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Search results 1 to 100 out of 2331 for Rag1

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0.04s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: The development of B and T cells depends on the rearrangement of variable (V),diversity (D), and joining (J) gene segments to produce mature Ig and T cellreceptor coding regions. This rearrangement process, known as V(D)Jrecombination is initiated by a complex consisting of multi-domain proteins RAG1 and RAG2. The RAG proteins catalyse DNA cleavage in the first phase of thereaction using a recombination signal sequence (RSS) that flanks V, D and Jsegments [, , ].Recombination activating protein 1 (RAG1) is the catalytic component of the RAG complex []. RAG1 contains a RING finger domain that can act as a ubiquitin ligase (E3), and can promote its own ubiquitylation and targets both karyopherin alpha 1 (KPNA1) and histone 3 (H3) [, ].Many of the proteins recognised by this entry are fragments.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 140  
Fragment?: true
Protein
Organism: Mus musculus
Length: 140  
Fragment?: true
Publication
First Author: Bellon SF
Year: 1997
Journal: Nat Struct Biol
Title: Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster.
Volume: 4
Issue: 7
Pages: 586-91
Publication
First Author: Jones JM
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Autoubiquitylation of the V(D)J recombinase protein RAG1.
Volume: 100
Issue: 26
Pages: 15446-51
Publication
First Author: Böiers C
Year: 2013
Journal: Cell Stem Cell
Title: Lymphomyeloid contribution of an immune-restricted progenitor emerging prior to definitive hematopoietic stem cells.
Volume: 13
Issue: 5
Pages: 535-48
Publication
First Author: Luis TC
Year: 2016
Journal: Nat Immunol
Title: Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.
Volume: 17
Issue: 12
Pages: 1424-1435
Publication
First Author: Welner RS
Year: 2009
Journal: J Immunol
Title: Asynchronous RAG-1 expression during B lymphopoiesis.
Volume: 183
Issue: 12
Pages: 7768-77
Publication
First Author: Forster A
Year: 2005
Journal: Nat Methods
Title: The invertor knock-in conditional chromosomal translocation mimic.
Volume: 2
Issue: 1
Pages: 27-30
Publication
First Author: Hatano S
Year: 2017
Journal: Cell Rep
Title: CD5-NK1.1+ γδ T Cells that Develop in a Bcl11b-Independent Manner Participate in Early Protection against Infection.
Volume: 21
Issue: 5
Pages: 1191-1202
Publication
First Author: Yang Q
Year: 2011
Journal: J Immunol
Title: Cutting edge: Natural helper cells derive from lymphoid progenitors.
Volume: 187
Issue: 11
Pages: 5505-9
Publication
First Author: Ng AP
Year: 2020
Journal: Nat Commun
Title: An Erg-driven transcriptional program controls B cell lymphopoiesis.
Volume: 11
Issue: 1
Pages: 3013
Publication
First Author: Gan T
Year: 2018
Journal: J Immunol
Title: MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.
Volume: 200
Issue: 5
Pages: 1682-1691
Publication
First Author: Li Y
Year: 2011
Journal: Cell
Title: Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation.
Volume: 147
Issue: 3
Pages: 629-40
Publication
First Author: Lee SC
Year: 2015
Journal: Blood
Title: Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.
Volume: 126
Issue: 2
Pages: 167-75
Publication
First Author: McCormack MP
Year: 2003
Journal: Mol Cell Biol
Title: The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
Volume: 23
Issue: 24
Pages: 9003-13
Publication
First Author: Li BE
Year: 2013
Journal: Blood
Title: Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Volume: 122
Issue: 12
Pages: 2039-46
Publication
First Author: Brucklacher-Waldert V
Year: 2017
Journal: Cell Rep
Title: Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation.
Volume: 19
Issue: 11
Pages: 2357-2370
Publication
First Author: Lenartić M
Year: 2017
Journal: J Immunol
Title: NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection.
Volume: 198
Issue: 4
Pages: 1531-1542
Publication
First Author: Buckley MW
Year: 2014
Journal: PLoS One
Title: Unexpected phenotype of mice lacking Shcbp1, a protein induced during T cell proliferation.
Volume: 9
Issue: 8
Pages: e105576
Publication
First Author: Nguyen HV
Year: 2020
Journal: Blood
Title: Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis.
Volume: 135
Issue: 13
Pages: 1019-1031
Publication
First Author: Sun D
Year: 2019
Journal: Cell Rep
Title: Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.
Volume: 27
Issue: 5
Pages: 1461-1471.e4
Publication
First Author: Sultana DA
Year: 2012
Journal: J Immunol
Title: Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.
Volume: 188
Issue: 9
Pages: 4385-93
Publication
First Author: Medvedovic J
Year: 2013
Journal: Immunity
Title: Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.
Volume: 39
Issue: 2
Pages: 229-44
Publication
First Author: Booth CAG
Year: 2018
Journal: Cancer Cell
Title: Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.
Volume: 33
Issue: 2
Pages: 274-291.e8
Publication
First Author: Schiering C
Year: 2017
Journal: Nature
Title: Feedback control of AHR signalling regulates intestinal immunity.
Volume: 542
Issue: 7640
Pages: 242-245
Publication
First Author: Cano F
Year: 2008
Journal: Oncogene
Title: Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.
Volume: 27
Issue: 13
Pages: 1945-50
Publication
First Author: Barberi T
Year: 2020
Journal: PLoS One
Title: C/EBPα induces Ebf1 gene expression in common lymphoid progenitors.
Volume: 15
Issue: 12
Pages: e0244161
Publication
First Author: De Obaldia ME
Year: 2013
Journal: Blood
Title: Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus.
Volume: 121
Issue: 1
Pages: 64-71
Publication
First Author: Jelenčić V
Year: 2018
Journal: Nat Immunol
Title: NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development.
Volume: 19
Issue: 10
Pages: 1083-1092
Publication
First Author: Malin S
Year: 2010
Journal: Nat Immunol
Title: Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Volume: 11
Issue: 2
Pages: 171-9
Publication
First Author: Leid J
Year: 2016
Journal: Circ Res
Title: Primitive Embryonic Macrophages are Required for Coronary Development and Maturation.
Volume: 118
Issue: 10
Pages: 1498-511
Publication
First Author: Simkus C
Year: 2009
Journal: Mol Immunol
Title: Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.
Volume: 46
Issue: 7
Pages: 1319-25
Publication
First Author: Jones JM
Year: 2011
Journal: Immunol Lett
Title: The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3.
Volume: 136
Issue: 2
Pages: 156-62
Publication
First Author: Mao MG
Year: 2012
Journal: Fish Shellfish Immunol
Title: Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephelus akaara).
Volume: 33
Issue: 4
Pages: 725-35
Protein
Organism: Mus musculus
Length: 1040  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1040  
Fragment?: false
Protein
Organism: Mus musculus
Length: 444  
Fragment?: true
Protein
Organism: Mus musculus
Length: 333  
Fragment?: true
Protein
Organism: Mus musculus
Length: 333  
Fragment?: true
Protein
Organism: Mus musculus
Length: 356  
Fragment?: true
Protein
Organism: Mus musculus
Length: 333  
Fragment?: true
Protein
Organism: Mus musculus
Length: 333  
Fragment?: true
Protein
Organism: Mus musculus
Length: 258  
Fragment?: true
Protein
Organism: Mus musculus
Length: 115  
Fragment?: true
Publication
First Author: Matthews AG
Year: 2009
Journal: Nat Immunol
Title: RAG: a recombinase diversified.
Volume: 10
Issue: 8
Pages: 817-21
Publication
First Author: Oettinger MA
Year: 1992
Journal: Trends Genet
Title: Activation of V(D)J recombination by RAG1 and RAG2.
