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Search results 1 to 100 out of 104 for Rdh8

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
50700 | RDH8
Type: gene
Organism: human
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Gene
711496 | RDH8
Type: gene
Organism: macaque, rhesus
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Gene
101751681 | RDH8
Type: gene
Organism: chicken
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Gene
100498153 | rdh8
Type: gene
Organism: frog, western clawed
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Gene
281449 | RDH8
Type: gene
Organism: cattle
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Gene
107966558 | RDH8
Type: gene
Organism: chimpanzee
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Gene
690953 | Rdh8
Type: gene
Organism: rat
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Gene
611300 | RDH8
Type: gene
Organism: dog, domestic
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Protein Coding Gene
MGI:2685028 | Rdh8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22621924 | J:188863
First Author: Chen C
Year: 2012
Journal: J Biol Chem
Title: Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12.
Volume: 287
Issue: 29
Pages: 24662-70
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Publication
28972139 | J:253136
First Author: Chen C
Year: 2017
Journal: J Biol Chem
Title: Interphotoreceptor retinoid-binding protein removes all-trans-retinol and retinal from rod outer segments, preventing lipofuscin precursor formation.
Volume: 292
Issue: 47
Pages: 19356-19365
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Publication
29773803 | J:262864
First Author: Chen Y
Year: 2018
Journal: Nat Commun
Title: A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.
Volume: 9
Issue: 1
Pages: 1976
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Publication
24712709 | J:213619
First Author: Wu Y
Year: 2014
Journal: Biochem J
Title: Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'.
Volume: 460
Issue: 3
Pages: 343-52
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Publication
31073029 | J:280810
First Author: Getter T
Year: 2019
Journal: J Biol Chem
Title: The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration.
Volume: 294
Issue: 24
Pages: 9461-9475
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Publication
19553623 | J:154653
First Author: Maeda A
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina.
Volume: 50
Issue: 11
Pages: 5435-43
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Publication
20801113 | J:169728
First Author: Parker RO
Year: 2010
Journal: Exp Eye Res
Title: Retinol dehydrogenases (RDHs) in the visual cycle.
Volume: 91
Issue: 6
Pages: 788-92
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Publication
19304658 | J:150515
First Author: Maeda A
Year: 2009
Journal: J Biol Chem
Title: Involvement of all-trans-retinal in acute light-induced retinopathy of mice.
Volume: 284
Issue: 22
Pages: 15173-83
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Publication
18048336 | J:128486
First Author: Maeda A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Redundant and unique roles of retinol dehydrogenases in the mouse retina.
Volume: 104
Issue: 49
Pages: 19565-70
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Publication
32265302 | J:292103
First Author: Liao C
Year: 2020
Journal: J Biol Chem
Title: Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.
Volume: 295
Issue: 20
Pages: 6958-6971
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Protein Coding Gene
MGP_CAROLIEiJ_G0031847 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034332 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034396 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034108 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034226 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034937 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033546 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014713 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032971 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15755727 | J:99930
First Author: Maeda A
Year: 2005
Journal: J Biol Chem
Title: Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.
Volume: 280
Issue: 19
Pages: 18822-32
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Publication
33523199 | J:302173
First Author: Boyer NP
Year: 2021
Journal: Invest Ophthalmol Vis Sci
Title: Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium.
Volume: 62
Issue: 2
Pages: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: WT#1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: WT#2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: KO#1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: KO#2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: KO#3
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7507562
Assay Type: Western blot
Annotation Date: 2023-07-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:7507583
Age: postnatal week 8
Image: 7
Specimen Label: WT#3
Detected: true
Specimen Num: 3
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Publication
24231350 | J:207755
First Author: Chen Y
Year: 2013
Journal: J Clin Invest
Title: Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.
Volume: 123
Issue: 12
Pages: 5119-34
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Publication
25414195 | J:230293
First Author: Zhao J
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin.
Volume: 55
Issue: 12
Pages: 8241-50
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Publication
28192797 | J:257639
First Author: Zhao J
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Aberrant Buildup of All-Trans-Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium.
Volume: 58
Issue: 2
Pages: 1063-1075
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Publication
26075817 | J:225430
First Author: Zhang J
Year: 2015
Journal: J Clin Invest
Title: Molecular pharmacodynamics of emixustat in protection against retinal degeneration.
Volume: 125
Issue: 7
Pages: 2781-94
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Publication
18658157 | J:142322
First Author: Maeda A
Year: 2008
Journal: J Biol Chem
Title: Retinopathy in mice induced by disrupted all-trans-retinal clearance.
Volume: 283
Issue: 39
Pages: 26684-93
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Publication
30038866 | J:280303
 
First Author: Taubitz T
Year: 2018
Journal: PeerJ
Title: Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.
Volume: 6
Pages: e5215
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Publication
24706818 | J:208628
First Author: Nociari MM
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.
Volume: 111
Issue: 14
Pages: E1402-8
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Publication
22184108 | J:182451
First Author: Chen Y
Year: 2012
Journal: J Biol Chem
Title: Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration.
Volume: 287
Issue: 7
Pages: 5059-69
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Publication
33154094 | J:331629
First Author: Ortega JT
Year: 2021
Journal: Mol Pharmacol
Title: Protective Effects of Flavonoids in Acute Models of Light-Induced Retinal Degeneration.
Volume: 99
Issue: 1
Pages: 60-77
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Publication
26225634 | J:230948
First Author: Schur RM
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments.
Volume: 56
Issue: 8
Pages: 4936-42
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Publication
22198730 | J:280311
First Author: Maeda A
Year: 2011
Journal: Nat Chem Biol
Title: Primary amines protect against retinal degeneration in mouse models of retinopathies.
Volume: 8
Issue: 2
Pages: 170-8
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Publication
30018116 | J:280617
First Author: Gao S
Year: 2018
Journal: Mol Pharmacol
Title: Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration.
Volume: 94
Issue: 4
Pages: 1132-1144
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Publication
25617130 | J:280312
 
