|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 86 out of 86 for Rars

0.024s
Type Details Score
Gene
Type: gene
Organism: chicken
Protein
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
Gene
Type: gene
Organism: human
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
DO Term
Publication
First Author: Dewamitta SR
Year: 2014
Journal: Br J Haematol
Title: Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.
Volume: 164
Issue: 2
Pages: 280-5
Publication
First Author: Leroy P
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.
Volume: 88
Issue: 22
Pages: 10138-42
Publication
First Author: Leid M
Year: 1992
Journal: Cell
Title: Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.
Volume: 68
Issue: 2
Pages: 377-95
Publication
First Author: Taneja R
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.
Volume: 92
Issue: 17
Pages: 7854-8
Publication
First Author: Chee LC
Year: 2013
Journal: J Leukoc Biol
Title: The granulocyte-colony stimulating factor receptor (G-CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation.
Volume: 93
Issue: 2
Pages: 235-43
Publication
First Author: Kastner P
Year: 2001
Journal: Oncogene
Title: Function of RARalpha during the maturation of neutrophils.
Volume: 20
Issue: 49
Pages: 7178-85
Publication
First Author: Kopf E
Year: 2000
Journal: J Biol Chem
Title: Dimerization with retinoid X receptors and phosphorylation modulate the retinoic acid-induced degradation of retinoic acid receptors alpha and gamma through the ubiquitin-proteasome pathway.
Volume: 275
Issue: 43
Pages: 33280-8
Publication
First Author: Soosaar A
Year: 1996
Journal: FEBS Lett
Title: Cell type specific regulation of COUP-TF II promoter activity.
Volume: 391
Issue: 1-2
Pages: 95-100
Publication
First Author: Saitou M
Year: 1995
Journal: Nature
Title: Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.
Volume: 374
Issue: 6518
Pages: 159-62
Publication
First Author: Yang L
Year: 2003
Journal: Endocrinology
Title: Overexpression of dominant negative retinoic acid receptor alpha causes alveolar abnormality in transgenic neonatal lungs.
Volume: 144
Issue: 7
Pages: 3004-11
Publication
First Author: Wang W
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
Volume: 108
Issue: 45
Pages: 18283-8
Publication
First Author: Al Tanoury Z
Year: 2014
Journal: J Cell Sci
Title: Phosphorylation of the retinoic acid receptor RARγ2 is crucial for the neuronal differentiation of mouse embryonic stem cells.
Volume: 127
Issue: Pt 9
Pages: 2095-105
Publication
First Author: Laursen KB
Year: 2018
Journal: J Biol Chem
Title: Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells.
Volume: 293
Issue: 30
Pages: 11891-11900
Publication
First Author: Krust A
Year: 1989
Journal: Proc Natl Acad Sci U S A
Title: A third human retinoic acid receptor, hRAR-gamma.
Volume: 86
Issue: 14
Pages: 5310-4
Publication
First Author: Lehmann JM
Year: 1991
Journal: Nucleic Acids Res
Title: Genomic organization of the retinoic acid receptor gamma gene.
Volume: 19
Issue: 3
Pages: 573-8
Publication
First Author: Renaud JP
Year: 1995
Journal: Nature
Title: Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
Volume: 378
Issue: 6558
Pages: 681-9
Protein Domain
Type: Family
Description: Steroid or nuclear hormone receptors (NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands []. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of them being implicated in diseases such as cancer, diabetes, hormone resistance syndromes, etc. While several NRs act as ligand-inducible transcription factors, many do not yet have a defined ligand and are accordingly termed 'orphan' receptors. During the last decade, more than 300 NRs have been described, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid andthyroid hormones. These proteins contain two highly conserved domainsthat are involved in determining their DNA and ligand-binding activities []. Three distinct RARs have been identified (termed RAR alpha, beta, and gamma) and are encoded by genes on separate chromosomes. Additional isoforms of the receptors have been described, all of which differ in the N-terminal regions. Comparison of the amino acid sequences of human and mouse RARs indicates that interspecies conservation in members of the RAR subfamily (either alpha, beta or gamma) is much higher than conservation of thereceptors within species []. These observations indicate that RAR-alpha, -beta and -gamma may perform specific functions. hRAR-gamma RNA has been shown to be the predominant RAR RNA species in human skin, suggestingthat hRAR-gamma mediates some of the retinoid effects in this tissue []. The crystal structure of the ligand-binding domain (LBD) of the hRAR-gammabound to all-trans retinoic acid has been determined to 2.0A resolution [].Overall, the fold is similar to that of the human RXR-alpha apo-LBD, exceptfor the C-terminal portion, which folds back towards the LBD core, contributing to the hydrophobic ligand pocket and `sealing' its entry site. A `mouse trap' mechanism is thus proposed, whereby a ligand-induced conformational transition re-positions the amphipathic α-helix of theactivating domain and forms a transcriptionally active receptor []. Synonym(s): 1B nuclear receptor
Publication
First Author: Zelent A
Year: 1989
Journal: Nature
Title: Cloning of murine alpha and beta retinoic acid receptors and a novel receptor gamma predominantly expressed in skin.
Volume: 339
Issue: 6227
Pages: 714-7
Publication
First Author: Kruyt FA
Year: 1992
Journal: Differentiation
Title: Retinoic acid resistance of the variant embryonal carcinoma cell line RAC65 is caused by expression of a truncated RAR alpha.
Volume: 49
Issue: 1
Pages: 27-37
Publication
First Author: Vernet N
Year: 2006
Journal: EMBO J
Title: Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells.
Volume: 25
Issue: 24
Pages: 5816-25
Publication
First Author: Balkan W
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Transgenic indicator mice for studying activated retinoic acid receptors during development.
Volume: 89
Issue: 8
Pages: 3347-51
Publication
First Author: Brun PJ
Year: 2015
Journal: FASEB J
Title: Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.
Volume: 29
Issue: 2
Pages: 671-83
Publication
First Author: Colbert MC
Year: 1997
Journal: J Clin Invest
Title: Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.
Volume: 100
Issue: 8
Pages: 1958-68
Publication
First Author: Kastner P
Year: 1997
Journal: Development
Title: Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes.
Volume: 124
Issue: 23
Pages: 4749-58
Publication
First Author: Ricote M
Year: 2006
Journal: J Leukoc Biol
Title: Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.
Volume: 80
Issue: 4
Pages: 850-61
Publication
First Author: Matt N
Year: 2008
Journal: Dev Biol
Title: Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.
Volume: 320
Issue: 1
Pages: 140-8
Publication
First Author: Beehler BC
Year: 1995
Journal: Arch Dermatol Res
Title: Gene expression of retinoic acid receptors and cellular retinoic acid-binding proteins in rhino and hairless mouse skin.
Volume: 287
Issue: 5
Pages: 488-93
Publication
First Author: Dupé V
Year: 2009
Journal: Dev Dyn
Title: Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells.
Volume: 238
Issue: 10
Pages: 2701-11
Publication
First Author: Chen CF
Year: 2005
Journal: J Biol Chem
Title: Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway.
Volume: 280
Issue: 4
Pages: 3012-21
Publication
First Author: Lohnes D
Year: 1994
Journal: Development
Title: Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.
Volume: 120
Issue: 10
Pages: 2723-48
Publication
First Author: Mendelsohn C
Year: 1994
Journal: Development
Title: Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.
Volume: 120
Issue: 10
Pages: 2749-71
Publication
First Author: Purton LE
Year: 2006
Journal: J Exp Med
Title: RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.
Volume: 203
Issue: 5
Pages: 1283-93
Publication
First Author: Visconte V
Year: 2012
Journal: Blood
Title: SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.
Volume: 120
Issue: 16
Pages: 3173-86
Publication
First Author: Snyder JM
Year: 2005
Journal: Pediatr Res
Title: Alveolarization in retinoic acid receptor-beta-deficient mice.
Volume: 57
Issue: 3
Pages: 384-91
Publication
First Author: Mendelsohn C
Year: 1994
Journal: Dev Biol
Title: Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal.
