Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
RALBP1, also known as RLIP76, is a Ral-binding GTPase activating protein implicated in a number of cell processes, including receptor-mediated endocytosis, cell migration, mitochondrial division and metabolite transport []. It transports glutathione-conjugates of electrophilic compounds and may contribute to the multidrug resistance []. It has been shown to mediate ATP-dependent transport of glutathione-conjugates and doxorubicin in human erythrocytes []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
594
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
148
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Awasthi S |
Year: |
2021 |
Journal: |
Cells |
Title: |
RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. |
Volume: |
10 |
Issue: |
11 |
|
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Bae YS |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice. |
Volume: |
433 |
Issue: |
2 |
Pages: |
175-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han K |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. |
Volume: |
7 |
Issue: |
9 |
Pages: |
e1000187 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamaguchi A |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1. |
Volume: |
272 |
Issue: |
50 |
Pages: |
31230-4 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
594
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
648
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
145
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
165
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
118
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
81
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Vatsyayan R |
Year: |
2010 |
Journal: |
Biochem Pharmacol |
Title: |
RLIP76: a versatile transporter and an emerging target for cancer therapy. |
Volume: |
79 |
Issue: |
12 |
Pages: |
1699-705 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma R |
Year: |
2001 |
Journal: |
Arch Biochem Biophys |
Title: |
RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. |
Volume: |
391 |
Issue: |
2 |
Pages: |
171-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mott HR |
Year: |
2014 |
Journal: |
Biochem Soc Trans |
Title: |
Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling. |
Volume: |
42 |
Issue: |
1 |
Pages: |
52-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sahu M |
Year: |
2014 |
Journal: |
Exp Eye Res |
Title: |
Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia. |
Volume: |
118 |
|
Pages: |
125-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Awasthi S |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Rlip depletion prevents spontaneous neoplasia in TP53 null mice. |
Volume: |
115 |
Issue: |
15 |
Pages: |
3918-3923 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuzaki T |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. |
Volume: |
277 |
Issue: |
21 |
Pages: |
19008-18 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Awasthi S |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
RLIP76 is a major determinant of radiation sensitivity. |
Volume: |
65 |
Issue: |
14 |
Pages: |
6022-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singhal J |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
RLIP76, a glutathione-conjugate transporter, plays a major role in the pathogenesis of metabolic syndrome. |
Volume: |
6 |
Issue: |
9 |
Pages: |
e24688 |
|
•
•
•
•
•
|
Publication |
First Author: |
Awasthi S |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
A central role of RLIP76 in regulation of glycemic control. |
Volume: |
59 |
Issue: |
3 |
Pages: |
714-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee S |
Year: |
2012 |
Journal: |
Cancer Res |
Title: |
RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. |
Volume: |
72 |
Issue: |
20 |
Pages: |
5165-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singhal SS |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
RLIP76 protein knockdown attenuates obesity due to a high-fat diet. |
Volume: |
288 |
Issue: |
32 |
Pages: |
23394-406 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mack C |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein. |
Volume: |
105 |
Issue: |
8 |
Pages: |
3094-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cusson-Hermance N |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation. |
Volume: |
280 |
Issue: |
44 |
Pages: |
36560-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singhal SS |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Mitogenic and drug-resistance mediating effects of PKCalpha require RLIP76. |
Volume: |
348 |
Issue: |
2 |
Pages: |
722-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singhal SS |
Year: |
2008 |
Journal: |
FEBS Lett |
Title: |
Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76. |
Volume: |
582 |
Issue: |
23-24 |
Pages: |
3408-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park SH |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. |
Volume: |
11 |
Issue: |
11 |
Pages: |
2349-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Neutzner M |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. |
Volume: |
67 |
Issue: |
14 |
Pages: |
6777-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ring HZ |
Year: |
1999 |
Journal: |
Genomics |
Title: |
Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17. |
Volume: |
56 |
Issue: |
3 |
Pages: |
350-2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dominguez S |
Year: |
2021 |
Journal: |
Cell Death Differ |
Title: |
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS. |
Volume: |
28 |
Issue: |
3 |
Pages: |
915-931 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lamkanfi M |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
A novel caspase-2 complex containing TRAF2 and RIP1. |
Volume: |
280 |
Issue: |
8 |
Pages: |
6923-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wurtzel JG |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. |
Volume: |
467 |
Issue: |
4 |
Pages: |
785-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meylan E |
Year: |
2004 |
Journal: |
Nat Immunol |
Title: |
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. |
Volume: |
5 |
Issue: |
5 |
Pages: |
503-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Misra RS |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. |
Volume: |
282 |
Issue: |
27 |
Pages: |
19365-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Irrinki KM |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. |
Volume: |
31 |
Issue: |
18 |
Pages: |
3745-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peters LL |
Year: |
1998 |
Journal: |
Genomics |
Title: |
Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human. |
Volume: |
54 |
Issue: |
2 |
Pages: |
348-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakahara M |
Year: |
2013 |
Journal: |
Mamm Genome |
Title: |
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. |
Volume: |
24 |
Issue: |
5-6 |
Pages: |
228-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brady KP |
Year: |
1997 |
Journal: |
Genome Res |
Title: |
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1085-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
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•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
European Mouse Mutant Archive |
Year: |
2003 |
Journal: |
Unpublished |
Title: |
Information obtained from the European Mouse Mutant Archive (EMMA) |
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Publication |
First Author: |
Araki K |
Year: |
1999 |
Journal: |
Cell Mol Biol (Noisy-le-grand) |
Title: |
Exchangeable gene trap using the Cre/mutated lox system. |
Volume: |
45 |
Issue: |
5 |
Pages: |
737-50 |
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