: 1
Pages: 124-31
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Publication
30467378 | J:294542
First Author: Zhao H
Year: 2019
Journal: Oncogene
Title: Conditional knockout of SHP2 in ErbB2 transgenic mice or inhibition in HER2-amplified breast cancer cell lines blocks oncogene expression and tumorigenesis.
Volume: 38
Issue: 13
Pages: 2275-2290
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Publication
25538234 | J:232693
First Author: Li XJ
Year: 2015
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst.
Volume: 290
Issue: 7
Pages: 3894-909
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Publication
28804122 | J:253876
First Author: Gu S
Year: 2018
Journal: Leukemia
Title: SHP2 is required for BCR-ABL1-induced hematologic neoplasia.
Volume: 32
Issue: 1
Pages: 203-213
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Publication
23530062 | J:204026
First Author: Coulombe G
Year: 2013
Journal: Mol Cell Biol
Title: Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice.
Volume: 33
Issue: 11
Pages: 2275-84
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Publication
24077964 | J:202827
First Author: Lapinski PE
Year: 2013
Journal: Dis Model Mech
Title: Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice.
Volume: 6
Issue: 6
Pages: 1448-58
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Publication
31562133 | J:285765
First Author: Bellio M
Year: 2019
Journal: Blood
Title: Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions.
Volume: 134
Issue: 25
Pages: 2304-2317
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Publication
27942593 | J:293588
First Author: Yi JS
Year: 2016
Journal: JCI Insight
Title: Low-dose dasatinib rescues cardiac function in Noonan syndrome.
Volume: 1
Issue: 20
Pages: e90220
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Publication
29774106 | J:294741
First Author: Tarnawsky SP
Year: 2018
Journal: Oncotarget
Title: Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice.
Volume: 9
Issue: 31
Pages: 21831-21843
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Publication
22890240 | J:191834
First Author: Liu X
Year: 2012
Journal: Cancer Res
Title: Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability.
Volume: 72
Issue: 20
Pages: 5296-306
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Publication
27582544 | J:309023
First Author: Gagné-Sansfaçon J
Year: 2016
Journal: Oncotarget
Title: SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development.
Volume: 7
Issue: 40
Pages: 65676-65695
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Publication
19541608 | J:150835
First Author: Nakamura T
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development.
Volume: 106
Issue: 27
Pages: 11270-5
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Publication
39570442 | J:359548
First Author: Guhathakurta D
Year: 2024
Journal: Cell Mol Neurobiol
Title: Rasopathy-Associated Mutation Ptpn11(D61Y) has Age-Dependent Effect on Synaptic Vesicle Recycling.
Volume: 44
Issue: 1
Pages: 77
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Publication
32584792 | J:301775
 
First Author: Yi JS
Year: 2020
Journal: JCI Insight
Title: Tyrosyl phosphorylation of PZR promotes hypertrophic cardiomyopathy in PTPN11-associated Noonan syndrome with multiple lentigines.
Volume: 5
Issue: 15
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Publication
25288766 | J:216593
First Author: Tajan M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.
Volume: 111
Issue: 42
Pages: E4494-503
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Publication
24875294 | J:226886
First Author: Bowen ME
Year: 2014
Journal: PLoS Genet
Title: SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.
Volume: 10
Issue: 5
Pages: e1004364
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Publication
33689087 | J:307835
     
First Author: Yi JS
Year: 2021
Journal: Cardiovasc Drugs Ther
Title: Low-dose Dasatinib Ameliorates Hypertrophic Cardiomyopathy in Noonan Syndrome with Multiple Lentigines.
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Publication
28582432 | J:246003
First Author: Wang J
Year: 2017
Journal: PLoS One
Title: In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy.
Volume: 12
Issue: 6
Pages: e0178905
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Publication
29644115 | J:287059
 
First Author: Zuo C
Year: 2018
Journal: Bone Res
Title: SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity.
Volume: 6
Pages: 12
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Publication
29464054 | J:310955
First Author: Deng L
Year: 2018
Journal: Oncotarget
Title: Rapid development of myeloproliferative neoplasm in mice with Ptpn11D61Y mutation and haploinsufficient for Dnmt3a.
Volume: 9
Issue: 5
Pages: 6055-6061
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Publication
29559584 | J:284401
 
First Author: Zheng H
Year: 2018
Journal: Sci Signal
Title: Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.
Volume: 11
Issue: 522
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Publication
10742110 | J:61487
First Author: Saxton TM
Year: 2000
Journal: Nat Genet
Title: The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.
Volume: 24
Issue: 4
Pages: 420-3
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Publication
38910965 | J:350175
 
First Author: Weiss EM
Year: 2024
Journal: Front Cell Neurosci
Title: Developmental effect of RASopathy mutations on neuronal network activity on a chip.
Volume: 18
Pages: 1388409
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Publication
28346493 | J:242312
First Author: Altmüller F
Year: 2017
Journal: PLoS Genet
Title: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Volume: 13
Issue: 3
Pages: e1006684
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Publication
33165997 | J:308779
First Author: Wang L
Year: 2021
Journal: FASEB J
Title: SHP2 regulates the development of intestinal epithelium by modifying OSTERIX+ crypt stem cell self-renewal and proliferation.
Volume: 35
Issue: 1
Pages: e21106
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Publication
10700187 | J:60750
First Author: Chen B
Year: 2000
Journal: Nat Genet
Title: Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
Volume: 24
Issue: 3
Pages: 296-9
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Publication
29808009 | J:336458
First Author: Ruess DA
Year: 2018
Journal: Nat Med
Title: Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.
Volume: 24
Issue: 7
Pages: 954-960
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Publication
29046360 | J:270161
First Author: Wang L
Year: 2018
Journal: FASEB J
Title: A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.
Volume: 32
Issue: 2
Pages: 875-887
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Publication
22371576 | J:182238
First Author: De Rocca Serra-Nédélec A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.
Volume: 109
Issue: 11
Pages: 4257-62
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Publication
24599474 | J:209617
First Author: Ehrman LA
Year: 2014
Journal: J Neurosci
Title: The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.
Volume: 34
Issue: 10
Pages: 3767-78
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Publication
12219085 | J:79073
First Author: Tebbutt NC
Year: 2002
Journal: Nat Med
Title: Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
Volume: 8
Issue: 10
Pages: 1089-97
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Publication
31634485 | J:294628
 
First Author: Gong H
Year: 2019
Journal: J Mol Cell Cardiol
Title: Shp2 in myocytes is essential for cardiovascular and neointima development.
Volume: 137
Pages: 71-81
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Publication
24431450 | J:205567
First Author: Li K
Year: 2014
Journal: J Neurosci
Title: Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum.
Volume: 34
Issue: 3
Pages: 922-31
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Publication
19017799 | J:142212
First Author: Krenz M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.
Volume: 105
Issue: 48
Pages: 18930-5
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Protein Coding Gene
MGP_CAROLIEiJ_G0027677 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029987 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99511 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029124 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029685 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029835 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029792 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029822 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030492 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028838 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024257 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028675 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16179375 | J:126616
First Author: Ai J
Year: 2006
Journal: Blood
Title: The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1.
Volume: 107
Issue: 2
Pages: 813-20
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Publication
24706815 | J:208629
First Author: Lajiness JD
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation.
Volume: 111
Issue: 14
Pages: E1374-82
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Publication
23929766 | J:233244
First Author: Kim HK
Year: 2014
Journal: J Bone Miner Res
Title: Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions.
Volume: 29
Issue: 3
Pages: 761-9
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Publication
23103841 | J:193632
First Author: Nabinger SC
Year: 2013
Journal: Leukemia
Title: The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Volume: 27
Issue: 2
Pages: 398-408
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Publication
38451719 | J:360580
 
First Author: Kan C
Year: 2024
Journal: JCI Insight
Title: Phase separation of SHP2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes.
Volume: 9
Issue: 8
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Publication
17056523 | J:140530
First Author: Nguyen TV
Year: 2006
Journal: J Immunol
Title: Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.
Volume: 177
Issue: 9
Pages: 5990-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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