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Search results 1 to 100 out of 105 for Rcan3

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0.044s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Calcipressin-3 (RCAN3) is a member of the calcipressin family. Overexpressed RCAN3 has been found to bind and inhibit the Ca2+/calmodulin-dependent phosphatase calcineurin, and further down-regulates nuclear factor of activated T cells (NFAT)-dependent cytokine gene expression in activated human Jurkat T cells []. RCAN3 can also interact with cardiac troponin I (TNNI3), a heart-specific inhibitory subunit of the troponin complex, and may play a role in cardiac contraction [].Calcipressins (RCANs) are a novel family of calcineurin regulators that have been suggested as key factors contributing to Down syndrome in humans. Three human calcipressins have been identified, calcipressin 1-3. Calcipressin 1 is also known as modulatory calcineurin-interacting protein 1 (MCIP1), Adapt78 and Down syndrome critical region 1 (DSCR1). Calcipressin 2 is variously known as MCIP2, ZAKI-4 and DSCR1-like 1. Calcipressin 3 is also called MCIP3 and DSCR1-like 2 []. Calcipressins contain an N-terminal RNA recognition motif (RRM), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and a C-terminal TxxP motif [].Calcineurin is a calcium-responsive enzyme that dephosphorylates the nuclear factor of activated T cells (NFAT). In doing so, it promotes its nuclear translocation and uniquely links calcium signalling to transcriptional regulation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Gene
Type: gene
Organism: human
Publication
First Author: Facchin F
Year: 2008
Journal: Gene
Title: Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms.
Volume: 407
Issue: 1-2
Pages: 159-68
Publication
First Author: Mulero MC
Year: 2007
Journal: Biochim Biophys Acta
Title: RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression.
Volume: 1773
Issue: 3
Pages: 330-41
Protein
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
Publication
First Author: Parry RV
Year: 2003
Journal: Nat Immunol
Title: Calcium-independent calcineurin regulation.
Volume: 4
Issue: 9
Pages: 821-3
Publication
First Author: Mehta S
Year: 2009
Journal: Mol Cell Biol
Title: Domain architecture of the regulators of calcineurin (RCANs) and identification of a divergent RCAN in yeast.
Volume: 29
Issue: 10
Pages: 2777-93
Publication
First Author: Serrano-Candelas E
Year: 2015
Journal: Biochem Biophys Res Commun
Title: RCAN 1 and 3 proteins regulate thymic positive selection.
Volume: 460
Issue: 2
Pages: 295-301
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 5
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 6
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 7
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2669984
Age: postnatal adult
Specimen Label: 8
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:2669985
Age: embryonic day 7.0
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:2669985
Age: embryonic day 11.0
Specimen Label: 2
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2669985
Age: embryonic day 15.0
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:2669980
Assay Type: Northern blot
Annotation Date: 2003-08-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:2669985
Age: embryonic day 17.0
Specimen Label: 4
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3618790
Assay Type: RT-PCR
Annotation Date: 2006-04-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1753628
Stage: TS28
Assay Id: MGI:3618803
Age: postnatal adult
Specimen Label: Dscr1l2
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3708297
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610521
Stage: TS21
Assay Id: MGI:3708373
Age: embryonic day 13.5
Image: 7
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3708297
Assay Type: RT-PCR
Annotation Date: 2007-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610524
Stage: TS24
Assay Id: MGI:3708373
Age: embryonic day 16.5
Image: 7
Specimen Label: E16.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7485936
Age: postnatal adult
Specimen Label: Thymus
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:7485936
Age: postnatal adult
Specimen Label: LN
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:7485936
Age: postnatal adult
Specimen Label: Spleen
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:7485936
Age: postnatal adult
Specimen Label: BM
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:7485936
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876824
Stage: TS24
Assay Id: MGI:7485941
Age: embryonic day 16.0
Specimen Label: Thymus E16
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:7485941
Age: embryonic day 16.0
Specimen Label: Liver E16
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:7486041
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/+>
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:7486041
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7486040
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/+>
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:7486040
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:7486042
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/+>
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7485869
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:7486042
Age: postnatal week 8-15
Specimen Label: hnRNP A1<+/->
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7485878
Assay Type: RT-PCR
Annotation Date: 2023-05-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:7485941
Age: postnatal adult
Specimen Label: Thymus Adult
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3618775
Assay Type: RNA in situ
Annotation Date: 2006-04-07
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753626
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:3618785
Age: embryonic day 18.5
Note: Expression is in the acruate nucleus, the dorsal medial and ventromedial hypothalamus.
Specimen Label: Dscr1l2
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:2453559
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Ubiquitous
Stage: TS23
Assay Id: MGI:4827662
Age: embryonic day 14.5
Image: euxassay_010962_15
Specimen Label: euxassay_010962_15
Detected: true
Specimen Num: 1
Publication
First Author: Strippoli P
Year: 2000
Journal: Gene
Title: The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes.
Volume: 257
Issue: 2
Pages: 223-32
Publication
First Author: Strippoli P
Year: 2000
Journal: Genomics
Title: A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).
Volume: 64
Issue: 3
Pages: 252-63
Publication
First Author: Davies KJ
Year: 2007
Journal: FASEB J
Title: Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
Volume: 21
Issue: 12
Pages: 3023-8
Publication
First Author: Bischof JM
Year: 2005
Journal: Physiol Genomics
Title: Genome-wide analysis of gene transcription in the hypothalamus.
Volume: 22
Issue: 2
Pages: 191-6
Publication  
First Author: Liu TY
Year: 2017
Journal: Open Biol
Title: Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.
Volume: 7
Issue: 1
Publication
First Author: Yang XY
Year: 2007
Journal: Dev Biol
Title: Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.
Volume: 303
Issue: 2
Pages: 825-37
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database