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Search results 1 to 100 out of 503 for Raf1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
5894 | RAF1
Type: gene
Organism: human
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Gene
549871 | raf1
Type: gene
Organism: frog, western clawed
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Gene
key_20620 | RAF1
Type: gene
Organism: cat, domestic
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Gene
24703 | Raf1
Type: gene
Organism: rat
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Gene
460182 | RAF1
Type: gene
Organism: chimpanzee
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Gene
484648 | RAF1
Type: gene
Organism: dog, domestic
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Gene
521196 | RAF1
Type: gene
Organism: cattle
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Gene
396245 | RAF1
Type: gene
Organism: chicken
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Gene
694725 | RAF1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR037494 | RAF1
Type: Family
Description: Ribulose-1,5-bis-phosphate carboxylase/oxygenase (Rubisco) is the rate-limiting carbon fixing enzyme of photosynthesis. Rubisco is a complex of eight large (RbcL) and eight small (RbcS) subunits that requires assembly chaperones. Rubisco accumulation factor 1 (Raf1) is a mayor chaperone involved in Rubisco assembly []. It acts downstream of chaperonin-assisted RbcL folding by stabilizing RbcL antiparallel dimers for assembly into RbcL8 complexes with four Raf1 dimers bound. Raf1 displacement by RbcS results in holoenzyme formation [, ]. It might regulate RuBisCO condensation and decondensation [].
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Protein Coding Gene
MGI:97847 | Raf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
348910 | RAF1P1
Type: gene
Organism: human
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Publication
26237510 | -
First Author: Hauser T
Year: 2015
Journal: Nat Struct Mol Biol
Title: Structure and mechanism of the Rubisco-assembly chaperone Raf1.
Volume: 22
Issue: 9
Pages: 720-8
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Publication
22942379 | -
First Author: Feiz L
Year: 2012
Journal: Plant Cell
Title: Ribulose-1,5-bis-phosphate carboxylase/oxygenase accumulation factor1 is required for holoenzyme assembly in maize.
Volume: 24
Issue: 8
Pages: 3435-46
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Publication
32636267 | -
First Author: Huang F
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Rubisco accumulation factor 1 (Raf1) plays essential roles in mediating Rubisco assembly and carboxysome biogenesis.
Volume: 117
Issue: 29
Pages: 17418-17428
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Publication
32451445 | -
First Author: Xia LY
Year: 2020
Journal: Nat Plants
Title: Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1.
Volume: 6
Issue: 6
Pages: 708-717
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Publication
28000790 | J:243447
 
First Author: Jeric I
Year: 2016
Journal: Nat Commun
Title: A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Volume: 7
Pages: 13781
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Publication
12901876 | J:85048
First Author: Nakayama K
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Raf1 plays a pivotal role in lipopolysaccharide-induced activation of dendritic cells.
Volume: 308
Issue: 2
Pages: 353-60
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Publication
11597136 | J:72223
First Author: Gray TA
Year: 2001
Journal: Genomics
Title: Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.
Volume: 77
Issue: 3
Pages: 119-26
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Publication
22826437 | J:189143
First Author: Wu X
Year: 2012
Journal: Mol Cell Biol
Title: Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants.
Volume: 32
Issue: 19
Pages: 3872-90
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Publication
26940993 | J:251085
 
First Author: Passariello CL
Year: 2016
Journal: J Mol Cell Cardiol
Title: RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome.
Volume: 93
Pages: 98-105
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Publication
33513349 | J:303935
First Author: Sanclemente M
Year: 2021
Journal: Cancer Cell
Title: RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression.
Volume: 39
Issue: 3
Pages: 294-296
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Protein
Q8C6X7
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Protein
Q8C3L4
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
Q53ZF0
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Publication
25512490 | J:216935
First Author: Xu B
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility.
Volume: 111
Issue: 52
Pages: 18643-8
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Publication
7587388 | J:29705
First Author: Aldaz CM
Year: 1995
Journal: Cytogenet Cell Genet
Title: Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3-->42.1.
Volume: 71
Issue: 3
Pages: 253-6
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Publication
19063885 | J:142680
First Author: Malik NM
Year: 2009
Journal: FEBS Lett
Title: Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
Volume: 583
Issue: 1
Pages: 61-9
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Publication
10775035 | J:80895
First Author: Kerkhoff E
Year: 2000
Journal: Cell Growth Differ
Title: Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.
Volume: 11
Issue: 4
Pages: 185-90
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Publication
37625265 | J:340290
 