Volume: 166
Issue: 1
Pages: 246-58
Publication
First Author: Flajollet S
Year: 2006
Journal: J Biol Chem
Title: Distinct roles of the steroid receptor coactivator 1 and of MED1 in retinoid-induced transcription and cellular differentiation.
Volume: 281
Issue: 29
Pages: 20338-48
Publication
First Author: Si J
Year: 2002
Journal: Blood
Title: IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner.
Volume: 100
Issue: 13
Pages: 4401-9
Publication
First Author: Goyette P
Year: 2000
Journal: J Biol Chem
Title: Characterization of retinoic acid receptor-deficient keratinocytes.
Volume: 275
Issue: 22
Pages: 16497-505
Publication
First Author: Dawson MI
Year: 2001
Journal: Int J Cancer
Title: Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition.
Volume: 91
Issue: 1
Pages: 8-21
Publication
First Author: Dollé P
Year: 1989
Journal: Nature
Title: Differential expression of genes encoding alpha, beta and gamma retinoic acid receptors and CRABP in the developing limbs of the mouse.
Volume: 342
Issue: 6250
Pages: 702-5
Publication
First Author: Boylan JF
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.
Volume: 90
Issue: 20
Pages: 9601-5
Publication
First Author: Zhuang YH
Year: 1994
Journal: J Steroid Biochem Mol Biol
Title: Immunolocalization of retinoic acid receptors in rat, mouse and human ovary and uterus.
Volume: 48
Issue: 1
Pages: 61-8
Publication
First Author: Vonesch JL
Year: 1994
Journal: Dev Dyn
Title: Stage and tissue-specific expression of the alcohol dehydrogenase 1 (Adh-1) gene during mouse development.
Volume: 199
Issue: 3
Pages: 199-213
Publication
First Author: Pereira FA
Year: 1995
Journal: J Steroid Biochem Mol Biol
Title: Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.
Volume: 53
Issue: 1-6
Pages: 503-8
Publication
First Author: Chambon P
Year: 1996
Journal: FASEB J
Title: A decade of molecular biology of retinoic acid receptors.
Volume: 10
Issue: 9
Pages: 940-54
Publication
First Author: Manshouri T
Year: 1997
Journal: Blood
Title: Downregulation of RAR alpha in mice by antisense transgene leads to a compensatory increase in RAR beta and RAR gamma and development of lymphoma.
Volume: 89
Issue: 7
Pages: 2507-15
Publication
First Author: Romand R
Year: 1998
Journal: J Comp Neurol
Title: Spatial distributions of retinoic acid receptor gene transcripts in the prenatal mouse inner ear.
Volume: 393
Issue: 3
Pages: 298-308
Publication
First Author: Zhang ZP
Year: 1998
Journal: J Biol Chem
Title: Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma.
Volume: 273
Issue: 51
Pages: 34016-21
Publication
First Author: Walkley CR
Year: 2004
Journal: Blood
Title: Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.
Volume: 103
Issue: 4
Pages: 1286-95
Publication
First Author: Si J
Year: 2007
Journal: J Clin Invest
Title: CaMKII regulates retinoic acid receptor transcriptional activity and the differentiation of myeloid leukemia cells.
Volume: 117
Issue: 5
Pages: 1412-21
Publication
First Author: Vucetic Z
Year: 2008
Journal: Mol Cell Biol
Title: Acinus-S' represses retinoic acid receptor (RAR)-regulated gene expression through interaction with the B domains of RARs.
Volume: 28
Issue: 8
Pages: 2549-58
Publication
First Author: Al Tanoury Z
Year: 2014
Journal: J Cell Sci
Title: Genes involved in cell adhesion and signaling: a new repertoire of retinoic acid receptor target genes in mouse embryonic fibroblasts.
Volume: 127
Issue: Pt 3
Pages: 521-33
Publication
First Author: Yang J
Year: 2015
Journal: Stem Cells
Title: Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.
Volume: 33
Issue: 5
Pages: 1390-404
Publication
First Author: Green AC
Year: 2017
Journal: Exp Cell Res
Title: Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells.
