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Search results 1 to 100 out of 539 for Rcan1

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0.037s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Protein Domain
Type: Family
Description: Calcipressin-1 (RCAN1, also known as DSCR1) is a calcineurin inhibitor that inactivates nuclear factor of activated T cells (NFATc) activity []. It is expressed in the primitive ventricle of the heart and during neurogenesis []. It is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the FLISPP motif, and this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation []. The DSCR1 (Down syndrome critical region 1) gene is present in the region of human chromosome 21, trisomy of which is associated with congenital heart defects observed in Down syndrome [].Calcipressins (RCANs) are a novel family of calcineurin regulators that have been suggested as key factors contributing to Down syndrome in humans. Three human calcipressins have been identified, calcipressin 1-3. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2 []. Calcipressins contain an N-terminal RNA recognition motif (RRM), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and a C-terminal TxxP motif [].Calcineurin is a calcium-responsive enzyme that dephosphorylates the nuclear factor of activated T cells (NFAT). In doing so, it promotes its nuclear translocation and uniquely links calcium signalling to transcriptional regulation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Casas C
Year: 2001
Journal: Mech Dev
Title: Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis.
Volume: 101
Issue: 1-2
Pages: 289-92
Publication
First Author: GenescĂ  L
Year: 2003
Journal: Biochem J
Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.
Volume: 374
Issue: Pt 2
Pages: 567-75
Publication
First Author: Lange AW
Year: 2004
Journal: Dev Biol
Title: DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice.
Volume: 266
Issue: 2
Pages: 346-60
Publication
First Author: Wu H
Year: 2007
Journal: J Biol Chem
Title: Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.
Volume: 282
Issue: 42
Pages: 30673-9
Publication
First Author: Rakowski-Anderson T
Year: 2012
Journal: Comp Med
Title: Fecal corticosterone levels in RCAN1 mutant mice.
Volume: 62
Issue: 2
Pages: 87-94
Publication
First Author: Riper DV
Year: 2008
Journal: Arch Biochem Biophys
Title: Regulation of vascular function by RCAN1 (ADAPT78).
Volume: 472
Issue: 1
Pages: 43-50
Publication
First Author: Martin KR
Year: 2012
Journal: Hum Mol Genet
Title: Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory.
Volume: 21
Issue: 13
Pages: 3025-41
Publication
First Author: Zanin MP
Year: 2013
Journal: J Neurochem
Title: RCAN1 regulates vesicle recycling and quantal release kinetics via effects on calcineurin activity.
Volume: 124
Issue: 3
Pages: 290-9
Publication
First Author: Yang YJ
Year: 2009
Journal: J Exp Med
Title: Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function.
Volume: 206
Issue: 1
Pages: 195-207
Publication
First Author: MĂ©ndez-Barbero N
Year: 2013
Journal: EMBO Mol Med
Title: A major role for RCAN1 in atherosclerosis progression.
Volume: 5
Issue: 12
Pages: 1901-17
Publication
First Author: Jung MS
Year: 2011
Journal: J Biol Chem
Title: Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.
Volume: 286
Issue: 46
Pages: 40401-12
Publication
First Author: Villahoz S
Year: 2018
Journal: Nat Commun
Title: Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture.
Volume: 9
Issue: 1
Pages: 4795
Publication
First Author: Porta S
Year: 2007
Journal: Hum Mol Genet
Title: RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration.
Volume: 16
Issue: 9
Pages: 1039-50
Publication
First Author: Li H
Year: 2018
Journal: Kidney Int
Title: Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.
Volume: 94
Issue: 6
Pages: 1160-1176
Publication
First Author: Peiris H
Year: 2016
Journal: PLoS Genet
Title: A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.
Volume: 12
Issue: 5
Pages: e1006033
Publication  
First Author: Patel A
Year: 2015
Journal: Nat Commun
Title: RCAN1 links impaired neurotrophin trafficking to aberrant development of the sympathetic nervous system in Down syndrome.
Volume: 6
Pages: 10119
Publication
First Author: Hoeffer CA
Year: 2007
Journal: J Neurosci
Title: The Down syndrome critical region protein RCAN1 regulates long-term potentiation and memory via inhibition of phosphatase signaling.
Volume: 27
Issue: 48
Pages: 13161-72
Publication
First Author: Xing L
Year: 2013
Journal: Mamm Genome
Title: Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1).
Volume: 24
Issue: 1-2
Pages: 30-43
Protein
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
Publication
First Author: Parry RV
Year: 2003
Journal: Nat Immunol
Title: Calcium-independent calcineurin regulation.
Volume: 4
Issue: 9
Pages: 821-3
Publication
First Author: Mehta S
Year: 2009
Journal: Mol Cell Biol
Title: Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast.
Volume: 29
Issue: 10
Pages: 2777-93
Publication  
First Author: Lee EH
Year: 2017
Journal: Biochem Pharmacol
Title: Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction.
Volume: 143
Pages: 107-117
Publication
First Author: Peiris H
Year: 2012
Journal: Endocrinology
Title: Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes.
Volume: 153
Issue: 11
Pages: 5212-21
Publication
First Author: Keating DJ
Year: 2008
Journal: Hum Mol Genet
Title: DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease.
Volume: 17
Issue: 7
Pages: 1020-30
Publication
First Author: Brait VH
Year: 2012
Journal: PLoS One
Title: Over-expression of DSCR1 protects against post-ischemic neuronal injury.
Volume: 7
Issue: 10
Pages: e47841
Publication
First Author: Wang W
Year: 2016
Journal: J Cell Biol
Title: DSCR1 is required for both axonal growth cone extension and steering.
Volume: 213
Issue: 4
Pages: 451-62
Publication
First Author: Shin J
Year: 2014
Journal: Cancer Lett
Title: A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis.
Volume: 342
Issue: 1
Pages: 70-81
Publication
First Author: Martin KR
Year: 2013
Journal: J Med Genet
Title: Upregulation of RCAN1 causes Down syndrome-like immune dysfunction.
Volume: 50
Issue: 7
Pages: 444-54
Publication
First Author: Yang YJ
Year: 2011
Journal: Am J Pathol
Title: Regulator of calcineurin 1 (Rcan1) is required for the development of pulmonary eosinophilia in allergic inflammation in mice.
Volume: 179
Issue: 3
Pages: 1199-210
Publication
First Author: Choi C
Year: 2021
Journal: J Pathol
Title: DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.
Volume: 255
Issue: 3
Pages: 296-310
Publication
First Author: Lee EH
Year: 2015
Journal: J Biol Chem
Title: Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation.
Volume: 290
Issue: 34
Pages: 21019-21031
Publication
First Author: Dierssen M
Year: 2011
Journal: PLoS One
Title: Behavioral characterization of a mouse model overexpressing DSCR1/ RCAN1.
Volume: 6
Issue: 2
Pages: e17010
Publication
First Author: Lee JC
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras.
Volume: 440
Issue: 1
Pages: 50-5
Publication
First Author: Hoeffer CA
Year: 2013
Journal: J Neurosci
Title: Regulator of calcineurin 1 modulates expression of innate anxiety and anxiogenic responses to selective serotonin reuptake inhibitor treatment.
Volume: 33
Issue: 43
Pages: 16930-44
Publication  
First Author: Rotter D
Year: 2018
Journal: EMBO Rep
Title: Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
Volume: 19
Issue: 12
Publication
First Author: Junkins RD
Year: 2013
Journal: J Immunol
Title: Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections.
Volume: 190
Issue: 10
Pages: 5178-86
Publication
First Author: Wu Z
Year: 2013
Journal: J Immunol
Title: Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation.
Volume: 191
Issue: 12
Pages: 5885-94
Publication
First Author: Pang Z
Year: 2018
Journal: PLoS One
Title: Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Volume: 13
Issue: 5
Pages: e0197491
Publication
First Author: Wu Y
Year: 2015
Journal: Neurobiol Aging
Title: Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.
Volume: 36
Issue: 1
Pages: 169-77
Publication
First Author: Baek KH
Year: 2009
Journal: Nature
Title: Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.
Volume: 459
Issue: 7250
Pages: 1126-30
Publication
First Author: Serrano-Candelas E
Year: 2015
Journal: Biochem Biophys Res Commun
Title: RCAN 1 and 3 proteins regulate thymic positive selection.
Volume: 460
Issue: 2
Pages: 295-301
Publication  
First Author: Sobrado M
Year: 2012
Journal: J Neuroinflammation
Title: Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury.
Volume: 9
Pages: 48
Publication  
First Author: Sang XY
Year: 2020
Journal: FASEB J
Title: Regulators of calcineurin 1 deficiency attenuates tubulointerstitial fibrosis through improving mitochondrial fitness.
Volume: 34
Issue: 11
Publication
First Author: Esteban V
Year: 2011
Journal: J Exp Med
Title: Regulator of calcineurin 1 mediates pathological vascular wall remodeling.
Volume: 208
Issue: 10
Pages: 2125-39
Publication
First Author: Xiao JJ
Year: 2022
Journal: Cell Death Dis
Title: Regulator of calcineurin 1 deletion attenuates mitochondrial dysfunction and apoptosis in acute kidney injury through JNK/Mff signaling pathway.
Volume: 13
Issue: 9
Pages: 774
Publication  
First Author: Rotter D
Year: 2014
Journal: J Mol Cell Cardiol
Title: Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
Volume: 74
Pages: 103-11
Publication
First Author: Liu Q
Year: 2009
Journal: Nat Cell Biol
Title: Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point.
Volume: 11
Issue: 2
Pages: 154-61
Publication
First Author: Belmont PJ
Year: 2008
Journal: J Biol Chem
Title: Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
Volume: 283
Issue: 20
Pages: 14012-21
Publication  
First Author: Song WJ
Year: 2013
Journal: Neurosci Lett
Title: Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.
Volume: 554
Pages: 135-40
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ryeom S
Year: 2003
Journal: Nat Immunol
Title: The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin.
Volume: 4
Issue: 9
Pages: 874-81
Publication  
First Author: Choi C
Year: 2023
Journal: Life Sci Alliance
Title: DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity.
Volume: 6
Issue: 2
Publication
First Author: Ryeom S
Year: 2008
Journal: Cancer Cell
Title: Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.
Volume: 13
Issue: 5
Pages: 420-31
Publication
First Author: Minami T
Year: 2013
Journal: Cell Rep
Title: The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases.
Volume: 4
Issue: 4
Pages: 709-23
Publication
First Author: Kluetzman KS
Year: 2005
Journal: Biochem Biophys Res Commun
Title: DSCR1 (ADAPT78) lethality: evidence for a protective effect of trisomy 21 genes?
Volume: 337
Issue: 2
Pages: 595-601
Publication
First Author: Muramatsu M
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Loss of Down Syndrome Critical Region-1 Mediated-Hypercholesterolemia Accelerates Corneal Opacity Via Pathological Neovessel Formation.
Volume: 40
Issue: 10
Pages: 2425-2439
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Stomach
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Muscle
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Testis
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Ovary
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Skin
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:2666080
Age: postnatal adult
Specimen Label: Eyes
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:2666080
Age: embryonic day 8.5
Specimen Label: E8.5
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:2665920
Assay Type: RT-PCR
Annotation Date: 2003-07-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603915
Stage: TS15
Assay Id: MGI:2666080
Age: embryonic day 9.5
Specimen Label: E9.5
Detected: true
Specimen Num: 14