First Author: Zhong S
Year: 2023
Journal: EBioMedicine
Title: Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model.
Volume: 95
Pages: 104763
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Publication
23391722 | J:196395
First Author: Deng Y
Year: 2013
Journal: J Clin Invest
Title: Endothelial ERK signaling controls lymphatic fate specification.
Volume: 123
Issue: 3
Pages: 1202-15
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Publication
27431613 | J:235140
   
First Author: Raguz J
Year: 2016
Journal: Elife
Title: Epidermal RAF prevents allergic skin disease.
Volume: 5
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Publication
21339642 | J:172034
First Author: Wu X
Year: 2011
Journal: J Clin Invest
Title: MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
Volume: 121
Issue: 3
Pages: 1009-25
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Publication
28548091 | J:249593
 
First Author: Yin JC
Year: 2017
Journal: Nat Commun
Title: Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome.
Volume: 8
Pages: 15518
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Publication
2341153 | J:10507
First Author: Elliott RW
Year: 1990
Journal: Genomics
Title: Localization of the rhodopsin gene to the distal half of mouse chromosome 6.
Volume: 6
Issue: 4
Pages: 635-44
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Publication
23529931 | J:198221
First Author: Deng Y
Year: 2013
Journal: Blood
Title: Endothelial RAF1/ERK activation regulates arterial morphogenesis.
Volume: 121
Issue: 19
Pages: 3988-96, S1-9
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Publication
25096573 | J:311798
First Author: Zanucco E
Year: 2014
Journal: J Biol Chem
Title: Elimination of B-RAF in oncogenic C-RAF-expressing alveolar epithelial type II cells reduces MAPK signal intensity and lung tumor growth.
Volume: 289
Issue: 39
Pages: 26804-26816
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Publication
26722025 | J:309202
First Author: Liao J
Year: 2016
Journal: Anticancer Res
Title: Inhibition of Chronic Pancreatitis and Murine Pancreatic Intraepithelial Neoplasia by a Dual Inhibitor of c-RAF and Soluble Epoxide Hydrolase in LSL-KrasG¹²D/Pdx-1-Cre Mice.
Volume: 36
Issue: 1
Pages: 27-37
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Publication
24530606 | J:225239
First Author: Li X
Year: 2014
Journal: Gastroenterology
Title: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Volume: 146
Issue: 5
Pages: 1301-12.e1-10
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Publication
33331896 | J:338790
First Author: Cui Y
Year: 2021
Journal: Hum Mol Genet
Title: Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway.
Volume: 29
Issue: 23
Pages: 3793-3806
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Publication
17396120 | J:121660
First Author: Zhong J
Year: 2007
Journal: Nat Neurosci
Title: Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.
Volume: 10
Issue: 5
Pages: 598-607
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Publication
15305288 | J:91734
First Author: Wang Y
Year: 2004
Journal: Dev Dyn
Title: Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.
Volume: 231
Issue: 1
Pages: 72-87
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Protein Coding Gene
MGP_CAROLIEiJ_G0028755 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0031152 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0031121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0031052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0031132 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030576 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97847 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0031591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0030239 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030971 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0031051 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030959 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0031618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0030323 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022506 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029783 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10329666 | J:55090
First Author: Lin JH
Year: 1999
Journal: J Biol Chem
Title: The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1.
Volume: 274
Issue: 21
Pages: 14706-15
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Publication
11157055 | J:93687
First Author: Jesenberger V
Year: 2001
Journal: J Exp Med
Title: Protective role of Raf-1 in Salmonella-induced macrophage apoptosis.
Volume: 193
Issue: 3
Pages: 353-64
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Publication
18922468 | J:141095
First Author: Noble C
Year: 2008
Journal: Mol Cell
Title: CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
Volume: 31
Issue: 6
Pages: 862-72
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Publication
9767153 | J:50696
First Author: Wojnowski L
Year: 1998
Journal: Mech Dev
Title: Craf-1 protein kinase is essential for mouse development.
Volume: 76
Issue: 1-2
Pages: 141-9
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Publication
11296227 | J:89619
First Author: Hüser M
Year: 2001
Journal: EMBO J
Title: MEK kinase activity is not necessary for Raf-1 function.
Volume: 20
Issue: 8
Pages: 1940-51
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Publication
14576068 | J:89053
First Author: Kamata T
Year: 2004
Journal: Blood
Title: Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation.
Volume: 103
Issue: 7
Pages: 2568-70
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Publication
29590115 | J:260523
