| Type | Details | Score | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | human |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | frog, western clawed |  | • • • • • | 
          
              | Protein Domain | 
              
                | Type: | Domain |  
                | Description: | The structures of the immunity protein Rap1a , responsible for the inhibition and neutralization of Ssp1 endopeptidase, revealed two distinct folds. The structure of the Ssp1-Rap1a complex revealed a tightly bound heteromeric assembly with two effector molecules flanking a Rap1a dimer. The Rap1a subunit displays a compact globular structure constructed from five α-helices that assemble to form the highly stable symmetric dimer []. |  | • • • • • | 
          
              | Gene |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chimpanzee |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | dog, domestic |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | cattle |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | chicken |  | • • • • • | 
          
              | Gene | 
              
                | Type: | gene |  
                | Organism: | macaque, rhesus |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Srikannathasan V |  
                | Year: | 2013 |  
                | Journal: | Acta Crystallogr D Biol Crystallogr |  
                | Title: | Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. |  
                | Volume: | 69 |  
                | Issue: | Pt 12 |  
                | Pages: | 2468-82 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wang Y |  
                | Year: | 2022 |  
                | Journal: | Cell Rep |  
                | Title: | Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia. |  
                | Volume: | 40 |  
                | Issue: | 8 |  
                | Pages: | 111259 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Li Y |  
                | Year: | 2007 |  
                | Journal: | J Immunol |  
                | Title: | Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. |  
                | Volume: | 179 |  
                | Issue: | 12 |  
                | Pages: | 8322-31 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Li L |  
                | Year: | 2010 |  
                | Journal: | Cell Immunol |  
                | Title: | Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. |  
                | Volume: | 266 |  
                | Issue: | 1 |  
                | Pages: | 7-13 |  | • • • • • | 
          
              | Protein | 
              
                | Organism: | Mus musculus/domesticus |  
                | Length: | 184  |  
                | Fragment?: | false |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Stadtmann A |  
                | Year: | 2011 |  
                | Journal: | Eur J Immunol |  
                | Title: | Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. |  
                | Volume: | 41 |  
                | Issue: | 7 |  
                | Pages: | 2074-85 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Huk DJ |  
                | Year: | 2018 |  
                | Journal: | Thyroid |  
                | Title: | Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer. |  
                | Volume: | 28 |  
                | Issue: | 9 |  
                | Pages: | 1153-1161 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Dorn A |  
                | Year: | 2012 |  
                | Journal: | Cell Immunol |  
                | Title: | Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response. |  
                | Volume: | 276 |  
                | Issue: | 1-2 |  
                | Pages: | 187-95 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yan J |  
                | Year: | 2008 |  
                | Journal: | Mol Cell Biol |  
                | Title: | Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. |  
                | Volume: | 28 |  
                | Issue: | 18 |  
                | Pages: | 5803-10 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Duchniewicz M |  
                | Year: | 2006 |  
                | Journal: | Mol Cell Biol |  
                | Title: | Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. |  
                | Volume: | 26 |  
                | Issue: | 2 |  
                | Pages: | 643-53 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Jeyaraj SC |  
                | Year: | 2012 |  
                | Journal: | Am J Physiol Cell Physiol |  
                | Title: | Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells. |  
                | Volume: | 303 |  
                | Issue: | 5 |  
                | Pages: | C499-511 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Pan BX |  
                | Year: | 2008 |  
                | Journal: | J Neurosci |  
                | Title: | Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1. |  
                | Volume: | 28 |  
                | Issue: | 9 |  
                | Pages: | 2089-98 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Awasthi A |  
                | Year: | 2010 |  
                | Journal: | J Exp Med |  
                | Title: | Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes. |  
                | Volume: | 207 |  
                | Issue: | 9 |  
                | Pages: | 1923-38 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Lakshmikanthan S |  
                | Year: | 2018 |  
                | Journal: | J Cell Sci |  
                | Title: | Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. |  
                | Volume: | 131 |  
                | Issue: | 1 |  
                |  |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wang JC |  
                | Year: | 2017 |  
                | Journal: | J Cell Sci |  
                | Title: | The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. |  
                | Volume: | 130 |  
                | Issue: | 6 |  
                | Pages: | 1094-1109 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Yamamoto K |  
                | Year: | 2023 |  
                | Journal: | FASEB J |  
                | Title: | Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. |  
                | Volume: | 37 |  
                | Issue: | 12 |  
                | Pages: | e23310 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Carmona G |  
                | Year: | 2009 |  
                | Journal: | Blood |  
                | Title: | Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. |  
                | Volume: | 113 |  
                | Issue: | 2 |  
                | Pages: | 488-97 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Su W |  
                | Year: | 2015 |  
                | Journal: | Blood |  
                | Title: | Rap1 and its effector RIAM are required for lymphocyte trafficking. |  
                | Volume: | 126 |  
                | Issue: | 25 |  
                | Pages: | 2695-703 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Potla U |  
                | Year: | 2014 |  
                | Journal: | J Clin Invest |  
                | Title: | Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. |  
                | Volume: | 124 |  
                | Issue: | 4 |  
                | Pages: | 1757-69 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wittchen ES |  
                | Year: | 2013 |  
                | Journal: | PLoS One |  
                | Title: | Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo. |  
                | Volume: | 8 |  
                | Issue: | 9 |  
                | Pages: | e73070 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Williams MD |  
                | Year: | 2024 |  
                | Journal: | Am J Physiol Heart Circ Physiol |  
                | Title: | pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A. |  
                | Volume: | 327 |  
                | Issue: | 5 |  
                | Pages: | H1210-H1229 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Chrzanowska-Wodnicka M |  
                | Year: | 2015 |  
                | Journal: | PLoS One |  
                | Title: | Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature. |  
                | Volume: | 10 |  
                | Issue: | 12 |  
                | Pages: | e0145689 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Dower NA |  
                | Year: | 1992 |  
                | Journal: | Mamm Genome |  
                | Title: | Organization and chromosomal locations of Rap1a/Krev sequences in the mouse. |  
                | Volume: | 3 |  
                | Issue: | 3 |  
                | Pages: | 162-7 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Mediero A |  
                | Year: | 2014 |  
                | Journal: | FASEB J |  
                | Title: | Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements. |  
                | Volume: | 28 |  
                | Issue: | 11 |  
                | Pages: | 4901-13 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Stefanini L |  
                | Year: | 2018 |  
                | Journal: | Blood |  
                | Title: | Functional redundancy between RAP1 isoforms in murine platelet production and function. |  
                | Volume: | 132 |  
                | Issue: | 18 |  
                | Pages: | 1951-1962 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Lakshmikanthan S |  
                | Year: | 2011 |  
                | Journal: | Blood |  
                | Title: | Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃. |  
                | Volume: | 118 |  
                | Issue: | 7 |  
                | Pages: | 2015-26 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Xu W |  
                | Year: | 2018 |  
                | Journal: | Arterioscler Thromb Vasc Biol |  
                | Title: | Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions. |  
                | Volume: | 38 |  
                | Issue: | 10 |  
                | Pages: | 2410-2422 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Maddala R |  
                | Year: | 2015 |  
                | Journal: | Dev Biol |  
                | Title: | Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. |  
                | Volume: | 406 |  
                | Issue: | 1 |  
                | Pages: | 74-91 |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus caroli |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | mouse, laboratory |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus pahari |  | • • • • • | 
          
              | Protein Coding Gene | 
              
                | Type: | protein_coding_gene |  
                | Organism: | Mus spretus |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Birukova AA |  
                | Year: | 2015 |  
                | Journal: | Biochim Biophys Acta |  
                | Title: | Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1. |  
                | Volume: | 1852 |  
                | Issue: | 5 |  
                | Pages: | 778-91 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Kitayama H |  
                | Year: | 1989 |  
                | Journal: | Cell |  
                | Title: | A ras-related gene with transformation suppressor activity. |  
                | Volume: | 56 |  
                | Issue: | 1 |  
                | Pages: | 77-84 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Wang Z |  
                | Year: | 2006 |  
                | Journal: | Mol Cell Biol |  
                | Title: | Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. |  
                | Volume: | 26 |  
                | Issue: | 6 |  
                | Pages: | 2130-45 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Freeman SA |  
                | Year: | 2017 |  
                | Journal: | J Cell Sci |  
                | Title: | Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor. |  
                | Volume: | 130 |  
                | Issue: | 1 |  
                | Pages: | 152-163 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Khattar E |  
                | Year: | 2019 |  
                | Journal: | Nat Commun |  
                | Title: | Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy. |  
                | Volume: | 10 |  
                | Issue: | 1 |  
                | Pages: | 5349 |  | • • • • • | 
          
