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Search results 1 to 100 out of 116 for Rapgef2

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9693 | RAPGEF2
Type: gene
Organism: human
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Gene
100145659 | rapgef2
Type: gene
Organism: frog, western clawed
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Gene
310533 | Rapgef2
Type: gene
Organism: rat
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Gene
461577 | RAPGEF2
Type: gene
Organism: chimpanzee
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Gene
100139484 | RAPGEF2
Type: gene
Organism: cattle
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Gene
100856359 | RAPGEF2
Type: gene
Organism: dog, domestic
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Gene
422418 | RAPGEF2
Type: gene
Organism: chicken
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Gene
704717 | RAPGEF2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR030739 | RapGEF2
Type: Family
Description: RapGEF2 (CNrasGEF) is a Rap guanine nucleotide exchange factor that specifically activates Rap1 []. It is involved in embryonic hematopoiesis [], proper development of the midline commissures []and neuronal migration in the developing cerebral cortex []. It functions in the cAMP-induced Erk signalling pathway that leads to neuritogenesis []. It has a role in regulating cell proliferation and apoptosis [].
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Protein Coding Gene
MGI:2659071 | Rapgef2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23800469 | J:201420
First Author: Emery AC
Year: 2013
Journal: Sci Signal
Title: Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.
Volume: 6
Issue: 281
Pages: ra51
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Publication
20595512 | J:165879
First Author: Satyanarayana A
Year: 2010
Journal: Blood
Title: RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis.
Volume: 116
Issue: 16
Pages: 2921-31
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Publication
16272156 | J:198912
First Author: Amsen EM
Year: 2006
Journal: J Biol Chem
Title: The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells.
Volume: 281
Issue: 1
Pages: 121-8
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Publication
21864586 | J:178740
First Author: Bilasy SE
Year: 2011
Journal: Neurosci Res
Title: RA-GEF-1 (Rapgef2) is essential for proper development of the midline commissures.
Volume: 71
Issue: 3
Pages: 200-9
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Publication
25189171 | -
 
First Author: Ye T
Year: 2014
Journal: Nat Commun
Title: Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
Volume: 5
Pages: 4826
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Publication
33345400 | J:352826
First Author: Jang YN
Year: 2021
Journal: Neuropathol Appl Neurobiol
Title: RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Volume: 47
Issue: 5
Pages: 625-639
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Publication
29747665 | J:270573
First Author: Maeta K
Year: 2018
Journal: Mol Brain
Title: Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.
Volume: 11
Issue: 1
Pages: 27
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Publication
27390776 | J:240358
 
First Author: Maeta K
Year: 2016
Journal: eNeuro
Title: Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.
Volume: 3
Issue: 3
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Protein
Q3TA27
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Publication
28948210 | J:255838
 
First Author: Jiang SZ
Year: 2017
Journal: eNeuro
Title: NCS-Rapgef2, the Protein Product of the Neuronal Rapgef2 Gene, Is a Specific Activator of D1 Dopamine Receptor-Dependent ERK Phosphorylation in Mouse Brain.
Volume: 4
Issue: 5
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Protein
Q8CHG7
Organism: Mus musculus/domesticus
Length: 1496  
Fragment?: false
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Protein
A0A0A6YWG7
Organism: Mus musculus/domesticus
Length: 1644  
Fragment?: false
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Protein
E9QNQ4
Organism: Mus musculus/domesticus
Length: 1494  
Fragment?: false
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Protein
Q6NXI4
Organism: Mus musculus/domesticus
Length: 1511  
Fragment?: true
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Publication
32600317 | J:319394
First Author: Ishihara S
Year: 2020
Journal: BMC Biol
Title: Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.
Volume: 18
Issue: 1
Pages: 75
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Publication
33268547 | J:302143
First Author: Jiang SZ
Year: 2021
Journal: J Neurosci
Title: Cocaine-Dependent Acquisition of Locomotor Sensitization and Conditioned Place Preference Requires D1 Dopaminergic Signaling through a Cyclic AMP, NCS-Rapgef2, ERK, and Egr-1/Zif268 Pathway.
Volume: 41
Issue: 4
Pages: 711-725
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Publication
28917843 | J:251354
First Author: Farag MI
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Rapgef2, a guanine nucleotide exchange factor for Rap1 small GTPases, plays a crucial role in adherence junction (AJ) formation in radial glial cells through ERK-mediated upregulation of the AJ-constituent protein expression.
Volume: 493
Issue: 1
Pages: 139-145
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Publication
32917586 | J:313612
 
First Author: Arimura N
Year: 2020
Journal: Sci Adv
Title: DSCAM regulates delamination of neurons in the developing midbrain.
Volume: 6
Issue: 36
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Protein Coding Gene
MGP_CAROLIEiJ_G0025082 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027272 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027283 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2659071 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026474 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027002 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027106 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027246 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026208 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026525 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026024 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3760885
Age: embryonic day 10.5
Specimen Label: +/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3760885
Age: embryonic day 10.5
Specimen Label: -/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3760885
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3760886
Age: embryonic day 6.5
Specimen Label: 6.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3760886
Age: embryonic day 7.5
Specimen Label: 7.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3760886
Age: embryonic day 8.5
Specimen Label: 8.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3760886
Age: embryonic day 9.5
Specimen Label: 9.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3760886
Age: embryonic day 10.5
Specimen Label: 10.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3760876
Assay Type: RT-PCR
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3760886
Age: embryonic day 11.5
Specimen Label: 11.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:3760891
Age: embryonic day 6.5
Specimen Label: 6.5
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:3760891
Age: embryonic day 7.5
Specimen Label: 7.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3760891
Age: embryonic day 8.5
Specimen Label: 8.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3760891
Age: embryonic day 9.5
Specimen Label: 9.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:3760891
Age: embryonic day 10.5
Specimen Label: 10.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3760878
Assay Type: Western blot
Annotation Date: 2007-11-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3760891
Age: embryonic day 11.5
Specimen Label: 11.5
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_09
Specimen Label: euxassay_014449_09
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_10
Specimen Label: euxassay_014449_10
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_11
Specimen Label: euxassay_014449_11
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_12
Specimen Label: euxassay_014449_12
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_14
Specimen Label: euxassay_014449_14
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_15
Specimen Label: euxassay_014449_15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4424862
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827611
Age: embryonic day 14.5
Image: euxassay_014449_17
Specimen Label: euxassay_014449_17
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:3760878
Assay Type: Immunohistochemistry
Annotation Date: 2007-11-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1626713
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3760892
Age: embryonic day 8.5
Note: Expression is widespread.
Specimen Label: 2F
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:3760878
Assay Type: Immunohistochemistry
Annotation Date: 2007-11-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1608613
Pattern: Not Specified
Stage: TS13
Assay Id: MGI:3760892
Age: embryonic day 8.5
Note: Expression is widespread.
Specimen Label: 2F
Detected: true
Specimen Num: 1
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Publication
- | J:83238
   
First Author: Okazaki N
Year: 2003
Journal: GenBank Submission
Title: Mus musculus mRNA for mKIAA0313 protein
Pages: AB093228
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Publication
19453629 | J:149445
First Author: Bilasy SE
Year: 2009
Journal: Eur J Neurosci
Title: Dorsal telencephalon-specific RA-GEF-1 knockout mice develop heterotopic cortical mass and commissural fiber defect.
Volume: 29
Issue: 10
Pages: 1994-2008
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Publication
26490870 | J:226686
First Author: Mayanagi T
Year: 2015
Journal: J Neurosci
Title: PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
Volume: 35
Issue: 42
Pages: 14327-40
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Publication
17826737 | J:125199
First Author: Wei P
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Defective vascular morphogenesis and mid-gestation embryonic death in mice lacking RA-GEF-1.
Volume: 363
Issue: 1
Pages: 106-12
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Publication
23885123 | J:217266
First Author: Monteiro AC
Year: 2013
Journal: Mol Biol Cell
Title: JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Volume: 24
Issue: 18
Pages: 2849-60
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Publication
19635461 | J:152727
First Author: Kanemura H
Year: 2009
Journal: Biochem Biophys Res Commun
Title: Impaired vascular development in the yolk sac and allantois in mice lacking RA-GEF-1.
Volume: 387
Issue: 4
Pages: 754-9
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Publication
12465718 | J:86755
First Author: Okazaki N
Year: 2002
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 9
Issue: 5
Pages: 179-88
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
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