First Author: Pfeiffer V
Year: 2018
Journal: PLoS One
Title: Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.
Volume: 13
Issue: 3
Pages: e0192067
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Publication
24129679 | J:206060
First Author: Doma E
Year: 2013
Journal: Cancer Res
Title: Skin tumorigenesis stimulated by Raf inhibitors relies upon Raf functions that are dependent and independent of ERK.
Volume: 73
Issue: 23
Pages: 6926-37
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Publication
31017896 | J:275014
First Author: Holter MC
Year: 2019
Journal: PLoS Genet
Title: The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learning.
Volume: 15
Issue: 4
Pages: e1008108
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Publication
22365547 | J:182703
First Author: Napoli I
Year: 2012
Journal: Neuron
Title: A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo.
Volume: 73
Issue: 4
Pages: 729-42
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Publication
6308607 | J:7145
First Author: Rapp UR
Year: 1983
Journal: Proc Natl Acad Sci U S A
Title: Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.
Volume: 80
Issue: 14
Pages: 4218-22
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Publication
6690719 | J:7278
First Author: Kozak C
Year: 1984
Journal: J Virol
Title: A new oncogene, c-raf, is located on mouse chromosome 6.
Volume: 49
Issue: 1
Pages: 297-9
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Publication
6320371 | J:7324
First Author: Kan NC
Year: 1984
Journal: Science
Title: A common onc gene sequence transduced by avian carcinoma virus MH2 and by murine sarcoma virus 3611.
Volume: 223
Issue: 4638
Pages: 813-6
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Publication
6324342 | J:32615
First Author: Mark GE
Year: 1984
Journal: Science
Title: Primary structure of v-raf: relatedness to the src family of oncogenes.
Volume: 224
Issue: 4646
Pages: 285-9
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Publication
3399964 | J:9274
First Author: Ingvarsson S
Year: 1988
Journal: Somat Cell Mol Genet
Title: Rat c-raf oncogene is located on chromosome 4 and may be activated by sequences from chromosome 13.
Volume: 14
Issue: 4
Pages: 401-5
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Publication
2463463 | J:30955
First Author: Yoo-Warren H
Year: 1988
Journal: Mol Cell Biol
Title: Two regulatory domains flank the mouse H19 gene.
Volume: 8
Issue: 11
Pages: 4707-15
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Publication
2758403 | J:9909
First Author: Tailor S
Year: 1989
Journal: Cancer Genet Cytogenet
Title: Localization of the raf-1 protooncogene on chromosome 6 of the mouse.
Volume: 40
Issue: 1
Pages: 89-94
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Publication
1992343 | J:40446
First Author: Kolch W
Year: 1991
Journal: Nature
Title: Raf-1 protein kinase is required for growth of induced NIH/3T3 cells.
Volume: 349
Issue: 6308
Pages: 426-8
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Publication
8455932 | J:4634
First Author: Wadewitz AG
Year: 1993
Journal: Oncogene
Title: Developmental and cell lineage specificity of raf family gene expression in mouse testis.
Volume: 8
Issue: 4
Pages: 1055-62
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Publication
8340392 | J:14199
First Author: Miltenberger RJ
Year: 1993
Journal: J Biol Chem
Title: An inhibitory Raf-1 mutant suppresses expression of a subset of v-raf-activated genes.
Volume: 268
Issue: 21
Pages: 15674-80
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Publication
8036007 | J:19420
First Author: Cleveland JL
Year: 1994
Journal: Oncogene
Title: v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.
Volume: 9
Issue: 8
Pages: 2217-26
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Publication
8048167 | J:19273
First Author: Avruch J
Year: 1994
Journal: Trends Biochem Sci
Title: Raf meets Ras: completing the framework of a signal transduction pathway.
Volume: 19
Issue: 7
Pages: 279-83
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Publication
7935384 | J:20915
First Author: Yamauchi N
Year: 1994
Journal: Mol Cell Biol
Title: The Ras/Raf signaling pathway is required for progression of mouse embryos through the two-cell stage.
Volume: 14
Issue: 10
Pages: 6655-62
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Publication
7649477 | J:28434
First Author: McCarthy SA
Year: 1995
Journal: Genes Dev
Title: Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.
Volume: 9
Issue: 16
Pages: 1953-64
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Publication
8566003 | J:30266
First Author: Taylor-Fishwick DA
Year: 1995
Journal: Eur J Immunol
Title: Raf-1 provides a dominant but not exclusive signal for the induction of CD69 expression on T cells.
Volume: 25
Issue: 12
Pages: 3215-21
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Publication
8999914 | J:38671
First Author: Ferrier AF
Year: 1997
Journal: J Biol Chem
Title: Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility.
Volume: 272
Issue: 4
Pages: 2136-42
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Publication
9038343 | J:38499
First Author: Hughes PE
Year: 1997
Journal: Cell
Title: Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway.
Volume: 88
Issue: 4
Pages: 521-30
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Publication
9281368 | J:42824
First Author: Raptis L
Year: 1997
Journal: Exp Cell Res
Title: v-Ras and v-Raf block differentiation of transformable C3H10T1/2-derived preadipocytes at lower levels than required for neoplastic transformation.
Volume: 235
Issue: 1
Pages: 188-97
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Publication
15703070 | J:97885
 
