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Search results 1 to 100 out of 3050 for Rag1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5896 | RAG1
Type: gene
Organism: human
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Gene
100145555 | rag1
Type: gene
Organism: frog, western clawed
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Gene
84600 | Rag1
Type: gene
Organism: rat
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Gene
483420 | RAG1
Type: gene
Organism: dog, domestic
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Gene
466489 | RAG1
Type: gene
Organism: chimpanzee
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Gene
506302 | RAG1
Type: gene
Organism: cattle
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Gene
423164 | RAG1
Type: gene
Organism: chicken
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Gene
30663 | rag1
Type: gene
Organism: zebrafish
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Gene
697322 | RAG1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR024627 | RAG1
Type: Family
Description: The development of B and T cells depends on the rearrangement of variable (V),diversity (D), and joining (J) gene segments to produce mature Ig and T cellreceptor coding regions. This rearrangement process, known as V(D)Jrecombination is initiated by a complex consisting of multi-domain proteins RAG1 and RAG2. The RAG proteins catalyse DNA cleavage in the first phase of thereaction using a recombination signal sequence (RSS) that flanks V, D and Jsegments [, , ].Recombination activating protein 1 (RAG1) is the catalytic component of the RAG complex []. RAG1 contains a RING finger domain that can act as a ubiquitin ligase (E3), and can promote its own ubiquitylation and targets both karyopherin alpha 1 (KPNA1) and histone 3 (H3) [, ].Many of the proteins recognised by this entry are fragments.
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Protein Coding Gene
MGI:97848 | Rag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9228952 | J:159276
First Author: Bellon SF
Year: 1997
Journal: Nat Struct Biol
Title: Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.
Volume: 4
Issue: 7
Pages: 586-91
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Publication
14671314 | J:88204
First Author: Jones JM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Autoubiquitylation of the V(D)J recombinase protein RAG1.
Volume: 100
Issue: 26
Pages: 15446-51
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Protein
Q3TR87
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
Q8C2F3
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Publication
19118899 | -
First Author: Simkus C
Year: 2009
Journal: Mol Immunol
Title: Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.
Volume: 46
Issue: 7
Pages: 1319-25
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Publication
21256161 | -
First Author: Jones JM
Year: 2011
Journal: Immunol Lett
Title: The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.
Volume: 136
Issue: 2
Pages: 156-62
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Publication
22796426 | -
First Author: Mao MG
Year: 2012
Journal: Fish Shellfish Immunol
Title: Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephelus akaara).
Volume: 33
Issue: 4
Pages: 725-35
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Protein
Q78NA6
Organism: Mus musculus/domesticus
Length: 1040  
Fragment?: false
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Protein
P15919
Organism: Mus musculus/domesticus
Length: 1040  
Fragment?: false
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Protein
Q6XC89
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: true
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Publication
37629019 | J:339649
 
First Author: Kumaraswami K
Year: 2023
Journal: Int J Mol Sci
Title: Rag1 Deficiency Impairs Arteriogenesis in Mice.
Volume: 24
Issue: 16
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Protein
Q8C2U3
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
Q5W9W8
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Protein
Q5W9W9
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Protein
A0A1B4Z9R9
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: true
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Protein
Q99NN8
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q5W9X0
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Protein
Q5W9W7
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Publication
19621044 | -
First Author: Matthews AG
Year: 2009
Journal: Nat Immunol
Title: RAG: a recombinase diversified.
Volume: 10
Issue: 8
Pages: 817-21
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Publication
1492366 | J:4508
First Author: Oettinger MA
Year: 1992
Journal: Trends Genet
Title: Activation of V(D)J recombination by RAG1 and RAG2.
Volume: 8
Issue: 12
Pages: 413-6
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Publication
26124138 | J:223802
First Author: Singh SK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Role of RAG1 autoubiquitination in V(D)J recombination.
Volume: 112
Issue: 28
Pages: 8579-83
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Publication
9464529 | J:45540
First Author: Fuller K
Year: 1997
Journal: Mol Immunol
Title: Identification and characterization of the murine Rag1 promoter.
Volume: 34
Issue: 12-13
Pages: 939-54
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Publication
14499112 | J:85807
First Author: Yokota T
Year: 2003
Journal: Immunity
Title: Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression.
Volume: 19
Issue: 3
Pages: 365-75
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Publication
12629039 | J:159076
First Author: Yurchenko V
Year: 2003
Journal: Genes Dev
Title: The RAG1 N-terminal domain is an E3 ubiquitin ligase.
Volume: 17
Issue: 5
Pages: 581-5
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Publication
29925675 | J:264321
First Author: Schabla NM
Year: 2018
Journal: J Immunol
Title: VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation.
Volume: 201
Issue: 3
Pages: 930-939
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Publication
21617701 | J:175726
First Author: Pike-Overzet K
Year: 2011
Journal: Leukemia
Title: Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Volume: 25
Issue: 9
Pages: 1471-83
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Publication
21115692 | J:330361
First Author: Ji Y
Year: 2010
Journal: J Exp Med
Title: Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
Volume: 207
Issue: 13
Pages: 2809-16
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Publication
10446057 | J:56778
First Author: Yu W
Year: 1999
Journal: Science
Title: Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2.
Volume: 285
Issue: 5430
Pages: 1080-4
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Publication
10586023 | J:79416
First Author: Kuwata N
Year: 1999
Journal: J Immunol
Title: Cutting edge: absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene.
Volume: 163
Issue: 12
Pages: 6355-9
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Publication
8052633 | J:19623
First Author: Cortes P
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
Volume: 91
Issue: 16
Pages: 7633-7
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Protein Domain
IPR035714 | RAG1_imp-bd
Type: Domain
Description: This region of RAG1 is responsible for binding to importin alpha [].
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Publication
34402853 | J:323218
 
First Author: Beilinson HA
Year: 2021
Journal: J Exp Med
Title: The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination.
Volume: 218
Issue: 10
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Publication
19180472 | J:144467
First Author: Toda T
Year: 2009
Journal: Eur J Immunol
Title: The immature B-cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse.
Volume: 39
Issue: 2
Pages: 600-11
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Publication
8953043 | J:37305
First Author: Han S
Year: 1996
Journal: Science
Title: Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
Volume: 274
Issue: 5295
Pages: 2094-7
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Publication
15254250 | J:92238
First Author: De P
Year: 2004
Journal: Mol Cell Biol
Title: DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.
Volume: 24
Issue: 15
Pages: 6850-60
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Publication
20398922 | J:160370
First Author: Ji Y
Year: 2010
Journal: Cell
Title: The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.
Volume: 141
Issue: 3
Pages: 419-31
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Publication
35948399 | J:349573
First Author: Burn TN
Year: 2022
Journal: J Immunol
Title: The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages.
Volume: 209
Issue: 5
Pages: 938-949
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Publication
18408759 | J:138509
First Author: Nepal RM
Year: 2008
Journal: Oncogene
Title: AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.
Volume: 27
Issue: 34
Pages: 4752-6
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Publication
26303526 | J:228215
First Author: Shetty K
Year: 2015
Journal: Mol Cell Biol
Title: Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.
Volume: 35
Issue: 21
Pages: 3701-13
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Publication
34260911 | J:330749
First Author: Kumari R
Year: 2021
Journal: Cell Rep
Title: MicroRNA miR-29c regulates RAG1 expression and modulates V(D)J recombination during B cell development.
Volume: 36
Issue: 2
Pages: 109390
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Publication
26887046 | J:265589
First Author: Ott de Bruin L
Year: 2016
Journal: Oncotarget
Title: Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes.
Volume: 7
Issue: 11
Pages: 12962-74
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Publication
19396172 | J:159059
First Author: Yin FF
Year: 2009
Journal: Nat Struct Mol Biol
Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Volume: 16
Issue: 5
Pages: 499-508
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Publication
8777717 | J:31229
First Author: Spanopoulou E
Year: 1995
Journal: Immunity
Title: Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.
Volume: 3
Issue: 6
Pages: 715-26
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Publication
9036966 | J:38505
First Author: McMahan CJ
Year: 1997
Journal: J Immunol
Title: Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2.
Volume: 158
Issue: 5
Pages: 2202-10
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Publication
25847946 | J:222628
First Author: Hao B
Year: 2015
Journal: J Exp Med
Title: An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
Volume: 212
Issue: 5
Pages: 809-24
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Publication
10601033 | J:159089
First Author: Kim DR
Year: 1999
Journal: Genes Dev
Title: Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.
Volume: 13
Issue: 23
Pages: 3070-80
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Publication
12644467 | J:83592
First Author: Peak MM
Year: 2003
Journal: J Biol Chem
Title: The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.
Volume: 278
Issue: 20
Pages: 18235-40
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Publication
38022635 | J:348008
 
First Author: Castiello MC
Year: 2023
Journal: Front Immunol
Title: Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations.
Volume: 14
Pages: 1268620
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Publication
37195219 | J:340103
First Author: Xu LS
Year: 2023
Journal: J Immunol
Title: Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.
Volume: 211
Issue: 1
Pages: 71-80
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Publication
7584150 | J:29752
First Author: Grawunder U
Year: 1995
Journal: Immunity
Title: Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Volume: 3
Issue: 5
Pages: 601-8
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Publication
23325855 | J:200466
First Author: Little AJ
Year: 2013
Journal: Nucleic Acids Res
Title: Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.
Volume: 41
Issue: 5
Pages: 3289-301
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Publication
22157821 | J:181758
First Author: Kassmeier MD
Year: 2012
Journal: EMBO J
Title: VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.
Volume: 31
Issue: 4
Pages: 945-58
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Publication
19324890 | J:173031
First Author: Maitra R
Year: 2009
Journal: Nucleic Acids Res
Title: A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions.
Volume: 37
Issue: 10
Pages: 3301-9
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Publication
20122409 | J:158989
First Author: Grazini U
Year: 2010
Journal: Mol Cell
Title: The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
Volume: 37
Issue: 2
Pages: 282-93
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Publication
24415779 | J:209385
First Author: Horowitz JE
Year: 2014
Journal: J Immunol
Title: Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.
Volume: 192
Issue: 4
Pages: 1609-19
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Publication
18768869 | J:139090
First Author: Wong SY
Year: 2008
Journal: J Immunol
Title: A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction.
Volume: 181
Issue: 6
Pages: 4124-30
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Publication
10601032 | J:58995
First Author: Landree MA
Year: 1999
Journal: Genes Dev
Title: Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.
Volume: 13
Issue: 23
Pages: 3059-69
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Publication
38467629 | J:360918
First Author: Xu M
Year: 2024
Journal: Nat Commun
Title: The thymocyte-specific RNA-binding protein Arpp21 provides TCR repertoire diversity by binding to the 3'-UTR and promoting Rag1 mRNA expression.
Volume: 15
Issue: 1
Pages: 2194
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Publication
19126872 | J:146912
First Author: Giblin W
Year: 2009
Journal: Blood
Title: Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
Volume: 113
Issue: 13
Pages: 2965-75
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Publication
21149691 | J:245257
First Author: Grundy GJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.
Volume: 107
Issue: 52
Pages: 22487-92
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Publication
11745397 | J:73351
First Author: Barreto V
Year: 2001
Journal: Eur J Immunol
Title: Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.
Volume: 31
Issue: 12
Pages: 3763-72
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Publication
29743177 | J:264758
First Author: Ott de Bruin LM
Year: 2018
Journal: Blood
Title: Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.
Volume: 132
Issue: 3
Pages: 281-292
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Publication
15345219 | J:93605
First Author: Shigematsu H
Year: 2004
Journal: Immunity
Title: Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin.
Volume: 21
Issue: 1
Pages: 43-53
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Publication
15746243 | J:99536
First Author: Igarashi H
Year: 2005
Journal: Int Immunol
Title: Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids.
Volume: 17
Issue: 5
Pages: 501-11
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Publication
19096010 | J:146923
First Author: Yokota T
Year: 2009
Journal: Blood
Title: The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Volume: 113
Issue: 13
Pages: 2914-23
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Publication
10679087 | J:60800
First Author: Shultz LD
Year: 2000
Journal: J Immunol
Title: NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Volume: 164
Issue: 5
Pages: 2496-507
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Publication
14581608 | J:86464
First Author: Dudley DD
Year: 2003
Journal: J Exp Med
Title: Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
Volume: 198
Issue: 9
Pages: 1439-50
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Publication
19812384 | J:155473
First Author: Düber S
Year: 2009
Journal: Blood
Title: Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells.
Volume: 114
Issue: 24
Pages: 4960-7
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Publication
18469817 | J:136208
First Author: Amin RH
Year: 2008
Journal: Nat Immunol
Title: Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.
Volume: 9
Issue: 6
Pages: 613-22
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Publication
19502389 | J:171489
First Author: Botelho FM
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice.
Volume: 42
Issue: 4
Pages: 394-403
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Publication
17984203 | J:130255
First Author: Bergstrom KS
Year: 2008
Journal: Infect Immun
Title: Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen.
Volume: 76
Issue: 2
Pages: 796-811
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Publication
10948160 | J:64080
First Author: Izadjoo MJ
Year: 2000
Journal: Infect Immun
Title: Impaired control of Brucella melitensis infection in Rag1-deficient mice.
Volume: 68
Issue: 9
Pages: 5314-20
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Publication
37401759 | J:355079
   
First Author: Ascani A
Year: 2023
Journal: Elife
Title: The role of B cells in immune cell activation in polycystic ovary syndrome.
Volume: 12
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Publication
11106561 | J:66131
First Author: Santos MM
Year: 2000
Journal: Am J Pathol
Title: Iron overload and heart fibrosis in mice deficient for both beta2-microglobulin and Rag1.
Volume: 157
Issue: 6
Pages: 1883-92
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Publication
22918632 | J:214061
First Author: Ding QJ
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: Lack of immunoglobulins does not prevent C1q binding to RGC and does not alter the progression of experimental glaucoma.
Volume: 53
Issue: 10
Pages: 6370-7
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Publication
23589621 | J:202548
First Author: González H
Year: 2013
Journal: J Immunol
Title: Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease.
Volume: 190
Issue: 10
Pages: 5048-56
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Publication
28775298 | J:287390
First Author: Winkler CW
Year: 2017
Journal: Sci Rep
Title: Sexual and Vertical Transmission of Zika Virus in anti-interferon receptor-treated Rag1-deficient mice.
Volume: 7
Issue: 1
Pages: 7176
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Publication
19192480 | J:148211
First Author: Fantini MC
Year: 2009
Journal: Gastroenterology
Title: Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.
Volume: 136
Issue: 4
Pages: 1308-16, e1-3
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Publication
18752298 | J:299330
First Author: Buenafe AC
Year: 2009
Journal: J Neurosci Res
Title: Recombinase-activating gene 1-associated expression of the myelin basic protein 1-11-specific transgenic T-cell receptor in H-2b mice.
Volume: 87
Issue: 1
Pages: 42-9
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Publication
11313258 | J:69354
First Author: Igarashi H
Year: 2001
Journal: Blood
Title: Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice.
Volume: 97
Issue: 9
Pages: 2680-7
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Publication
21354115 | J:170703
 
First Author: McGowan PO
Year: 2011
Journal: Brain Res
Title: Impaired social recognition memory in recombination activating gene 1-deficient mice.
Volume: 1383
Pages: 187-95
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Publication
27604627 | J:331335
First Author: Dickey LL
Year: 2016
Journal: J Neuroinflammation
Title: MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease.
Volume: 13
Issue: 1
Pages: 240
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Publication
15021880 | J:90487
First Author: Yannoutsos N
Year: 2004
Journal: Nat Immunol
Title: A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.
Volume: 5
Issue: 4
Pages: 443-50
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Publication
9486849 | J:45810
First Author: Nacht M
Year: 1998
Journal: Cell Growth Differ
Title: V(D)J recombination is not required for the development of lymphoma in p53-deficient mice.
Volume: 9
Issue: 2
Pages: 131-8
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First Author: Roland MM
Year: 2023
Journal: Front Immunol
Title: B-cell-specific MhcII regulates microbiota composition in a primarily IgA-independent manner.
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First Author: Zhou XF
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells.
Volume: 109
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Pages: 20083-8
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First Author: Kong WS
Year: 2021
Journal: Sci Rep
Title: Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s.
Volume: 11
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First Author: Wen Y
Year: 2020
Journal: Hypertension
Title: C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking.
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First Author: Jacenik D
Year: 2023
Journal: Front Immunol
Title: MK2 drives progression of pancreas and colon cancers by suppressing CD8(+) T cell cytotoxic function and is a potential immunotherapy target.
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