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Search results 1 to 100 out of 116 for Rasgrf2

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0.038s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: RasGRF2 belongs to the RasGRF family. It is a dual Ras/Rac guanine nucleotide exchange factor (GEF) that has been shown to be necessary for long-term potentiation in situ [, ]. It is also involved in T-cell signalling responses through Ras GTPases []. RasGRF2 has been linked to alcoholism [].RasGRF is a Ras family guanine nucleotide exchange factor sharing homology with Saccharomyces cerevisiae Cdc25 that stimulates nucleotide exchange on S. cerevisiae RAS []. RasGRF N-terminal region contains a Dbl homology (DH) domain which is generally present in GEFs for the Rho family of small G proteins, whereas the C-terminal Cdc25-related domain is linked to Ras GTPase signalling []. The presence of regulatory domains for Rho and Ras GTPases implicates the role of RasGRF in the control of the both pathways []. Two RasGRF, RasGRF1 and 2, have been identified in mammals []. Their function can be inhibited by its interaction with Cdc42 in its inactive GDP bound form. Reciprocally, the effects of Cdc42 on cytoskeletal dynamics can be inhibited by RasGRF1/2 [].
Publication      
First Author: Zeng H
Year: 2013
Journal: MGI Direct Data Submission
Title: Generation of an inducible Rasgrf2-cre knockin allele
Publication
First Author: Ruiz S
Year: 2007
Journal: Mol Cell Biol
Title: RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses.
Volume: 27
Issue: 23
Pages: 8127-42
Publication
First Author: Bethge P
Year: 2017
Journal: PLoS One
Title: An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.
Volume: 12
Issue: 6
Pages: e0179460
Publication
First Author: Kim TH
Year: 2016
Journal: Cell Rep
Title: Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex.
Volume: 17
Issue: 12
Pages: 3385-3394
Publication
First Author: Fam NP
Year: 1997
Journal: Mol Cell Biol
Title: Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras.
Volume: 17
Issue: 3
Pages: 1396-406
Publication
First Author: Dipoppa M
Year: 2018
Journal: Neuron
Title: Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.
Volume: 98
Issue: 3
Pages: 602-615.e8
Publication
First Author: Madisen L
Year: 2015
Journal: Neuron
Title: Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.
Volume: 85
Issue: 5
Pages: 942-58
Publication  
First Author: Harris JA
Year: 2014
Journal: Front Neural Circuits
Title: Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation.
Volume: 8
Pages: 76
Publication      
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Jimeno D
Year: 2016
Journal: J Cell Sci
Title: RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.
Volume: 129
Issue: 4
Pages: 729-42
Publication
First Author: Schwechter B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission.
Volume: 110
Issue: 35
Pages: 14462-7
Publication
First Author: Easton AC
Year: 2014
Journal: Psychopharmacology (Berl)
Title: Rasgrf2 controls noradrenergic involvement in the acute and subchronic effects of alcohol in the brain.
Volume: 231
Issue: 21
Pages: 4199-209
Publication
First Author: Ruiz S
Year: 2009
Journal: PLoS One
Title: The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Volume: 4
Issue: 12
Pages: e8229
Allele
Name: RAS protein-specific guanine nucleotide-releasing factor 2; targeted mutation 1, Hongkui Zeng
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant stock, targeted mutation
Genotype
Symbol: Rasgrf2/Rasgrf2<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: ht
Has Mutant Allele: true
Allele
Name: RAS protein-specific guanine nucleotide-releasing factor 2; targeted mutation 2.1, Hongkui Zeng
Allele Type: Targeted
Attribute String: Recombinase
Publication categories: ProxyCollection
Strain
Attribute String: mutant strain, targeted mutation, congenic
Publication
First Author: Fan WT
Year: 1998
Journal: Curr Biol
Title: The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways.
Volume: 8
Issue: 16
Pages: 935-8
Publication
First Author: Cen H
Year: 1993
Journal: Mol Cell Biol
Title: Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.
Volume: 13
Issue: 12
Pages: 7718-24
Publication
First Author: Crespo P
Year: 2011
Journal: Bioarchitecture
Title: Ras and Rho GTPases on the move: The RasGRF connection.
Volume: 1
Issue: 4
Pages: 200-204
Publication
First Author: Fernández-Medarde A
Year: 2011
Journal: Biochim Biophys Acta
Title: The RasGrf family of mammalian guanine nucleotide exchange factors.
Volume: 1815
Issue: 2
Pages: 170-88
Protein
Organism: Mus musculus
Length: 252  
Fragment?: true
Protein
Organism: Mus musculus
Length: 588  
Fragment?: true
Protein
Organism: Mus musculus
Length: 387  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1189  
Fragment?: false
Protein
Organism: Mus musculus
Length: 1188  
Fragment?: false
Publication
First Author: Calvo F
Year: 2011
Journal: Nat Cell Biol
Title: RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.
Volume: 13
Issue: 7
Pages: 819-26
Publication
First Author: Bernardi RE
Year: 2019
Journal: J Neurosci
Title: The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.
Volume: 39
Issue: 32
Pages: 6325-6338
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Fam NP
Year: 1997
Journal: Genomics
Title: Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene.
Volume: 39
Issue: 1
Pages: 118-20
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_17
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_16
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_07
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_17
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_16
Detected: true
Specimen Num: 10
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_15
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_14
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_11
Detected: true
Specimen Num: 5
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_10
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_09
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_08
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_15
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_14
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_13
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_12
Detected: true
Specimen Num: 6
GXD Expression  
Probe: MGI:4423920
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1753723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827628
Age: embryonic day 14.5
Image: euxassay_009649_11
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 28
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 14
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191192
Age: postnatal day 4
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191192
Age: embryonic day 18.5
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191192
Age: embryonic day 15.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191192
Age: embryonic day 13.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6181935
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191192
Age: embryonic day 11.5
Detected: false
Specimen Num: 1
Publication
First Author: Li S
Year: 2006
Journal: J Neurosci
Title: Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.
Volume: 26
Issue: 6
Pages: 1721-9
Publication  
First Author: Gómez C
Year: 2017
Journal: Mol Cell Neurosci
Title: Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.
Volume: 85
Pages: 127-147
Publication
First Author: Li S
Year: 2006
Journal: Curr Biol
Title: The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.
Volume: 16
Issue: 23
Pages: 2303-13
Publication
First Author: Arai JA
Year: 2009
Journal: J Neurosci
Title: Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.
Volume: 29
Issue: 5
Pages: 1496-502
Publication
First Author: Chen L
Year: 1993
Journal: Dev Genet
Title: A murine CDC25/ras-GRF-related protein implicated in Ras regulation.
Volume: 14
Issue: 5
Pages: 339-46
Publication
First Author: Fernández-Medarde A
Year: 2002
Journal: Mol Cell Biol
Title: Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.
Volume: 22
Issue: 8
Pages: 2498-504
Publication
First Author: Tian X
Year: 2004
Journal: EMBO J
Title: Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.
Volume: 23
Issue: 7
Pages: 1567-75
Publication
First Author: Jin SX
Year: 2010
Journal: PLoS One
Title: Long-term potentiation in the CA1 hippocampus induced by NR2A subunit-containing NMDA glutamate receptors is mediated by Ras-GRF2/Erk map kinase signaling.
Volume: 5
Issue: 7
Pages: e11732
Publication
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff