|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 172 for Rab32

<< First    < Previous  |  Next >    Last >>
0.038s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
10981 | RAB32
Type: gene
Organism: human
•
•
•
•
•
Gene
496729 | rab32
Type: gene
Organism: frog, western clawed
•
•
•
•
•
Gene
365042 | Rab32
Type: gene
Organism: rat
•
•
•
•
•
Gene
748474 | RAB32
Type: gene
Organism: chimpanzee
•
•
•
•
•
Gene
528099 | RAB32
Type: gene
Organism: cattle
•
•
•
•
•
Gene
100856634 | RAB32
Type: gene
Organism: dog, domestic
•
•
•
•
•
Gene
421616 | RAB32
Type: gene
Organism: chicken
•
•
•
•
•
Gene
702431 | RAB32
Type: gene
Organism: macaque, rhesus
•
•
•
•
•
Protein Coding Gene
MGI:1915094 | Rab32
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Publication
14499590 | J:85758
First Author: Cohen-Solal KA
Year: 2003
Journal: Biochim Biophys Acta
Title: Identification and characterization of mouse Rab32 by mRNA and protein expression analysis.
Volume: 1651
Issue: 1-2
Pages: 68-75
•
•
•
•
•
Publication
31399401 | J:293385
First Author: Aguilar A
Year: 2019
Journal: Blood Adv
Title: Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Volume: 3
Issue: 15
Pages: 2368-2380
•
•
•
•
•
Publication
26885862 | J:231298
First Author: Li Y
Year: 2016
Journal: Immunity
Title: Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment.
Volume: 44
Issue: 2
Pages: 422-37
•
•
•
•
•
Publication
26620560 | J:230050
First Author: Marubashi S
Year: 2016
Journal: J Biol Chem
Title: RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
Volume: 291
Issue: 3
Pages: 1427-40
•
•
•
•
•
Publication
30338217 | J:267497
First Author: Xie X
Year: 2018
Journal: FEBS Open Bio
Title: Rab32-related antimicrobial pathway is involved in the progression of dextran sodium sulfate-induced colitis.
Volume: 8
Issue: 10
Pages: 1658-1668
•
•
•
•
•
Publication
32703879 | J:297588
First Author: Chen M
Year: 2020
Journal: Science
Title: Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.
Volume: 369
Issue: 6502
Pages: 450-455
•
•
•
•
•
Publication
37625588 | J:341218
First Author: Noda K
Year: 2023
Journal: J Biol Chem
Title: Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages.
Volume: 299
Issue: 10
Pages: 105191
•
•
•
•
•
Publication
19403694 | J:215882
First Author: Tamura K
Year: 2009
Journal: Mol Biol Cell
Title: Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
Volume: 20
Issue: 12
Pages: 2900-8
•
•
•
•
•
Protein Coding Gene
MGP_CAROLIEiJ_G0015112 | -
Type: protein_coding_gene
Organism: Mus caroli
•
•
•
•
•
Protein Coding Gene
MGP_129S1SvImJ_G0017009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AJ_G0016987 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_AKRJ_G0016951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_BALBcJ_G0016945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C3HHeJ_G0016770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGI_C57BL6J_1915094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_C57BL6NJ_G0017407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CASTEiJ_G0016352 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0016742 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0016850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0016845 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0016925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0016875 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0017445 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0016137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0016414 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0023731 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0015920 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875298
Note: kidney
Specimen Label: UC Davis_1875298
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875302
Note: kidney
Specimen Label: UC Davis_1875302
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875303
Note: kidney
Specimen Label: UC Davis_1875303
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1868128
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875307
Note: vas deferens
Specimen Label: UC Davis_1875307
Detected: false
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875304
Specimen Label: UC Davis_1875304
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1928728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875306
Specimen Label: UC Davis_1875306
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1885228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875296
Specimen Label: UC Davis_1875296
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Absent
Sex: Male
Emaps: EMAPS:1929028
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875305
Specimen Label: UC Davis_1875305
Detected: false
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875297
Specimen Label: UC Davis_1875297
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3276428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691773
Age: postnatal adult
Image: UC Davis_1875301
Specimen Label: UC Davis_1875301
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
26275310 | J:233984
First Author: Kirov JV
Year: 2015
Journal: PLoS One
Title: Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.
Volume: 10
Issue: 8
Pages: e0134155
•
•
•
•
•
Publication
30333037 | J:267504
First Author: Kiyama T
Year: 2018
Journal: Mol Neurodegener
Title: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis.
Volume: 13
Issue: 1
Pages: 56
•
•
•
•
•
Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
•
•
•
•
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
17043139 | J:114509
First Author: Wasmeier C
Year: 2006
Journal: J Cell Biol
Title: Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.
Volume: 175
Issue: 2
Pages: 271-81
•
•
•
•
•
Publication
23174301 | J:320062
First Author: Marks MS
Year: 2012
Journal: Curr Biol
Title: Organelle biogenesis: en BLOC exchange for RAB32 and RAB38.
