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Search results 1 to 100 out of 179 for Rapgef3

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0.055s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Zhou L
Year: 2016
Journal: Transl Psychiatry
Title: Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.
Volume: 6
Issue: 9
Pages: e881
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kai AK
Year: 2013
Journal: FASEB J
Title: Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome.
Volume: 27
Issue: 10
Pages: 4122-35
Publication
First Author: Laurent AC
Year: 2015
Journal: Cardiovasc Res
Title: Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Volume: 105
Issue: 1
Pages: 55-64
Publication
First Author: Yan J
Year: 2013
Journal: Mol Cell Biol
Title: Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.
Volume: 33
Issue: 5
Pages: 918-26
Publication  
First Author: He X
Year: 2019
Journal: Life Sci
Title: Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis.
Volume: 221
Pages: 1-12
Publication
First Author: Curry FE
Year: 2019
Journal: Acta Physiol (Oxf)
Title: Epac1-/- mice have elevated baseline permeability and do not respond to histamine as measured with dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights.
Volume: 225
Issue: 3
Pages: e13199
Publication
First Author: Sivertsen Ã…srud K
Year: 2020
Journal: Acta Physiol (Oxf)
Title: Epac1 null mice have nephrogenic diabetes insipidus with deficient corticopapillary osmotic gradient and weaker collecting duct tight junctions.
Volume: 229
Issue: 1
Pages: e13442
Publication
First Author: Suzuki S
Year: 2010
Journal: J Biol Chem
Title: Differential roles of Epac in regulating cell death in neuronal and myocardial cells.
Volume: 285
Issue: 31
Pages: 24248-59
Publication
First Author: Wang H
Year: 2013
Journal: J Clin Invest
Title: Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain.
Volume: 123
Issue: 12
Pages: 5023-34
Publication
First Author: Ohnuki Y
Year: 2014
Journal: J Physiol
Title: Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2-adrenoceptor stimulation.
Volume: 592
Issue: 24
Pages: 5461-75
Publication
First Author: Singhmar P
Year: 2018
Journal: Pain
Title: Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy.
Volume: 159
Issue: 5
Pages: 884-893
Publication
First Author: Kato Y
Year: 2019
Journal: J Physiol Sci
Title: Epac1 deficiency inhibits basic fibroblast growth factor-mediated vascular smooth muscle cell migration.
Volume: 69
Issue: 2
Pages: 175-184
Publication
First Author: Kato Y
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Epac1 Deficiency Attenuated Vascular Smooth Muscle Cell Migration and Neointimal Formation.
Volume: 35
Issue: 12
Pages: 2617-25
Publication
First Author: Gong B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.
Volume: 110
Issue: 48
Pages: 19615-20
Publication
First Author: Almahariq M
Year: 2015
Journal: Biochem J
Title: Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression.
Volume: 465
Issue: 2
Pages: 295-303
Publication
First Author: Xiao J
Year: 2021
Journal: J Biol Chem
Title: Intracellular receptor EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K-/eNOS-dependent manner during inflammation.
Volume: 297
Issue: 5
Pages: 101315
Publication
First Author: Yang W
Year: 2023
Journal: Invest Ophthalmol Vis Sci
Title: Upregulation of Epac1 Promotes Pericyte Loss by Inducing Mitochondrial Fission, Reactive Oxygen Species Production, and Apoptosis.
Volume: 64
Issue: 11
Pages: 34
Publication  
First Author: Wang H
Year: 2016
Journal: Sci Rep
Title: Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.
Volume: 6
Pages: 36552
Publication  
First Author: Jiang Y
Year: 2017
Journal: Mediators Inflamm
Title: Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature.
Volume: 2017
Pages: 2860956
Publication  
First Author: Liu L
Year: 2022
Journal: Exp Eye Res
Title: Epac1 and PKA regulate of P2X7 and NLRP3 inflammasome proteins in the retinal vasculature.
Volume: 218
Pages: 108987
Publication  
First Author: Liu L
Year: 2017
Journal: Mol Vis
Title: Epac1 agonist decreased inflammatory proteins in retinal endothelial cells, and loss of Epac1 increased inflammatory proteins in the retinal vasculature of mice.
Volume: 23
Pages: 1-7
Publication
First Author: Jiang Y
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Compound 49b Regulates ZO-1 and Occludin Levels in Human Retinal Endothelial Cells and in Mouse Retinal Vasculature.
Volume: 58
Issue: 1
Pages: 185-189
Publication  
First Author: Curtiss E
Year: 2018
Journal: Mediators Inflamm
Title: Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines.
Volume: 2018
Pages: 3809092
Publication
First Author: Liu L
Year: 2018
Journal: PLoS One
Title: Epac1 protects the retina against ischemia/reperfusion-induced neuronal and vascular damage.
Volume: 13
Issue: 9
Pages: e0204346
Publication
First Author: Fazal L
Year: 2017
Journal: Circ Res
Title: Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Volume: 120
Issue: 4
Pages: 645-657
Publication
First Author: Laudette M
Year: 2021
Journal: Cell Death Dis
Title: Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Volume: 12
Issue: 9
Pages: 824
Publication
First Author: Patschan D
Year: 2010
Journal: Am J Physiol Renal Physiol
Title: Epac-1 activator 8-O-cAMP augments renoprotective effects of syngeneic [corrected] murine EPCs in acute ischemic kidney injury.
Volume: 298
Issue: 1
Pages: F78-85
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3765323
Age: embryonic day 19.0
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3765323
Age: postnatal day 0
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3765323
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3765323
Age: postnatal week 12
Specimen Label: 12wk
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:3765324
Age: embryonic day 19.0
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:3765324
Age: postnatal day 0
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3765324
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3765324
Age: postnatal week 12
Specimen Label: 12wk
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Stage: TS26
Assay Id: MGI:3765325
Age: embryonic day 19.0
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:3765325
Age: postnatal day 0
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3765325
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3765325
Age: postnatal week 12
Specimen Label: 12wk
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672826
Stage: TS26
Assay Id: MGI:3765326
Age: embryonic day 19.0
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:3765326
Age: postnatal day 0
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3765326
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3765326
Age: postnatal week 12
Specimen Label: 12wk
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3765338
Age: embryonic day 19.0
Specimen Label: Fetus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3765338
Age: postnatal day 0
Specimen Label: Neonate
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3765338
Age: postnatal week 3
Specimen Label: 3wk
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3765314
Assay Type: RT-PCR
Annotation Date: 2007-12-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3765338
Age: postnatal week 12
Specimen Label: 12wk
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:7464613
Assay Type: RT-PCR
Annotation Date: 2023-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783827
Stage: TS27
Assay Id: MGI:7464635
Age: postnatal day 2
Image: 1
Specimen Label: P2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7464613
Assay Type: RT-PCR
Annotation Date: 2023-04-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783828
Stage: TS28
Assay Id: MGI:7464635
Age: postnatal day 24
Image: 1
Specimen Label: P24
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_08
Specimen Label: euxassay_005054_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_09
Specimen Label: euxassay_005054_09
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_10
Specimen Label: euxassay_005054_10
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_11
Specimen Label: euxassay_005054_11
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_12
Specimen Label: euxassay_005054_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_13
Specimen Label: euxassay_005054_13
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_07
Specimen Label: euxassay_005054_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_07
Specimen Label: euxassay_005054_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_08
Specimen Label: euxassay_005054_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_09
Specimen Label: euxassay_005054_09
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_11
Specimen Label: euxassay_005054_11
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_12
Specimen Label: euxassay_005054_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:1579112
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827612
Age: embryonic day 14.5
Image: euxassay_005054_13
Specimen Label: euxassay_005054_13
Detected: true
Specimen Num: 7
Publication
First Author: Rajagopal S
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
Volume: 304
Issue: 5
Pages: G527-35
Publication
First Author: Cai W
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.
Volume: 475
Issue: 1
Pages: 1-7
Publication
First Author: Singhmar P
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.
Volume: 113
Issue: 11
Pages: 3036-41
Publication  
First Author: Liu W
Year: 2020
Journal: J Exp Med
Title: Neuronal Epac1 mediates retinal neurodegeneration in mouse models of ocular hypertension.
Volume: 217
Issue: 4
Publication  
First Author: Liu L
Year: 2022
Journal: Mol Vis
Title: TNFAIP3 is anti-inflammatory in the retinal vasculature.
Volume: 28
Pages: 124-129
Publication
First Author: Liu L
Year: 2022
Journal: Invest Ophthalmol Vis Sci
Title: PKA and Epac1 Reduce Nek7 to Block the NLRP3 Inflammasome Proteins in the Retinal Vasculature.
Volume: 63
Issue: 1
Pages: 14
Publication
First Author: Artamonov MV
Year: 2015
Journal: J Biol Chem
Title: Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.
Volume: 290
Issue: 16
Pages: 10353-67
Publication
First Author: Liu J
Year: 2015
Journal: Sci China Life Sci
Title: Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy.
Volume: 58
Issue: 6
Pages: 521-30
Publication
First Author: Herfindal L
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.
Volume: 437
Issue: 4
Pages: 603-8