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Search results 1 to 100 out of 117 for Ptpn22

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0.052s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) acts as negative regulator of T-cell receptor (TCR) signalling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signalling molecules [].Variations of the PTPN22 gene affects the susceptibility of systemic lupus erythematosus (SLE) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Cloutier JF
Year: 1996
Journal: EMBO J
Title: Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Volume: 15
Issue: 18
Pages: 4909-18
Publication
First Author: Kyogoku C
Year: 2004
Journal: Am J Hum Genet
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
Volume: 75
Issue: 3
Pages: 504-7
Publication
First Author: Vermeren S
Year: 2016
Journal: J Immunol
Title: PTPN22 Is a Critical Regulator of Fcγ Receptor-Mediated Neutrophil Activation.
Volume: 197
Issue: 12
Pages: 4771-4779
Publication
First Author: Zhang X
Year: 2020
Journal: FASEB J
Title: PTPN22 interacts with EB1 to regulate T-cell receptor signaling.
Volume: 34
Issue: 7
Pages: 8959-8974
Publication  
First Author: Purvis HA
Year: 2020
Journal: Front Immunol
Title: Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses.
Volume: 11
Pages: 376
Publication
First Author: Maine CJ
Year: 2012
Journal: J Immunol
Title: PTPN22 alters the development of regulatory T cells in the thymus.
Volume: 188
Issue: 11
Pages: 5267-75
Publication
First Author: Wang Y
Year: 2013
Journal: Immunity
Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
Volume: 39
Issue: 1
Pages: 111-22
Publication
First Author: Dai X
Year: 2013
Journal: J Clin Invest
Title: A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
Volume: 123
Issue: 5
Pages: 2024-36
Publication
First Author: Salmond RJ
Year: 2014
Journal: Nat Immunol
Title: The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Volume: 15
Issue: 9
Pages: 875-883
Publication
First Author: Zhang J
Year: 2011
Journal: Nat Genet
Title: The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.
Volume: 43
Issue: 9
Pages: 902-7
Publication
First Author: Maine CJ
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection.
Volume: 113
Issue: 46
Pages: E7231-E7239
Publication
First Author: Chang HH
Year: 2013
Journal: J Immunol
Title: PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis.
Volume: 191
Issue: 5
Pages: 2134-43
Publication
First Author: Fousteri G
Year: 2015
Journal: Diabetologia
Title: Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice.
Volume: 58
Issue: 6
Pages: 1319-28
Publication
First Author: Purvis HA
Year: 2018
Journal: Eur J Immunol
Title: Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice.
Volume: 48
Issue: 2
Pages: 306-315
Publication
First Author: Clarke F
Year: 2018
Journal: Sci Rep
Title: The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.
Volume: 8
Issue: 1
Pages: 12692
Publication    
First Author: Brownlie RJ
Year: 2019
Journal: JCI Insight
Title: Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors.
Volume: 5
Publication
First Author: Maine CJ
Year: 2014
Journal: J Immunol
Title: PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.
Volume: 192
Issue: 4
Pages: 1415-24
Publication
First Author: Sood S
Year: 2016
Journal: J Immunol
Title: Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.
Volume: 197
Issue: 2
Pages: 429-40
Publication
First Author: Burn GL
Year: 2016
Journal: Sci Signal
Title: Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity.
Volume: 9
Issue: 448
Pages: ra99
Publication
First Author: Zheng P
Year: 2013
Journal: Diabetes
Title: PTPN22 silencing in the NOD model indicates the type 1 diabetes-associated allele is not a loss-of-function variant.
Volume: 62
Issue: 3
Pages: 896-904
Publication
First Author: Brownlie RJ
Year: 2012
Journal: Sci Signal
Title: Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function.
Volume: 5
Issue: 252
Pages: ra87
Publication
First Author: Clarke F
Year: 2017
Journal: PLoS One
Title: Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells.
Volume: 12
Issue: 10
Pages: e0186625
Publication  
First Author: Knipper JA
Year: 2020
Journal: Front Immunol
Title: PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion.
Volume: 11
Pages: 52
Publication
First Author: Davidson D
Year: 2016
Journal: Cell Rep
Title: The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.
Volume: 17
Issue: 10
Pages: 2776-2788
Publication
First Author: Spalinger MR
Year: 2019
Journal: Mucosal Immunol
Title: Loss of PTPN22 abrogates the beneficial effect of cohousing-mediated fecal microbiota transfer in murine colitis.
Volume: 12
Issue: 6
Pages: 1336-1347
Protein
Organism: Mus musculus
Length: 802  
Fragment?: false
Publication
First Author: Zikherman J
Year: 2009
Journal: J Immunol
Title: PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
Volume: 182
Issue: 7
Pages: 4093-106
Publication
First Author: Yeh LT
Year: 2013
Journal: J Immunol
Title: Different modulation of Ptpn22 in effector and regulatory T cells leads to attenuation of autoimmune diabetes in transgenic nonobese diabetic mice.
Volume: 191
Issue: 2
Pages: 594-607
Publication
First Author: Metzler G
Year: 2017
Journal: J Immunol
Title: The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.
Volume: 199
Issue: 7
Pages: 2249-2260
Publication
First Author: Brownlie RJ
Year: 2017
Journal: Nat Commun
Title: Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Volume: 8
Issue: 1
Pages: 1343
Publication
First Author: Spalinger MR
Year: 2019
Journal: J Clin Invest
Title: Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner.
Volume: 129
Issue: 6
Pages: 2527-2541
Publication
First Author: Liu J
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A biosynthetic pathway for anandamide.
Volume: 103
Issue: 36
Pages: 13345-50
Publication
First Author: Spalinger MR
Year: 2016
Journal: J Clin Invest
Title: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
Volume: 126
Issue: 5
Pages: 1783-800
Publication
First Author: Liu J
Year: 2008
Journal: Neuropharmacology
Title: Multiple pathways involved in the biosynthesis of anandamide.
Volume: 54
Issue: 1
Pages: 1-7
Publication
First Author: Holmes DA
Year: 2015
Journal: J Exp Med
Title: Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling.
Volume: 212
Issue: 7
Pages: 1081-93
Publication
First Author: Wu DJ
Year: 2014
Journal: PLoS One
Title: Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.
Volume: 9
Issue: 2
Pages: e86677
Publication
First Author: Spalinger MR
Year: 2013
Journal: PLoS One
Title: Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.
Volume: 8
Issue: 8
Pages: e72384
Publication
First Author: Jofra T
Year: 2019
Journal: Clin Exp Immunol
Title: Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.
Volume: 197
Issue: 3
Pages: 263-275
Publication
First Author: Zhang Z
Year: 2016
Journal: Cell Rep
Title: Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation.
Volume: 16
Issue: 12
Pages: 3146-3156
Publication
First Author: Lin WW
Year: 2015
Journal: Sci Signal
Title: The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development.
Volume: 8
Issue: 392
Pages: ra88
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Lin X
Year: 2016
Journal: Diabetes
Title: CRISPR-Cas9-Mediated Modification of the NOD Mouse Genome With Ptpn22R619W Mutation Increases Autoimmune Diabetes.
Volume: 65
Issue: 8
Pages: 2134-8
Publication
First Author: Gjörloff-Wingren A
Year: 2000
Journal: Eur J Immunol
Title: Subcellular localization of intracellular protein tyrosine phosphatases in T cells.
Volume: 30
Issue: 8
Pages: 2412-21
Publication  
First Author: Wang S
Year: 2010
Journal: BMC Mol Biol
Title: Identification of a variant form of tyrosine phosphatase LYP.
Volume: 11
Pages: 78
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666523
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_11
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_12
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_13
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_14
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_15
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_08
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_15
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:349160
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1666823
Pattern: Uniform
Stage: TS23
Assay Id: MGI:4827518
Age: embryonic day 14.5
Image: euxassay_000154_16
Detected: true
Specimen Num: 7
Publication
First Author: Gregorieff A
Year: 1998
Journal: J Biol Chem
Title: Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk).
Volume: 273
Issue: 21
Pages: 13217-22
Publication
First Author: Matthews RJ
Year: 1992
Journal: Mol Cell Biol
Title: Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.
Volume: 12
Issue: 5
Pages: 2396-405
Publication
First Author: Hasegawa K
Year: 2004
Journal: Science
Title: PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.
Volume: 303
Issue: 5658
Pages: 685-9
Publication
First Author: Gorman JA
Year: 2017
Journal: Nat Immunol
Title: The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.
Volume: 18
Issue: 7
Pages: 744-752
Publication
First Author: Liu CC
Year: 2015
Journal: PLoS One
Title: Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.
Volume: 10
Issue: 5
Pages: e0127617
Publication
First Author: Watanabe N
Year: 2005
Journal: Mol Cell Biochem
Title: Leupaxin binds to PEST domain tyrosine phosphatase PEP.
Volume: 269
Issue: 1-2
Pages: 13-7
Publication
First Author: Johannesson M
Year: 2005
Journal: Genes Immun
Title: Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
Volume: 6
Issue: 7
Pages: 575-83
Publication
First Author: Davidson D
Year: 2003
Journal: Mol Cell Biol
Title: Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.
Volume: 23
Issue: 6
Pages: 2017-28
Publication
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms