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Search results 1 to 100 out of 513 for Rbl1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5933 | RBL1
Type: gene
Organism: human
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Gene
100216140 | rbl1
Type: gene
Organism: frog, western clawed
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Gene
680111 | Rbl1
Type: gene
Organism: rat
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Gene
477221 | RBL1
Type: gene
Organism: dog, domestic
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Gene
735916 | RBL1
Type: gene
Organism: chimpanzee
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Gene
524870 | RBL1
Type: gene
Organism: cattle
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Gene
419126 | RBL1
Type: gene
Organism: chicken
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Gene
795522 | rbl1
Type: gene
Organism: zebrafish
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Gene
701650 | RBL1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028310 | RBL1
Type: Family
Description: This entry represents the retinoblastoma-like protein 1 (RBL1, also known as p107). Members of this family contain a conserved domain named the 'pocket' that interacts with the LXCXE motif found in viral proteins, such as SV40 large T antigen []. RBL1 is a component of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [, ].
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Protein Coding Gene
MGI:103300 | Rbl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6NTA5
Organism: Mus musculus/domesticus
Length: 682  
Fragment?: true
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Publication
17854503 | -
 
First Author: Dick FA
Year: 2007
Journal: Cell Div
Title: Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?
Volume: 2
Pages: 26
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Protein
Q8CCD4
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
Q3UI58
Organism: Mus musculus/domesticus
Length: 817  
Fragment?: false
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Protein
Q64701
Organism: Mus musculus/domesticus
Length: 1063  
Fragment?: false
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Protein
Q6PAR4
Organism: Mus musculus/domesticus
Length: 1063  
Fragment?: false
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Publication
17531812 | -
First Author: Litovchick L
Year: 2007
Journal: Mol Cell
Title: Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.
Volume: 26
Issue: 4
Pages: 539-51
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Publication
17671431 | -
First Author: Schmit F
Year: 2007
Journal: Cell Cycle
Title: LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes.
Volume: 6
Issue: 15
Pages: 1903-13
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Publication
17932945 | J:266951
First Author: Lara MF
Year: 2008
Journal: Mol Carcinog
Title: p107 acts as a tumor suppressor in pRb-deficient epidermis.
Volume: 47
Issue: 2
Pages: 105-13
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Publication
12860570 | J:108045
First Author: Sindermann JR
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Vascular ligation response is independent of p107: stressing the role of the related p130.
Volume: 285
Issue: 2
Pages: H915-8
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Publication
9620848 | J:48194
First Author: Robanus-Maandag E
Year: 1998
Journal: Genes Dev
Title: p107 is a suppressor of retinoblastoma development in pRb-deficient mice.
Volume: 12
Issue: 11
Pages: 1599-609
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Publication
15574596 | J:94277
First Author: Dannenberg JH
Year: 2004
Journal: Genes Dev
Title: Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
Volume: 18
Issue: 23
Pages: 2952-62
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Publication
22286767 | J:191778
First Author: Sangwan M
Year: 2012
Journal: Oncogene
Title: Established and new mouse models reveal E2f1 and Cdk2 dependency of retinoblastoma, and expose effective strategies to block tumor initiation.
Volume: 31
Issue: 48
Pages: 5019-28
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Publication
20713602 | J:163915
First Author: Scimè A
Year: 2010
Journal: J Cell Biol
Title: Oxidative status of muscle is determined by p107 regulation of PGC-1alpha.
Volume: 190
Issue: 4
Pages: 651-62
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Publication
16271529 | J:129672
First Author: Scimè A
Year: 2005
Journal: Cell Metab
Title: Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha.
Volume: 2
Issue: 5
Pages: 283-95
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Publication
23145321 | J:206777
 
First Author: Costa C
Year: 2012
Journal: Sci Rep
Title: A novel tumor suppressor network in squamous malignancies.
Volume: 2
Pages: 828
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Publication
26639898 | J:228312
 
First Author: Tarangelo A
Year: 2015
Journal: Nat Commun
Title: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression.
Volume: 6
Pages: 10028
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Publication
9819431 | J:51060
First Author: LeCouter JE
Year: 1998
Journal: Mol Cell Biol
Title: Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.
Volume: 18
Issue: 12
Pages: 7455-65
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Publication
12379853 | J:79883
First Author: García-Cao M
Year: 2002
Journal: Nat Genet
Title: A role for the Rb family of proteins in controlling telomere length.
Volume: 32
Issue: 3
Pages: 415-9
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Publication
15353549 | J:92520
First Author: Vanderluit JL
Year: 2004
Journal: J Cell Biol
Title: p107 regulates neural precursor cells in the mammalian brain.
Volume: 166
Issue: 6
Pages: 853-63
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Publication
9418868 | J:44897
First Author: Mulligan GJ
Year: 1998
Journal: Mol Cell Biol
Title: p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB.
Volume: 18
Issue: 1
Pages: 206-20
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Publication
8682294 | J:34725
First Author: Cobrinik D
Year: 1996
Journal: Genes Dev
Title: Shared role of the pRB-related p130 and p107 proteins in limb development.
Volume: 10
Issue: 13
Pages: 1633-44
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Publication
10630640 | J:59341
First Author: Lipinski MM
Year: 1999
Journal: Oncogene
Title: The retinoblastoma gene family in differentiation and development.
Volume: 18
Issue: 55
Pages: 7873-82
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Publication
8682293 | J:34058
First Author: Lee MH
Year: 1996
Journal: Genes Dev
Title: Targeted disruption of p107: functional overlap between p107 and Rb.
Volume: 10
Issue: 13
Pages: 1621-32
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Publication
25252918 | J:217195
First Author: Santos M
Year: 2014
Journal: Cancer Res
Title: In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.
Volume: 74
Issue: 22
Pages: 6565-6577
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Publication
18940733 | J:149791
First Author: Viatour P
Year: 2008
Journal: Cell Stem Cell
Title: Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.
Volume: 3
Issue: 4
Pages: 416-28
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Publication
17502351 | J:123662
First Author: Yeh N
Year: 2007
Journal: Mol Cell Biol
Title: Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.
Volume: 27
Issue: 14
Pages: 5161-71
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Publication
17591923 | J:134919
First Author: Vanderluit JL
Year: 2007
Journal: J Cell Biol
Title: The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.
Volume: 178
Issue: 1
Pages: 129-39
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Publication
28550162 | J:244489
First Author: Kim E
Year: 2017
Journal: J Exp Med
Title: Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression.
Volume: 214
Issue: 7
Pages: 1901-1912
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Publication
15188427 | J:91212
First Author: Ruiz S
Year: 2004
Journal: Dev Dyn
Title: Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis.
Volume: 230
Issue: 3
Pages: 410-8
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Publication
19864318 | J:249296
First Author: Spiller CM
Year: 2010
Journal: Biol Reprod
Title: Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice.
Volume: 82
Issue: 2
Pages: 433-43
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Publication
15148303 | J:90140
First Author: Ruiz S
Year: 2004
Journal: Development
Title: Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis.
Volume: 131
Issue: 11
Pages: 2737-48
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Publication
15193257 | J:90785
First Author: Chen D
Year: 2004
Journal: Cancer Cell
Title: Cell-specific effects of RB or RB/p107 loss on retinal development implicate an intrinsically death-resistant cell-of-origin in retinoblastoma.
Volume: 5
Issue: 6
Pages: 539-51
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Publication
15124025 | J:89721
First Author: MacLean HE
Year: 2004
Journal: J Clin Invest
Title: The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes.
Volume: 113
Issue: 9
Pages: 1334-43
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Publication
31611390 | J:282081
First Author: Lázaro S
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes.
Volume: 116
Issue: 44
Pages: 22300-22306
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Publication
31270502 | J:306050
First Author: Segovia C
Year: 2019
Journal: Nat Med
Title: Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.
Volume: 25
Issue: 7
Pages: 1073-1081
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Publication
35954335 | J:327351
 
First Author: Lázaro S
Year: 2022
Journal: Cancers (Basel)
Title: Pten and p53 Loss in the Mouse Lung Causes Adenocarcinoma and Sarcomatoid Carcinoma.
Volume: 14
Issue: 15
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Publication
9192872 | J:41047
First Author: Hurford RK Jr
Year: 1997
Journal: Genes Dev
Title: pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
Volume: 11
Issue: 11
Pages: 1447-63
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Publication
9751770 | J:119775
First Author: Harrington EA
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: pRB plays an essential role in cell cycle arrest induced by DNA damage.
Volume: 95
Issue: 20
Pages: 11945-50
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Publication
19341623 | J:149842
First Author: Liu Y
Year: 2009
Journal: Cell Stem Cell
Title: Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.
Volume: 4
Issue: 4
Pages: 336-47
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Publication
19649275 | J:151312
First Author: Garcia MA
Year: 2009
Journal: PLoS One
Title: Activation of NF-kB pathway by virus infection requires Rb expression.
Volume: 4
Issue: 7
Pages: e6422
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Publication
19887614 | J:154440
First Author: Simpson DS
Year: 2009
Journal: Cancer Res
Title: Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.
Volume: 69
Issue: 22
Pages: 8733-41
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Publication
24227978 | J:210112
First Author: Nair RM
Year: 2013
Journal: Saudi J Ophthalmol
Title: Animal models in retinoblastoma research.
Volume: 27
Issue: 3
Pages: 141-6
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Publication
19887370 | J:159963
First Author: Reed CA
Year: 2010
Journal: J Biol Chem
Title: Unique impact of RB loss on hepatic proliferation: tumorigenic stresses uncover distinct pathways of cell cycle control.
Volume: 285
Issue: 2
Pages: 1089-96
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Publication
19509021 | J:154413
First Author: Harb G
Year: 2009
Journal: Diabetes
Title: The retinoblastoma protein and its homolog p130 regulate the G1/S transition in pancreatic beta-cells.
Volume: 58
Issue: 8
Pages: 1852-62
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Publication
22942253 | J:192917
First Author: Shin MK
Year: 2012
Journal: Cancer Res
Title: Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer.
Volume: 72
Issue: 20
Pages: 5418-27
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Publication
12086466 | J:77813
First Author: Rossi F
Year: 2002
Journal: Dev Biol
Title: p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development.
Volume: 247
Issue: 2
Pages: 271-85
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Publication
17936268 | J:127522
First Author: Wang Y
Year: 2007
Journal: Dev Biol
Title: The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression.
Volume: 311
Issue: 2
Pages: 478-86
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Publication
21059851 | J:166671
First Author: Wirt SE
Year: 2010
Journal: J Cell Biol
Title: G1 arrest and differentiation can occur independently of Rb family function.
Volume: 191
Issue: 4
Pages: 809-25
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Publication
23765217 | J:207640
First Author: Benavente CA
Year: 2013
Journal: Oncotarget
Title: Cross-species genomic and epigenomic landscape of retinoblastoma.
Volume: 4
Issue: 6
Pages: 844-59
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Publication
26317218 | J:243021
First Author: Filtz EA
Year: 2015
Journal: PLoS One
Title: Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice.
Volume: 10
Issue: 8
Pages: e0136729
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Publication
23669396 | J:200953
First Author: Garfin PM
Year: 2013
Journal: J Exp Med
Title: Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.
Volume: 210
Issue: 6
Pages: 1087-97
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Publication
28165337 | J:240402
First Author: Wu N
Year: 2017
Journal: J Clin Invest
Title: A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.
Volume: 127
Issue: 3
Pages: 888-898
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Publication
19786571 | J:154999
First Author: Laurie N
Year: 2009
Journal: Mol Cell Biol
Title: Changes in retinoblastoma cell adhesion associated with optic nerve invasion.
Volume: 29
Issue: 23
Pages: 6268-82
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Publication
21515735 | J:173754
First Author: Brennan RC
Year: 2011
Journal: Cancer Res
Title: Targeting the p53 pathway in retinoblastoma with subconjunctival Nutlin-3a.
Volume: 71
Issue: 12
Pages: 4205-13
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Publication
12096340 | J:77982
First Author: Vooijs M
Year: 2002
Journal: Oncogene
Title: Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.
Volume: 21
Issue: 30
Pages: 4635-45
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Publication
12810584 | J:83783
First Author: Marino S
Year: 2003
Journal: Development
Title: Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.
Volume: 130
Issue: 15
Pages: 3359-68
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Publication
17956737 | J:130181
First Author: Ajioka I
Year: 2007
Journal: Cell
Title: Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice.
Volume: 131
Issue: 2
Pages: 378-90
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Publication
22237625 | J:181495
First Author: Shin MK
Year: 2012
Journal: Cancer Res
Title: Pocket proteins suppress head and neck cancer.
Volume: 72
Issue: 5
Pages: 1280-9
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Publication
20019750 | J:171794
First Author: Lambertz I
Year: 2010
Journal: Cell Death Differ
Title: Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.
Volume: 17
Issue: 4
Pages: 633-41
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Publication
12702649 | J:82802
First Author: Ruiz S
Year: 2003
Journal: Development
Title: Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.
Volume: 130
Issue: 11
Pages: 2341-53
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Publication
21875955 | J:177573
First Author: Viatour P
Year: 2011
Journal: J Exp Med
Title: Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway.
Volume: 208
Issue: 10
Pages: 1963-76
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Publication
22484813 | J:184538
First Author: Conkrite K
Year: 2012
Journal: J Clin Invest
Title: Cooperation between Rb and Arf in suppressing mouse retinoblastoma.
Volume: 122
Issue: 5
Pages: 1726-33
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Publication
28928282 | J:263656
First Author: Oshikawa M
Year: 2017
Journal: Development
Title: Dnmt1-dependent Chk1 pathway suppression is protective against neuron division.
Volume: 144
Issue: 18
Pages: 3303-3314
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Publication
15190215 | J:103618
First Author: Zhang J
Year: 2004
Journal: Cell Cycle
Title: The first knockout mouse model of retinoblastoma.
Volume: 3
Issue: 7
Pages: 952-9
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Publication
17363591 | J:120315
First Author: Johnson DA
Year: 2007
Journal: Cancer Res
Title: Neuronal differentiation and synaptogenesis in retinoblastoma.
Volume: 67
Issue: 6
Pages: 2701-11
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Publication
17080083 | J:115580
First Author: Laurie NA
Year: 2006
Journal: Nature
Title: Inactivation of the p53 pathway in retinoblastoma.
Volume: 444
Issue: 7115
Pages: 61-6
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Publication
24013229 | J:212743
First Author: Park JW
Year: 2014
Journal: Oncogene
Title: High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
Volume: 33
Issue: 26
Pages: 3383-91
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Publication
17235288 | J:119919
First Author: MacPherson D
Year: 2007
Journal: EMBO J
Title: Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.
Volume: 26
Issue: 3
Pages: 784-94
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Publication
21840489 | J:176061
First Author: McEvoy J
Year: 2011
Journal: Cancer Cell
Title: Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.
Volume: 20
Issue: 2
Pages: 260-75
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Publication
34430805 | J:332714
First Author: Gurdita A
Year: 2021
Journal: iScience
Title: InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes.
Volume: 24
Issue: 8
Pages: 102905
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Publication
23146901 | J:203239
First Author: Landman AS
Year: 2013
Journal: Oncogene
Title: Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.
Volume: 32
Issue: 40
Pages: 4798-805
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Publication
23615279 | J:198577
First Author: Oshikawa M
Year: 2013
Journal: Development
Title: Cortical excitatory neurons become protected from cell division during neurogenesis in an Rb family-dependent manner.
Volume: 140
Issue: 11
Pages: 2310-20
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Publication
19564414 | J:152616
First Author: McClellan KA
Year: 2009
Journal: Mol Cell Biol
Title: The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.
Volume: 29
Issue: 17
Pages: 4701-13
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Publication
24056077 | J:203999
First Author: Svoboda DS
Year: 2013
Journal: Dev Biol
Title: Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis.
Volume: 384
Issue: 1
Pages: 101-13
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Publication
22864477 | J:193515
First Author: Nittner D
Year: 2012
Journal: Nat Cell Biol
Title: Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
Volume: 14
Issue: 9
Pages: 958-65
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Publication
15231717 | J:91406
First Author: MacPherson D
Year: 2004
Journal: Genes Dev
Title: Cell type-specific effects of Rb deletion in the murine retina.
Volume: 18
Issue: 14
Pages: 1681-94
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Publication
21816922 | J:174680
First Author: Conkrite K
Year: 2011
Journal: Genes Dev
Title: miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.
Volume: 25
Issue: 16
Pages: 1734-45
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Publication
24086435 | J:207746
First Author: Park JW
Year: 2013
Journal: PLoS One
Title: High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins.
Volume: 8
Issue: 9
Pages: e75056
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Publication
20679727 | J:165289
First Author: Jiang Z
Year: 2010
Journal: J Clin Invest
Title: Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status.
Volume: 120
Issue: 9
Pages: 3296-309
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Publication
19706423 | J:153091
First Author: Berman SD
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Volume: 106
Issue: 35
Pages: 14932-6
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Publication
24143284 | J:201041
First Author: Park DS
Year: 2013
Journal: Biol Open
Title: Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system.
Volume: 2
Issue: 9
Pages: 968-78
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Publication
23558950 | J:228631
First Author: Chen D
Year: 2013
Journal: Cell Death Differ
Title: E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3.
Volume: 20
Issue: 7
Pages: 931-40
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Publication
28402854 | J:250813
First Author: Walters BJ
Year: 2017
Journal: Cell Rep
Title: In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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