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Search results 1 to 100 out of 1362 for Rela

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Type Details Score
Gene
5970 | RELA
Type: gene
Organism: human
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Gene
508233 | RELA
Type: gene
Organism: cattle
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Gene
396027 | RELA
Type: gene
Organism: chicken
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Gene
715919 | RELA
Type: gene
Organism: macaque, rhesus
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Gene
407869 | rela
Type: gene
Organism: frog, western clawed
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Gene
483729 | RELA
Type: gene
Organism: dog, domestic
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Gene
309165 | Rela
Type: gene
Organism: rat
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Gene
466665 | RELA
Type: gene
Organism: chimpanzee
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Gene
415099 | rela
Type: gene
Organism: zebrafish
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Gene
key_30885 | RELA
Type: gene
Organism: rabbit, European
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Protein Domain
IPR030495 | RelA
Type: Family
Description: This entry represents RelA, also known as nuclear factor NF-kappa-B p65 subunit. RelA and p50 is the mostly commonly found heterodimer complex among NF-kappaB homodimers and heterodimers, and is the functional component participating in nuclear transclocation and activation of NF-kappaB [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].The prototypical NF-kB complex is a p50/RelA heterodimer. NF-kB is largely sequestered in the cytoplasm through its association with an IkB inhibitor []. Cytoplasmic events culminating in the phosphorylation of IkB-alpha lead to its polyubiquitylation and proteasome-mediated degradation. The liberated NF-kB complex translocates to the nucleus. In the nucleus, site-specific acetylation and phosphorylation of RelA regulates the actions of the NF-kB complex [, ].
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Protein Coding Gene
MGI:103290 | Rela
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A4L9Q2
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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GXD Expression
GXD Expression
Probe: MGI:7618260
Assay Type: Immunohistochemistry
Annotation Date: 2024-04-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914226
Pattern: Widespread
Stage: TS26
Assay Id: MGI:7618285
Age: embryonic day 18.5
Image: 5F RelA
Note: Expression in proximal tibia widely detected.
Specimen Label: 5F RelA
Detected: true
Specimen Num: 1
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Publication
16135789 | -
First Author: Chen LF
Year: 2005
Journal: Mol Cell Biol
Title: NF-kappaB RelA phosphorylation regulates RelA acetylation.
Volume: 25
Issue: 18
Pages: 7966-75
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Gene
105369347 | RELA-DT
Type: gene
Organism: human
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Publication
15122352 | -
First Author: Chen LF
Year: 2004
Journal: Nat Rev Mol Cell Biol
Title: Shaping the nuclear action of NF-kappaB.
Volume: 5
Issue: 5
Pages: 392-401
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Publication
9450761 | -
First Author: Chen FE
Year: 1998
Journal: Nature
Title: Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA.
Volume: 391
Issue: 6665
Pages: 410-3
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Publication
22435556 | -
First Author: Smale ST
Year: 2012
Journal: Immunol Rev
Title: Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors.
Volume: 246
Issue: 1
Pages: 193-204
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Publication
22302935 | -
First Author: Hayden MS
Year: 2012
Journal: Genes Dev
Title: NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Volume: 26
Issue: 3
Pages: 203-34
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Protein
A0A494B901
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein
Q4U113
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Gene
100422456 | LOC100422456
Type: gene
Organism: human
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Protein
Q04207
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q548Y4
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q3U3Q8
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
A0A494BA44
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q8BTL4
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Publication
14724177 | J:119420
First Author: Zhang JY
Year: 2004
Journal: Genes Dev
Title: NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.
Volume: 18
Issue: 1
Pages: 17-22
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Publication
31160364 | J:289426
 
First Author: Kim Y
Year: 2019
Journal: Infect Immun
Title: NF-κB RelA Is Required for Hepatoprotection during Pneumonia and Sepsis.
Volume: 87
Issue: 8
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Publication
17237440 | J:143632
First Author: Quinton LJ
Year: 2007
Journal: J Immunol
Title: Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia.
Volume: 178
Issue: 3
Pages: 1896-903
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Publication
27454298 | J:237113
First Author: Lesina M
Year: 2016
Journal: J Clin Invest
Title: RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.
Volume: 126
Issue: 8
Pages: 2919-32
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Publication
19201871 | J:144791
First Author: Bode KA
Year: 2009
Journal: J Immunol
Title: Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.
Volume: 182
Issue: 4
Pages: 2176-84
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Publication
10894954 | J:63247
First Author: Lemmer ER
Year: 2000
Journal: Cytogenet Cell Genet
Title: Genomic structure and chromosome location of the mouse RelA p65 gene (Rela).
Volume: 89
Issue: 1-2
Pages: 129-32
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Publication
21216972 | J:190223
First Author: Pittet LA
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia.
Volume: 45
Issue: 3
Pages: 573-81
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Publication
24739902 | J:214775
First Author: Kumari S
Year: 2014
Journal: J Invest Dermatol
Title: Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin.
Volume: 134
Issue: 10
Pages: 2541-2550
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DO Term
DOID:0080892 | RELA fusion-positive ependymoma
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Publication
21706061 | J:197511
First Author: Li H
Year: 2012
Journal: Oncogene
Title: Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination.
Volume: 31
Issue: 5
Pages: 611-23
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Publication
12881425 | J:84916
First Author: Duran A
Year: 2003
Journal: EMBO J
Title: Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation.
Volume: 22
Issue: 15
Pages: 3910-8
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Publication
31981416 | J:291620
First Author: Yu S
Year: 2020
Journal: FEBS Lett
Title: RelA promotes proliferation but inhibits osteogenic and chondrogenic differentiation of mesenchymal stem cells.
Volume: 594
Issue: 9
Pages: 1368-1378
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Publication
18250470 | J:131977
First Author: Steinbrecher KA
Year: 2008
Journal: J Immunol
Title: Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.
Volume: 180
Issue: 4
Pages: 2588-99
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Publication
16192349 | J:102492
First Author: Jacque E
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: RelA repression of RelB activity induces selective gene activation downstream of TNF receptors.
Volume: 102
Issue: 41
Pages: 14635-40
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Publication
19710460 | J:152303
First Author: Liu Z
Year: 2009
Journal: J Immunol
Title: Divergent roles of RelA and c-Rel in establishing chromosomal loops upon activation of the Igkappa gene.
Volume: 183
Issue: 6
Pages: 3819-30
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Publication
21131967 | J:170429
First Author: Levy D
Year: 2011
Journal: Nat Immunol
Title: Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
Volume: 12
Issue: 1
Pages: 29-36
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Publication
7603567 | J:28390
First Author: Beg AA
Year: 1995
Journal: Nature
Title: Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.
Volume: 376
Issue: 6536
Pages: 167-70
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Publication
11805150 | J:76222
First Author: Alcamo E
Year: 2002
Journal: J Exp Med
Title: Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs.
Volume: 195
Issue: 2
Pages: 233-44
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Publication
27830706 | J:242716
 
First Author: Kobayashi H
Year: 2016
Journal: Nat Commun
Title: Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes.
Volume: 7
Pages: 13336
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191198
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rela
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191198
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rela
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191198
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rela
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191198
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rela
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191198
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rela
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191198
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rela
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6182097
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191198
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rela
Detected: true
Specimen Num: 7
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Publication
22466650 | J:184541
First Author: Quinton LJ
Year: 2012
Journal: J Clin Invest
Title: Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice.
Volume: 122
Issue: 5
Pages: 1758-63
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Publication
8918242 | J:36469
First Author: Linker RA
Year: 1996
Journal: Gene
Title: Cloning of the murine relA (p65 NF-kappa B) gene and comparison to the human gene reveals a distinct first intron.
Volume: 176
Issue: 1-2
Pages: 119-24
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Publication
32101750 | J:288116
First Author: Ngo KA
Year: 2020
Journal: Cell Rep
Title: Dissecting the Regulatory Strategies of NF-κB RelA Target Genes in the Inflammatory Response Reveals Differential Transactivation Logics.
Volume: 30
Issue: 8
Pages: 2758-2775.e6
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Publication
20610653 | J:162240
First Author: Wang J
Year: 2010
Journal: J Immunol
Title: NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication.
Volume: 185
Issue: 3
Pages: 1720-9
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Publication
23041330 | J:257245
First Author: Neuhöfer P
Year: 2013
Journal: Gastroenterology
Title: Deletion of IκBα activates RelA to reduce acute pancreatitis in mice through up-regulation of Spi2A.
Volume: 144
Issue: 1
Pages: 192-201
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Publication
21737676 | J:183037
First Author: Msaki A
Year: 2011
Journal: Mol Biol Cell
Title: The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration.
Volume: 22
Issue: 17
Pages: 3032-40
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Publication
17167080 | J:144659
First Author: Inta I
Year: 2006
Journal: J Neurosci
Title: Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia.
Volume: 26
Issue: 50
Pages: 12896-903
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Publication
10518539 | J:111325
First Author: Grossmann M
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects.
Volume: 96
Issue: 21
Pages: 11848-53
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Publication
19003818 | J:141395
First Author: Vallabhapurapu S
Year: 2008
Journal: Eur J Immunol
Title: Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells.
Volume: 38
Issue: 12
Pages: 3508-19
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Publication
22761446 | J:190241
First Author: Itoh S
Year: 2012
Journal: J Biol Chem
Title: GSK-3α and GSK-3β proteins are involved in early stages of chondrocyte differentiation with functional redundancy through RelA protein phosphorylation.
Volume: 287
Issue: 35
Pages: 29227-36
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Publication
24860143 | J:302685
First Author: Haenold R
Year: 2014
Journal: J Cell Sci
Title: NF-κB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS.
Volume: 127
Issue: Pt 14
Pages: 3052-65
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Publication
21419662 | J:169863
First Author: Powolny-Budnicka I
Year: 2011
Journal: Immunity
Title: RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Volume: 34
Issue: 3
Pages: 364-74
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HT Experiment
E-MTAB-3436 | RelA in pancreatic cancer
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
15199130 | J:91366
First Author: Gugasyan R
Year: 2004
Journal: Mol Cell Biol
Title: The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.
