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Search results 1 to 80 out of 80 for Rasal1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
8437 | RASAL1
Type: gene
Organism: human
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Gene
493411 | rasal1
Type: gene
Organism: frog, western clawed
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Gene
360814 | Rasal1
Type: gene
Organism: rat
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Gene
486277 | RASAL1
Type: gene
Organism: dog, domestic
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Gene
452269 | RASAL1
Type: gene
Organism: chimpanzee
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Gene
512872 | RASAL1
Type: gene
Organism: cattle
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Gene
771057 | RASAL1
Type: gene
Organism: chicken
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Gene
714353 | RASAL1
Type: gene
Organism: macaque, rhesus
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Gene
101885701 | rasal1
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:1330842 | Rasal1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028555 | RASAL1
Type: Family
Description: GAP1 (GTPase-activating protein 1) family members include RASA2 (GAP1m), RASAL (RASAL1), GAP1(IP4BP or RASA3), and CAPRI (RASA4). They all display Ras GAP activity. With the exception of RASA2, they all possess an arginine finger-dependent GAP activity on Rap1 [, ]. They contain N-terminal tandem C2 domain repeats, a centrally located Ras-GAP domain, and a PH (pleckstrin homology) domain containing a Btk motif [].RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes. Its tandem C2 domains bind phospholipids upon an elevation in the intracellular free Ca2+ concentration ([Ca2+]i) [].
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Publication
31641113 | J:281521
First Author: Thaker YR
Year: 2019
Journal: Nat Commun
Title: GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
Volume: 10
Issue: 1
Pages: 4804
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Publication
39032134 | J:359420
     
First Author: Shen X
Year: 2024
Journal: Mol Oncol
Title: The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K-AKT pathway.
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Protein
Q9Z268
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q3TQ19
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: true
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Publication
17052212 | -
First Author: Yarwood S
Year: 2006
Journal: Biochem Soc Trans
Title: The GAP1 family of GTPase-activating proteins: spatial and temporal regulators of small GTPase signalling.
Volume: 34
Issue: Pt 5
Pages: 846-50
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Publication
19433443 | -
First Author: Kupzig S
Year: 2009
Journal: Mol Cell Biol
Title: The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.
Volume: 29
Issue: 14
Pages: 3929-40
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Publication
17640920 | -
First Author: Jin H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
Volume: 104
Issue: 30
Pages: 12353-8
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Publication
16431904 | -
First Author: Kupzig S
Year: 2006
Journal: J Biol Chem
Title: GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins.
Volume: 281
Issue: 15
Pages: 9891-900
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Publication
30158531 | J:265032
First Author: Xu X
Year: 2018
Journal: Nat Commun
Title: High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis.
Volume: 9
Issue: 1
Pages: 3509
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Publication
35857828 | J:331889
First Author: Xu R
Year: 2022
Journal: Sci Transl Med
Title: A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers.
Volume: 14
Issue: 654
Pages: eabf1922
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Publication
20418885 | J:160617
First Author: Bechtel W
Year: 2010
Journal: Nat Med
Title: Methylation determines fibroblast activation and fibrogenesis in the kidney.
Volume: 16
Issue: 5
Pages: 544-50
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Protein Coding Gene
MGP_CAROLIEiJ_G0027667 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030011 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029986 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029706 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1330842 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030441 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029824 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029780 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029811 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030482 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029190 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024249 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028667 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9751798 | J:50120
First Author: Allen M
Year: 1998
Journal: Gene
Title: Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog.
Volume: 218
Issue: 1-2
Pages: 17-25
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_01
Specimen Label: euxassay_002215_01
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_02
Specimen Label: euxassay_002215_02
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_03
Specimen Label: euxassay_002215_03
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_04
Specimen Label: euxassay_002215_04
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_05
Specimen Label: euxassay_002215_05
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_20
Specimen Label: euxassay_002215_20
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_21
Specimen Label: euxassay_002215_21
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:1370520
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827622
Age: embryonic day 14.5
Image: euxassay_002215_22
Specimen Label: euxassay_002215_22
Detected: true
Specimen Num: 8
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Publication
12080145 | J:77001
First Author: Perelygin AA
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Positional cloning of the murine flavivirus resistance gene.
Volume: 99
Issue: 14
Pages: 9322-7
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Publication
18077674 | J:130568
First Author: Kurrasch DM
Year: 2007
Journal: J Neurosci
Title: The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
Volume: 27
Issue: 50
Pages: 13624-34
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(Rasal1-EGFP)IH211Gsat | MGI:4847365
Name: transgene insertion IH211, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003889 | STOCK Tg(Rasal1-EGFP)IH211Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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