              | Publication | 
              
                | First Author: | Salinas GF |  
                | Year: | 2012 |  
                | Journal: | J Neuroimmunol |  
                | Title: | Sustained Rap1 activation in autoantigen-specific T lymphocytes attenuates experimental autoimmune encephalomyelitis. |  
                | Volume: | 250 |  
                | Issue: | 1-2 |  
                | Pages: | 35-43 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4429596 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2010-02-19 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1876828 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:4429597 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | +/+ |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4429596 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2010-02-19 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1876828 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:4429597 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | -/- |  
                | Detected: | false |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4429596 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2010-02-19 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1876728 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:4429597 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | +/+ |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:4429596 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2010-02-19 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1876728 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:4429597 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | -/- |  
                | Detected: | false |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5006824 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-14 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:360411 |  
                |  |  
                | Stage: | TS01 |  
                | Assay Id: | MGI:5007476 |  
                | Age: | embryonic day 0.5 |  
                |  |  
                |  |  
                | Specimen Label: | None |  
                | Detected: | true |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5006824 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-14 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:360443 |  
                |  |  
                | Stage: | TS03 |  
                | Assay Id: | MGI:5007476 |  
                | Age: | embryonic day 2.0 |  
                |  |  
                |  |  
                | Specimen Label: | None |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5006824 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-14 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:360464 |  
                |  |  
                | Stage: | TS04 |  
                | Assay Id: | MGI:5007476 |  
                | Age: | embryonic day 3.5 |  
                |  |  
                |  |  
                | Specimen Label: | None |  
                | Detected: | true |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5910737 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2017-10-04 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1754424 |  
                |  |  
                | Stage: | TS24 |  
                | Assay Id: | MGI:5910911 |  
                | Age: | embryonic day 16.0 |  
                |  |  
                |  |  
                | Specimen Label: | 5A WT |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5910737 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2017-10-04 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1754424 |  
                |  |  
                | Stage: | TS24 |  
                | Assay Id: | MGI:5910911 |  
                | Age: | embryonic day 16.0 |  
                |  |  
                |  |  
                | Specimen Label: | 5A KD |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5910737 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2017-10-04 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1689424 |  
                |  |  
                | Stage: | TS24 |  
                | Assay Id: | MGI:5910916 |  
                | Age: | embryonic day 16.0 |  
                |  |  
                |  |  
                | Specimen Label: | 5A WT |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5910737 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2017-10-04 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1689424 |  
                |  |  
                | Stage: | TS24 |  
                | Assay Id: | MGI:5910916 |  
                | Age: | embryonic day 16.0 |  
                |  |  
                |  |  
                | Specimen Label: | 5A KD |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5006824 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-14 |  
                | Strength: | Present |  
                | Sex: | Female |  
                | Emaps: | EMAPS:3575528 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:5007476 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | None |  
                | Detected: | true |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:5006824 |  
                | Assay Type: | RT-PCR |  
                | Annotation Date: | 2011-06-14 |  
                | Strength: | Present |  
                | Sex: | Female |  
                | Emaps: | EMAPS:3570528 |  
                |  |  
                | Stage: | TS28 |  
                | Assay Id: | MGI:5007476 |  
                | Age: | postnatal |  
                |  |  
                |  |  
                | Specimen Label: | None |  
                | Detected: | true |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610515 |  
                |  |  
                | Stage: | TS15 |  
                | Assay Id: | MGI:7449120 |  
                | Age: | embryonic day 9.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 6 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Control |  
                | Detected: | false |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 4 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610517 |  
                |  |  
                | Stage: | TS17 |  
                | Assay Id: | MGI:7449121 |  
                | Age: | embryonic day 10.5 |  
                |  |  
                |  |  
                | Specimen Label: | Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 6 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610520 |  
                |  |  
                | Stage: | TS20 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 12.5 |  
                |  |  
                |  |  
                | Specimen Label: | E12.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 5 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610520 |  
                |  |  
                | Stage: | TS20 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 12.5 |  
                |  |  
                |  |  
                | Specimen Label: | E12.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 6 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610520 |  
                |  |  
                | Stage: | TS20 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 12.5 |  
                |  |  
                |  |  
                | Specimen Label: | E12.5 Cre/+ |  
                | Detected: | false |  
                | Specimen Num: | 7 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610520 |  
                |  |  
                | Stage: | TS20 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 12.5 |  
                |  |  
                |  |  
                | Specimen Label: | E12.5 Cre/+ |  
                | Detected: | false |  
                | Specimen Num: | 8 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610521 |  
                |  |  
                | Stage: | TS21 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 13.5 |  
                |  |  
                |  |  
                | Specimen Label: | E13.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 9 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610521 |  
                |  |  
                | Stage: | TS21 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 13.5 |  
                |  |  
                |  |  
                | Specimen Label: | E13.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 10 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610521 |  
                |  |  
                | Stage: | TS21 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 13.5 |  
                |  |  
                |  |  
                | Specimen Label: | E13.5 Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 11 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Present |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610521 |  
                |  |  
                | Stage: | TS21 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 13.5 |  
                |  |  
                |  |  
                | Specimen Label: | E13.5 Cre/+ |  
                | Detected: | true |  
                | Specimen Num: | 12 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610519 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | E11.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 1 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610519 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | E11.5 Control |  
                | Detected: | false |  
                | Specimen Num: | 2 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610519 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | E11.5 Cre/+ |  
                | Detected: | false |  
                | Specimen Num: | 3 |  | • • • • • | 
          
              | GXD Expression | 
              
                | Probe: | MGI:7448891 |  
                | Assay Type: | Western blot |  
                | Annotation Date: | 2023-03-31 |  
                | Strength: | Absent |  
                | Sex: | Not Specified |  
                | Emaps: | EMAPS:1610519 |  
                |  |  
                | Stage: | TS19 |  
                | Assay Id: | MGI:7449123 |  
                | Age: | embryonic day 11.5 |  
                |  |  
                |  |  
                | Specimen Label: | E11.5 Cre/+ |  
                | Detected: | false |  
                | Specimen Num: | 4 |  | • • • • • |