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Search results 1 to 100 out of 138 for Ptpn13

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0.052s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: This entry represents non-receptor PTPase type 13 (also known as PTPL1, FAP-1 and PTP-BL). Studies indicate that this PTPase is involved in multiple regulatory functions including: negative regulation of FAS-induced apoptosis and NGFR-mediated pro-apoptotic signalling, regulation of the phophorylation status of ephrinB receptors in neurons, regulation of cytokinesis in epithelial cells, and the regulation of negative proliferation signals in breast cancer cells [, , , ]. This protein has been shown to interact with a wide variety of partners, an ability conferred by the presence of five distinct PDZ domains, and is thus suggested to function as an integrator between different signalling pathways. Multiple isoforms of this protein are formed by alternative splicing, which can dramatically affect its protein binding characteristics [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 1015  
Fragment?: false
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Sardina JL
Year: 2014
Journal: Biochim Biophys Acta
Title: PTPN13 regulates cellular signalling and β-catenin function during megakaryocytic differentiation.
Volume: 1843
Issue: 12
Pages: 2886-99
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Hagemann N
Year: 2013
Journal: Oncogene
Title: The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
Volume: 32
Issue: 39
Pages: 4602-13
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 2453  
Fragment?: false
Protein
Organism: Mus musculus
Length: 2451  
Fragment?: false
Publication
First Author: Irie S
Year: 1999
Journal: FEBS Lett
Title: Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation.
Volume: 460
Issue: 2
Pages: 191-8
Publication
First Author: Palmer A
Year: 2002
Journal: Mol Cell
Title: EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.
Volume: 9
Issue: 4
Pages: 725-37
Publication
First Author: Herrmann L
Year: 2003
Journal: Mol Biol Cell
Title: The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis.
Volume: 14
Issue: 1
Pages: 230-40
Publication
First Author: Freiss G
Year: 1998
Journal: Mol Endocrinol
Title: Extinction of insulin-like growth factor-I mitogenic signaling by antiestrogen-stimulated Fas-associated protein tyrosine phosphatase-1 in human breast cancer cells.
Volume: 12
Issue: 4
Pages: 568-79
Publication
First Author: Erdmann KS
Year: 2000
Journal: Oncogene
Title: The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.
Volume: 19
Issue: 34
Pages: 3894-901
Publication
First Author: van den Maagdenberg AM
Year: 1996
Journal: Cytogenet Cell Genet
Title: The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21.
Volume: 74
Issue: 1-2
Pages: 153-5
Publication
First Author: Nedachi T
Year: 2004
Journal: Development
Title: Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation.
Volume: 131
Issue: 20
Pages: 4987-98
Publication
First Author: Kawano S
Year: 2009
Journal: J Biol Chem
Title: Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2.
Volume: 284
Issue: 35
Pages: 23793-805
Publication
First Author: Bauler TJ
Year: 2008
Journal: PLoS One
Title: The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
Volume: 3
Issue: 12
Pages: e4014
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Hendriks W
Year: 1995
Journal: J Cell Biochem
Title: Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins.
Volume: 59
Issue: 4
Pages: 418-30
Publication
First Author: Chida D
Year: 1995
Journal: FEBS Lett
Title: Characterization of a protein tyrosine phosphatase (RIP) expressed at a very early stage of differentiation in both mouse erythroleukemia and embryonal carcinoma cells.
Volume: 358
Issue: 3
Pages: 233-9
Publication
First Author: Sato T
Year: 1995
Journal: Science
Title: FAP-1: a protein tyrosine phosphatase that associates with Fas.
Volume: 268
Issue: 5209
Pages: 411-5
Publication
First Author: Nakahira M
Year: 2007
Journal: Immunity
Title: Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL.
Volume: 26
Issue: 2
Pages: 163-76
Publication
First Author: Wansink DG
Year: 2004
Journal: Physiol Genomics
Title: Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity.
