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Search results 1 to 100 out of 116 for Rc3h1

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Hits by Category

Hits by Strain

Type Details Score
Gene
149041 | RC3H1
Type: gene
Organism: human
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Gene
100485305 | rc3h1
Type: gene
Organism: frog, western clawed
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Gene
457530 | RC3H1
Type: gene
Organism: chimpanzee
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Gene
680586 | Rc3h1
Type: gene
Organism: rat
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Gene
480065 | RC3H1
Type: gene
Organism: dog, domestic
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Gene
100336754 | RC3H1
Type: gene
Organism: cattle
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Gene
424439 | RC3H1
Type: gene
Organism: chicken
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Gene
707745 | RC3H1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2685397 | Rc3h1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR032671 | RC3H1
Type: Family
Description: Roquin-1 (RC3H1) is a post-transcriptional repressor required to repress follicular helper T cells (Tfh) and autoimmunity []. It binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. For instance, it controls ICOS (inducible costimulator) expression through binding to the 3' UTR of ICOS mRNA and by interacting with proteins that confer post-transcriptional repression []. Besides ICOS, it also represses Ox40 and interferon-gamma in T cells, and this helps to prevent inappropriate T cell activation and Tfh cell differentiation [, ].Roquin-1 and its paralogue, Roquin-2 (Rc3h2), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [, ]. Tfhs are helper T-cells specialised in facilitating B-cell responses [].
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Publication
15917799 | J:98938
First Author: Vinuesa CG
Year: 2005
Journal: Nature
Title: A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
Volume: 435
Issue: 7041
Pages: 452-8
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Publication
20639877 | J:162534
First Author: Glasmacher E
Year: 2010
Journal: Nat Immunol
Title: Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.
Volume: 11
Issue: 8
Pages: 725-33
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Publication
23583642 | J:196137
First Author: Pratama A
Year: 2013
Journal: Immunity
Title: Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
Volume: 38
Issue: 4
Pages: 669-80
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Publication
23583643 | J:196136
First Author: Vogel KU
Year: 2013
Journal: Immunity
Title: Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Volume: 38
Issue: 4
Pages: 655-68
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Gene
105371620 | RC3H1-DT
Type: gene
Organism: human
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Gene
106481790 | RC3H1-IT1
Type: gene
Organism: human
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Protein
Q4VGL6
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
A0A668KLW6
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Protein
Q3UT88
Organism: Mus musculus/domesticus
Length: 1130  
Fragment?: false
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Protein
H7BX02
Organism: Mus musculus/domesticus
Length: 1121  
Fragment?: false
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Publication
25261207 | -
 
First Author: Qi H
Year: 2014
Journal: Adv Exp Med Biol
Title: Tfh cell differentiation and their function in promoting B-cell responses.
Volume: 841
Pages: 153-80
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Publication
24815331 | J:213226
 
First Author: Montufar-Solis D
Year: 2014
Journal: Sci Rep
Title: Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice.
Volume: 4
Pages: 4920
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Publication
25062971 | J:216075
First Author: Schaefer JS
Year: 2014
Journal: Gene
Title: A role for IL-10 in the transcriptional regulation of Roquin-1.
Volume: 549
Issue: 1
Pages: 134-40
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Publication
31636267 | J:281595
First Author: Tavernier SJ
Year: 2019
Journal: Nat Commun
Title: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Volume: 10
Issue: 1
Pages: 4779
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Publication
28011265 | J:241964
First Author: Montufar-Solis D
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice.
Volume: 483
Issue: 1
Pages: 590-595
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Protein Coding Gene
MGP_CAROLIEiJ_G0014756 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016644 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016410 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685397 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017047 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015990 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016385 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016491 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016489 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016562 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017083 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027992 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015563 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
23451046 | J:199407
First Author: Schaefer JS
Year: 2013
Journal: PLoS One
Title: Small intestine inflammation in Roquin-mutant and Roquin-deficient mice.
Volume: 8
Issue: 2
Pages: e56436
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Publication
24251878 | J:251759
First Author: Griffiths KL
Year: 2013
Journal: J Cell Mol Med
Title: Investigation into the prevalence of a novel dendritic-like cell subset in vivo.
Volume: 17
Issue: 12
Pages: 1608-18
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Publication
34879274 | J:347542
First Author: Zhao H
Year: 2021
Journal: Cell Rep
Title: Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity.
Volume: 37
Issue: 10
Pages: 110083
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Publication
31013298 | J:274679
First Author: Allchin RL
Year: 2019
Journal: PLoS One
Title: Structural and diffusion weighted MRI demonstrates responses to ibrutinib in a mouse model of follicular helper (Tfh) T-cell lymphoma.
Volume: 14
Issue: 4
Pages: e0215765
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Publication
- | J:234246
     
First Author: White D
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for curlyfry
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Publication
23066015 | J:193421
First Author: Ji YR
Year: 2012
Journal: J Biol Chem
Title: Enforced expression of roquin protein in T cells exacerbates the incidence and severity of experimental arthritis.
Volume: 287
Issue: 50
Pages: 42269-77
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Publication
25201726 | J:220094
First Author: Ji YR
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter.
Volume: 452
Issue: 3
Pages: 822-7
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Publication
29127149 | J:252603
First Author: Cui X
Year: 2017
Journal: J Immunol
Title: Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.
Volume: 199
Issue: 12
Pages: 4066-4077
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Publication
30914691 | J:275600
First Author: Lee SY
Year: 2019
Journal: Sci Rep
Title: Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquinsan/san mice through regulating the balance of TFH cells, GC B cells, Treg and Breg.
Volume: 9
Issue: 1
Pages: 5227
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Publication
19221396 | J:146796
First Author: Linterman MA
Year: 2009
Journal: J Exp Med
Title: Follicular helper T cells are required for systemic autoimmunity.
Volume: 206
Issue: 3
Pages: 561-76
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Publication
26255671 | J:229326
First Author: Mino T
Year: 2015
Journal: Oncotarget
Title: Regnase-1 and Roquin regulate inflammatory mRNAs.
Volume: 6
Issue: 20
Pages: 17869-70
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Publication
18172933 | J:175161
First Author: Yu D
Year: 2007
Journal: Nature
Title: Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.
Volume: 450
Issue: 7167
Pages: 299-303
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Publication
21844204 | J:177784
First Author: Bertossi A
Year: 2011
Journal: J Exp Med
Title: Loss of Roquin induces early death and immune deregulation but not autoimmunity.
Volume: 208
Issue: 9
Pages: 1749-56
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Publication
25026077 | J:261058
First Author: Schlundt A
Year: 2014
Journal: Nat Struct Mol Biol
Title: Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Volume: 21
Issue: 8
Pages: 671-8
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Publication
29873267 | J:349644
 
First Author: Park JS
Year: 2018
Journal: Int J Immunopathol Pharmacol
Title: Combinatory treatment using tacrolimus and a STAT3 inhibitor regulate Treg cells and plasma cells.
Volume: 32
Pages: 2058738418778724
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Publication
22700722 | J:189087
First Author: Ellyard JI
Year: 2012
Journal: Blood
Title: Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice.
Volume: 120
Issue: 4
Pages: 812-21
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Publication
28747346 | J:251016
First Author: Nagalingam G
Year: 2017
Journal: J Immunol
Title: Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation.
Volume: 199
Issue: 5
Pages: 1796-1804
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Publication
26496200 | J:229554
   
First Author: Ramiscal RR
Year: 2015
Journal: Elife
Title: Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation.
Volume: 4
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Publication
25193700 | J:220096
First Author: Okudaira N
Year: 2014
Journal: Biochem Biophys Res Commun
Title: A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.
Volume: 452
Issue: 3
Pages: 665-8
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Publication
25697406 | J:221791
 
First Author: Srivastava M
Year: 2015
Journal: Nat Commun
Title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Volume: 6
Pages: 6253
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Publication
26000482 | J:228359
First Author: Mino T
Year: 2015
Journal: Cell
Title: Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
Volume: 161
Issue: 5
Pages: 1058-1073
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Publication
33986739 | J:312303
 
First Author: Park MJ
Year: 2021
Journal: Front Immunol
Title: Programmed Death-Ligand 1 Expression Potentiates the Immune Modulatory Function Of Myeloid-Derived Suppressor Cells in Systemic Lupus Erythematosus.
Volume: 12
Pages: 606024
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Publication
19217324 | J:146622
First Author: Linterman MA
Year: 2009
Journal: Immunity
Title: Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Volume: 30
Issue: 2
Pages: 228-41
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Publication
28188245 | J:252716
First Author: Drees C
Year: 2017
Journal: J Immunol
Title: Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.
Volume: 198
Issue: 7
Pages: 2747-2759
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Publication
30232334 | J:267623
First Author: Essig K
Year: 2018
Journal: Nat Commun
Title: Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Volume: 9
Issue: 1
Pages: 3810
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Publication
27010430 | J:236832
 
First Author: Janowski R
Year: 2016
Journal: Nat Commun
Title: Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Volume: 7
Pages: 11032
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Publication
22685317 | J:189550
First Author: Chang PP
Year: 2012
Journal: J Immunol
Title: Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.
Volume: 189
Issue: 2
Pages: 701-10
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Publication
31126966 | J:277714
First Author: von Gamm M
Year: 2019
Journal: J Exp Med
Title: Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
Volume: 216
Issue: 7
Pages: 1700-1723
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Publication
21788582 | J:186792
First Author: Silva DG
Year: 2011
Journal: Diabetes
Title: Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells.
Volume: 60
Issue: 8
Pages: 2102-11
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Publication
37988467 | J:359664
First Author: Schmidt H
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Volume: 120
Issue: 48
Pages: e2309205120
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Publication
25282160 | J:259145
First Author: Jeltsch KM
Year: 2014
Journal: Nat Immunol
Title: Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Volume: 15
Issue: 11
Pages: 1079-89
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Publication
20668237 | J:163595
First Author: Teh CE
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.
Volume: 107
Issue: 33
Pages: 14709-14
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Publication
29246441 | J:259200
First Author: Essig K
Year: 2017
Journal: Immunity
Title: Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Volume: 47
Issue: 6
Pages: 1067-1082.e12
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Publication
23159227 | J:190440
First Author: Lee SK
Year: 2012
Journal: Immunity
Title: Interferon-γ excess leads to pathogenic accumulation of follicular helper T cells and germinal centers.
Volume: 37
Issue: 5
Pages: 880-92
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Publication
34811541 | J:324878
First Author: Behrens G
Year: 2021
Journal: Nat Immunol
Title: Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Volume: 22
Issue: 12
Pages: 1563-1576
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Publication
34471108 | J:310403
First Author: Hoefig KP
Year: 2021
Journal: Nat Commun
Title: Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
Volume: 12
Issue: 1
Pages: 5208
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Publication
29352114 | J:258592
First Author: Rehage N
Year: 2018
Journal: Nat Commun
Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Volume: 9
Issue: 1
Pages: 299
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Publication
16889948 | J:211461
First Author: Cook MC
Year: 2006
Journal: Curr Opin Immunol
Title: ENU-mutagenesis: insight into immune function and pathology.
Volume: 18
Issue: 5
Pages: 627-33
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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