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Search results 1 to 100 out of 1749 for Rag2

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
539859 | LOC539859
Type: gene
Organism: cattle
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Gene
5897 | RAG2
Type: gene
Organism: human
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Gene
466490 | RAG2
Type: gene
Organism: chimpanzee
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Gene
782387 | RAG2
Type: gene
Organism: cattle
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Gene
423165 | RAG2
Type: gene
Organism: chicken
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Gene
30658 | rag2
Type: gene
Organism: zebrafish
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Gene
716837 | RAG2
Type: gene
Organism: macaque, rhesus
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Gene
100494391 | rag2
Type: gene
Organism: frog, western clawed
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Gene
key_33724 | RAG2
Type: gene
Organism: rabbit, European
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Gene
295953 | Rag2
Type: gene
Organism: rat
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Gene
483419 | RAG2
Type: gene
Organism: dog, domestic
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Protein Domain
IPR004321 | RAG2
Type: Family
Description: The variable portion of the genes encoding immunoglobulins and T cell receptors are assembled from component V, D, and J DNA segments by a site-specific recombination reaction termed V(D)J recombination. V(D)J recombination is targeted to specific sites on the chromosome by recombination signal sequences (RSSs) that flank antigen receptor gene segments. The RSS consists of a conserved heptamer (consensus, 5'-CACAGTG-3') and nonamer (consensus, 5'-ACAAAAACC-3') separated by a spacer of either 12 or 23 bp. Efficient recombination occurs between a 12-RSS and a 23-RSS, a restriction known as the 12/23 rule.V(D)J recombination can be divided into two phases, DNA cleavage and DNA joining. DNA cleavage requires two lymphocyte-specific factors, theproducts of the recombination activating genes, RAG1 and RAG2, which together recognise the RSSs and create double strand breaks at the RSS-coding segment junctions []. RAG-mediated DNA cleavage occurs in a synaptic complex termed the paired complex, which is constituted from two distinct RSS-RAG complexes, a 12-SC and a 23-SC (where SC stands for signal complex). The DNA cleavage reaction involves two distinct enzymatic steps, initial nicking that creates a 3'-OH between a coding segment and its RSS, followed by hairpin formation in which the newly created 3'-OH attacks a phosphodiester bond on the opposite DNA strand. This generates ablunt, 5' phosphorylated signal end containing all of the RSS elements, and a covalently sealed hairpin coding end. The second phase of V(D)J recombination, in which broken DNA fragments are processed and joined, is less well characterised. Signal ends are typically joinedprecisely to form a signal joint, whereas joining of the coding ends requires the hairpin structure to be opened and typically involves nucleotide addition and deletionbefore formation of the coding joint. The factors involved in these processes include ubiquitously expressed proteins involved in the repair of DNA double strandbreaks by nonhomologous end joining, terminal deoxynucleotidyl transferase, and Artemis protein.In addition to their critical roles in RSS recognition and DNA cleavage, the RAG proteins may perform two distinct types of functions in thepostcleavage phase of V(D)J. A structural function has been inferredfrom the finding that, after DNA cleavage in vitro, the DNA ends remain associated with the RAG proteins in a "four end"complex known as the cleaved signalcomplex. After release of the coding ends in vitro, and after coding joint formation in vivo, the RAG proteins remain in astable signal end complex (SEC) containing the two signal ends. These postcleavage complexes may serveas essential scaffolds for the second phase of the reaction, with the RAG proteins acting to organise the DNA processing and joining events. The second type of RAG protein-mediated postcleavage activity is the catalysis of phosphodiester bond hydrolysis and strand transfer reactions. The RAG proteins are capable of opening hairpin coding ends in vitro. The RAG proteinsalso show 3' flap endonuclease activity that may contribute to coding end processing/joining and can utilise the3' OH group on the signal ends to attack hairpin coding ends (forming hybrid or open/shut joints) or virtually any DNA duplex (forming a transposition product).
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Protein Coding Gene
MGI:97849 | Rag2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P21784
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
B7ZMX3
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q542D1
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q80Z95
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q8CD87
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q99NM2
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Publication
11961538 | -
First Author: Fugmann SD
Year: 2002
Journal: Nature
Title: DNA repair: breaking the seal.
Volume: 416
Issue: 6882
Pages: 691-4
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Publication
10446057 | J:56778
First Author: Yu W
Year: 1999
Journal: Science
Title: Coordinate regulation of RAG1 and RAG2 by cell type-specific DNA elements 5' of RAG2.
Volume: 285
Issue: 5430
Pages: 1080-4
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Publication
21368836 | J:170462
First Author: Deriano L
Year: 2011
Journal: Nature
Title: The RAG2 C terminus suppresses genomic instability and lymphomagenesis.
Volume: 471
Issue: 7336
Pages: 119-23
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Publication
12531919 | J:81837
First Author: Akamatsu Y
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice.
Volume: 100
Issue: 3
Pages: 1209-14
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Publication
17476358 | J:122108
First Author: Marrella V
Year: 2007
Journal: J Clin Invest
Title: A hypomorphic R229Q Rag2 mouse mutant recapitulates human Omenn syndrome.
Volume: 117
Issue: 5
Pages: 1260-9
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Publication
21243488 | J:254587
First Author: Laszkiewicz A
Year: 2011
Journal: Immunogenetics
Title: Complexity of transcriptional regulation within the Rag locus: identification of a second Nwc promoter region within the Rag2 intron.
Volume: 63
Issue: 3
Pages: 183-7
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Publication
8953043 | J:37305
First Author: Han S
Year: 1996
Journal: Science
Title: Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
Volume: 274
Issue: 5295
Pages: 2094-7
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Publication
18033247 | J:159138
First Author: Matthews AG
Year: 2007
Journal: Nature
Title: RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
Volume: 450
Issue: 7172
Pages: 1106-10
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Publication
30872621 | J:276940
First Author: Jin Y
Year: 2019
Journal: Sci Rep
Title: The R229Q mutation of Rag2 does not characterize severe immunodeficiency in mice.
Volume: 9
Issue: 1
Pages: 4415
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Publication
26303526 | J:228215
First Author: Shetty K
Year: 2015
Journal: Mol Cell Biol
Title: Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.
Volume: 35
Issue: 21
Pages: 3701-13
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Publication
25847946 | J:222628
First Author: Hao B
Year: 2015
Journal: J Exp Med
Title: An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development.
Volume: 212
Issue: 5
Pages: 809-24
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Publication
10485655 | J:57268
First Author: Monroe RJ
Year: 1999
Journal: Immunity
Title: RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues.
Volume: 11
Issue: 2
Pages: 201-12
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Publication
20398922 | J:160370
First Author: Ji Y
Year: 2010
Journal: Cell
Title: The in vivo pattern of binding of RAG1 and RAG2 to antigen receptor loci.
Volume: 141
Issue: 3
Pages: 419-31
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Publication
15964836 | J:159157
First Author: Elkin SK
Year: 2005
Journal: J Biol Chem
Title: A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
Volume: 280
Issue: 31
Pages: 28701-10
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Publication
18025461 | J:159139
First Author: Ramón-Maiques S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2.
Volume: 104
Issue: 48
Pages: 18993-8
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Publication
26692406 | J:246880
First Author: Xu K
Year: 2016
Journal: Eur J Immunol
Title: Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.
Volume: 46
Issue: 4
Pages: 1011-9
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Publication
26833222 | J:236288
 
First Author: Lescale C
Year: 2016
Journal: Nat Commun
Title: RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair.
Volume: 7
Pages: 10529
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Publication
9827902 | J:50882
First Author: Goldman JP
Year: 1998
Journal: Br J Haematol
Title: Enhanced human cell engraftment in mice deficient in RAG2 and the common cytokine receptor gamma chain.
Volume: 103
Issue: 2
Pages: 335-42
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Publication
7584150 | J:29752
First Author: Grawunder U
Year: 1995
Journal: Immunity
Title: Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Volume: 3
Issue: 5
Pages: 601-8
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Publication
17452104 | J:124559
First Author: Golumbek PT
Year: 2007
Journal: Neuromuscul Disord
Title: Strength and corticosteroid responsiveness of mdx mice is unchanged by RAG2 gene knockout.
Volume: 17
Issue: 5
Pages: 376-84
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Publication
12433370 | J:171970
First Author: Liang HE
Year: 2002
Journal: Immunity
Title: The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development.
Volume: 17
Issue: 5
Pages: 639-51
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Publication
11745397 | J:73351
First Author: Barreto V
Year: 2001
Journal: Eur J Immunol
Title: Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice.
Volume: 31
Issue: 12
Pages: 3763-72
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Publication
20547828 | J:163408
First Author: Cassani B
Year: 2010
Journal: J Exp Med
Title: Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome.
Volume: 207
Issue: 7
Pages: 1525-40
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Publication
24052573 | J:209540
First Author: Maina V
Year: 2013
Journal: J Leukoc Biol
Title: Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration.
Volume: 94
Issue: 6
Pages: 1221-30
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Publication
21149691 | J:245257
First Author: Grundy GJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.
Volume: 107
Issue: 52
Pages: 22487-92
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Publication
20234091 | J:159686
First Author: Couëdel C
Year: 2010
Journal: J Clin Invest
Title: Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.
Volume: 120
Issue: 4
Pages: 1337-44
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Strain
MGI:2164331 | STOCK Rag2
Attribute String: mutant stock
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Publication
12871643 | J:84563
First Author: Hsu LY
Year: 2003
Journal: Immunity
Title: A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
Volume: 19
Issue: 1
Pages: 105-17
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Publication
25257108 | J:216973
 
First Author: Clark SM
Year: 2015
Journal: Behav Brain Res
Title: Dissociation between sickness behavior and emotionality during lipopolysaccharide challenge in lymphocyte deficient Rag2(-/-) mice.
Volume: 278
Pages: 74-82
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Publication
18469817 | J:136208
First Author: Amin RH
Year: 2008
Journal: Nat Immunol
Title: Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.
Volume: 9
Issue: 6
Pages: 613-22
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HT Experiment
GSE56358 | Transcriptional landscape of Rag2 -/- thymocytes [ShortRNA-Seq]
Series Id: E-GEOD-56358
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
14769852 | J:119401
First Author: Borghesi L
Year: 2004
Journal: J Exp Med
Title: B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.
Volume: 199
Issue: 4
Pages: 491-502
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Publication
22581861 | J:188874
First Author: Johnson K
Year: 2012
Journal: J Immunol
Title: IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.
Volume: 188
Issue: 12
Pages: 6084-92
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Publication
15021880 | J:90487
First Author: Yannoutsos N
Year: 2004
Journal: Nat Immunol
Title: A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.
Volume: 5
Issue: 4
Pages: 443-50
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Publication
17908937 | J:126924
First Author: McCaughtry TM
Year: 2007
Journal: J Exp Med
Title: Thymic emigration revisited.
Volume: 204
Issue: 11
Pages: 2513-20
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Publication
10458165 | J:56779
First Author: Yu W
Year: 1999
Journal: Nature
Title: Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.
Volume: 400
Issue: 6745
Pages: 682-7
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Publication
1492366 | J:4508
First Author: Oettinger MA
Year: 1992
Journal: Trends Genet
Title: Activation of V(D)J recombination by RAG1 and RAG2.
Volume: 8
Issue: 12
Pages: 413-6
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Publication
16365147 | J:118827
First Author: Borghesi L
Year: 2005
Journal: J Exp Med
Title: E47 is required for V(D)J recombinase activity in common lymphoid progenitors.
Volume: 202
Issue: 12
Pages: 1669-77
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Publication
17980153 | J:128511
First Author: Son YM
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Modulation of RAG/DNA complex by HSP70 in V(D)J recombination.
Volume: 365
Issue: 1
Pages: 113-7
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Publication
26809474 | J:230654
 
First Author: Ogawa Y
Year: 2016
Journal: Elife
Title: MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.
Volume: 5
Pages: e09394
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Publication
8662087 | J:34489
First Author: Hansen JD
Year: 1996
Journal: Immunogenetics
Title: The recombination activating gene 2 (RAG2) of the rainbow trout Oncorhynchus mykiss.
Volume: 44
Issue: 3
Pages: 203-11
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Publication
19396172 | J:159059
First Author: Yin FF
Year: 2009
Journal: Nat Struct Mol Biol
Title: Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Volume: 16
Issue: 5
Pages: 499-508
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Publication
19411637 | J:150149
First Author: Jin W
Year: 2009
Journal: Blood
Title: Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.
Volume: 113
Issue: 26
Pages: 6603-10
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Publication
34740961 | J:337378
First Author: Winkels H
Year: 2021
Journal: J Immunol
Title: Thymus-Derived CD4(+)CD8(+) Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch.
Volume: 207
Issue: 11
Pages: 2720-2732
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Publication
10591187 | J:58714
First Author: Shreedhar V
Year: 1999
Journal: Immunity
Title: Dendritic cells require T cells for functional maturation in vivo.
Volume: 11
Issue: 5
Pages: 625-36
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Publication
25707801 | J:245396
First Author: Kim MS
Year: 2015
Journal: Nature
Title: Crystal structure of the V(D)J recombinase RAG1-RAG2.
Volume: 518
Issue: 7540
Pages: 507-11
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Publication
8777717 | J:31229
First Author: Spanopoulou E
Year: 1995
Journal: Immunity
Title: Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG1 and RAG2.
Volume: 3
Issue: 6
Pages: 715-26
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Publication
8816481 | J:35347
First Author: Cuomo CA
Year: 1996
Journal: Mol Cell Biol
Title: DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences.
Volume: 16
Issue: 10
Pages: 5683-90
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Publication
9036966 | J:38505
First Author: McMahan CJ
Year: 1997
Journal: J Immunol
Title: Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2.
Volume: 158
Issue: 5
Pages: 2202-10
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Publication
15971274 | J:100437
First Author: Cebrat M
Year: 2005
Journal: Eur J Immunol
Title: Identification of a third evolutionarily conserved gene within the RAG locus and its RAG1-dependent and -independent regulation.