Volume: 19
Issue: 1
Pages: 50-60
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3693569
Assay Type: RT-PCR
Annotation Date: 2007-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1771322
Stage: TS22
Assay Id: MGI:3693777
Age: embryonic day 14.5
Detected: true
Specimen Num: 1
GXD Expression        
Probe: MGI:3693569
Assay Type: RT-PCR
Annotation Date: 2007-01-15
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1771322
Stage: TS22
Assay Id: MGI:3693777
Age: embryonic day 14.5
Specimen Num: 2
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1671516
Stage: TS16
Assay Id: MGI:6192390
Age: embryonic day 10.0
Image: 5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1671520
Stage: TS20
Assay Id: MGI:6192390
Age: embryonic day 12.0
Image: 5
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3670212
Stage: TS12
Assay Id: MGI:6192390
Age: embryonic day 8.5
Image: 5
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3033363
Age: embryonic day 13.5
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:6431267
Assay Type: RT-PCR
Annotation Date: 2020-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586222
Stage: TS22
Assay Id: MGI:6431277
Age: embryonic day 14.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893924
Stage: TS24
Assay Id: MGI:6192390
Age: embryonic day 16.0
Image: 5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6192390
Age: postnatal week 1
Image: 5
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6192382
Assay Type: RT-PCR
Annotation Date: 2018-07-31
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:6192390
Age: postnatal week 6
Image: 5
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:6431267
Assay Type: RT-PCR
Annotation Date: 2020-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3510422
Stage: TS22
Assay Id: MGI:6431277
Age: embryonic day 14.5
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:1096626
Assay Type: Northern blot
Annotation Date: 2004-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3033363
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6431267
Assay Type: RT-PCR
Annotation Date: 2020-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:6431277
Age: embryonic day 14.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6272759
Age: postnatal
Note: No specific expression in placenta.
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: High expression within ependymal cell layer of fourth ventricle.
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1702326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: High expression in epithelia of stomach.
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3525122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6272759
Age: embryonic day 14.5
Note: Authors report expression in some non-epithelial cells, such as connective tissue surrounding the vertebra in day 14.5 embryos.
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1683524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752824
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603915
Pattern: Widespread
Stage: TS15
Assay Id: MGI:6272759
Age: embryonic day 9.5
Note: High expression in all cells of the embryo.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2808924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3286024
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3292826
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: Low expression in epithelial cells of the gut.
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3269326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: High expression in epithelia of bronchioli of lung.
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1868526
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: Expression within seminiferous tubules of testis.
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2825726
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6272759
Age: embryonic day 18.5
Note: Expression in cells forming Bowman's capsule of kidney.
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1760524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3609677
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610142
Age: embryonic day 14.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3609677
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610142
Age: embryonic day 16.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression in epithelial cells surrounding vesicles of the brain.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6272757
Assay Type: RNA in situ
Annotation Date: 2019-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2860124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6272759
Age: embryonic day 16.5
Note: Expression restricted to epithelial cells. Expression in epithelia of skin, esophagus, nasal cavity, lung, kidney, ureter and bladder.v
Detected: true
Specimen Num: 3
Publication
First Author: Cuppen E
Year: 1998
Journal: Mol Biol Cell
Title: PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL.
Volume: 9
Issue: 3
Pages: 671-83
Publication
First Author: Sawada M
Year: 1994
Journal: Biochem Biophys Res Commun
Title: cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells.
Volume: 203
Issue: 1
Pages: 479-84
Publication
First Author: Cuppen E
Year: 1999
Journal: FEBS Lett
Title: Identification and molecular characterization of BP75, a novel bromodomain-containing protein.
Volume: 459
Issue: 3
Pages: 291-8
Publication
First Author: Lorber B
Year: 2005
Journal: Eur J Neurosci
Title: Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury.
Volume: 21
Issue: 9
Pages: 2375-83
Publication
First Author: van Ham M
Year: 2003
Journal: Genes Cells
Title: Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL.
Volume: 8
Issue: 7
Pages: 631-44
Publication
First Author: Cuppen E
Year: 2000
Journal: Eur J Cell Biol
Title: The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.
Volume: 79
Issue: 4
Pages: 283-93
Publication
First Author: van den Berk LC
Year: 2004
Journal: Mol Biol Rep
Title: The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain.
Volume: 31
Issue: 4
Pages: 203-15
Publication
First Author: Abaan OD
Year: 2013
Journal: Exp Cell Res
Title: Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.
Volume: 319
Issue: 1
Pages: 1-11
Publication
First Author: Kalyani R
Year: 2016
Journal: Mol Cells
Title: Genes Frequently Coexpressed with Hoxc8 Provide Insight into the Discovery of Target Genes.
Volume: 39
Issue: 5
Pages: 395-402
Publication
First Author: Zhang Z
Year: 2017
Journal: Sci Rep
Title: Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.
Volume: 7
Issue: 1
Pages: 14796
Publication  
First Author: Hendriks W
Year: 1995
Journal: Biochem J
Title: A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain.
Volume: 305 ( Pt 2)
Pages: 499-504