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Search results 1 to 100 out of 428 for Ptpn6

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Type Details Score
Gene
5777 | PTPN6
Type: gene
Organism: human
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Gene
512312 | PTPN6
Type: gene
Organism: cattle
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Gene
427947 | PTPN6
Type: gene
Organism: chicken
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Gene
335573 | ptpn6
Type: gene
Organism: zebrafish
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Gene
714374 | PTPN6
Type: gene
Organism: macaque, rhesus
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Gene
100144699 | ptpn6
Type: gene
Organism: frog, western clawed
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Gene
116689 | Ptpn6
Type: gene
Organism: rat
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Gene
486717 | PTPN6
Type: gene
Organism: dog, domestic
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Gene
748032 | PTPN6
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:96055 | Ptpn6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
31819256 | J:290374
First Author: Speir M
Year: 2020
Journal: Nat Immunol
Title: Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Volume: 21
Issue: 1
Pages: 54-64
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Publication
22698917 | J:208527
First Author: Xu E
Year: 2012
Journal: Diabetes
Title: Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.
Volume: 61
Issue: 8
Pages: 1949-58
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Publication
- | J:183826
     
First Author: Schultz LD
Year: 2012
Journal: MGI Direct Data Submission
Title: A new spontaneous mutation in Ptpn6 - me-v2J
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Publication
19419305 | J:168664
First Author: Babij P
Year: 2009
Journal: J Bone Miner Res
Title: New variants in the Enpp1 and Ptpn6 genes cause low BMD, crystal-related arthropathy, and vascular calcification.
Volume: 24
Issue: 9
Pages: 1552-64
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Publication
36194675 | J:333063
First Author: Ventura PMO
Year: 2022
Journal: EMBO Rep
Title: Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses.
Volume: 23
Issue: 11
Pages: e55399
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Publication
21435452 | J:169850
First Author: Nesterovitch AB
Year: 2011
Journal: Am J Pathol
Title: Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.
Volume: 178
Issue: 4
Pages: 1701-14
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Publication
24327268 | J:319047
First Author: Xu E
Year: 2014
Journal: Hepatology
Title: Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.
Volume: 59
Issue: 5
Pages: 1803-15
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Publication
33532715 | J:308563
First Author: Yam-Puc JC
Year: 2021
Journal: iScience
Title: Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death.
Volume: 24
Issue: 2
Pages: 102038
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Publication
28533521 | J:288106
First Author: Adhikari A
Year: 2017
Journal: Sci Rep
Title: Hepatocyte SHP-1 is a Critical Modulator of Inflammation During Endotoxemia.
Volume: 7
Issue: 1
Pages: 2218
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Publication
23521885 | J:195276
First Author: Abram CL
Year: 2013
Journal: Immunity
Title: Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.
Volume: 38
Issue: 3
Pages: 489-501
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Publication
29776962 | J:264292
First Author: Wen LZ
Year: 2018
Journal: Cancer Res
Title: SHP-1 Acts as a Tumor Suppressor in Hepatocarcinogenesis and HCC Progression.
Volume: 78
Issue: 16
Pages: 4680-4691
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Publication
33133093 | J:341802
 
First Author: Myers DR
Year: 2020
Journal: Front Immunol
Title: Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Volume: 11
Pages: 576310
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Publication
28410990 | J:254534
First Author: Gurung P
Year: 2017
Journal: Immunity
Title: Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Volume: 46
Issue: 4
Pages: 635-648
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Protein Coding Gene
MGP_CAROLIEiJ_G0028846 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031232 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030963 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96055 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0031080 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0031030 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031160 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0031068 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0030059 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030429 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022607 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029888 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1732748 | J:2618
First Author: Yi TL
Year: 1992
Journal: Mol Cell Biol
Title: Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
Volume: 12
Issue: 2
Pages: 836-46
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Publication
10419485 | J:56522
First Author: Martin A
Year: 1999
Journal: J Biol Chem
Title: Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.
Volume: 274
Issue: 31
Pages: 21725-34
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Publication
11970996 | J:125454
First Author: Deng C
Year: 2002
Journal: J Immunol
Title: Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.
Volume: 168
Issue: 9
Pages: 4511-8
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Publication
27354309 | J:246953
First Author: Martinez RJ
Year: 2016
Journal: Eur J Immunol
Title: Targeted loss of SHP1 in murine thymocytes dampens TCR signaling late in selection.
Volume: 46
Issue: 9
Pages: 2103-10
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Publication
- | J:264807
     
First Author: Choi JH
Year: 2018
Journal: MGI Direct Data Submission
Title: Choi JH; Zhong X; Nair-GillMutagenetix entry for farfalla_norttuna.
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Publication
- | J:265075
     
