|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 219 for Rap1a

<< First    < Previous  |  Next >    Last >>
0.036s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Domain
Description: The structures of the immunity protein Rap1a , responsible for the inhibition and neutralization of Ssp1 endopeptidase, revealed two distinct folds. The structure of the Ssp1-Rap1a complex revealed a tightly bound heteromeric assembly with two effector molecules flanking a Rap1a dimer. The Rap1a subunit displays a compact globular structure constructed from five alpha-helices that assemble to form the highly stable symmetric dimer [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Publication
First Author: Srikannathasan V
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens.
Volume: 69
Issue: Pt 12
Pages: 2468-82
Publication
First Author: Li Y
Year: 2007
Journal: J Immunol
Title: Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
Volume: 179
Issue: 12
Pages: 8322-31
Publication
First Author: Li L
Year: 2010
Journal: Cell Immunol
Title: Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms.
Volume: 266
Issue: 1
Pages: 7-13
Publication
First Author: Stadtmann A
Year: 2011
Journal: Eur J Immunol
Title: Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.
Volume: 41
Issue: 7
Pages: 2074-85
Publication
First Author: Dorn A
Year: 2012
Journal: Cell Immunol
Title: Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
Volume: 276
Issue: 1-2
Pages: 187-95
Publication
First Author: Yan J
Year: 2008
Journal: Mol Cell Biol
Title: Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.
Volume: 28
Issue: 18
Pages: 5803-10
Protein
Organism: Mus musculus
Length: 184  
Fragment?: false
Publication
First Author: Duchniewicz M
Year: 2006
Journal: Mol Cell Biol
Title: Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion.
Volume: 26
Issue: 2
Pages: 643-53
Publication
First Author: Jeyaraj SC
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.
Volume: 303
Issue: 5
Pages: C499-511
Publication
First Author: Pan BX
Year: 2008
Journal: J Neurosci
Title: Enhanced cortico-amygdala efficacy and suppressed fear in absence of Rap1.
Volume: 28
Issue: 9
Pages: 2089-98
Publication
First Author: Awasthi A
Year: 2010
Journal: J Exp Med
Title: Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes.
Volume: 207
Issue: 9
Pages: 1923-38
Publication
First Author: Wang JC
Year: 2017
Journal: J Cell Sci
Title: The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse.
Volume: 130
Issue: 6
Pages: 1094-1109
Publication
First Author: Carmona G
Year: 2009
Journal: Blood
Title: Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.
Volume: 113
Issue: 2
Pages: 488-97
Publication  
First Author: Lakshmikanthan S
Year: 2018
Journal: J Cell Sci
Title: Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.
Volume: 131
Issue: 1
Publication
First Author: Potla U
Year: 2014
Journal: J Clin Invest
Title: Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
Volume: 124
Issue: 4
Pages: 1757-69
Publication
First Author: Wittchen ES
Year: 2013
Journal: PLoS One
Title: Rap1 GTPase activation and barrier enhancement in rpe inhibits choroidal neovascularization in vivo.
Volume: 8
Issue: 9
Pages: e73070
Publication
First Author: Chrzanowska-Wodnicka M
Year: 2015
Journal: PLoS One
Title: Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.
Volume: 10
Issue: 12
Pages: e0145689
Publication
First Author: Su W
Year: 2015
Journal: Blood
Title: Rap1 and its effector RIAM are required for lymphocyte trafficking.
Volume: 126
Issue: 25
Pages: 2695-703
Publication
First Author: Dower NA
Year: 1992
Journal: Mamm Genome
Title: Organization and chromosomal locations of Rap1a/Krev sequences in the mouse.
Volume: 3
Issue: 3
Pages: 162-7
Publication
First Author: Mediero A
Year: 2014
Journal: FASEB J
Title: Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.
Volume: 28
Issue: 11
Pages: 4901-13
Publication
First Author: Stefanini L
Year: 2018
Journal: Blood
Title: Functional redundancy between RAP1 isoforms in murine platelet production and function.
Volume: 132
Issue: 18
Pages: 1951-1962
Publication
First Author: Lakshmikanthan S
Year: 2011
Journal: Blood
Title: Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin αvβ₃.
Volume: 118
Issue: 7
Pages: 2015-26
Publication
First Author: Xu W
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Small GTPase Rap1A/B Is Required for Lymphatic Development and Adrenomedullin-Induced Stabilization of Lymphatic Endothelial Junctions.
Volume: 38
Issue: 10
Pages: 2410-2422
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Birukova AA
Year: 2015
Journal: Biochim Biophys Acta
Title: Prostacyclin post-treatment improves LPS-induced acute lung injury and endothelial barrier recovery via Rap1.
Volume: 1852
Issue: 5
Pages: 778-91
Publication
First Author: Kitayama H
Year: 1989
Journal: Cell
Title: A ras-related gene with transformation suppressor activity.
Volume: 56
Issue: 1
Pages: 77-84
Publication
First Author: Wang Z
Year: 2006
Journal: Mol Cell Biol
Title: Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.
Volume: 26
Issue: 6
Pages: 2130-45
Publication
First Author: Freeman SA
Year: 2017
Journal: J Cell Sci
Title: Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor.
Volume: 130
Issue: 1
Pages: 152-163
Publication
First Author: Khattar E
Year: 2019
Journal: Nat Commun
Title: Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
Volume: 10
Issue: 1
Pages: 5349
GXD Expression      
Probe: MGI:5006824
Assay Type: RT-PCR
Annotation Date: 2011-06-14
Strength: Present
Sex: Female
Emaps: EMAPS:3570528
Stage: TS28
Assay Id: MGI:5007476
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4429596
Assay Type: Western blot
Annotation Date: 2010-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4429597
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:4429596
Assay Type: Western blot
Annotation Date: 2010-02-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:4429597
Age: postnatal
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5910737
Assay Type: Western blot
Annotation Date: 2017-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:5910911
Age: embryonic day 16.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5910737
Assay Type: Western blot
Annotation Date: 2017-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:5910911
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5006824
Assay Type: RT-PCR
Annotation Date: 2011-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360443
Stage: TS03
Assay Id: MGI:5007476
Age: embryonic day 2.0
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5006824
Assay Type: RT-PCR
Annotation Date: 2011-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:5007476
Age: embryonic day 0.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5006824
Assay Type: RT-PCR
Annotation Date: 2011-06-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:5007476
Age: embryonic day 3.5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:4429596
Assay Type: Western blot
Annotation Date: 2010-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:4429597
Age: postnatal
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:4429596
Assay Type: Western blot
Annotation Date: 2010-02-19
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:4429597
Age: postnatal
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5006824
Assay Type: RT-PCR
Annotation Date: 2011-06-14
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:5007476
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5910737
Assay Type: Western blot
Annotation Date: 2017-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:5910916
Age: embryonic day 16.0
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5910737
Assay Type: Western blot
Annotation Date: 2017-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:5910916
Age: embryonic day 16.0
Detected: true
Specimen Num: 2
GXD Expression      
Assay Type: In situ reporter (knock in)
Annotation Date: 2010-02-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4429594
Age: embryonic day 12.5
Detected: true
Specimen Num: 1
Publication
First Author: Maddala R
Year: 2015
Journal: Dev Biol
Title: Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
Volume: 406
Issue: 1
Pages: 74-91
Publication
First Author: Lakshmikanthan S
Year: 2015
Journal: EMBO Rep
Title: Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function.
Volume: 16
Issue: 5
Pages: 628-37
Publication
First Author: Kaneko K
Year: 2019
Journal: J Clin Invest
Title: Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.
Volume: 129
Issue: 9
Pages: 3786-3791
Publication
First Author: Nagai T
Year: 2016
Journal: Neuron
Title: Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.
Volume: 89
Issue: 3
Pages: 550-65
Publication
First Author: Ferrara-Romeo I
Year: 2018
Journal: PLoS One
Title: Mice lacking RAP1 show early onset and higher rates of DEN-induced hepatocellular carcinomas in female mice.
Volume: 13
Issue: 10
Pages: e0204909
Publication  
First Author: Wong KHK
Year: 2018
Journal: J Mol Cell Cardiol
Title: Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations.
Volume: 115
Pages: 1-9
Publication
First Author: Morton AM
Year: 2007
Journal: J Immunol
Title: Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo.
Volume: 179
Issue: 12
Pages: 8026-34
Publication
First Author: Dillon TJ
Year: 2005
Journal: Mol Cell Biol
Title: Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.
Volume: 25
Issue: 10
Pages: 4117-28
Publication
First Author: Bromberger T
Year: 2018
Journal: Blood
Title: Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice.
Volume: 132
Issue: 26
Pages: 2754-2762
Publication
First Author: Wani MA
Year: 1997
Journal: Somat Cell Mol Genet
Title: Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.
Volume: 23
Issue: 2
Pages: 123-33
Publication
First Author: Lin KB
Year: 2008
Journal: Immunity
Title: The rap GTPases regulate B cell morphology, immune-synapse formation, and signaling by particulate B cell receptor ligands.
Volume: 28
Issue: 1
Pages: 75-87
Publication
First Author: Ebisuno Y
Year: 2010
Journal: Blood
Title: Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.
Volume: 115
Issue: 4
Pages: 804-14
Publication
First Author: Kondoh N
Year: 1996
Journal: Biochim Biophys Acta
Title: The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells.
Volume: 1313
Issue: 1
Pages: 41-6
Publication
First Author: Katayama Y
Year: 2009
Journal: Blood
Title: Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells.
Volume: 114
Issue: 9
Pages: 1768-75
Publication  
First Author: Königsberger S
Year: 2010
Journal: PLoS One
Title: HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.
Volume: 5
Issue: 9
Publication
First Author: Sadrian B
Year: 2012
Journal: Mol Cell Neurosci
Title: Rap1gap2 regulates axon outgrowth in olfactory sensory neurons.
Volume: 50
Issue: 3-4
Pages: 272-82
Publication
First Author: Milani R
Year: 2010
Journal: J Cell Biochem
Title: Phosphoproteome reveals an atlas of protein signaling networks during osteoblast adhesion.
Volume: 109
Issue: 5
Pages: 957-66
Publication
First Author: Regier DS
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.
Volume: 102
Issue: 21
Pages: 7595-600
Publication
First Author: Cahill ME
Year: 2016
Journal: Neuron
Title: Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.
Volume: 89
Issue: 3
Pages: 566-82
Publication  
First Author: Ishihara S
Year: 2015
Journal: Nat Commun
Title: Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.
Volume: 6
Pages: 8982
Publication
First Author: Ni J
Year: 2016
Journal: J Biol Chem
Title: MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.
Volume: 291
Issue: 47
Pages: 24406-24417
Publication
First Author: Le Borgne M
Year: 2014
Journal: Development
Title: The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.
Volume: 141
Issue: 10
Pages: 2096-107
Publication
First Author: Strazza M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.
Volume: 114
Issue: 10
Pages: 2693-2698
Publication
First Author: Subramanian J
Year: 2013
Journal: J Neurosci
Title: Rap1 signaling prevents L-type calcium channel-dependent neurotransmitter release.
Volume: 33
Issue: 17
Pages: 7245-52
Publication
First Author: Obara Y
Year: 2007
Journal: J Neurochem
Title: The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells.
Volume: 101
Issue: 2
Pages: 470-82
Publication
First Author: Wang SF
Year: 2008
Journal: Blood
Title: Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling.
Volume: 111
Issue: 5
Pages: 2878-86
Publication
First Author: Sabbatini ME
Year: 2008
Journal: J Biol Chem
Title: Rap1 activation plays a regulatory role in pancreatic amylase secretion.
Volume: 283
Issue: 35
Pages: 23884-94
Publication
First Author: Takahashi M
Year: 2008
Journal: Genes Cells
Title: Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells.
Volume: 13
Issue: 6
Pages: 549-69
Publication
First Author: Aivatiadou E
Year: 2009
Journal: Mol Reprod Dev
Title: cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.
Volume: 76
Issue: 4
Pages: 407-16
Publication
First Author: Miyata M
Year: 2009
Journal: J Cell Sci
Title: Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.
Volume: 122
Issue: Pt 23
Pages: 4319-29
Publication
First Author: Jossin Y
Year: 2011
Journal: Nat Neurosci
Title: Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex.
Volume: 14
Issue: 6
Pages: 697-703
Publication
First Author: Stieglitz B
Year: 2008
Journal: EMBO J
Title: Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.
Volume: 27
Issue: 14
Pages: 1995-2005
Publication
First Author: Ménasché G
Year: 2007
Journal: Mol Cell Biol
Title: RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation.
Volume: 27
Issue: 11
Pages: 4070-81
Publication
First Author: Mathews CE
Year: 2002
Journal: Free Radic Biol Med
Title: Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice.
Volume: 32
Issue: 8
Pages: 744-51
Publication
First Author: Ueda Y
Year: 2016
Journal: J Immunol
Title: Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition.
Volume: 196
Issue: 7
Pages: 3019-31