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Search results 1 to 90 out of 90 for Rc3h2

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
54542 | RC3H2
Type: gene
Organism: human
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Gene
311909 | Rc3h2
Type: gene
Organism: rat
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Gene
464715 | RC3H2
Type: gene
Organism: chimpanzee
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Gene
491344 | RC3H2
Type: gene
Organism: dog, domestic
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Gene
783330 | RC3H2
Type: gene
Organism: cattle
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Gene
417109 | RC3H2
Type: gene
Organism: chicken
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Gene
559834 | rc3h2
Type: gene
Organism: zebrafish
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Gene
695984 | RC3H2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2442789 | Rc3h2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR032670 | RC3H2
Type: Family
Description: Roquin-2 is an E3 ubiquitin ligase required for ROS-induced ubiquitination and degradation of ASK1 (Apoptosis signal-regulating kinase 1) []. It also mediates mRNA deadenylation by recognising a conserved class of stem-loop RNA degradation motifs []. Its structure has been revealed [].Roquin-2 and its paralogue, Roquin-1 (Rc3h1), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [, ].
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Publication
23583642 | J:196137
First Author: Pratama A
Year: 2013
Journal: Immunity
Title: Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.
Volume: 38
Issue: 4
Pages: 669-80
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Publication
23583643 | J:196136
First Author: Vogel KU
Year: 2013
Journal: Immunity
Title: Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Volume: 38
Issue: 4
Pages: 655-68
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Publication
23663784 | -
First Author: Leppek K
Year: 2013
Journal: Cell
Title: Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
Volume: 153
Issue: 4
Pages: 869-81
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Protein
P0C090
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
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Protein
Q148V5
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
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Protein
A2AVP4
Organism: Mus musculus/domesticus
Length: 1125  
Fragment?: false
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Protein
Q148V4
Organism: Mus musculus/domesticus
Length: 1187  
Fragment?: false
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Publication
24448648 | -
First Author: Maruyama T
Year: 2014
Journal: Sci Signal
Title: Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.
Volume: 7
Issue: 309
Pages: ra8
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Publication
26249698 | -
First Author: Sakurai S
Year: 2015
Journal: Acta Crystallogr F Struct Biol Commun
Title: Structure of human Roquin-2 and its complex with constitutive-decay element RNA.
Volume: 71
Issue: Pt 8
Pages: 1048-54
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Protein Coding Gene
MGP_CAROLIEiJ_G0023516 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025670 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025640 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025665 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025426 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2442789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026111 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025537 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025499 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025624 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025530 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024631 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024969 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024436 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:4423655
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3270422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614713
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4423655
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614713
Age: embryonic day 14.5
Note: Cortical plate expression was greater than in the intermediate zone.
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423655
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614713
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4423655
Assay Type: RNA in situ
Annotation Date: 2024-03-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7614713
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
31636267 | J:281595
First Author: Tavernier SJ
Year: 2019
Journal: Nat Commun
Title: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation.
Volume: 10
Issue: 1
Pages: 4779
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Publication
25026077 | J:261058
First Author: Schlundt A
Year: 2014
Journal: Nat Struct Mol Biol
Title: Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Volume: 21
Issue: 8
Pages: 671-8
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Publication
25697406 | J:221791
 
First Author: Srivastava M
Year: 2015
Journal: Nat Commun
Title: Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Volume: 6
Pages: 6253
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Publication
28188245 | J:252716
First Author: Drees C
Year: 2017
Journal: J Immunol
Title: Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.
Volume: 198
Issue: 7
Pages: 2747-2759
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Publication
30232334 | J:267623
First Author: Essig K
Year: 2018
Journal: Nat Commun
Title: Roquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation.
Volume: 9
Issue: 1
Pages: 3810
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Publication
27010430 | J:236832
 
First Author: Janowski R
Year: 2016
Journal: Nat Commun
Title: Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Volume: 7
Pages: 11032
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Publication
37988467 | J:359664
First Author: Schmidt H
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Volume: 120
Issue: 48
Pages: e2309205120
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Publication
25282160 | J:259145
First Author: Jeltsch KM
Year: 2014
Journal: Nat Immunol
Title: Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Volume: 15
Issue: 11
Pages: 1079-89
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Publication
29246441 | J:259200
First Author: Essig K
Year: 2017
Journal: Immunity
Title: Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells.
Volume: 47
Issue: 6
Pages: 1067-1082.e12
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Publication
34811541 | J:324878
First Author: Behrens G
Year: 2021
Journal: Nat Immunol
Title: Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses.
Volume: 22
Issue: 12
Pages: 1563-1576
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Publication
34471108 | J:310403
First Author: Hoefig KP
Year: 2021
Journal: Nat Commun
Title: Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
Volume: 12
Issue: 1
Pages: 5208
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Publication
29352114 | J:258592
First Author: Rehage N
Year: 2018
Journal: Nat Commun
Title: Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA.
Volume: 9
Issue: 1
Pages: 299
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Publication
29055695 | J:256883
First Author: Zhou J
Year: 2017
Journal: Biochim Biophys Acta
Title: Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Volume: 1860
Issue: 12
Pages: 1159-1168
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Publication
- | J:66660
       
First Author: Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration
Year: 2001
Title: LocusLink Collaboration
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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