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Search results 1 to 100 out of 143 for Ptpn22

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
26191 | PTPN22
Type: gene
Organism: human
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Gene
100495002 | ptpn22
Type: gene
Organism: frog, western clawed
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Gene
295338 | Ptpn22
Type: gene
Organism: rat
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Gene
483124 | PTPN22
Type: gene
Organism: dog, domestic
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Gene
457136 | PTPN22
Type: gene
Organism: chimpanzee
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Gene
518992 | PTPN22
Type: gene
Organism: cattle
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Gene
772032 | PTPN22
Type: gene
Organism: chicken
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Gene
565606 | ptpn22
Type: gene
Organism: zebrafish
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Gene
707433 | PTPN22
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR016276 | PTPN22
Type: Family
Description: Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [].
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Protein Coding Gene
MGI:107170 | Ptpn22
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
8890164 | J:169817
First Author: Cloutier JF
Year: 1996
Journal: EMBO J
Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Volume: 15
Issue: 18
Pages: 4909-18
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Publication
15273934 | -
First Author: Kyogoku C
Year: 2004
Journal: Am J Hum Genet
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Volume: 75
Issue: 3
Pages: 504-7
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Publication
27807193 | J:269074
First Author: Vermeren S
Year: 2016
Journal: J Immunol
Title: PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.
Volume: 197
Issue: 12
Pages: 4771-4779
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Publication
28786745 | J:324321
First Author: Spalinger MR
Year: 2017
Journal: Autophagy
Title: PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner.
Volume: 13
Issue: 9
Pages: 1590-1601
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Publication
32469452 | J:307313
First Author: Zhang X
Year: 2020
Journal: FASEB J
Title: PTPN22 interacts with EB1 to regulate T-cell receptor signaling.
Volume: 34
Issue: 7
Pages: 8959-8974
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Publication
35587260 | J:342728
   
First Author: James J
Year: 2022
Journal: Elife
Title: Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.
Volume: 11
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Publication
32194571 | J:304655
 
First Author: Purvis HA
Year: 2020
Journal: Front Immunol
Title: Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Volume: 11
Pages: 376
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Publication
35767715 | J:343975
First Author: Wang X
Year: 2022
Journal: Blood
Title: Protein tyrosine phosphatase PTPN22 negatively modulates platelet function and thrombus formation.
Volume: 140
Issue: 9
Pages: 1038-1051
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Publication
22539785 | J:188743
First Author: Maine CJ
Year: 2012
Journal: J Immunol
Title: PTPN22 alters the development of regulatory T cells in the thymus.
Volume: 188
Issue: 11
Pages: 5267-75
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Publication
23871208 | J:208241
First Author: Wang Y
Year: 2013
Journal: Immunity
Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Volume: 39
Issue: 1
Pages: 111-22
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Publication
25715232 | J:333635
First Author: Salmond RJ
Year: 2015
Journal: Cell Cycle
Title: Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis.
Volume: 14
Issue: 5
Pages: 705-11
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Publication
21841778 | J:176519
First Author: Zhang J
Year: 2011
Journal: Nat Genet
Title: The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.
Volume: 43
Issue: 9
Pages: 902-7
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Publication
25108421 | J:259368
First Author: Salmond RJ
Year: 2014
Journal: Nat Immunol
Title: The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Volume: 15
Issue: 9
Pages: 875-883
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Publication
27799548 | J:238853
First Author: Maine CJ
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.
Volume: 113
Issue: 46
Pages: E7231-E7239
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Publication
23619366 | J:201448
First Author: Dai X
Year: 2013
Journal: J Clin Invest
Title: A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Volume: 123
Issue: 5
Pages: 2024-36
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Publication
23913970 | J:205805
First Author: Chang HH
Year: 2013
Journal: J Immunol
Title: PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Volume: 191
Issue: 5
Pages: 2134-43
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Publication
28948613 | J:258225
First Author: Purvis HA
Year: 2018
Journal: Eur J Immunol
Title: Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.
Volume: 48
Issue: 2
Pages: 306-315
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Publication
30139951 | J:278018
First Author: Clarke F
Year: 2018
Journal: Sci Rep
Title: The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Volume: 8
Issue: 1
Pages: 12692
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Publication
24453256 | J:209446
First Author: Maine CJ
Year: 2014
Journal: J Immunol
Title: PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Volume: 192
Issue: 4
Pages: 1415-24
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Publication
31732921 | J:327311
First Author: Shi X
Year: 2020
Journal: Endocrine
Title: Regulation of B cell homeostasis by Ptpn22 contributes to type 1 diabetes in NOD mice.
Volume: 67
Issue: 3
Pages: 535-543
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Publication
31335326 | J:298853
   