Volume: 350
Issue: 1
Pages: 284-297
Publication
First Author: Subbarayan V
Year: 1997
Journal: Mech Dev
Title: Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms.
Volume: 66
Issue: 1-2
Pages: 131-42
Publication  
First Author: Juin SK
Year: 2021
Journal: Biomolecules
Title: GYY4137 Regulates Extracellular Matrix Turnover in the Diabetic Kidney by Modulating Retinoid X Receptor Signaling.
Volume: 11
Issue: 10
Publication
First Author: Ghyselinck NB
Year: 1997
Journal: Int J Dev Biol
Title: Role of the retinoic acid receptor beta (RARbeta) during mouse development.
Volume: 41
Issue: 3
Pages: 425-47
Publication
First Author: Dupé V
Year: 1999
Journal: Development
Title: Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse.
Volume: 126
Issue: 22
Pages: 5051-9
Publication
First Author: Romand R
Year: 2002
Journal: Mech Dev
Title: The retinoic acid receptors RARalpha and RARgamma are required for inner ear development.
Volume: 119
Issue: 2
Pages: 213-23
Publication
First Author: Dollé P
Year: 1990
Journal: Development
Title: Retinoic acid receptors and cellular retinoid binding proteins. I. A systematic study of their differential pattern of transcription during mouse organogenesis.
Volume: 110
Issue: 4
Pages: 1133-51
Publication
First Author: Tairis N
Year: 1994
Journal: J Biol Chem
Title: Arg269 and Lys220 of retinoic acid receptor-beta are important for the binding of retinoic acid.
Volume: 269
Issue: 30
Pages: 19516-22
Publication
First Author: Bloch-Zupan A
Year: 1994
Journal: Differentiation
Title: Expression of nuclear retinoic acid receptors during mouse odontogenesis.
Volume: 57
Issue: 3
Pages: 195-203
Publication
First Author: Gaemers IC
Year: 1997
Journal: Endocrinology
Title: Effect of retinoid status on the messenger ribonucleic acid expression of nuclear retinoid receptors alpha, beta, and gamma, and retinoid X receptors alpha, beta, and gamma in the mouse testis.
Volume: 138
Issue: 4
Pages: 1544-51
Publication
First Author: Naitoh H
Year: 1998
Journal: J Craniofac Genet Dev Biol
Title: Altered expression of retinoic acid (RA) receptor mRNAs in the fetal mouse secondary palate by all-trans and 13-cis RAs: implications for RA-induced teratogenesis.
Volume: 18
Issue: 4
Pages: 202-10
Publication
First Author: Zhang ZP
Year: 2003
Journal: Arch Biochem Biophys
Title: Arginine of retinoic acid receptor beta which coordinates with the carboxyl group of retinoic acid functions independent of the amino acid residues responsible for retinoic acid receptor subtype ligand specificity.
Volume: 409
Issue: 2
Pages: 375-84
Publication  
First Author: Lin RL
Year: 2017
Journal: Front Physiol
Title: Hypersensitivity of Vagal Pulmonary Afferents Induced by Tumor Necrosis Factor Alpha in Mice.
Volume: 8
Pages: 411
Publication
First Author: Darwiche N
Year: 1994
Journal: Endocrinology
Title: Specificity of retinoid receptor gene expression in mouse cervical epithelia.
Volume: 134
Issue: 5
Pages: 2018-25
Protein
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
Publication
First Author: Schwabe JW
Year: 2004
Journal: Sci STKE
Title: Nuclear receptors: the evolution of diversity.
Volume: 2004
Issue: 217
Pages: pe4
Publication
First Author: Nishikawa J
Year: 1995
Journal: Nucleic Acids Res
Title: Vitamin D receptor contains multiple dimerization interfaces that are functionally different.
Volume: 23
Issue: 4
Pages: 606-11
Publication
First Author: De Vos P
Year: 1994
Journal: Nucleic Acids Res
Title: Human androgen receptor expressed in HeLa cells activates transcription in vitro.
Volume: 22
Issue: 7
Pages: 1161-6