Volume: 35
Issue: 7
Pages: 2230-8
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Publication
10047542 | J:53147
First Author: Kelsoe G
Year: 1999
Journal: Curr Opin Immunol
Title: V(D)J hypermutation and receptor revision: coloring outside the lines.
Volume: 11
Issue: 1
Pages: 70-5
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Publication
18775324 | J:138773
First Author: Du H
Year: 2008
Journal: Mol Cell
Title: Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.
Volume: 31
Issue: 5
Pages: 641-9
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Allele
Rag2<tm1Fwa> | MGI:1858556
Name: recombination activating gene 2; targeted mutation 1, Frederick W Alt
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
15452180 | J:93376
First Author: Hagenbeek TJ
Year: 2004
Journal: J Exp Med
Title: The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.
Volume: 200
Issue: 7
Pages: 883-94
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Publication
9486849 | J:45810
First Author: Nacht M
Year: 1998
Journal: Cell Growth Differ
Title: V(D)J recombination is not required for the development of lymphoma in p53-deficient mice.
Volume: 9
Issue: 2
Pages: 131-8
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Publication
35845169 | J:328687
First Author: Riding AM
Year: 2022
Journal: iScience
Title: Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
Volume: 25
Issue: 7
Pages: 104660
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Publication
19299725 | J:147122
First Author: Hendricks DW
Year: 2009
Journal: J Immunol
Title: Uneven colonization of the lymphoid periphery by T cells that undergo early TCR{alpha} rearrangements.
Volume: 182
Issue: 7
Pages: 4267-74
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Publication
18987320 | J:143195
First Author: Kruschinski A
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas.
Volume: 105
Issue: 45
Pages: 17481-6
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Publication
12618483 | J:113641
First Author: Kondo E
Year: 2003
Journal: Int Immunol
Title: Expression of recombination-activating gene in mature peripheral T cells in Peyer's patch.
Volume: 15
Issue: 3
Pages: 393-402
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Publication
17785508 | J:126057
First Author: Curry JD
Year: 2007
Journal: J Exp Med
Title: Chromosomal reinsertion of broken RSS ends during T cell development.
Volume: 204
Issue: 10
Pages: 2293-303
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Publication
22267219 | J:181283
First Author: Ochiai K
Year: 2012
Journal: Nat Immunol
Title: A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.
Volume: 13
Issue: 3
Pages: 300-7
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Publication
21115692 | J:330361
First Author: Ji Y
Year: 2010
Journal: J Exp Med
Title: Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
Volume: 207
Issue: 13
Pages: 2809-16
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Publication
21693708 | J:175922
First Author: Lira A
Year: 2011
Journal: J Biol Chem
Title: Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.
Volume: 286
Issue: 33
Pages: 28783-93
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Publication
16087873 | J:100927
First Author: Zhang YW
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease.
Volume: 102
Issue: 33
Pages: 11740-5
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Publication
21354115 | J:170703
 
First Author: McGowan PO
Year: 2011
Journal: Brain Res
Title: Impaired social recognition memory in recombination activating gene 1-deficient mice.
Volume: 1383
Pages: 187-95
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Publication
18375979 | J:173072
First Author: Lu CP
Year: 2008
Journal: Nucleic Acids Res
Title: Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.
Volume: 36
Issue: 9
Pages: 2864-73
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Publication
10610182 | J:134764
First Author: Madsen LS
Year: 1999
Journal: Nat Genet
Title: A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor.
Volume: 23
Issue: 3
Pages: 343-7
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Publication
10799872 | J:124430
First Author: Colucci F
Year: 2000
Journal: J Immunol
Title: A new look at Syk in alpha beta and gamma delta T cell development using chimeric mice with a low competitive hematopoietic environment.
Volume: 164
Issue: 10
Pages: 5140-5
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Publication
38388173 | J:345968
 
First Author: Safari F
Year: 2024
Journal: Life Sci Alliance
Title: SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth.
Volume: 7
Issue: 5
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Publication
24218622 | J:203055
First Author: Chan EA
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2.
Volume: 110
Issue: 48
Pages: E4628-37
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Publication
9294126 | J:43047
First Author: Daugherty A
Year: 1997
Journal: J Clin Invest
Title: The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.
Volume: 100
Issue: 6
Pages: 1575-80
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Publication
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First Author: Oshima M
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Journal: Cancer Res
Title: Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 transgenic mice.
Volume: 65
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11397712 | J:103188
First Author: Reardon CA
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Title: Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice.
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15713121 | J:117493
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Title: High-mobility-group A1 (HMGA1) proteins down-regulate the expression of the recombination activating gene 2 (RAG2).
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28978470 | J:254861
First Author: Hu Z
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Title: CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment.
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21873191 | J:176461
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Allele
Rag2<em3Lutzy> | MGI:6753157
Name: recombination activating gene 2; endonuclease-mediated mutation 3, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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