Volume: 8
Issue: 12
Pages: 413-6
Publication
First Author: Singh SK
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Role of RAG1 autoubiquitination in V(D)J recombination.
Volume: 112
Issue: 28
Pages: 8579-83
Publication
First Author: Yokota T
Year: 2003
Journal: Immunity
Title: Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression.
Volume: 19
Issue: 3
Pages: 365-75
Publication
First Author: Fuller K
Year: 1997
Journal: Mol Immunol
Title: Identification and characterization of the murine Rag1 promoter.
Volume: 34
Issue: 12-13
Pages: 939-54
Publication
First Author: Yurchenko V
Year: 2003
Journal: Genes Dev
Title: The RAG1 N-terminal domain is an E3 ubiquitin ligase.
Volume: 17
Issue: 5
Pages: 581-5
Publication
First Author: Schabla NM
Year: 2018
Journal: J Immunol
Title: VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation.
Volume: 201
Issue: 3
Pages: 930-939
Publication
First Author: Pike-Overzet K
Year: 2011
Journal: Leukemia
Title: Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Volume: 25
Issue: 9
Pages: 1471-83
Publication
First Author: Yu W
Year: 1999
Journal: Science
Title: Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2.
Volume: 285
Issue: 5430
Pages: 1080-4
Publication
First Author: Kuwata N
Year: 1999
Journal: J Immunol
Title: Cutting edge: absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene.
Volume: 163
Issue: 12
Pages: 6355-9
Publication
First Author: Toda T
Year: 2009
Journal: Eur J Immunol
Title: The immature B-cell subpopulation with low RAG1 expression is increased in the autoimmune New Zealand Black mouse.
Volume: 39
Issue: 2
Pages: 600-11
Publication
First Author: Han S
Year: 1996
Journal: Science
Title: Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
Volume: 274
Issue: 5295
Pages: 2094-7
Publication
First Author: De P
Year: 2004
Journal: Mol Cell Biol
Title: DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.
Volume: 24
Issue: 15
Pages: 6850-60
Publication
First Author: Ji Y
Year: 2010
Journal: Cell
Title: The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.
Volume: 141
Issue: 3
Pages: 419-31
Publication
First Author: Hao B
Year: 2015
Journal: J Exp Med
Title: An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
Volume: 212
Issue: 5
Pages: 809-24
Publication
First Author: Nepal RM
Year: 2008
Journal: Oncogene
Title: AID and RAG1 do not contribute to lymphomagenesis in Emu c-myc transgenic mice.
Volume: 27
Issue: 34
Pages: 4752-6
Publication
First Author: Shetty K
Year: 2015
Journal: Mol Cell Biol
Title: Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.
Volume: 35
Issue: 21
Pages: 3701-13
Publication
First Author: Cortes P
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
Volume: 91
Issue: 16
Pages: 7633-7
Protein Domain
Type: Domain
Description: This region of RAG1 is responsible for binding to importin alpha [].
Publication
First Author: Ott de Bruin L
Year: 2016
Journal: Oncotarget
Title: Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes.
Volume: 7
Issue: 11
Pages: 12962-74
Publication
First Author: Yin FF
Year: 2009
Journal: Nat Struct Mol Biol
Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Volume: 16
Issue: 5
Pages: 499-508
Publication
First Author: Spanopoulou E
Year: 1995
Journal: Immunity
Title: Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.
Volume: 3
Issue: 6
Pages: 715-26
Publication
First Author: McMahan CJ
Year: 1997
Journal: J Immunol
Title: Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2.
Volume: 158
Issue: 5
Pages: 2202-10
Publication
First Author: Peak MM
Year: 2003
Journal: J Biol Chem
Title: The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.
Volume: 278
Issue: 20
Pages: 18235-40
Publication
First Author: Kim DR
Year: 1999
Journal: Genes Dev
Title: Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase.
Volume: 13
Issue: 23
Pages: 3070-80
Publication      
First Author: National Laboratory Animal Center
Year: 2013
Journal: MGI Direct Data Submission
Title: Transgene insertion mice at National Laboratory Animal Center, National Applied Research Laboratories.
Allele
Name: recombination activating 1; targeted mutation 1, Terence H Rabbitts
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: Transgene insertion 33, National Applied Research Laboratories
Allele Type: Transgenic
Attribute String: Inducible, Recombinase, Reporter
Publication categories: ProxyCollection
Genotype
Symbol: Rag1/Rag1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Lmo2/Lmo2 Rag1/Rag1<+>
Background: involves: 129S/SvEv
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ewsr1/Ewsr1<+> Rag1/Rag1<+>
Background: involves: 129S/SvEv
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Rag1/? Shcbp1/Shcbp1
Background: involves: C57BL/6N
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Horowitz JE
Year: 2014
Journal: J Immunol
Title: Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.
Volume: 192
Issue: 4
Pages: 1609-19
Publication
First Author: Grawunder U
Year: 1995
Journal: Immunity
Title: Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Volume: 3
Issue: 5
Pages: 601-8
Publication
First Author: Kassmeier MD
Year: 2012
Journal: EMBO J
Title: VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.
Volume: 31
Issue: 4
Pages: 945-58
Publication
First Author: Maitra R
Year: 2009
Journal: Nucleic Acids Res
Title: A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions.
Volume: 37
Issue: 10
Pages: 3301-9
Publication
First Author: Little AJ
Year: 2013
Journal: Nucleic Acids Res
Title: Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.
Volume: 41
Issue: 5
Pages: 3289-301
Publication
First Author: Grazini U
Year: 2010
Journal: Mol Cell
Title: The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining.
Volume: 37
Issue: 2
Pages: 282-93
Publication
First Author: Wong SY
Year: 2008
Journal: J Immunol
Title: A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction.
Volume: 181
Issue: 6
Pages: 4124-30
Publication
First Author: Landree MA
Year: 1999
Journal: Genes Dev
Title: Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.
Volume: 13
Issue: 23
Pages: 3059-69
Publication
First Author: Giblin W
Year: 2009
Journal: Blood
Title: Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.
Volume: 113
Issue: 13
Pages: 2965-75
Publication
First Author: Grundy GJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.
Volume: 107
Issue: 52
Pages: 22487-92
Publication
First Author: Barreto V
Year: 2001
Journal: Eur J Immunol
Title: Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.
Volume: 31
Issue: 12
Pages: 3763-72
Publication
First Author: Ott de Bruin LM
Year: 2018
Journal: Blood
Title: Hypomorphic Rag1 mutations alter the preimmune repertoire at early stages of lymphoid development.
Volume: 132
Issue: 3
Pages: 281-292
Publication
First Author: Shigematsu H
Year: 2004
Journal: Immunity
Title: Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin.
Volume: 21
Issue: 1
Pages: 43-53
Publication
First Author: Dudley DD
Year: 2003
Journal: J Exp Med
Title: Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.
Volume: 198
Issue: 9
Pages: 1439-50
Publication
First Author: Yannoutsos N
Year: 2004
Journal: Nat Immunol
Title: A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.
Volume: 5
Issue: 4
Pages: 443-50
Publication
First Author: Igarashi H
Year: 2005
Journal: Int Immunol
Title: Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids.
Volume: 17
Issue: 5
Pages: 501-11
Publication
First Author: Yokota T
Year: 2009
Journal: Blood
Title: The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Volume: 113
Issue: 13
Pages: 2914-23
Publication
First Author: Igarashi H
Year: 2001
Journal: Blood
Title: Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice.
Volume: 97
Issue: 9
Pages: 2680-7
Publication
First Author: Shultz LD
Year: 2000
Journal: J Immunol
Title: NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Volume: 164
Issue: 5
Pages: 2496-507