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Search results 1 to 100 out of 994 for Ptprc

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5788 | PTPRC
Type: gene
Organism: human
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Gene
457607 | PTPRC
Type: gene
Organism: chimpanzee
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Gene
407152 | PTPRC
Type: gene
Organism: cattle
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Gene
386580 | PTPRC
Type: gene
Organism: chicken
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Gene
559154 | ptprc
Type: gene
Organism: zebrafish
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Gene
712657 | PTPRC
Type: gene
Organism: macaque, rhesus
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Gene
100493434 | ptprc
Type: gene
Organism: frog, western clawed
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Gene
24699 | Ptprc
Type: gene
Organism: rat
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Gene
490255 | PTPRC
Type: gene
Organism: dog, domestic
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Protein Domain
IPR016335 | Ptprc
Type: Family
Description: Receptor-type tyrosine-protein phosphatase C, also known as CD45, is a tyrosine-protein phosphatase required for T-cell activation through the antigen receptor []. It acts as a positive regulator of T-cell co-activation upon binding to DPP4 (CD26) [].
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Protein Coding Gene
MGI:97810 | Ptprc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q05C79
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Publication
2845400 | J:22340
First Author: Charbonneau H
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.
Volume: 85
Issue: 19
Pages: 7182-6
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Gene
108281163 | LOC108281163
Type: gene
Organism: human
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GXD Expression
GXD Expression
 
Probe: MGI:952870
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4827525
Age: embryonic day 14.5
Note: Expression is present in single cells in which the intercellular distance between stained cells is approximately equal to the cell diameter of an individual cell. A thumbnail photo of the staining is contained in the table.
Specimen Label: Table S9 - Ptprc
Detected: true
Specimen Num: 1
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Protein
P06800
Organism: Mus musculus/domesticus
Length: 1293  
Fragment?: false
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Protein
S4R1M0
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
Q8C6Q7
Organism: Mus musculus/domesticus
Length: 879  
Fragment?: true
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Protein
Q3U382
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
A0A0A6YXM4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
Q64730
Organism: Mus musculus/domesticus
Length: 1343  
Fragment?: false
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Publication
11593028 | -
First Author: Ishii T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: CD26-mediated signaling for T cell activation occurs in lipid rafts through its association with CD45RO.
Volume: 98
Issue: 21
Pages: 12138-43
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191166
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ptprc
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191166
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ptprc
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191166
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ptprc
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191166
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ptprc
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ptprc
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ptprc
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6181624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191166
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ptprc
Detected: true
Specimen Num: 7
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Protein
Q5XFY7
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Publication
8954783 | J:36984
First Author: Bruyns E
Year: 1996
Journal: Genomics
Title: Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.
Volume: 38
Issue: 1
Pages: 79-83
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Publication
- | J:152064
     
First Author: Siggs OM
Year: 2009
Journal: MGI Direct Data Submission
Title: Record for belittle, updated 17 Aug 2009 (Accessed 3 September 2009)
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Publication
- | J:265143
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Half_measure.
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Publication
- | J:254899
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for guotie2
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Publication
24068938 | J:214487
First Author: Caignard G
Year: 2013
Journal: PLoS Pathog
Title: Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
Volume: 9
Issue: 9
Pages: e1003637
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Publication
30820040 | J:295283
First Author: Kresinsky A
Year: 2019
Journal: Oncogene
Title: Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.
Volume: 38
Issue: 24
Pages: 4773-4787
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Publication
20505149 | J:161440
First Author: Wu Z
Year: 2010
Journal: J Immunol
Title: Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
Volume: 185
Issue: 1
Pages: 231-8
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Publication
22724066 | J:225105
First Author: Andrews TD
Year: 2012
Journal: Open Biol
Title: Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.
Volume: 2
Issue: 5
Pages: 120061
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Publication
34001904 | J:332772
First Author: Jin H
Year: 2021
Journal: Nat Commun
Title: Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.
Volume: 12
Issue: 1
Pages: 2863
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Publication
21423172 | J:171925
First Author: Siggs OM
Year: 2011
Journal: Nat Immunol
Title: The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.
Volume: 12
Issue: 5
Pages: 434-40
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Protein Coding Gene
MGP_CAROLIEiJ_G0014660 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016528 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016488 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016314 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97810 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016949 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016287 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016392 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027896 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015467 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2944116 | J:8412
First Author: Saga Y
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Sequences of Ly-5 cDNA: isoform-related diversity of Ly-5 mRNA.
Volume: 83
Issue: 18
Pages: 6940-4
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Publication
1822988 | J:12548
First Author: Zebedee SL
Year: 1991
Journal: Dev Immunol
Title: Comparison of mouse Ly5a and Ly5b leucocyte common antigen alleles.
Volume: 1
Issue: 4
Pages: 243-54
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Publication
3037546 | J:8781
First Author: Saga Y
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.
Volume: 84
Issue: 15
Pages: 5364-8
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Publication
3211131 | J:9538
First Author: Saga Y
Year: 1988
Journal: Mol Cell Biol
Title: Organization of the Ly-5 gene.
Volume: 8
Issue: 11
Pages: 4889-95
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Publication
3864163 | J:8080
First Author: Shen FW
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Cloning of Ly-5 cDNA.
Volume: 82
Issue: 21
Pages: 7360-3
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Publication
2948186 | J:8545
First Author: Raschke WC
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Cloned murine T200 (Ly-5) cDNA reveals multiple transcripts within B- and T-lymphocyte lineages.
Volume: 84
Issue: 1
Pages: 161-5
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Publication
2955416 | J:8780
First Author: Thomas ML
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: B-cell variant of mouse T200 (Ly-5): evidence for alternative mRNA splicing.
Volume: 84
Issue: 15
Pages: 5360-3
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Publication
34847567 | J:338101
First Author: Gearty SV
Year: 2022
Journal: Nature
Title: An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
Volume: 602
Issue: 7895
Pages: 156-161
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Publication
10970857 | J:64671
First Author: Baker M
Year: 2000
Journal: EMBO J
Title: Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.
Volume: 19
Issue: 17
Pages: 4644-54
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Publication
19129486 | J:143867
First Author: Hermiston ML
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.
Volume: 106
Issue: 2
Pages: 546-51
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Publication
21273420 | J:168546
First Author: Zhu Y
Year: 2011
Journal: J Neurosci
Title: CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.
Volume: 31
Issue: 4
Pages: 1355-65
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Publication
22902503 | J:187147
First Author: Zikherman J
Year: 2012
Journal: Nature
Title: Endogenous antigen tunes the responsiveness of naive B cells but not T cells.
Volume: 489
Issue: 7414
Pages: 160-4
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Publication
31167773 | J:277898
First Author: Noviski M
Year: 2019
Journal: J Immunol
Title: Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens.
Volume: 203
Issue: 2
Pages: 418-428
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Publication
22135465 | J:180527
First Author: Zikherman J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
Volume: 109
Issue: 1
Pages: E3-12
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Publication
16356861 | J:113310
First Author: Hermiston ML
Year: 2005
Journal: Immunity
Title: The juxtamembrane wedge negatively regulates CD45 function in B cells.
Volume: 23
Issue: 6
Pages: 635-47
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Publication
28605013 | J:248486
First Author: Sacquin A
Year: 2017
Journal: Eur J Immunol
Title: The strength of BCR signaling shapes terminal development of follicular helper T cells in mice.
Volume: 47
Issue: 8
Pages: 1295-1304
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Publication
9120275 | J:110837
First Author: Wallace VA
Year: 1997
Journal: J Immunol
Title: Alterations in the level of CD45 surface expression affect the outcome of thymic selection.
Volume: 158
Issue: 7
Pages: 3205-14
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Publication
27732840 | J:240773
First Author: Oberle SG
Year: 2016
Journal: Cell Rep
Title: A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire.
Volume: 17
Issue: 3
Pages: 627-635
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Publication
18602924 | J:152523
First Author: Yang J
Year: 2008
Journal: J Immunol Methods
Title: Transgenic tools for analysis of the haematopoietic system: knock-in CD45 reporter and deletor mice.
Volume: 337
Issue: 2
Pages: 81-7
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Publication
31641081 | J:284396
 
First Author: Courtney AH
Year: 2019
Journal: Sci Signal
Title: CD45 functions as a signaling gatekeeper in T cells.
Volume: 12
Issue: 604
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Publication
12393487 | J:115557
First Author: Virts EL
Year: 2003
Journal: Blood
Title: A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency.
Volume: 101
Issue: 3
Pages: 849-55
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Publication
37295435 | J:337915
First Author: Wu Y
Year: 2023
Journal: Dev Cell
Title: MicroRNA-223 limits murine hemogenic endothelial cell specification and myelopoiesis.
Volume: 58
Issue: 14
Pages: 1237-1249.e5
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Publication
32423405 | J:306361
First Author: Xu W
Year: 2020
Journal: Respir Res
Title: MiR-223 plays a protecting role in neutrophilic asthmatic mice through the inhibition of NLRP3 inflammasome.
Volume: 21
Issue: 1
Pages: 116
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Publication
19269962 | J:149759
First Author: Panchal RG
Year: 2009
Journal: J Biol Chem
Title: Reduced expression of CD45 protein-tyrosine phosphatase provides protection against anthrax pathogenesis.
Volume: 284
Issue: 19
Pages: 12874-85
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Publication
19683682 | J:282686
First Author: Panchal RG
Year: 2009
Journal: Cell Host Microbe
Title: Reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection.
Volume: 6
Issue: 2
Pages: 162-73
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Publication
36638795 | J:332907
First Author: Nyberg WA
Year: 2023
Journal: Cell
Title: An evolved AAV variant enables efficient genetic engineering of murine T cells.
Volume: 186
Issue: 2
Pages: 446-460.e19
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Publication
38262409 | J:346133
First Author: Zhang N
Year: 2024
Journal: Cell
Title: Cell surface RNAs control neutrophil recruitment.
Volume: 187
Issue: 4
Pages: 846-860.e17
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Publication
26657143 | J:233175
First Author: Chang J
Year: 2016
Journal: Nat Med
Title: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Volume: 22
Issue: 1
Pages: 78-83
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Publication
12209639 | J:136398
First Author: Shivtiel S
Year: 2002
Journal: Eur J Immunol
Title: Receptor editing in CD45-deficient immature B cells.
Volume: 32
Issue: 8
Pages: 2264-73
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Publication
12021782 | J:254163
First Author: Shih TA
Year: 2002
Journal: Nat Immunol
Title: Role of BCR affinity in T cell dependent antibody responses in vivo.
Volume: 3
Issue: 6
Pages: 570-5
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Publication
32978280 | J:303626
First Author: Daly CA
Year: 2020
Journal: J Immunol
Title: B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool.
Volume: 205
Issue: 9
Pages: 2362-2374
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Publication
10829061 | J:63075
First Author: Braun U
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenes.
Volume: 97
Issue: 13
Pages: 7429-34
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Publication
23315077 | J:193323
First Author: Nobrega C
Year: 2013
Journal: J Immunol
Title: T cells home to the thymus and control infection.
Volume: 190
Issue: 4
Pages: 1646-58
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Publication
19875815 | J:185867
First Author: Tadagavadi RK
Year: 2010
Journal: J Am Soc Nephrol
Title: Renal dendritic cells ameliorate nephrotoxic acute kidney injury.
Volume: 21
Issue: 1
Pages: 53-63
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Publication
- | J:216796
     
First Author: Zeng M
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for guotie. Updated January 09, 2015
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Publication
27185283 | J:236940
First Author: Mercier FE
Year: 2016
Journal: Stem Cell Reports
Title: Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.
Volume: 6
Issue: 6
Pages: 985-92
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Publication
11163182 | J:66501
First Author: Majeti R
Year: 2000
Journal: Cell
Title: An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
Volume: 103
Issue: 7
Pages: 1059-70
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Publication
- | J:272745
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Chor_muang.
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Publication
- | J:272777
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Gyoza.
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Publication
- | J:12077
 
First Author: Komuro K
Year: 1975
Journal: Immunogenetics
Title: Ly-5: a new lymphocyte antigen system.
Volume: 1
Pages: 452-456
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Publication
2886425 | J:8805
First Author: Seldin MF
Year: 1987
Journal: Immunogenetics
Title: Allelic variants of Ly-5 in inbred and natural populations of mice.
Volume: 26
Issue: 1-2
Pages: 74-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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