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Search results 1 to 100 out of 106 for Rassf5

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Type Details Score
Gene
83593 | RASSF5
Type: gene
Organism: human
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Gene
743977 | RASSF5
Type: gene
Organism: chimpanzee
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Gene
607454 | RASSF5
Type: gene
Organism: dog, domestic
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Gene
539767 | RASSF5
Type: gene
Organism: cattle
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Gene
419844 | RASSF5
Type: gene
Organism: chicken
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Gene
100150414 | rassf5
Type: gene
Organism: zebrafish
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Gene
695382 | RASSF5
Type: gene
Organism: macaque, rhesus
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Gene
100487574 | rassf5
Type: gene
Organism: frog, western clawed
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Gene
54355 | Rassf5
Type: gene
Organism: rat
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Protein Domain
IPR033623 | RASSF5
Type: Family
Description: The Ras association domain (RASSF) proteins are named due to the presence of a Ras association (RA) domain in their N or C terminus that can potentially interact with the Ras GTPase family of proteins. These GTPases control a variety of cellular processes, such as membrane trafficking, apoptosis, and proliferation. RASSF proteins contain several other functional domains that modulate associations with other proteins. RASSF proteins with the RA domain at the C terminus (which are termed C-terminal or classical RASSF) usually also include a Salvador-RASSF-Hippo (SARAH) domain involved in several protein-protein interactions and for homo- and heterodimerisation of RASSF isoforms. N-terminal RASSF proteins (with the RA domain in the N terminus) do not usually contain a SARAH domain [].At least 10 RASSF family members have been characterised (with multiple splice variants), many of which have been shown to play a role in tumour suppression. RASSF proteins also act as scaffolding agents in microtubule stability, regulate mitotic cell division, control cell migration and cell adhesion, and modulate NF-KB activity and the duration of inflammation. Loss of RASSF expression through promoter methylation has been shown in numerous types of cancer, including leukemia, melanoma, breast and prostate cancer [].RASSF5 is one of the C-terminal (also known as classical) RASSF proteins, characterised by an RA domain in the C terminus. RASSF5 is also referred to as NORE1 or RAPL, and is known to exist as at least three transcripts. RASSF5 is primarily involved in the control of apoptosis, through involvement in a number of different apoptosis pathways [, ], and functions as a tumor suppressor []. One transcript (A) has been suggested to be involved in developing the nervous system []. It has also been reported that RASSF5 is involved in the regulation of p27 localisation [].
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Protein Coding Gene
MGI:1926375 | Rassf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20810663 | J:166871
First Author: Park J
Year: 2010
Journal: J Biol Chem
Title: Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
Volume: 285
Issue: 45
Pages: 35029-38
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Publication
21194982 | J:168749
First Author: Katagiri K
Year: 2011
Journal: Immunity
Title: Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.
Volume: 34
Issue: 1
Pages: 24-38
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Publication
25109282 | -
First Author: Zhou XH
Year: 2014
Journal: Oncol Rep
Title: RASSF5 inhibits growth and invasion and induces apoptosis in osteosarcoma cells through activation of MST1/LATS1 signaling.
Volume: 32
Issue: 4
Pages: 1505-12
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Publication
24165023 | -
First Author: Nakamura T
Year: 2013
Journal: Genes Cells
Title: Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase.
Volume: 18
Issue: 11
Pages: 1020-31
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Publication
12676952 | -
First Author: Vos MD
Year: 2003
Journal: J Biol Chem
Title: The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung.
Volume: 278
Issue: 24
Pages: 21938-43
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Protein
A0A1D5RM65
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Protein
D3Z6G2
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
Q5EBH1
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Publication
24607545 | J:212135
First Author: Volodko N
Year: 2014
Journal: FEBS Lett
Title: RASSF tumor suppressor gene family: biological functions and regulation.
Volume: 588
Issue: 16
Pages: 2671-84
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Publication
23357313 | -
First Author: Chan JJ
Year: 2013
Journal: Adv Biol Regul
Title: Comparative analysis of interactions of RASSF1-10.
Volume: 53
Issue: 2
Pages: 190-201
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Publication
33393458 | J:313924
   
First Author: Sandoval M
Year: 2021
Journal: Elife
Title: Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.
Volume: 10
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Publication
27063791 | J:242946
First Author: Darlington TM
Year: 2016
Journal: Genes Brain Behav
Title: Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling.
Volume: 15
Issue: 5
Pages: 474-90
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Protein Coding Gene
MGP_CAROLIEiJ_G0014569 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016399 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016394 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016220 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1926375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016192 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016323 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016891 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015862 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027803 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015373 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
12845325 | J:84667
First Author: Katagiri K
Year: 2003
Journal: Nat Immunol
Title: RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1.
Volume: 4
Issue: 8
Pages: 741-8
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Publication
11857081 | J:113977
First Author: Ortiz-Vega S
Year: 2002
Journal: Oncogene
Title: The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.
Volume: 21
Issue: 9
Pages: 1381-90
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Publication
16698549 | J:247424
First Author: Harjes E
Year: 2006
Journal: Structure
Title: GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1.
Volume: 14
Issue: 5
Pages: 881-8
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Publication
15361866 | J:92670
First Author: Katagiri K
Year: 2004
Journal: Nat Immunol
Title: Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking.
Volume: 5
Issue: 10
Pages: 1045-51
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GXD Expression
GXD Expression
   
Probe: MGI:3708315
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3708358
Age: embryonic day 13.5
Image: 5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3708315
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:3708358
Age: embryonic day 16.5
Image: 5
Specimen Label: E16.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423922
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827636
Age: embryonic day 14.5
Image: euxassay_009651_11
Specimen Label: euxassay_009651_11
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4423922
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827636
Age: embryonic day 14.5
Image: euxassay_009651_12
Specimen Label: euxassay_009651_12
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4423922
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827636
Age: embryonic day 14.5
Image: euxassay_009651_14
Specimen Label: euxassay_009651_14
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4423922
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1752323
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827636
Age: embryonic day 14.5
Image: euxassay_009651_15
Specimen Label: euxassay_009651_15
Detected: true
Specimen Num: 4
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Publication
11864565 | J:79038
First Author: Khokhlatchev A
Year: 2002
Journal: Curr Biol
Title: Identification of a novel Ras-regulated proapoptotic pathway.
Volume: 12
Issue: 4
Pages: 253-65
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Publication
20346707 | J:160767
First Author: Raab M
Year: 2010
Journal: Immunity
Title: T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes.
Volume: 32
Issue: 4
Pages: 541-56
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Publication
15972452 | J:119527
First Author: Kanemitsu N
Year: 2005
Journal: Blood
Title: CXCL13 is an arrest chemokine for B cells in high endothelial venules.
Volume: 106
Issue: 8
Pages: 2613-8
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Publication
19965628 | J:156834
First Author: Ebisuno Y
Year: 2010
Journal: Blood
Title: Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in RAPL-dependent and -independent manners.
Volume: 115
Issue: 4
Pages: 804-14
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Publication
11965544 | J:76151
First Author: Tommasi S
Year: 2002
Journal: Oncogene
Title: RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.
Volume: 21
Issue: 17
Pages: 2713-20
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Publication
11978988 | J:76602
First Author: Yao R
Year: 2001
Journal: Cytogenet Cell Genet
Title: Chromosome mapping and sequence variation of the murine Ras effector gene Nore1.
Volume: 95
Issue: 1-2
Pages: 126-8
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Publication
24146755 | J:209114
First Author: Gordon M
Year: 2013
Journal: PLoS One
Title: The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury.
Volume: 8
Issue: 10
Pages: e75483
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Publication
19073936 | J:142674
First Author: Zhou D
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Volume: 105
Issue: 51
Pages: 20321-6
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Publication
22173032 | J:181102
First Author: Lee D
Year: 2012
Journal: EMBO Rep
Title: Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Volume: 13
Issue: 2
Pages: 163-9
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Publication
16892067 | J:112648
First Author: Katagiri K
Year: 2006
Journal: Nat Immunol
Title: Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.
Volume: 7
Issue: 9
Pages: 919-28
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Publication
18596699 | J:137819
First Author: Stieglitz B
Year: 2008
Journal: EMBO J
Title: Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.
Volume: 27
Issue: 14
Pages: 1995-2005
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Publication
19956688 | J:155383
First Author: Choi J
Year: 2009
Journal: PLoS One
Title: Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.
Volume: 4
Issue: 11
Pages: e8011
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Publication
9488663 | J:46202
First Author: Vavvas D
Year: 1998
Journal: J Biol Chem
Title: Identification of Nore1 as a potential Ras effector.
Volume: 273
Issue: 10
Pages: 5439-42
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Publication
17198697 | J:119549
First Author: Yang XY
Year: 2007
Journal: Dev Biol
Title: Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.
Volume: 303
Issue: 2
Pages: 825-37
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Publication
26273529 | J:227247
 
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
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Publication
22967998 | J:190524
First Author: Shalom-Barak T
Year: 2012
Journal: Dev Biol
Title: Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network.
Volume: 372
Issue: 1
Pages: 143-55
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17517604 | -
First Author: Hwang E
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway.
Volume: 104
Issue: 22
Pages: 9236-41
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Protein Domain
IPR024205 | Mst1_SARAH_domain
Type: Domain
Description: The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) families, the SARAH domain mediates signal transduction from Hpo via the Sav scaffolding protein to the downstream component Wts (Warts); the phosphorylation of Wts by Hpo triggers cell cycle arrest and apoptosis by down-regulating cyclin E, Diap 1 and other targets [, ]. The SARAH domain is also involved in dimerisation, as in the human Hpo orthologue, Mst1, which homodimerises via its C-terminal SARAH domain. The SARAH domain is found associated with other domains, such as protein kinase domains, WW/rsp5/WWP domain (), C1 domain (), LIM domain (), or the Ras-associating (RA) domain ().This entry represents the C-terminal SARAH domain of Mst1. The Mst1 SARAH domain interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process [].
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Publication
14654011 | -
First Author: Scheel H
Year: 2003
Journal: Curr Biol
Title: A novel interaction motif, SARAH, connects three classes of tumor suppressor.
Volume: 13
Issue: 23
Pages: R899-900
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