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Search results 1 to 94 out of 94 for Rce1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
9986 | RCE1
Type: gene
Organism: human
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Gene
539539 | RCE1
Type: gene
Organism: cattle
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Gene
713224 | RCE1
Type: gene
Organism: macaque, rhesus
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Gene
549000 | rce1
Type: gene
Organism: frog, western clawed
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Gene
309153 | Rce1
Type: gene
Organism: rat
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Gene
483705 | RCE1
Type: gene
Organism: dog, domestic
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Gene
451355 | RCE1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR039731 | Rce1
Type: Family
Description: Rce1 is an integral membrane, metal-dependent endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins, such as Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatase []. It is classified as type II CAAX prenyl protease [, ]and is included in peptidase family M79. Its structure has been solved [].
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Protein Coding Gene
MGI:1336895 | Rce1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16973961 | J:143675
First Author: Wahlstrom AM
Year: 2007
Journal: Blood
Title: Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease.
Volume: 109
Issue: 2
Pages: 763-8
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Protein
P57791
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Publication
24134311 | J:208391
First Author: Jaworski J
Year: 2014
Journal: Biochem J
Title: A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.
Volume: 457
Issue: 2
Pages: 289-300
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Publication
32398789 | J:301315
First Author: Karlsson C
Year: 2021
Journal: Leukemia
Title: Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
Volume: 35
Issue: 2
Pages: 606-609
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Publication
14625273 | J:87958
First Author: Bergo MO
Year: 2004
Journal: J Biol Chem
Title: On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
Volume: 279
Issue: 6
Pages: 4729-36
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Publication
16495543 | J:107392
First Author: Fueller F
Year: 2006
Journal: Infect Immun
Title: Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.
Volume: 74
Issue: 3
Pages: 1712-7
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Publication
10085069 | J:53886
First Author: Kim E
Year: 1999
Journal: J Biol Chem
Title: Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
Volume: 274
Issue: 13
Pages: 8383-90
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Protein
A0A286YCQ7
Organism: Mus musculus/domesticus
Length: 230  
Fragment?: true
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Protein
A0A494B9U4
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
A0A494BAL8
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Protein
A0A286YCK9
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein
Q99KQ3
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Publication
29424242 | -
First Author: Hampton SE
Year: 2018
Journal: Crit Rev Biochem Mol Biol
Title: Rce1: mechanism and inhibition.
Volume: 53
Issue: 2
Pages: 157-174
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Publication
24291792 | -
First Author: Manolaridis I
Year: 2013
Journal: Nature
Title: Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1.
Volume: 504
Issue: 7479
Pages: 301-5
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Protein
A0A286YDK5
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: false
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Publication
11038283 | -
First Author: Hollander I
Year: 2000
Journal: Anal Biochem
Title: Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides.
Volume: 286
Issue: 1
Pages: 129-37
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Publication
10825201 | -
First Author: Trueblood CE
Year: 2000
Journal: Mol Cell Biol
Title: The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities.
Volume: 20
Issue: 12
Pages: 4381-92
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Publication
12433685 | J:82644
First Author: Aiyagari AL
Year: 2003
Journal: Blood
Title: Hematologic effects of inactivating the Ras processing enzyme Rce1.
Volume: 101
Issue: 6
Pages: 2250-2
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Publication
11739732 | J:80937
First Author: Bergo MO
Year: 2002
Journal: Mol Cell Biol
Title: Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.
Volume: 22
Issue: 1
Pages: 171-81
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Publication
15659645 | J:99222
First Author: Michaelson D
Year: 2005
Journal: Mol Biol Cell
Title: Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases.
Volume: 16
Issue: 4
Pages: 1606-16
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Publication
32910507 | J:293700
First Author: Yao H
Year: 2020
Journal: Aging Cell
Title: Targeting RAS-converting enzyme 1 overcomes senescence and improves progeria-like phenotypes of ZMPSTE24 deficiency.
Volume: 19
Issue: 8
Pages: e13200
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Publication
21555557 | J:171900
First Author: Christiansen JR
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
Volume: 108
Issue: 21
Pages: 8862-6
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Protein Coding Gene
MGP_CAROLIEiJ_G0022511 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024634 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1336895 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025082 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024373 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024501 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024587 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024498 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023620 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0023936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014008 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023425 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9593748 | J:47950
First Author: Dode L
Year: 1998
Journal: J Biol Chem
Title: Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA.
Volume: 273
Issue: 22
Pages: 13982-94
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Publication
12235369 | J:79501
First Author: Bergo MO
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
Volume: 99
Issue: 20
Pages: 13049-54
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663514
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663514
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663512
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663512
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663513
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:2663466
Assay Type: Western blot
Annotation Date: 2003-06-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:2663513
Age: embryonic day 14.5
Image: 5
Specimen Label: Rce1 -/-
Detected: true
Specimen Num: 2
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Publication
20154137 | -
First Author: Kjos M
Year: 2010
Journal: J Bacteriol
Title: The abi proteins and their involvement in bacteriocin self-immunity.
Volume: 192
Issue: 8
Pages: 2068-76
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Publication
16361710 | -
First Author: Plummer LJ
Year: 2006
Journal: J Biol Chem
Title: Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.
Volume: 281
Issue: 8
Pages: 4596-605
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Protein Domain
IPR003675 | Rce1-like
Type: Family
Description: This family (also known as the ABI (abortive infection) family) contains putative intramembrane proteases (IMPs) and has homologues in all three domains of life, including Rce1 from S. cerevisiae []. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases []. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis []. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP family, the glutamate IMPs [].
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Publication
11399759 | J:70661
First Author: Leung GK
Year: 2001
Journal: J Biol Chem
Title: Biochemical studies of Zmpste24-deficient mice.
Volume: 276
Issue: 31
Pages: 29051-8
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Publication
11121396 | J:67598
First Author: Bergo MO
Year: 2001
Journal: J Biol Chem
Title: Isoprenylcysteine carboxyl methyltransferase deficiency in mice.
Volume: 276
Issue: 8
Pages: 5841-5
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Publication
17652517 | J:123768
First Author: Coffinier C
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
Volume: 104
Issue: 33
Pages: 13432-7
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Publication
27147662 | J:231728
First Author: Christiansen JR
Year: 2016
Journal: J Neurosci
Title: Deficiency of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Leads to Progressive Loss of Photoreceptor Function.
Volume: 36
Issue: 18
Pages: 5107-14
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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