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Search results 1 to 100 out of 163 for Ptx3

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0.04s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Pentraxins are a family of evolutionarily conserved molecules with regulatory role in inflammation. They share the "pentraxin signature"(His-x-Cys-x-Ser/Thr-Trp-x-Ser, where x is any amino acid) and can be divided into a short and a long arm based on their structural organization. Short pentraxins, feature a peculiar quaternary structure with five or ten identical protomer subunits arranged into symmetric pentamers, such as CRP and SAP, are secreted proteins produced by hepatocytes in response to IL-6. Long pentraxins, on the other end, display an unrelated amino-terminal region coupled to a C-terminal pentraxin domain. PTX3 is the prototype of the long pentraxin subfamily produced by myeloid and stromal cells, but not by hepatocytes, in response to primary pro-inflammatory cytokines or microbial moieties []. Pentraxin-related protein PTX3 is a long pentraxin that provides defence against infectious agents and plays several functions in tissue repair and regulation of cancer-related inflammation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 381  
Fragment?: false
Publication
First Author: Bottazzi B
Year: 2016
Journal: J Hepatol
Title: The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.
Volume: 64
Issue: 6
Pages: 1416-27
Publication  
First Author: Doni A
Year: 2019
Journal: Front Immunol
Title: The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer.
Volume: 10
Pages: 712
Publication
First Author: Introna M
Year: 1996
Journal: Blood
Title: Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.
Volume: 87
Issue: 5
Pages: 1862-72
Publication
First Author: Altmeyer A
Year: 1995
Journal: J Biol Chem
Title: Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein.
Volume: 270
Issue: 43
Pages: 25584-90
Publication
First Author: Bonavita E
Year: 2015
Journal: Cell
Title: PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Volume: 160
Issue: 4
Pages: 700-14
Publication
First Author: Cappuzzello C
Year: 2016
Journal: J Invest Dermatol
Title: Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.
Volume: 136
Issue: 1
Pages: 293-300
Publication
First Author: Suzuki S
Year: 2013
Journal: PLoS One
Title: Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction.
Volume: 8
Issue: 1
Pages: e53133
Publication
First Author: Reading PC
Year: 2008
Journal: J Immunol
Title: Antiviral activity of the long chain pentraxin PTX3 against influenza viruses.
Volume: 180
Issue: 5
Pages: 3391-8
Publication
First Author: Garlanda C
Year: 2002
Journal: Nature
Title: Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.
Volume: 420
Issue: 6912
Pages: 182-6
Publication
First Author: Bottazzi B
Year: 2015
Journal: PLoS One
Title: Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
Volume: 10
Issue: 3
Pages: e0120807
Publication
First Author: Jaillon S
Year: 2007
Journal: J Exp Med
Title: The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.
Volume: 204
Issue: 4
Pages: 793-804
Publication
First Author: Norata GD
Year: 2009
Journal: Circulation
Title: Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis.
Volume: 120
Issue: 8
Pages: 699-708
Publication
First Author: Salio M
Year: 2008
Journal: Circulation
Title: Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction.
Volume: 117
Issue: 8
Pages: 1055-64
Publication
First Author: Souza DG
Year: 2009
Journal: Am J Pathol
Title: The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.
Volume: 174
Issue: 4
Pages: 1309-18
Publication
First Author: Diniz SN
Year: 2004
Journal: J Leukoc Biol
Title: PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages.
Volume: 75
Issue: 4
Pages: 649-56
Publication
First Author: Scarchilli L
Year: 2007
Journal: J Biol Chem
Title: PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion.
Volume: 282
Issue: 41
Pages: 30161-70
Publication
First Author: Doni A
Year: 2015
Journal: J Exp Med
Title: An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.
Volume: 212
Issue: 6
Pages: 905-25
Publication
First Author: Ievoli E
Year: 2011
Journal: Matrix Biol
Title: Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly.
Volume: 30
Issue: 5-6
Pages: 330-7
Publication
First Author: Salustri A
Year: 2004
Journal: Development
Title: PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.
Volume: 131
Issue: 7
Pages: 1577-86
Publication
First Author: Han B
Year: 2012
Journal: Lab Invest
Title: Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.
Volume: 92
Issue: 9
Pages: 1285-96
Publication
First Author: Jaillon S
Year: 2014
Journal: Immunity
Title: The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Volume: 40
Issue: 4
Pages: 621-32
Publication
First Author: Lech M
Year: 2011
Journal: PLoS One
Title: Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus.