First Author: Puntel A
Year: 2015
Journal: Biomaterials
Title: Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.
Volume: 44
Pages: 103-10
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Publication
34863682 | J:319666
 
First Author: Tao L
Year: 2022
Journal: Exp Eye Res
Title: Repressing c-Jun N-terminal kinase signaling mitigates retinal pigment epithelium degeneration in mice with failure to clear all-trans-retinal.
Volume: 214
Pages: 108877
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Publication
29162627 | J:280317
First Author: Orban T
Year: 2018
Journal: J Pharmacol Exp Ther
Title: A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration.
Volume: 364
Issue: 2
Pages: 207-220
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Publication
24726920 | J:229872
 
First Author: Sawada O
Year: 2014
Journal: Exp Eye Res
Title: All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.
Volume: 123
Pages: 27-36
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Publication
22220722 | J:184334
First Author: Okano K
Year: 2012
Journal: J Neurochem
Title: Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage.
Volume: 121
Issue: 1
Pages: 146-56
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Publication
30185665 | J:282073
 
First Author: Palczewska G
Year: 2018
Journal: JCI Insight
Title: Two-photon imaging of the mammalian retina with ultrafast pulsing laser.
Volume: 3
Issue: 17
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Publication
34847075 | J:318826
 
First Author: Boguslawski J
Year: 2022
Journal: J Clin Invest
Title: In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope.
Volume: 132
Issue: 2
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Publication
19494204 | J:154536
First Author: Maeda T
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance.
Volume: 50
Issue: 10
Pages: 4917-25
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Publication
29401616 | J:267644
First Author: Schur RM
Year: 2018
Journal: FASEB J
Title: New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models.
Volume: 32
Issue: 6
Pages: 3289-3300
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Publication
26400086 | J:226547
First Author: Zhou J
Year: 2015
Journal: J Biol Chem
Title: Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition.
Volume: 290
Issue: 45
Pages: 27215-27
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Publication
27315541 | J:254616
First Author: Parmar T
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure.
Volume: 57
Issue: 7
Pages: 3257-67
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Publication
29602770 | J:261487
First Author: Parmar T
Year: 2018
Journal: J Immunol
Title: Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration.
Volume: 200
Issue: 9
Pages: 3128-3141
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Publication
27875314 | J:237618
First Author: Palczewska G
Year: 2016
Journal: J Biol Chem
Title: Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.
Volume: 291
Issue: 52
Pages: 26937-26949
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Publication
27992460 | J:256799
First Author: Fontaine V
Year: 2016
Journal: PLoS One
Title: Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo.
Volume: 11
Issue: 12
Pages: e0167793
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Publication
21076393 | J:167525
First Author: Palczewska G
Year: 2010
Journal: Nat Med
Title: Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes.
Volume: 16
Issue: 12
Pages: 1444-9
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Publication
21383019 | J:172084
First Author: Shiose S
Year: 2011
Journal: J Biol Chem
Title: Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice.
Volume: 286
Issue: 17
Pages: 15543-55
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Publication
34509473 | J:340540
First Author: Ma X
Year: 2021
Journal: J Biol Chem
Title: ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Volume: 297
Issue: 4
Pages: 101185
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Publication
25015357 | J:230135
First Author: Flynn E
Year: 2014
Journal: Invest Ophthalmol Vis Sci
Title: Fundus autofluorescence and photoreceptor cell rosettes in mouse models.
Volume: 55
Issue: 9
Pages: 5643-52
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Publication
24952647 | J:227607
First Author: Palczewska G
Year: 2014
Journal: Nat Med
Title: Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye.
Volume: 20
Issue: 7
Pages: 785-9
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Publication
16566595 | J:107544
First Author: Maeda A
Year: 2006
Journal: Biochemistry
Title: Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters.
Volume: 45
Issue: 13
Pages: 4210-9
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Publication
24706832 | J:208625
First Author: Maeda A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.
Volume: 111
Issue: 14
Pages: E1428-37
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Publication
23572532 | J:280319
First Author: Kohno H
Year: 2013
Journal: J Biol Chem
Title: Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.
Volume: 288
Issue: 21
Pages: 15326-41
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Publication
27460988 | J:259993
First Author: Chen Y
Year: 2016
Journal: Sci Signal
Title: Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.
Volume: 9
Issue: 438
Pages: ra74
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Publication
23341467 | J:196891
First Author: Chen Y
Year: 2013
Journal: J Biol Chem
Title: Autophagy protects the retina from light-induced degeneration.
Volume: 288
Issue: 11
Pages: 7506-18
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Publication
24639355 | J:210001
First Author: Kohno H
Year: 2014
Journal: J Immunol
Title: CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration.
Volume: 192
Issue: 8
Pages: 3816-27
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Publication
20404157 | J:160326
First Author: Maeda A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Palmitoylation stabilizes unliganded rod opsin.
Volume: 107
Issue: 18
Pages: 8428-33
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Publication
27008858 | J:234197
First Author: Wong BH
Year: 2016
Journal: J Biol Chem
Title: Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.
Volume: 291
Issue: 20
Pages: 10501-14
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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