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Search results 1 to 100 out of 161 for Rbbp8

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
5932 | RBBP8
Type: gene
Organism: human
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Gene
455333 | RBBP8
Type: gene
Organism: chimpanzee
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Gene
480175 | RBBP8
Type: gene
Organism: dog, domestic
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Gene
512977 | RBBP8
Type: gene
Organism: cattle
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Gene
421071 | RBBP8
Type: gene
Organism: chicken
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Gene
503536 | rbbp8
Type: gene
Organism: zebrafish
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Gene
677718 | RBBP8
Type: gene
Organism: macaque, rhesus
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Gene
100380142 | rbbp8
Type: gene
Organism: frog, western clawed
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Gene
291787 | Rbbp8
Type: gene
Organism: rat
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Protein Domain
IPR033594 | RBBP8
Type: Family
Description: Retinoblastoma-binding protein 8 (RBBP8), also known as CtIP, is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [, ]. CtIP interacts with the BRCA1 tumour suppressor []. BRCA1 and CtIP are required to recruit Dna2 at DSBs in homologous recombination, ensuring robust DSB resection []. CtIP it is not a tumuor suppressor itself, instead, it can promote tumourigenesis. This is probably related to its role in the formation of chromosomal rearrangements through the microhomology-mediated end joining (MMEJ) pathway, a relatively error-prone pathway of DSB repair [].
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Protein Coding Gene
MGI:2442995 | Rbbp8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23712259 | J:197743
First Author: Reczek CR
Year: 2013
Journal: J Cell Biol
Title: The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression.
Volume: 201
Issue: 5
Pages: 693-707
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Publication
27058754 | J:252618
First Author: Reczek CR
Year: 2016
Journal: Oncotarget
Title: The DNA resection protein CtIP promotes mammary tumorigenesis.
Volume: 7
Issue: 22
Pages: 32172-83
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Protein
Q05CC7
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: true
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Protein
A0A3Q4L2U0
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein
A0A3Q4EGK0
Organism: Mus musculus/domesticus
Length: 612  
Fragment?: false
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Protein
A0A3Q4EGL1
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
Q80YR6
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q8VE67
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: true
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Gene
140893 | RBBP8NL
Type: gene
Organism: human
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Gene
100420552 | RBBP8P1
Type: gene
Organism: human
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Gene
100420607 | RBBP8P2
Type: gene
Organism: human
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Publication
25909997 | -
First Author: Hoa NN
Year: 2015
Journal: PLoS One
Title: BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination.
Volume: 10
Issue: 4
Pages: e0124495
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Publication
25558984 | -
First Author: Davies OR
Year: 2015
Journal: Nat Struct Mol Biol
Title: CtIP tetramer assembly is required for DNA-end resection and repair.
Volume: 22
Issue: 2
Pages: 150-157
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Publication
17965729 | -
First Author: Sartori AA
Year: 2007
Journal: Nature
Title: Human CtIP promotes DNA end resection.
Volume: 450
Issue: 7169
Pages: 509-14
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Publication
16093251 | J:105074
First Author: Darakhshan F
Year: 2006
Journal: Carcinogenesis
Title: Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.
Volume: 27
Issue: 2
Pages: 311-8
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Protein Coding Gene
MGP_CAROLIEiJ_G0021998 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024153 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024115 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024082 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0023881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2442995 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0024559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0023853 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0023982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0023947 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024065 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0023976 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0024605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023424 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018736 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0022913 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
38067190 | J:343329
 
First Author: Wu-Baer F
Year: 2023
Journal: Cells
Title: ATM/ATR Phosphorylation of CtIP on Its Conserved Sae2-like Domain Is Required for Genotoxin-Induced DNA Resection but Dispensable for Animal Development.
Volume: 12
Issue: 23
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Publication
16249056 | J:103616
First Author: Chinnadurai G
Year: 2006
Journal: Biochim Biophys Acta
Title: CtIP, a candidate tumor susceptibility gene is a team player with luminaries.
Volume: 1765
Issue: 1
Pages: 67-73
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Publication
16581787 | J:107424
First Author: Liu F
Year: 2006
Journal: Mol Cell Biol
Title: CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
Volume: 26
Issue: 8
Pages: 3124-34
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: p53-/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Bard1-/-; p53-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3511674
Assay Type: Western blot
Annotation Date: 2004-12-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:3511695
Age: embryonic day 9.5
Specimen Label: Brca1-/-; p53-/-
Detected: true
Specimen Num: 3
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Publication
32989150 | J:296722
First Author: Wang XS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Volume: 117
Issue: 41
Pages: 25700-25711
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Publication
25582120 | J:219278
First Author: Badie S
Year: 2015
Journal: EMBO J
Title: BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
Volume: 34
Issue: 3
Pages: 410-24
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Publication
31097467 | J:310934
First Author: Liu X
Year: 2019
Journal: J Exp Med
Title: CtIP is essential for early B cell proliferation and development in mice.
Volume: 216
Issue: 7
Pages: 1648-1663
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Publication
24837676 | J:215245
First Author: Makharashvili N
Year: 2014
Journal: Mol Cell
Title: Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
Volume: 54
Issue: 6
Pages: 1022-33
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Publication
15831459 | J:97648
First Author: Chen PL
Year: 2005
Journal: Mol Cell Biol
Title: Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency.
Volume: 25
Issue: 9
Pages: 3535-42
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Publication
21160476 | J:167994
First Author: Helmink BA
Year: 2011
Journal: Nature
Title: H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Volume: 469
Issue: 7329
Pages: 245-9
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Publication
24842372 | J:213733
First Author: Polato F
Year: 2014
Journal: J Exp Med
Title: CtIP-mediated resection is essential for viability and can operate independently of BRCA1.
Volume: 211
Issue: 6
Pages: 1027-36
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Publication
23254285 | J:194603
First Author: Bothmer A
Year: 2013
Journal: J Exp Med
Title: Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching.
Volume: 210
Issue: 1
Pages: 115-23
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Publication
12832489 | J:84329
First Author: McCarthy EE
Year: 2003
Journal: Mol Cell Biol
Title: Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability.
Volume: 23
Issue: 14
Pages: 5056-63
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Publication
34521752 | J:310613
 
First Author: Wang XS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Volume: 118
Issue: 38
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Publication
29709199 | J:320083
 
First Author: Syed A
Year: 2018
Journal: Annu Rev Biochem
Title: The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Volume: 87
Pages: 263-294
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Publication
18171670 | J:319979
First Author: Chen L
Year: 2008
Journal: J Biol Chem
Title: Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.
Volume: 283
Issue: 12
Pages: 7713-20
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Publication
30657944 | J:319683
First Author: Mohiuddin M
Year: 2019
Journal: Nucleic Acids Res
Title: CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.
Volume: 47
Issue: 6
Pages: 2966-2980
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Publication
22645310 | J:186644
First Author: Nakamura K
Year: 2012
Journal: Mol Cell Biol
Title: Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.
Volume: 32
Issue: 15
Pages: 2966-78
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Publication
19654328 | J:156979
First Author: Snow JW
Year: 2009
Journal: J Biol Chem
Title: Translational isoforms of FOG1 regulate GATA1-interacting complexes.
Volume: 284
Issue: 43
Pages: 29310-9
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Publication
22369660 | J:320080
First Author: Wang B
Year: 2012
Journal: Cell Biosci
Title: BRCA1 tumor suppressor network: focusing on its tail.
Volume: 2
Issue: 1
Pages: 6
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Publication
32548123 | J:299723
 
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
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Publication
27100196 | J:253278
First Author: Greig LC
Year: 2016
Journal: Neuron
Title: Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex.
Volume: 90
Issue: 2
Pages: 261-77
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Coding Gene
MGI:3606212 | Rbbp8nl
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
690416 | Rbbp8nl
Type: gene
Organism: rat
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom