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Search results 1 to 100 out of 133 for Rassf1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
11186 | RASSF1
Type: gene
Organism: human
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Gene
100497994 | rassf1
Type: gene
Organism: frog, western clawed
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Gene
363140 | Rassf1
Type: gene
Organism: rat
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Gene
744944 | RASSF1
Type: gene
Organism: chimpanzee
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Gene
607929 | RASSF1
Type: gene
Organism: dog, domestic
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Gene
510276 | RASSF1
Type: gene
Organism: cattle
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Gene
447811 | rassf1
Type: gene
Organism: zebrafish
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Gene
702385 | RASSF1
Type: gene
Organism: macaque, rhesus
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Gene
101750777 | RASSF1
Type: gene
Organism: chicken
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Protein Domain
IPR033600 | RASSF1
Type: Family
Description: The Ras association domain (RASSF) proteins are named due to the presence of a Ras association (RA) domain in their N or C terminus that can potentially interact with the Ras GTPase family of proteins. These GTPases control a variety of cellular processes, such as membrane trafficking, apoptosis, and proliferation. RASSF proteins contain several other functional domains that modulate associations with other proteins. RASSF proteins with the RA domain at the C terminus (which are termed C-terminal or classical RASSF) usually also include a Salvador-RASSF-Hippo (SARAH) domain involved in several protein-protein interactions and for homo- and heterodimerisation of RASSF isoforms. N-terminal RASSF proteins (with the RA domain in the N terminus) do not usually contain a SARAH domain [].At least 10 RASSF family members have been characterised (with multiple splice variants), many of which have been shown to play a role in tumour suppression. RASSF proteins also act as scaffolding agents in microtubule stability, regulate mitotic cell division, control cell migration and cell adhesion, and modulate NF-KB activity and the duration of inflammation. Loss of RASSF expression through promoter methylation has been shown in numerous types of cancer, including leukemia, melanoma, breast and prostate cancer [].RASSF1 is one of the C-terminal (also known as classical) RASSF proteins, characterised by an RA domain in the C terminus. Human RASSF1 has multiple transcripts as a result of alternative splicing and differential promoter usage. RASSF1A and 1C are the most widely studied and characterised of these. While they are both involved in regulation of growth and migration via microtubule localization, they have very different biological properties [].RASSF1A is a tumor suppressor primarily important in microtubule stability, but implicated in a number of different functions, including cell-cycle regulation, spindle assembly, chromosome attachment, apoptosis and inflamation control, amongst others [].In contrast, RASSF1C has not been shown to be a tumor suppressor, and has even been implicated as an oncogene by a number of mechanisms []. It has been reported to activate cell proliferation through interaction with IGFBP-5, and may also interact with TFPI-2, which is involved in angiogenesis and tumor growth/metastasis [, ]. RASSF1C has also been reported to interact with and stabilise microtubules [].
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Protein Coding Gene
MGI:1928386 | Rassf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
102060282 | RASSF1-AS1
Type: gene
Organism: human
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Publication
16135822 | J:101369
First Author: van der Weyden L
Year: 2005
Journal: Mol Cell Biol
Title: The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis.
Volume: 25
Issue: 18
Pages: 8356-67
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Publication
20955597 | -
 
First Author: Reeves ME
Year: 2010
Journal: BMC Cancer
Title: Ras-association domain family 1C protein promotes breast cancer cell migration and attenuates apoptosis.
Volume: 10
Pages: 562
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Publication
15205320 | -
First Author: Dallol A
Year: 2004
Journal: Cancer Res
Title: RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics.
Volume: 64
Issue: 12
Pages: 4112-6
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Publication
16007340 | -
First Author: Amaar YG
Year: 2005
Journal: J Bone Miner Res
Title: Ras-association domain family 1 protein, RASSF1C, is an IGFBP-5 binding partner and a potential regulator of osteoblast cell proliferation.
Volume: 20
Issue: 8
Pages: 1430-9
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Publication
22232300 | -
First Author: Chen X
Year: 2012
Journal: Acta Biochim Biophys Sin (Shanghai)
Title: Tissue factor pathway inhibitor-2 may interact with nuclear protein RASSF1C.
Volume: 44
Issue: 2
Pages: 183-5
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Publication
15378022 | -
First Author: Rong R
Year: 2004
Journal: Oncogene
Title: Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest.
Volume: 23
Issue: 50
Pages: 8216-30
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Protein
D6REH3
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: false
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Protein
Q3UIV8
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
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Protein
Q99MK9
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
B0QZV7
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Protein
A9YZW8
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Publication
24607545 | J:212135
First Author: Volodko N
Year: 2014
Journal: FEBS Lett
Title: RASSF tumor suppressor gene family: biological functions and regulation.
Volume: 588
Issue: 16
Pages: 2671-84
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Publication
23357313 | -
First Author: Chan JJ
Year: 2013
Journal: Adv Biol Regul
Title: Comparative analysis of interactions of RASSF1-10.
Volume: 53
Issue: 2
Pages: 190-201
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Publication
15665283 | J:95683
First Author: Tommasi S
Year: 2005
Journal: Cancer Res
Title: Tumor susceptibility of Rassf1a knockout mice.
Volume: 65
Issue: 1
Pages: 92-8
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Publication
23294242 | J:214568
First Author: Takenaka M
Year: 2013
Journal: Genes Cells
Title: C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
Volume: 18
Issue: 3
Pages: 203-10
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Publication
22710434 | J:191036
First Author: van der Weyden L
Year: 2012
Journal: Cancer Res
Title: Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.
Volume: 72
Issue: 15
Pages: 3817-3827
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Publication
11965544 | J:76151
First Author: Tommasi S
Year: 2002
Journal: Oncogene
Title: RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.
Volume: 21
Issue: 17
Pages: 2713-20
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Publication
18391979 | J:138515
First Author: van der Weyden L
Year: 2008
Journal: Oncogene
Title: Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.
Volume: 27
Issue: 32
Pages: 4503-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0032648 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035236 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035230 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1928386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035750 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035069 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035145 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035771 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034372 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015516 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033793 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
29735543 | J:262304
First Author: Schmidt ML
Year: 2018
Journal: Cancer Res
Title: RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.
Volume: 78
Issue: 10
Pages: 2614-2623
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Publication
20890045 | J:165327
First Author: Del Re DP
Year: 2010
Journal: J Clin Invest
Title: Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.
Volume: 120
Issue: 10
Pages: 3555-67
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Publication
17379520 | J:121661
First Author: Guo C
Year: 2007
Journal: Curr Biol
Title: RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.
Volume: 17
Issue: 8
Pages: 700-5
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Publication
19652091 | J:167115
First Author: Oceandy D
Year: 2009
Journal: Circulation
Title: Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.
Volume: 120
Issue: 7
Pages: 607-16
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Publication
30315205 | J:280042
First Author: Li W
Year: 2019
Journal: Cell Death Differ
Title: Suppressor of hepatocellular carcinoma RASSF1A activates autophagy initiation and maturation.
Volume: 26
Issue: 8
Pages: 1379-1395
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Publication
16140931 | J:102145
First Author: Dallol A
Year: 2005
Journal: Cancer Res
Title: Involvement of the RASSF1A tumor suppressor gene in controlling cell migration.
Volume: 65
Issue: 17
Pages: 7653-9
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Publication
19335548 | J:269437
First Author: van der Weyden L
Year: 2009
Journal: Int J Exp Pathol
Title: Megaoesophagus in Rassf1a-null mice.
Volume: 90
Issue: 2
Pages: 101-8
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GXD Expression
GXD Expression
     
Probe: MGI:3845379
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3845795
Age: postnatal
Specimen Label: 1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3845379
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3845795
Age: postnatal
Specimen Label: 2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3845379
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3845795
Age: postnatal
Specimen Label: 3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3845379
Assay Type: RT-PCR
Annotation Date: 2009-05-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3845795
Age: postnatal
Specimen Label: 4
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7797438
Assay Type: RNA in situ
Annotation Date: 2025-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7797475
Age: embryonic day 12.5
Image: 11K
Note: Expression in subset of ONBL cells.