Volume: 22
Issue: 22
Pages: R963-5
•
•
•
•
•
Publication
23247405 | J:320067
First Author: Bultema JJ
Year: 2013
Journal: Small GTPases
Title: Cell type-specific Rab32 and Rab38 cooperate with the ubiquitous lysosome biogenesis machinery to synthesize specialized lysosome-related organelles.
Volume: 4
Issue: 1
Pages: 16-21
•
•
•
•
•
Publication
26818140 | -
 
First Author: Coppola U
Year: 2016
Journal: BMC Evol Biol
Title: Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective.
Volume: 16
Pages: 26
•
•
•
•
•
Publication
12186851 | -
First Author: Alto NM
Year: 2002
Journal: J Cell Biol
Title: Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics.
Volume: 158
Issue: 4
Pages: 659-68
•
•
•
•
•
Publication
9497254 | -
First Author: Oh J
Year: 1998
Journal: Am J Hum Genet
Title: Mutation analysis of patients with Hermansky-Pudlak syndrome: a frameshift hot spot in the HPS gene and apparent locus heterogeneity.
Volume: 62
Issue: 3
Pages: 593-8
•
•
•
•
•
Protein Domain
IPR026053 | HPS1
Type: Family
Description: Defects in human HPS1 are the cause of Hermansky-Pudlak syndrome type 1 (HPS1). Hermansky-Pudlak syndrome (HPS) is an often-fatal autosomal recessive disease in which albinism, bleeding, and lysosomal storage result from defects of diverse cytoplasmic organelles: melanosomes, platelet dense bodies, and lysosomes [, ].Human HPS1 is a transmembrane protein component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 [].
•
•
•
•
•
Publication
24788816 | -
First Author: Wang S
Year: 2014
Journal: PLoS One
Title: A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor.
Volume: 9
Issue: 5
Pages: e96242
•
•
•
•
•
Publication
22042847 | -
First Author: Spanò S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella.
Volume: 108
Issue: 45
Pages: 18418-23
•
•
•
•
•
Publication
24531472 | -
First Author: Kohler AC
Year: 2014
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural and enzymatic characterization of a host-specificity determinant from Salmonella.
Volume: 70
Issue: Pt 2
Pages: 384-91
•
•
•
•
•
Protein Domain
IPR030697 | Rab29/Rab38/Rab32
Type: Family
Description: This entry represents the Rab29/Rab38/Rab32 subfamily. They are members of the Rab family of small GTPases. Human Rab32 was first identified in platelets but it is expressed in a variety of cell types, where it functions as an A-kinase anchoring protein (AKAP) []. Rab32 and closely related Rab38 are functionally redundant regulators of melanosomal protein trafficking and melanocyte pigmentation [, ].Ras-related protein Rab29 (also known as RAB7L) is related to Rab32 and Rab38. Rab29 regulates phagocytosis and traffic from the Golgi to the lysosome []. It is associated with trans-Golgi network (TGN) and is essential for maintaining the integrity of the TGN. Together with LRRK2, it plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner []. Rab29, Rab32 and Rab38 can be cleaved by GtgE, which is an effector protein from Salmonella Typhimurium that modulates trafficking of the Salmonella-containing vacuole (SCV) []. By targeting these GTPases, GtgE allows survival of the pathogen by preventing the delivery of antimicrobial factors to the SCV [].
•
•
•
•
•
Publication
25220469 | J:233558
First Author: Zhang Z
Year: 2014
Journal: Structure
Title: Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2.
Volume: 22
Issue: 10
Pages: 1408-20
•
•
•
•
•
Publication
11836498 | J:75144
First Author: Suzuki T
Year: 2002
Journal: Nat Genet
Title: Hermansky-Pudlak syndrome is caused by mutations in HPS4, the human homolog of the mouse light-ear gene.
Volume: 30
Issue: 3
Pages: 321-4
•
•
•
•
•
Protein
D3Z7V5
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
•
•
•
•
•
Publication
22637480 | -
First Author: Nottingham RM
Year: 2012
Journal: J Biol Chem
Title: RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36.
Volume: 287
Issue: 27
Pages: 22740-8
•
•
•
•
•
Protein Domain
IPR026091 | HPS4
Type: Family
Description: Hermansky-Pudlak syndrome (HPS) is a disorder of organelle biogenesis in which oculocutaneous albinism, bleeding and pulmonary fibrosis result from defects of melanosomes, platelet dense granules and lysosomes []. HPS is common in Puerto Rico, where is mostly caused by mutations in the genes HPS1 or HPS3. Another HPS locus, HPS4 was identified by using mouse models []. It was suggested that HPS4 and HPS1 proteins may function in the same pathway of organelle biogenesis [].This family represents BLOC-3 complex member HPS4, a component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 [].
•
•
•
•
•
Protein
A0A140LIS2
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom