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Search results 1 to 100 out of 217 for Rab8a

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0.039s

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein
Q0PD50
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Gene
4218 | RAB8A
Type: gene
Organism: human
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Gene
468760 | RAB8A
Type: gene
Organism: chimpanzee
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Gene
100125881 | RAB8A
Type: gene
Organism: cattle
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Gene
428352 | RAB8A
Type: gene
Organism: chicken
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Gene
571897 | rab8a
Type: gene
Organism: zebrafish
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Gene
100423251 | RAB8A
Type: gene
Organism: macaque, rhesus
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Gene
100125217 | rab8a
Type: gene
Organism: frog, western clawed
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Gene
403773 | RAB8A
Type: gene
Organism: dog, domestic
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Gene
117103 | Rab8a
Type: gene
Organism: rat
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Protein Coding Gene
MGI:96960 | Rab8a
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28079283 | J:240410
First Author: Li H
Year: 2017
Journal: FEBS Lett
Title: Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts.
Volume: 591
Issue: 3
Pages: 491-499
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Publication
19625297 | J:152919
First Author: Hsiao YC
Year: 2009
Journal: Hum Mol Genet
Title: Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking.
Volume: 18
Issue: 20
Pages: 3926-41
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Publication
24399445 | J:210104
First Author: Vacca B
Year: 2014
Journal: Hum Mol Genet
Title: Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.
Volume: 23
Issue: 11
Pages: 2834-46
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Publication
28696211 | J:247087
First Author: Chen Q
Year: 2017
Journal: Diabetes
Title: Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Volume: 66
Issue: 9
Pages: 2387-2399
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Publication
24983211 | J:215464
 
First Author: Yin G
Year: 2014
Journal: Neurobiol Dis
Title: α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner.
Volume: 70
Pages: 149-61
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Publication
28596241 | J:248502
First Author: Feng Q
Year: 2017
Journal: J Cell Sci
Title: Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy.
Volume: 130
Issue: 15
Pages: 2491-2505
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Publication
30285101 | J:277416
First Author: Pan ZN
Year: 2019
Journal: Biol Reprod
Title: RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†.
Volume: 100
Issue: 3
Pages: 711-720
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Publication
27529348 | J:236981
First Author: Ying G
Year: 2016
Journal: PLoS One
Title: Small GTPases Rab8a and Rab11a Are Dispensable for Rhodopsin Transport in Mouse Photoreceptors.
Volume: 11
Issue: 8
Pages: e0161236
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Publication
24213529 | J:211898
First Author: Sato T
Year: 2014
Journal: J Cell Sci
Title: Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.
Volume: 127
Issue: Pt 2
Pages: 422-31
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Publication
22354172 | J:184563
First Author: Sakamori R
Year: 2012
Journal: J Clin Invest
Title: Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Volume: 122
Issue: 3
Pages: 1052-65
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Publication
26015543 | J:239365
First Author: Das S
Year: 2015
Journal: Development
Title: Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.
Volume: 142
Issue: 12
Pages: 2147-62
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Publication
33662399 | J:313266
 
First Author: Stypulkowski E
Year: 2021
Journal: J Biol Chem
Title: Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.
Volume: 296
Pages: 100488
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Publication
11773082 | J:75312
First Author: Kuroda TS
Year: 2002
Journal: J Biol Chem
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Volume: 277
Issue: 11
Pages: 9212-8
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Publication
25158853 | J:311758
First Author: Wu L
Year: 2014
Journal: Dev Cell
Title: Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
Volume: 30
Issue: 4
Pages: 378-93
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Publication
20592197 | J:161846
First Author: Westfall JE
Year: 2010
Journal: J Neurosci
Title: Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.
Volume: 30
Issue: 26
Pages: 8759-68
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Publication
24421332 | J:208267
First Author: Kobayashi T
Year: 2014
Journal: J Cell Biol
Title: The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.
Volume: 204
Issue: 2
Pages: 215-29
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Publication
12578829 | J:83108
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
Volume: 278
Issue: 17
Pages: 15373-80
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Publication
18094055 | J:200405
First Author: Yamamura R
Year: 2008
Journal: Mol Biol Cell
Title: The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
Volume: 19
Issue: 3
Pages: 971-83
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Publication
12590134 | J:83162
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.
Volume: 278
Issue: 17
Pages: 15390-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0031211 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033756 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033682 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033750 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033459 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_96960 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034270 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033438 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033592 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033581 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034287 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032494 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032902 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021676 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032331 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
1886711 | J:11402
First Author: Nimmo ER
Year: 1991
Journal: Oncogene
Title: The MEL gene: a new member of the RAB/YPT class of RAS-related genes.
Volume: 6
Issue: 8
Pages: 1347-51
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Publication
17597763 | J:123415
First Author: Sato T
Year: 2007
Journal: Nature
Title: The Rab8 GTPase regulates apical protein localization in intestinal cells.
Volume: 448
Issue: 7151
Pages: 366-9
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Publication
23175844 | J:192810
First Author: Esseltine JL
Year: 2012
Journal: J Neurosci
Title: Rab8 modulates metabotropic glutamate receptor subtype 1 intracellular trafficking and signaling in a protein kinase C-dependent manner.
Volume: 32
Issue: 47
Pages: 16933-42a
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GXD Expression
GXD Expression
   
Probe: MGI:7529954
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:7529975
Age: embryonic day 15.5
Image: S4
Specimen Label: FL (E15.5)
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7529954
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:7529975
Age: embryonic day 17.5
Image: S4
Specimen Label: FL (E17.5)
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7529954
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283427
Stage: TS27
Assay Id: MGI:7529975
Age: postnatal newborn
Image: S4
Specimen Label: S.I.
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7529954
Assay Type: RT-PCR
Annotation Date: 2023-09-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7529975
Age: postnatal adult
Image: S4
Specimen Label: Adult brain
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7547268
Assay Type: RT-PCR
Annotation Date: 2023-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7547303
Age: embryonic day 15.5
Image: 6
Specimen Label: Cenpj+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7547268
Assay Type: RT-PCR
Annotation Date: 2023-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:7547303
Age: embryonic day 15.5
Image: 6
Specimen Label: CenpjCKO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5751265
Age: embryonic day 18.5
Image: 8A Ahi1+/+
Note: Expression is in photoreceptor neuroblasts.
Specimen Label: 8A Ahi1+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1859026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:5751265
Age: embryonic day 18.5
Image: 8A Ahi1-/-
Note: Expression is in photoreceptor neuroblasts.
Specimen Label: 8A Ahi1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5751265
Age: postnatal
Image: 8B Ahi1+/+ top
Specimen Label: 8B Ahi1+/+ top
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5751265
Age: postnatal
Image: 8B Ahi1+/+ bottom
Specimen Label: 8B Ahi1+/+ bottom
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3568628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5751265
Age: postnatal
Image: 8B Ahi1-/- top
Specimen Label: 8B Ahi1-/- top
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5751264
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-07
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3568628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5751265
Age: postnatal
Image: 8B Ahi1-/- bottom
Specimen Label: 8B Ahi1-/- bottom
Detected: true
Specimen Num: 6
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Publication
8643544 | J:36261
First Author: Ren M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase.
Volume: 93
Issue: 10
Pages: 5151-5
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Publication
18381201 | J:134499
First Author: Muramatsu K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Neuron-specific recombination by Cre recombinase inserted into the murine tau locus.
Volume: 370
Issue: 3
Pages: 419-23
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Publication
20048263 | J:296099
First Author: Follit JA
Year: 2010
Journal: J Cell Biol
Title: The cytoplasmic tail of fibrocystin contains a ciliary targeting sequence.
Volume: 188
Issue: 1
Pages: 21-8
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Publication
25673875 | J:311072
First Author: Knowles BC
Year: 2015
Journal: J Cell Sci
Title: Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
Volume: 128
Issue: 8
Pages: 1617-26
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Publication
28076793 | J:254044
First Author: Burikhanov R
Year: 2017
Journal: Cell Rep
Title: Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.
Volume: 18
Issue: 2
Pages: 508-519
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Publication
25860027 | J:222401
First Author: Zhang B
Year: 2015
Journal: PLoS Biol
Title: GSK3β-Dzip1-Rab8 cascade regulates ciliogenesis after mitosis.
Volume: 13
Issue: 4
Pages: e1002129
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Publication
14722103 | J:166024
First Author: Fukuda M
Year: 2004
Journal: J Biol Chem
Title: Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
Volume: 279
Issue: 13
Pages: 13065-75
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Publication
10501980 | J:57794
First Author: Carver EA
Year: 1999
Journal: Mamm Genome
Title: Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.
Volume: 10
Issue: 10
Pages: 1039-40
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Publication
26833786 | J:236573
First Author: Nakajo A
Year: 2016
Journal: J Cell Biol
Title: EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
Volume: 212
Issue: 3
Pages: 297-306
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Publication
19061864 | J:142909
First Author: Uechi Y
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Rap2 function requires palmitoylation and recycling endosome localization.
Volume: 378
Issue: 4
Pages: 732-7
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Publication
22068051 | J:180161
First Author: Dupont N
Year: 2011
Journal: EMBO J
Title: Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β.
Volume: 30
Issue: 23
Pages: 4701-11
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Publication
11266470 | J:67601
First Author: Hume AN
Year: 2001
Journal: J Cell Biol
Title: Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
Volume: 152
Issue: 4
Pages: 795-808
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Publication
1675193 | J:11233
First Author: Howard TA
Year: 1991
Journal: Genomics
Title: A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19.
Volume: 10
Issue: 1
Pages: 207-13
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Publication
24469809 | J:206657
First Author: Ye X
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Volume: 111
Issue: 6
Pages: 2164-9
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Publication
8649810 | J:31975
First Author: Rao G
Year: 1996
Journal: Oncogene
Title: Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.
Volume: 12
Issue: 5
Pages: 1165-72
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Publication
16093251 | J:105074
First Author: Darakhshan F
Year: 2006
Journal: Carcinogenesis
Title: Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Volume: 27
Issue: 2
Pages: 311-8
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Publication
37042948 | J:340074
First Author: Wu J
Year: 2023
Journal: Blood Adv
Title: EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.
Volume: 7
Issue: 14
Pages: 3382-3394
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Publication
25975226 | J:317793
First Author: De Zio D
Year: 2015
Journal: Cell Mol Life Sci
Title: Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth.
Volume: 72
Issue: 21
Pages: 4173-91
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Publication
27019864 | J:240239
First Author: Weis VG
Year: 2016
Journal: Cell Mol Gastroenterol Hepatol
Title: Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.
Volume: 2
Issue: 2
Pages: 131-157
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Publication
24947469 | J:226310
 
First Author: Veleri S
Year: 2014
Journal: Nat Commun
Title: Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.
Volume: 5
Pages: 4207
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Publication
17765678 | J:124940
First Author: Nechiporuk T
Year: 2007
Journal: Dev Cell
Title: Failure of epithelial tube maintenance causes hydrocephalus and renal cysts in Dlg5-/- mice.
Volume: 13
Issue: 3
Pages: 338-50
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Publication
8833158 | J:31844
First Author: Ishikawa TO
Year: 1996
Journal: Genomics
Title: Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors.
Volume: 32
Issue: 2
Pages: 285-8
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Publication
29038301 | J:255486
First Author: Agbu SO
Year: 2018
Journal: J Cell Biol
Title: The small GTPase RSG1 controls a final step in primary cilia initiation.
Volume: 217
Issue: 1
Pages: 413-427
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Publication
30626697 | J:273130
First Author: Ding W
Year: 2019
Journal: J Neurosci
Title: Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex.
Volume: 39
Issue: 11
Pages: 1994-2010
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Publication
20551175 | J:161201
First Author: Gao N
Year: 2010
Journal: Genes Dev
Title: Cdx2 regulates endo-lysosomal function and epithelial cell polarity.
Volume: 24
Issue: 12
Pages: 1295-305
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Publication
25063677 | J:215917
First Author: Yu S
Year: 2014
Journal: EMBO J
Title: TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
Volume: 33
Issue: 17
Pages: 1882-95
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Publication
29330353 | J:260459
First Author: Azizoglu DB
Year: 2017
Journal: Genes Dev
Title: Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis.
Volume: 31
Issue: 23-24
Pages: 2376-2390
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Publication
1981054 | J:10993
First Author: Saunders AM
Year: 1990
Journal: Genomics
Title: A molecular genetic linkage map of mouse chromosome 7.
Volume: 8
Issue: 3
Pages: 525-35
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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