First Author: Gentschev I
Year: 2005
Journal: BMC Cancer
Title: Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice.
Volume: 5
Pages: 15
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Publication
15289381 | J:102149
First Author: Harris IS
Year: 2004
Journal: Circulation
Title: Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload.
Volume: 110
Issue: 6
Pages: 718-23
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Publication
18212057 | J:134211
First Author: Kuznetsov AV
Year: 2008
Journal: Mol Cell Biol
Title: Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets.
Volume: 28
Issue: 7
Pages: 2304-13
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Publication
18356164 | J:137583
First Author: Galmiche A
Year: 2008
Journal: J Biol Chem
Title: Isoform-specific interaction of C-RAF with mitochondria.
Volume: 283
Issue: 21
Pages: 14857-66
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Publication
19812696 | J:154101
First Author: Rohrbeck A
Year: 2009
Journal: PLoS One
Title: Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1.
Volume: 4
Issue: 10
Pages: e7315
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Publication
22209329 | J:180124
First Author: Wimmer R
Year: 2012
Journal: Dev Cell
Title: Angiogenic sprouting requires the fine tuning of endothelial cell cohesion by the Raf-1/Rok-α complex.
Volume: 22
Issue: 1
Pages: 158-71
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Publication
19529782 | J:192081
First Author: Rohrbeck A
Year: 2009
Journal: PLoS One
Title: Molecular characterization of lung dysplasia induced by c-Raf-1.
Volume: 4
Issue: 5
Pages: e5637
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Publication
32781248 | J:300684
 
First Author: He J
Year: 2020
Journal: Mol Cell Endocrinol
Title: The role of miR-7 as a potential switch in the mouse hypothalamus-pituitary-ovary axis through regulation of gonadotropins.
Volume: 518
Pages: 110969
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GXD Expression
GXD Expression
   
Probe: MGI:1328948
Assay Type: Northern blot
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1329346
Age: embryonic day 10.5
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1328948
Assay Type: Northern blot
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1329346
Age: embryonic day 10.5
Image: 2
Specimen Label: +/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1328948
Assay Type: Northern blot
Annotation Date: 1999-02-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1329346
Age: embryonic day 10.5
Image: 2
Specimen Label: +/-
Detected: true
Specimen Num: 3
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