Volume: 6
Issue: 5
Pages: e20118
Publication
First Author: Moalli F
Year: 2011
Journal: J Immunol
Title: The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa.
Volume: 186
Issue: 9
Pages: 5425-34
Publication
First Author: Chorny A
Year: 2016
Journal: J Exp Med
Title: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
Volume: 213
Issue: 10
Pages: 2167-85
Publication
First Author: Moalli F
Year: 2010
Journal: Blood
Title: Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus.
Volume: 116
Issue: 24
Pages: 5170-80
Publication
First Author: Jaillon S
Year: 2013
Journal: J Immunol
Title: Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.
Volume: 191
Issue: 4
Pages: 1873-82
Publication
First Author: Job ER
Year: 2014
Journal: J Immunol
Title: A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Volume: 192
Issue: 1
Pages: 271-81
Publication
First Author: Ravizza T
Year: 2001
Journal: Neuroscience
Title: Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Volume: 105
Issue: 1
Pages: 43-53
Publication
First Author: Ronca R
Year: 2015
Journal: Cancer Cell
Title: Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
Volume: 28
Issue: 2
Pages: 225-39
Publication
First Author: Foo SS
Year: 2015
Journal: PLoS Pathog
Title: Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.
Volume: 11
Issue: 2
Pages: e1004649
Publication
First Author: Gupta G
Year: 2020
Journal: Cell Rep
Title: The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response.
Volume: 33
Issue: 11
Pages: 108513
Publication
First Author: Deban L
Year: 2010
Journal: Nat Immunol
Title: Regulation of leukocyte recruitment by the long pentraxin PTX3.
Volume: 11
Issue: 4
Pages: 328-34
Publication
First Author: Paeschke A
Year: 2016
Journal: Eur J Immunol
Title: The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.
Volume: 46
Issue: 3
Pages: 619-33
Publication
First Author: Rajkovic I
Year: 2018
Journal: J Mol Med (Berl)
Title: Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke.
Volume: 96
Issue: 12
Pages: 1319-1332
Publication
First Author: Bonacina F
Year: 2019
Journal: Cardiovasc Res
Title: Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity.
Volume: 115
Issue: 13
Pages: 1861-1872
Publication
First Author: Ummenthum K
Year: 2016
Journal: Eur J Immunol
Title: Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.
Volume: 46
Issue: 3
Pages: 701-11
Publication
First Author: Batista NV
Year: 2019
Journal: J Immunol
Title: The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals.
Volume: 202
Issue: 6
Pages: 1807-1814
Publication
First Author: Yoshida M
Year: 2018
Journal: Oncotarget
Title: Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.
Volume: 9
Issue: 9
Pages: 8489-8501
Publication
First Author: Tranguch S
Year: 2007
Journal: Biol Reprod
Title: Maternal pentraxin 3 deficiency compromises implantation in mice.
Volume: 77
Issue: 3
Pages: 425-32
Publication
First Author: Yao G
Year: 2014
Journal: Mol Cell Endocrinol
Title: MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3.
Volume: 382
Issue: 1
Pages: 244-53
Publication
First Author: Shimizu T
Year: 2015
Journal: J Mol Cell Cardiol
Title: Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.
Volume: 89
Issue: Pt B
Pages: 306-13
Publication
First Author: Wang L
Year: 2016
Journal: J Pathol
Title: Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation.
Volume: 240
Issue: 4
Pages: 495-506
Publication
First Author: Guo H
Year: 2020
Journal: Int J Obes (Lond)
Title: Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue.
Volume: 44
Issue: 2
Pages: 525-538
Publication
First Author: Bozza S
Year: 2006
Journal: Blood
Title: Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation.
Volume: 108
Issue: 10
Pages: 3387-96
Publication
First Author: Bonacina F
Year: 2016
Journal: Biochim Biophys Acta
Title: Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.
Volume: 1862
Issue: 6
Pages: 1182-90
Publication  
First Author: Fossati G
Year: 2019
Journal: EMBO J
Title: Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Volume: 38
Issue: 1
Publication
First Author: Norata GD
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells.
Volume: 28
Issue: 5
Pages: 925-31
Publication
First Author: Carrizzo A
Year: 2015
Journal: Circulation
Title: Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway.