First Author: Choi JH
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Vermeil.
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Publication
- | J:272440
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for naphthalene.
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Publication
8348149 | J:11892
First Author: Tsui HW
Year: 1993
Journal: Nat Genet
Title: Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene.
Volume: 4
Issue: 2
Pages: 124-9
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Publication
363947 | J:6065
First Author: Sidman CL
Year: 1978
Journal: J Immunol
Title: The mouse mutant "motheaten." II. Functional studies of the immune system.
Volume: 121
Issue: 6
Pages: 2399-404
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Publication
7923924 | J:21151
First Author: Bignon JS
Year: 1994
Journal: Clin Immunol Immunopathol
Title: Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function.
Volume: 73
Issue: 2
Pages: 168-79
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Publication
18987138 | J:153390
First Author: Christophi GP
Year: 2009
Journal: J Virol
Title: Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease.
Volume: 83
Issue: 2
Pages: 522-39
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Publication
15905501 | J:99043
First Author: Carter JD
Year: 2005
Journal: J Immunol
Title: Deficiency of the Src homology region 2 domain-containing phosphatase 1 (SHP-1) causes enrichment of CD4+CD25+ regulatory T cells.
Volume: 174
Issue: 11
Pages: 6627-38
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Publication
10698306 | J:60297
First Author: Martin A
Year: 1999
Journal: Mol Immunol
Title: SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames.
Volume: 36
Issue: 15-16
Pages: 1029-41
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Publication
9263478 | J:42157
First Author: Shultz LD
Year: 1997
Journal: Trends Biotechnol
Title: Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Volume: 15
Issue: 8
Pages: 302-7
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Publication
56406 | J:5624
First Author: Shultz LD
Year: 1976
Journal: J Immunol
Title: Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.
Volume: 116
Issue: 4
Pages: 936-43
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Publication
11745639 | J:72655
First Author: Wishcamper CA
Year: 2001
Journal: J Comp Neurol
Title: Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brain.
Volume: 441
Issue: 2
Pages: 118-33
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Publication
25919645 | J:223807
First Author: Gruber RC
Year: 2015
Journal: Glia
Title: The control of reactive oxygen species production by SHP-1 in oligodendrocytes.
Volume: 63
Issue: 10
Pages: 1753-71
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Publication
10201897 | J:53576
First Author: Johnson KG
Year: 1999
Journal: J Immunol
Title: TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.
Volume: 162
Issue: 7
Pages: 3802-13
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Publication
12511594 | J:81122
First Author: Kamata T
Year: 2003
Journal: J Clin Invest
Title: src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammation.
Volume: 111
Issue: 1
Pages: 109-19
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Publication
11067945 | J:118386
First Author: Kruger J
Year: 2000
Journal: J Immunol
Title: Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice.
Volume: 165
Issue: 10
Pages: 5847-59
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Publication
6350031 | J:7162
First Author: Shultz LD
Year: 1983
Journal: Exp Hematol
Title: Hematopoietic stem cell function in motheaten mice.
Volume: 11
Issue: 7
Pages: 667-80
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Publication
9034146 | J:38943
First Author: Nakamura MC
Year: 1997
Journal: J Exp Med
Title: Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
Volume: 185
Issue: 4
Pages: 673-84
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Publication
25681345 | J:327803
First Author: Watson NB
Year: 2015
Journal: J Immunol
Title: SHP-1-dependent macrophage differentiation exacerbates virus-induced myositis.
Volume: 194
Issue: 6
Pages: 2796-809
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Publication
11145649 | J:66843
First Author: Hsu HC
Year: 2001
Journal: J Immunol
Title: Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Volume: 166
Issue: 2
Pages: 772-80
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Publication
8070815 | J:18549
 
First Author: Tsui FW
Year: 1994
Journal: Immunol Rev
Title: Molecular basis of the motheaten phenotype.
Volume: 138
Pages: 185-206
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Publication
19875169 | J:155341
First Author: Inoue T
Year: 2009
Journal: Mol Immunol
Title: SHP-1 exhibits a pro-apoptotic function in antigen-stimulated mast cells: positive regulation of mitochondrial death pathways and negative regulation of survival signaling pathways.
Volume: 47
Issue: 2-3
Pages: 222-32
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Publication
6361123 | J:7274
First Author: McCoy KL
Year: 1984
Journal: J Immunol
Title: Spontaneous production of colony-stimulating activity by splenic Mac-1 antigen-positive cells from autoimmune motheaten mice.
Volume: 132
Issue: 1
Pages: 272-6
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Publication
1270804 | J:5648
First Author: Lutzner MA
Year: 1976
Journal: J Immunol
Title: Motheater: an immunodeficient mouse with markedly less ability to survive that the nude mouse in a germfree environment.
Volume: 116
Issue: 5
Pages: 1496-7
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Publication
16265671 | J:156147
First Author: Zhao J
Year: 2006
Journal: Glia
Title: Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1beta.
Volume: 53
Issue: 3
Pages: 304-12
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Publication
3873348 | J:7856
First Author: McCoy KL
Year: 1985
Journal: Exp Hematol
Title: Effects of the motheaten gene on murine B-cell production.
Volume: 13
Issue: 6
Pages: 554-9
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Publication
16565987 | J:156128
First Author: Bonaparte KL
Year: 2006
Journal: Glia
Title: Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia.
Volume: 53
Issue: 8
Pages: 827-35
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Publication
18832698 | J:140765
First Author: Nakata K
Year: 2008
Journal: J Immunol
Title: Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1.
Volume: 181
Issue: 8
Pages: 5414-24
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Publication
10590266 | J:59134
First Author: Carter JD
Year: 1999
Journal: Int Immunol
Title: The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.
Volume: 11
Issue: 12
Pages: 1999-2014
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Publication
20696858 | J:163839
First Author: Fowler CC
Year: 2010
Journal: J Immunol
Title: SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cells.
Volume: 185
Issue: 6
Pages: 3256-67
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Publication
20952680 | J:165785
First Author: Iype T
Year: 2010
Journal: J Immunol
Title: The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells.
Volume: 185
Issue: 10
Pages: 6115-27
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Publication
17182570 | J:141929
First Author: Sathish JG
Year: 2007
Journal: J Immunol
Title: Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function.
Volume: 178
Issue: 1
Pages: 330-7
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Publication
664185 | J:5999
First Author: Ward JM
Year: 1978
Journal: Vet Pathol
Title: Pulmonary pathology of the motheaten mouse.
Volume: 15
Issue: 2
Pages: 170-8
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Publication
- | J:234259
     
First Author: Zhong X
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for candle
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Publication
- | J:171740
     
First Author: Beutler B
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2011/05/23
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Publication
- | J:272439
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for caterpillar.
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Publication
6380298 | J:7531
First Author: Shultz LD
Year: 1984
Journal: Am J Pathol
Title: "Viable motheaten," a new allele at the motheaten locus. I. Pathology.
Volume: 116
Issue: 2
Pages: 179-92
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Publication
9505936 | J:43013
First Author: Nakayama K
Year: 1997
Journal: Int J Exp Pathol
Title: Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase.
Volume: 78
Issue: 4
Pages: 245-57
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Publication
23001144 | J:188566
First Author: Yan D
Year: 2012
Journal: Nat Immunol
Title: Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs.
Volume: 13
Issue: 11
Pages: 1063-71
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Publication
18441283 | J:154284
First Author: Cho YS
Year: 2008
Journal: Am J Respir Cell Mol Biol
Title: Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation.
Volume: 39
Issue: 4
Pages: 412-9
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Publication
3551623 | J:14936
First Author: Shultz LD
Year: 1987
Journal: Am J Pathol
Title: Development of plasmacytoid cells with Russell bodies in autoimmune "viable motheaten" mice.
Volume: 127
Issue: 1
Pages: 38-50
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Publication
2783574 | J:14937
First Author: Van Zant G
Year: 1989
Journal: Exp Hematol
Title: Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).
Volume: 17
Issue: 2
Pages: 81-7
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Publication
16617349 | J:109558
First Author: Dubois MJ
Year: 2006
Journal: Nat Med
Title: The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Volume: 12
Issue: 5
Pages: 549-56
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Publication
7600299 | J:28348
First Author: Cyster JG
Year: 1995
Journal: Immunity
Title: Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection.
Volume: 2
Issue: 1
Pages: 13-24
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Publication
7840851 | J:20845
First Author: Kovarik J
Year: 1994
Journal: J Autoimmun
Title: The viable motheaten (mev) mouse--a new model for arthritis.
Volume: 7
Issue: 5
Pages: 575-88
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Publication
21357539 | J:170692
First Author: Ramachandran IR
Year: 2011
Journal: J Immunol
Title: The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function.
Volume: 186
Issue: 7
Pages: 3934-45
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Publication
8822276 | J:31222
First Author: Saitoh Y
Year: 1995
Journal: Autoimmunity
Title: Skewed VH and V kappa gene family expression and pairing occurs among B lymphocytes in autoimmune motheaten mice.
Volume: 21
Issue: 3
Pages: 185-193
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Publication
6334306 | J:7665
First Author: Sidman CL
Year: 1984
Journal: Proc Natl Acad Sci U S A
Title: Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice.
Volume: 81
Issue: 22
Pages: 7199-202
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Publication
20368344 | J:159974
First Author: Abu-Dayyeh I
Year: 2010
Journal: Infect Immun
Title: Comparative study of the ability of Leishmania mexicana promastigotes and amastigotes to alter macrophage signaling and functions.
Volume: 78
Issue: 6
Pages: 2438-45
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Publication
11745335 | J:72585
First Author: Forget G
Year: 2001
Journal: Eur J Immunol
Title: Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis.
Volume: 31
Issue: 11
Pages: 3185-96
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Publication
3891855 | J:7905
First Author: Sidman CL
Year: 1985
Journal: J Immunol
Title: A serum-derived molecule from autoimmune viable motheaten mice potentiates the action of a B cell maturation factor.
Volume: 135
Issue: 2
Pages: 870-2
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Publication
22509389 | J:187091
First Author: Cho SH
Year: 2012
Journal: PLoS One
Title: Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model.
Volume: 7
Issue: 4
Pages: e35114
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Publication
8118868 | J:16613
First Author: Hayes SM
Year: 1994
Journal: Cell Immunol
Title: Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Volume: 153
Issue: 2
Pages: 344-55
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Publication
15634925 | J:95832
First Author: Yu WM
Year: 2005
Journal: J Immunol
Title: Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1.
Volume: 174
Issue: 2
Pages: 1013-9
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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