Specimen Label: 11K
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7797438
Assay Type: RNA in situ
Annotation Date: 2025-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859024
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7797475
Age: embryonic day 16.5
Image: 11L
Note: Expression in subset of ONBL cells.
Specimen Label: 11L
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7797438
Assay Type: RNA in situ
Annotation Date: 2025-01-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1859027
Pattern: Regionally restricted
Stage: TS27
Assay Id: MGI:7797475
Age: postnatal day 0
Image: 11M
Note: Expression in subset of ONBL cells.
Specimen Label: 11M
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1024200
Assay Type: RNA in situ
Annotation Date: 2011-02-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:4881826
Age: embryonic day 14.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
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Publication
- | J:66356
   
First Author: Duh FM
Year: 1999
Journal: GenBank Submission
Title: Mus musculus 123F2 protein mRNA, complete cds
Pages: AF132851
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Publication
31311858 | J:281342
First Author: Francisco J
Year: 2019
Journal: J Biol Chem
Title: The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.
Volume: 294
Issue: 35
Pages: 13131-13144
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Publication
20890300 | J:164640
First Author: Tommasi S
Year: 2011
Journal: Oncogene
Title: Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy.
Volume: 30
Issue: 6
Pages: 690-700
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Publication
25368379 | J:224309
First Author: Donninger H
Year: 2015
Journal: Mol Cell Biol
Title: The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.
Volume: 35
Issue: 1
Pages: 277-87
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Publication
21097531 | J:169328
First Author: Sun J
Year: 2011
Journal: Carcinogenesis
Title: Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains.
Volume: 32
Issue: 3
Pages: 351-8
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Publication
26980762 | J:231761
First Author: Zhang X
Year: 2016
Journal: Cancer Res
Title: Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1.
Volume: 76
Issue: 9
Pages: 2824-35
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Publication
31086178 | J:275531
First Author: Dabral S
Year: 2019
Journal: Nat Commun
Title: A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
Volume: 10
Issue: 1
Pages: 2130
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Publication
24146755 | J:209114
First Author: Gordon M
Year: 2013
Journal: PLoS One
Title: The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.
Volume: 8
Issue: 10
Pages: e75483
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Publication
29382819 | J:260010
First Author: Papaspyropoulos A
Year: 2018
Journal: Nat Commun
Title: RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.
Volume: 9
Issue: 1
Pages: 424
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Publication
24776599 | J:229857
First Author: Mohamed TM
Year: 2014
Journal: Cardiovasc Res
Title: The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes.
Volume: 103
Issue: 1
Pages: 47-59
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Publication
18596699 | J:137819
First Author: Stieglitz B
Year: 2008
Journal: EMBO J
Title: Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.
Volume: 27
Issue: 14
Pages: 1995-2005
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Publication
25218637 | J:217712
First Author: Pefani DE
Year: 2014
Journal: Nat Cell Biol
Title: RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Volume: 16
Issue: 10
Pages: 962-71, 1-8
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Publication
17335777 | J:120330
First Author: Dmitriev RI
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Characterization of hampin/MSL1 as a node in the nuclear interactome.
Volume: 355
Issue: 4
Pages: 1051-7
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Publication
24813943 | J:215259
First Author: Del Re DP
Year: 2014
Journal: Mol Cell
Title: Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.
Volume: 54
Issue: 4
Pages: 639-50
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Publication
18772348 | J:146040
First Author: Jadin L
Year: 2008
Journal: FASEB J
Title: Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?
Volume: 22
Issue: 12
Pages: 4316-26
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Publication
11085536 | J:66052
First Author: Lerman MI
Year: 2000
Journal: Cancer Res
Title: The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
Volume: 60
Issue: 21
Pages: 6116-33
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Publication
25133424 | J:215828
First Author: Chamberlain CE
Year: 2014
Journal: J Clin Invest
Title: Menin determines K-RAS proliferative outputs in endocrine cells.
Volume: 124
Issue: 9
Pages: 4093-101
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Publication
18270576 | J:154087
First Author: Trimarchi JM
Year: 2008
Journal: PLoS One
Title: Individual retinal progenitor cells display extensive heterogeneity of gene expression.
Volume: 3
Issue: 2
Pages: e1588
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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