Volume: 131
Issue: 17
Pages: 1495-505; discussion 1505
Publication
First Author: D'Angelo C
Year: 2009
Journal: J Immunol
Title: Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease.
Volume: 183
Issue: 7
Pages: 4609-18
Publication
First Author: Varani S
Year: 2002
Journal: Mol Endocrinol
Title: Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility.
Volume: 16
Issue: 6
Pages: 1154-67
Publication
First Author: Chen J
Year: 2012
Journal: Kidney Int
Title: Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury.
Volume: 82
Issue: 11
Pages: 1195-207
Publication
First Author: Rudnicki A
Year: 2014
Journal: Hum Mol Genet
Title: microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation.
Volume: 23
Issue: 12
Pages: 3138-46
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Dias AA
Year: 2001
Journal: J Leukoc Biol
Title: TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis.
Volume: 69
Issue: 6
Pages: 928-36
GXD Expression      
Probe: MGI:5817436
Assay Type: RT-PCR
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524724
Stage: TS24
Assay Id: MGI:5817437
Age: embryonic day 16.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5817436
Assay Type: RT-PCR
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Stage: TS27
Assay Id: MGI:5817437
Age: postnatal day 0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5817436
Assay Type: RT-PCR
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524728
Stage: TS28
Assay Id: MGI:5817437
Age: postnatal day 8
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5817478
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1728627
Stage: TS27
Assay Id: MGI:5817479
Age: postnatal day 0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5817478
Assay Type: Western blot
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:5817479
Age: postnatal day 0
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5817478
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5817482
Age: postnatal day 0
Note: Expression is in the cellular outline of hair and supporting cells.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5817478
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3524727
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5817482
Age: postnatal day 0
Note: Expression is in the boundaries between hair and supporting cells, in hair cell stereocilia, and is strongest surrounding the supporting pillar cells.
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:5817478
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906127
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5817482
Age: postnatal day 0
Note: Expression is in the sensory epithelium.
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5817478
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1906127
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:5817482
Age: postnatal day 0
Note: Expression is in the cellular outline of hair and supporting cells.
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5817478
Assay Type: Immunohistochemistry
Annotation Date: 2017-01-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3582727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5817482
Age: postnatal day 0
Detected: true
Specimen Num: 1
Publication
First Author: Jeannin P
Year: 2005
Journal: Immunity
Title: Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.
Volume: 22
Issue: 5
Pages: 551-60
Publication
First Author: Souza DG
Year: 2002
Journal: Am J Pathol
Title: Increased mortality and inflammation in tumor necrosis factor-stimulated gene-14 transgenic mice after ischemia and reperfusion injury.
Volume: 160
Issue: 5
Pages: 1755-65
Publication
First Author: Kim J
Year: 2011
Journal: Cell Stem Cell
Title: Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.
Volume: 9
Issue: 5
Pages: 413-9
Publication
First Author: Tsukita S
Year: 2012
Journal: Cell Metab
Title: Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.
Volume: 16
Issue: 6
Pages: 825-32
Publication
First Author: Rong J
Year: 2012
Journal: PLoS One
Title: Identification of candidate susceptibility and resistance genes of mice infected with Streptococcus suis type 2.
Volume: 7
Issue: 2
Pages: e32150
Publication
First Author: Matsuda M
Year: 2017
Journal: J Biol Chem
Title: Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
Volume: 292
Issue: 20
Pages: 8369-8380
Publication  
First Author: Chui A
Year: 2020
Journal: Development
Title: Oxidative stress regulates progenitor behavior and cortical neurogenesis.
Volume: 147
Issue: 5
Publication
First Author: Wallén A
Year: 1999
Journal: Exp Cell Res
Title: Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice.
Volume: 253
Issue: 2
Pages: 737-46
Publication
First Author: Wilson DG
Year: 2012
Journal: Dev Biol
Title: Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning.
Volume: 363
Issue: 2
Pages: 413-25
Publication
First Author: Baizabal JM
Year: 2018
Journal: Neuron
Title: The Epigenetic State of PRDM16-Regulated Enhancers in Radial Glia Controls Cortical Neuron Position.
Volume: 98
Issue: 5
Pages: 945-962.e8
Publication
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
Publication
First Author: Abdallah BM
Year: 2011
Journal: J Bone Miner Res
Title: DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.
Volume: 26
Issue: 7
Pages: 1457-71
Publication
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47