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Search results 1 to 100 out of 193 for Ptx3

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Hits by Category

Type Details Score
Gene
5806 | PTX3
Type: gene
Organism: human
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Gene
541148 | PTX3
Type: gene
Organism: cattle
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Gene
100685178 | PTX3
Type: gene
Organism: dog, domestic
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Gene
548626 | PTX3
Type: gene
Organism: chicken
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Gene
704985 | PTX3
Type: gene
Organism: macaque, rhesus
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Gene
100494643 | ptx3
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR042837 | PTX3
Type: Family
Description: Pentraxin-related protein PTX3 is a long pentraxin that provides defence against infectious agents and plays several functions in tissue repair and regulation of cancer-related inflammation [].Pentraxins are a family of evolutionarily conserved molecules with regulatory role in inflammation. They share the "pentraxin signature"(His-x-Cys-x-Ser/Thr-Trp-x-Ser, where x is any amino acid) and can be divided into a short and a long arm based on their structural organization. Short pentraxins, feature a peculiar quaternary structure with five or ten identical protomer subunits arranged into symmetric pentamers, such as CRP and SAP, are secreted proteins produced by hepatocytes in response to IL-6. Long pentraxins, on the other end, display an unrelated amino-terminal region coupled to a C-terminal pentraxin domain. PTX3 is the prototype of the long pentraxin subfamily produced by myeloid and stromal cells, but not by hepatocytes, in response to primary pro-inflammatory cytokines or microbial moieties [].
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Gene
689388 | Ptx3
Type: gene
Organism: rat
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Gene
460807 | PTX3
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:104641 | Ptx3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P48759
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Publication
26921689 | -
First Author: Bottazzi B
Year: 2016
Journal: J Hepatol
Title: The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.
Volume: 64
Issue: 6
Pages: 1416-27
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Publication
31019517 | -
 
First Author: Doni A
Year: 2019
Journal: Front Immunol
Title: The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer.
Volume: 10
Pages: 712
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Publication
8634434 | J:31648
First Author: Introna M
Year: 1996
Journal: Blood
Title: Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.
Volume: 87
Issue: 5
Pages: 1862-72
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Publication
7592730 | J:29540
First Author: Altmeyer A
Year: 1995
Journal: J Biol Chem
Title: Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein.
Volume: 270
Issue: 43
Pages: 25584-90
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Publication
25679762 | J:219871
First Author: Bonavita E
Year: 2015
Journal: Cell
Title: PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Volume: 160
Issue: 4
Pages: 700-14
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Publication
23372656 | J:295325
First Author: Suzuki S
Year: 2013
Journal: PLoS One
Title: Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction.
Volume: 8
Issue: 1
Pages: e53133
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Publication
28864415 | J:311699
First Author: Koh SH
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection.
Volume: 493
Issue: 1
Pages: 671-676
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Publication
26763449 | J:229904
First Author: Cappuzzello C
Year: 2016
Journal: J Invest Dermatol
Title: Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.
Volume: 136
Issue: 1
Pages: 293-300
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Publication
34093560 | J:312765
 
First Author: Asgari F
Year: 2021
Journal: Front Immunol
Title: The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection.
Volume: 12
Pages: 666198
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Publication
18292565 | J:131523
First Author: Reading PC
Year: 2008
Journal: J Immunol
Title: Antiviral activity of the long chain pentraxin PTX3 against influenza viruses.
Volume: 180
Issue: 5
Pages: 3391-8
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Publication
25342475 | J:320631
First Author: Ishino M
Year: 2015
Journal: J Atheroscler Thromb
Title: Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury.
Volume: 22
Issue: 4
Pages: 372-8
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Publication
25786110 | J:295326
First Author: Bottazzi B
Year: 2015
Journal: PLoS One
Title: Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
Volume: 10
Issue: 3
Pages: e0120807
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Publication
17389238 | J:125610
First Author: Jaillon S
Year: 2007
Journal: J Exp Med
Title: The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.
Volume: 204
Issue: 4
Pages: 793-804
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Publication
12432394 | J:85080
First Author: Garlanda C
Year: 2002
Journal: Nature
Title: Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.
Volume: 420
Issue: 6912
Pages: 182-6
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Publication
19286566 | J:147054
First Author: Souza DG
Year: 2009
Journal: Am J Pathol
Title: The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.
Volume: 174
Issue: 4
Pages: 1309-18
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Publication
30319631 | J:337308
 
First Author: Marschner JA
Year: 2018
Journal: Front Immunol
Title: The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.
Volume: 9
Pages: 2173
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Publication
19667236 | J:167113
First Author: Norata GD
Year: 2009
Journal: Circulation
Title: Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis.
Volume: 120
Issue: 8
Pages: 699-708
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Publication
18268142 | J:148653
First Author: Salio M
Year: 2008
Journal: Circulation
Title: Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction.
Volume: 117
Issue: 8
Pages: 1055-64
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Publication
34305885 | J:312793
 
First Author: Balhara J
Year: 2021
Journal: Front Immunol
Title: PTX3 Deficiency Promotes Enhanced Accumulation and Function of CD11c+CD11b+ DCs in a Murine Model of Allergic Inflammation.
Volume: 12
Pages: 641311
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Publication
14726497 | J:89006
First Author: Diniz SN
Year: 2004
Journal: J Leukoc Biol
Title: PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages.
Volume: 75
Issue: 4
Pages: 649-56
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Publication
17675295 | J:126717
First Author: Scarchilli L
Year: 2007
Journal: J Biol Chem
Title: PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion.
Volume: 282
Issue: 41
Pages: 30161-70
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Publication
14998931 | J:91829
First Author: Salustri A
Year: 2004
Journal: Development
Title: PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.
Volume: 131
Issue: 7
Pages: 1577-86
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Publication
22732935 | J:188421
First Author: Han B
Year: 2012
Journal: Lab Invest
Title: Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.
Volume: 92
Issue: 9
Pages: 1285-96
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Publication
25964372 | J:224615
First Author: Doni A
Year: 2015
Journal: J Exp Med
Title: An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.
Volume: 212
Issue: 6
Pages: 905-25
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Publication
33953334 | J:312110
First Author: Oggioni M
Year: 2021
Journal: Sci Rep
Title: Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology.
Volume: 11
Issue: 1
Pages: 9616
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Publication
21619930 | J:175258
First Author: Ievoli E
Year: 2011
Journal: Matrix Biol
Title: Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly.
Volume: 30
Issue: 5-6
Pages: 330-7
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Publication
35194044 | J:322043
First Author: Liu M
Year: 2022
Journal: Nat Commun
Title: Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.
Volume: 13
Issue: 1
Pages: 1006
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Publication
24745336 | J:209948
First Author: Jaillon S
Year: 2014
Journal: Immunity
Title: The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Volume: 40
Issue: 4
Pages: 621-32
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Publication
21637713 | J:172567
First Author: Lech M
Year: 2011
Journal: PLoS One
Title: Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus.
Volume: 6
Issue: 5
Pages: e20118
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Publication
21441447 | J:172858
First Author: Moalli F
Year: 2011
Journal: J Immunol
Title: The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa.
Volume: 186
Issue: 9
Pages: 5425-34
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Publication
27621420 | J:237271
First Author: Chorny A
Year: 2016
Journal: J Exp Med
Title: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
Volume: 213
Issue: 10
Pages: 2167-85
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Publication
20829368 | J:167412
First Author: Moalli F
Year: 2010
Journal: Blood
Title: Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus.
Volume: 116
Issue: 24
Pages: 5170-80
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Publication
23863905 | J:205828
First Author: Jaillon S
Year: 2013
Journal: J Immunol
Title: Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.
Volume: 191
Issue: 4
Pages: 1873-82
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Publication
24307735 | J:207165
First Author: Job ER
Year: 2014
Journal: J Immunol
Title: A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Volume: 192
Issue: 1
Pages: 271-81
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Publication
11483299 | J:126907
First Author: Ravizza T
Year: 2001
Journal: Neuroscience
Title: Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Volume: 105
Issue: 1
Pages: 43-53
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Publication
26267536 | J:224913
First Author: Ronca R
Year: 2015
Journal: Cancer Cell
Title: Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
Volume: 28
Issue: 2
Pages: 225-39
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Publication
25695775 | J:229639
First Author: Foo SS
Year: 2015
Journal: PLoS Pathog
Title: Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.
Volume: 11
Issue: 2
Pages: e1004649
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Publication
33326783 | J:298860
First Author: Gupta G
Year: 2020
Journal: Cell Rep
Title: The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response.
Volume: 33
Issue: 11
Pages: 108513
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Publication
23325083 | J:341930
First Author: Lech M
Year: 2013
Journal: Kidney Int
Title: Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury.
Volume: 83
Issue: 4
Pages: 647-61
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Publication
30859179 | J:294976
First Author: Bonacina F
Year: 2019
Journal: Cardiovasc Res
Title: Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity.
Volume: 115
Issue: 13
Pages: 1861-1872
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Publication
30315331 | J:295247
First Author: Rajkovic I
Year: 2018
Journal: J Mol Med (Berl)
Title: Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke.
Volume: 96
Issue: 12
Pages: 1319-1332
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Publication
17538075 | J:128320
First Author: Tranguch S
Year: 2007
Journal: Biol Reprod
Title: Maternal pentraxin 3 deficiency compromises implantation in mice.
Volume: 77
Issue: 3
Pages: 425-32
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Publication
22425349 | J:322968
First Author: Real JM
Year: 2012
Journal: Mol Immunol
Title: Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice.
Volume: 51
Issue: 1
Pages: 82-90
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Publication
37542771 | J:340047
 
First Author: Qiu C
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Volume: 677
Pages: 20-25
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Publication
30718300 | J:272943
First Author: Batista NV
Year: 2019
Journal: J Immunol
Title: The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals.
Volume: 202
Issue: 6
Pages: 1807-1814
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Publication
26576501 | J:247256
First Author: Ummenthum K
Year: 2016
Journal: Eur J Immunol
Title: Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.
Volume: 46
Issue: 3
Pages: 701-11
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Publication
26578407 | J:234519
First Author: Paeschke A
Year: 2016
Journal: Eur J Immunol
Title: The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.
Volume: 46
Issue: 3
Pages: 619-33
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Publication
29492210 | J:295327
First Author: Yoshida M
Year: 2018
Journal: Oncotarget
Title: Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.
Volume: 9
Issue: 9
Pages: 8489-8501
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Publication
24145127 | J:211516
First Author: Yao G
Year: 2014
Journal: Mol Cell Endocrinol
Title: MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3.
Volume: 382
Issue: 1
Pages: 244-53
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Publication
26470821 | J:251451
First Author: Shimizu T
Year: 2015
Journal: J Mol Cell Cardiol
Title: Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.
Volume: 89
Issue: Pt B
Pages: 306-13
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Publication
27659908 | J:241740
First Author: Wang L
Year: 2016
Journal: J Pathol
Title: Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation.
Volume: 240
Issue: 4
Pages: 495-506
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Publication
29556234 | J:311866
 
First Author: Grčević D
Year: 2018
Journal: Front Immunol
Title: The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair.
Volume: 9
Pages: 417
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Publication
31209269 | J:303598
First Author: Guo H
Year: 2020
Journal: Int J Obes (Lond)
Title: Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue.
Volume: 44
Issue: 2
Pages: 525-538
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Publication
38068970 | J:343694
 
First Author: Granata V
Year: 2023
Journal: Int J Mol Sci
Title: Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions.
Volume: 24
Issue: 23
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Publication
20208538 | J:158981
First Author: Deban L
Year: 2010
Journal: Nat Immunol
Title: Regulation of leukocyte recruitment by the long pentraxin PTX3.
Volume: 11
Issue: 4
Pages: 328-34
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Publication
16840729 | J:140456
First Author: Bozza S
Year: 2006
Journal: Blood
Title: Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation.
Volume: 108
Issue: 10
Pages: 3387-96
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Publication
26976330 | J:256818
First Author: Bonacina F
Year: 2016
Journal: Biochim Biophys Acta
Title: Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.
Volume: 1862
Issue: 6
Pages: 1182-90
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Publication
30396995 | J:295098
 
First Author: Fossati G
Year: 2019
Journal: EMBO J
Title: Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Volume: 38
Issue: 1
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Publication
18218986 | J:159816
First Author: Norata GD
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells.
Volume: 28
Issue: 5
Pages: 925-31
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Publication
19734205 | J:152794
First Author: D'Angelo C
Year: 2009
Journal: J Immunol
Title: Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease.
Volume: 183
Issue: 7
Pages: 4609-18
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Publication
25747934 | J:234322
First Author: Carrizzo A
Year: 2015
Journal: Circulation
Title: Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway.
Volume: 131
Issue: 17
Pages: 1495-505; discussion 1505
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Publication
12040004 | J:76877
First Author: Varani S
Year: 2002
Journal: Mol Endocrinol
Title: Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility.
Volume: 16
Issue: 6
Pages: 1154-67
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Publication
36012705 | J:327934
 
First Author: Coltrini D
Year: 2022
Journal: Int J Mol Sci
Title: β-Galactosylceramidase Deficiency Causes Upregulation of Long Pentraxin-3 in the Central Nervous System of Krabbe Patients and Twitcher Mice.
Volume: 23
Issue: 16
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Publication
22895517 | J:198404
First Author: Chen J
Year: 2012
Journal: Kidney Int
Title: Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury.
Volume: 82
Issue: 11
Pages: 1195-207
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Publication
30105036 | J:311857
 
First Author: Shin MK
Year: 2018
Journal: Front Immunol
Title: Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling.
Volume: 9
Pages: 1790
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Publication
24470395 | J:210680
First Author: Rudnicki A
Year: 2014
Journal: Hum Mol Genet
Title: microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation.
Volume: 23
Issue: 12
Pages: 3138-46
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Publication
34411594 | J:317152
 
First Author: Dehghan Z
Year: 2021
Journal: Dev Biol
Title: MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development.
Volume: 480
Pages: 69-77
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Protein Coding Gene
MGP_CAROLIEiJ_G0025048 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026174 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026491 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025990 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11404378 | J:69952
First Author: Dias AA
Year: 2001
Journal: J Leukoc Biol
Title: TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis.
Volume: 69
Issue: 6
Pages: 928-36
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GXD Expression
GXD Expression
     
Probe: MGI:5817436
Assay Type: RT-PCR
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524724
Stage: TS24
Assay Id: MGI:5817437
Age: embryonic day 16.0
Specimen Label: E16
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5817436
Assay Type: RT-PCR
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:5817437
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 2
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