First Author: Brownlie RJ
Year: 2019
Journal: JCI Insight
Title: Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors.
Volume: 5
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Publication
25748328 | J:220848
First Author: Fousteri G
Year: 2015
Journal: Diabetologia
Title: Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.
Volume: 58
Issue: 6
Pages: 1319-28
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Publication
25513733 | J:319081
First Author: Fousteri G
Year: 2015
Journal: Clin Immunol
Title: PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Volume: 156
Issue: 2
Pages: 98-108
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Publication
27288531 | J:269078
First Author: Sood S
Year: 2016
Journal: J Immunol
Title: Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Volume: 197
Issue: 2
Pages: 429-40
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Publication
27703032 | J:260328
First Author: Burn GL
Year: 2016
Journal: Sci Signal
Title: Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.
Volume: 9
Issue: 448
Pages: ra99
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Publication
23193160 | J:259087
First Author: Brownlie RJ
Year: 2012
Journal: Sci Signal
Title: Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Volume: 5
Issue: 252
Pages: ra87
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Publication
29040339 | J:246520
First Author: Clarke F
Year: 2017
Journal: PLoS One
Title: Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
Volume: 12
Issue: 10
Pages: e0186625
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Publication
23193190 | J:208596
First Author: Zheng P
Year: 2013
Journal: Diabetes
Title: PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.
Volume: 62
Issue: 3
Pages: 896-904
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Publication
39227386 | J:361202
First Author: Lee J
Year: 2024
Journal: Nat Commun
Title: Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression.
Volume: 15
Issue: 1
Pages: 7688
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Protein
P29352
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Publication
26019128 | J:323901
First Author: Chang HH
Year: 2015
Journal: Arthritis Rheumatol
Title: The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.
Volume: 67
Issue: 9
Pages: 2323-34
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Publication
26438525 | J:354520
First Author: Fraser HI
Year: 2015
Journal: J Immunol
Title: Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.
Volume: 195
Issue: 10
Pages: 4841-52
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Publication
32047502 | J:304128
 
First Author: Knipper JA
Year: 2020
Journal: Front Immunol
Title: PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.
Volume: 11
Pages: 52
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Publication
27926878 | J:241670
First Author: Davidson D
Year: 2016
Journal: Cell Rep
Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Volume: 17
Issue: 10
Pages: 2776-2788
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Publication
31501515 | J:293503
First Author: Spalinger MR
Year: 2019
Journal: Mucosal Immunol
Title: Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.
Volume: 12
Issue: 6
Pages: 1336-1347
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Publication
19299707 | J:147129
First Author: Zikherman J
Year: 2009
Journal: J Immunol
Title: PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
Volume: 182
Issue: 7
Pages: 4093-106
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Publication
23752610 | J:204826
First Author: Yeh LT
Year: 2013
Journal: J Immunol
Title: Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.
Volume: 191
Issue: 2
Pages: 594-607
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Publication
28801357 | J:251618
First Author: Metzler G
Year: 2017
Journal: J Immunol
Title: The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.
Volume: 199
Issue: 7
Pages: 2249-2260
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Publication
29116089 | J:257206
First Author: Brownlie RJ
Year: 2017
Journal: Nat Commun
Title: Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Volume: 8
Issue: 1
Pages: 1343
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Publication
16938887 | J:169898
First Author: Liu J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A biosynthetic pathway for anandamide.
Volume: 103
Issue: 36
Pages: 13345-50
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Publication
31107248 | J:289725
First Author: Spalinger MR
Year: 2019
Journal: J Clin Invest
Title: Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
Volume: 129
Issue: 6
Pages: 2527-2541
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Publication
34417261 | J:341570
First Author: Orozco RC
Year: 2021
Journal: J Immunol
Title: Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity.
Volume: 207
Issue: 6
Pages: 1662-1671
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Publication
27043286 | J:234957
First Author: Spalinger MR
Year: 2016
Journal: J Clin Invest
Title: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Volume: 126
Issue: 5
Pages: 1783-800
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Publication
26077719 | J:226353
First Author: Holmes DA
Year: 2015
Journal: J Exp Med
Title: Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling.
Volume: 212
Issue: 7
Pages: 1081-93
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Publication
17631919 | J:132692
First Author: Liu J
Year: 2008
Journal: Neuropharmacology
Title: Multiple pathways involved in the biosynthesis of anandamide.
Volume: 54
Issue: 1
Pages: 1-7
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Publication
23991106 | J:221551
First Author: Spalinger MR
Year: 2013
Journal: PLoS One
Title: Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.
Volume: 8
Issue: 8
Pages: e72384
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Publication
24498279 | J:212852
First Author: Wu DJ
Year: 2014
Journal: PLoS One
Title: Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.
Volume: 9
Issue: 2
Pages: e86677
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Publication
31194881 | J:289869
First Author: Jofra T
Year: 2019
Journal: Clin Exp Immunol
Title: Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.
Volume: 197
Issue: 3
Pages: 263-275
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Publication
27653681 | J:239126
First Author: Zhang Z
Year: 2016
Journal: Cell Rep
Title: Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Volume: 16
Issue: 12
Pages: 3146-3156
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Publication
26329582 | J:259486
First Author: Lin WW
Year: 2015
Journal: Sci Signal
Title: The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.
Volume: 8
Issue: 392
Pages: ra88
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Protein Coding Gene
MGP_CAROLIEiJ_G0025458 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027662 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027627 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027404 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_107170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028118 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026860 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027379 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027489 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027519 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028173 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026902 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026407 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
27207523 | J:246242
First Author: Lin X
Year: 2016
Journal: Diabetes
Title: CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes.
Volume: 65
Issue: 8
Pages: 2134-8
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Publication
21044313 | J:170289
 
First Author: Wang S
Year: 2010
Journal: BMC Mol Biol
Title: Identification of a variant form of tyrosine phosphatase LYP.
Volume: 11
Pages: 78
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Publication
10940933 | J:169808
First Author: Gjörloff-Wingren A
Year: 2000
Journal: Eur J Immunol
Title: Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Volume: 30
Issue: 8
Pages: 2412-21
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666523
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Specimen Label: euxassay_000154_16
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_11
Specimen Label: euxassay_000154_11
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_12
Specimen Label: euxassay_000154_12
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_13
Specimen Label: euxassay_000154_13
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_14
Specimen Label: euxassay_000154_14
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_15
Specimen Label: euxassay_000154_15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Specimen Label: euxassay_000154_16
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_08
Specimen Label: euxassay_000154_08
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_15
Specimen Label: euxassay_000154_15
Detected: true
Specimen Num: 6
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•
GXD Expression
GXD Expression
 
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Specimen Label: euxassay_000154_16
Detected: true
Specimen Num: 7
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Publication
9582365 | J:47725
First Author: Gregorieff A
Year: 1998
Journal: J Biol Chem
Title: Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk).
Volume: 273
Issue: 21
Pages: 13217-22
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Publication
1373816 | J:32702
First Author: Matthews RJ
Year: 1992
Journal: Mol Cell Biol
Title: Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.
Volume: 12
Issue: 5
Pages: 2396-405
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Publication
14752163 | J:90029
First Author: Hasegawa K
Year: 2004
Journal: Science
Title: PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.
Volume: 303
Issue: 5658
Pages: 685-9
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Publication
28553952 | J:257959
First Author: Gorman JA
Year: 2017
Journal: Nat Immunol
Title: The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
Volume: 18
Issue: 7
Pages: 744-752
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Publication
25993510 | J:235414
First Author: Liu CC
Year: 2015
Journal: PLoS One
Title: Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.
Volume: 10
Issue: 5
Pages: e0127617
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Publication
15786712 | J:180575
First Author: Watanabe N
Year: 2005
Journal: Mol Cell Biochem
Title: Leupaxin binds to PEST domain tyrosine phosphatase PEP.
Volume: 269
Issue: 1-2
Pages: 13-7
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Publication
16015370 | J:101473
First Author: Johannesson M
Year: 2005
Journal: Genes Immun
Title: Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
Volume: 6
Issue: 7
Pages: 575-83
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