Volume: 24
Issue: 13
Pages: 5733-45
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Publication
9195998 | J:39706
First Author: Fernandes M
Year: 1997
Journal: Mamm Genome
Title: The mouse homologs of RELA and MLK3 are located within a 120-kb fragment on chromosome 19.
Volume: 8
Issue: 7
Pages: 513-5
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Publication
16275766 | J:118856
First Author: Hwang ES
Year: 2005
Journal: J Exp Med
Title: IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.
Volume: 202
Issue: 9
Pages: 1289-300
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Publication
19342670 | J:147501
First Author: Mise-Omata S
Year: 2009
Journal: J Immunol
Title: The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation.
Volume: 182
Issue: 8
Pages: 4910-6
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Publication
24591377 | J:209870
First Author: Alves BN
Year: 2014
Journal: J Immunol
Title: IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Volume: 192
Issue: 7
Pages: 3121-32
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Publication
28600438 | J:244578
First Author: Badran YR
Year: 2017
Journal: J Exp Med
Title: Human RELA haploinsufficiency results in autosomal-dominant chronic mucocutaneous ulceration.
Volume: 214
Issue: 7
Pages: 1937-1947
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Author
Rela L
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Publication
34085926 | J:317349
   
First Author: Yu Q
Year: 2021
Journal: Elife
Title: Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid.
Volume: 10
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Publication
35618311 | J:337393
First Author: Yin K
Year: 2022
Journal: Genes Dev
Title: Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance.
Volume: 36
Issue: 9-10
Pages: 533-549
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Publication
15053878 | J:89305
First Author: Campbell KJ
Year: 2004
Journal: Mol Cell
Title: Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.
Volume: 13
Issue: 6
Pages: 853-65
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Publication
15345217 | J:93602
First Author: Grumont R
Year: 2004
Journal: Immunity
Title: The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression.
Volume: 21
Issue: 1
Pages: 19-30
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Publication
8864118 | J:36492
First Author: Beg AA
Year: 1996
Journal: Science
Title: An essential role for NF-kappaB in preventing TNF-alpha-induced cell death.
Volume: 274
Issue: 5288
Pages: 782-4
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Publication
28818856 | J:269277
First Author: Ijaz T
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: Deletion of NF-κB/RelA in Angiotensin II-Sensitive Mesenchymal Cells Blocks Aortic Vascular Inflammation and Abdominal Aortic Aneurysm Formation.
Volume: 37
Issue: 10
Pages: 1881-1890
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Publication
22844121 | J:189861
First Author: Yamamoto K
Year: 2012
Journal: J Immunol
Title: Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia.
Volume: 189
Issue: 5
Pages: 2450-9
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Publication
18200059 | J:137534
First Author: Rebholz B
Year: 2008
Journal: J Invest Dermatol
Title: Role of NF-kappaB/RelA and MAPK pathways in keratinocytes in response to sulfur mustard.
Volume: 128
Issue: 7
Pages: 1626-32
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Publication
31409641 | J:279989
First Author: Xu J
Year: 2019
Journal: Cancer Res
Title: Long Noncoding RNA MIR17HG Promotes Colorectal Cancer Progression via miR-17-5p.
Volume: 79
Issue: 19
Pages: 4882-4895
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Publication
24908679 | J:260562
First Author: Mise-Omata S
Year: 2014
Journal: Int Immunol
Title: NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation.
Volume: 26
Issue: 11
Pages: 607-18
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Publication
26853469 | J:230713
First Author: Moles A
Year: 2016
Journal: Oncogene
Title: A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-κB-dependent liver regeneration and cancer.
Volume: 35
Issue: 35
Pages: 4623-32
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Publication
21813505 | J:205221
First Author: Dooher JE
Year: 2011
Journal: Mol Cancer Res
Title: C/EBPα, C/EBPα oncoproteins, or C/EBPβ preferentially bind NF-κB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction.
Volume: 9
Issue: 10
Pages: 1395-405
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Publication
28188806 | J:256243
First Author: Geismann C
Year: 2017
Journal: Biochim Biophys Acta
Title: Role of CCL20 mediated immune cell recruitment in NF-κB mediated TRAIL resistance of pancreatic cancer.
Volume: 1864
Issue: 5
Pages: 782-796
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Publication
33068426 | J:304140
First Author: Anand A
Year: 2021
Journal: Carcinogenesis
Title: Elimination of NF-κB signaling in Vimentin+ stromal cells attenuates tumorigenesis in a mouse model of Barrett's Esophagus.
Volume: 42
Issue: 3
Pages: 405-413
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Publication
24010952 | J:231869
First Author: Yamamoto K
Year: 2014
Journal: Am J Respir Cell Mol Biol
Title: Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia.
Volume: 50
Issue: 2
Pages: 253-62
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Publication
10330116 | J:55125
First Author: Nishikimi A
Year: 1999
Journal: Biol Reprod
Title: Nuclear translocation of nuclear factor kappa B in early 1-cell mouse embryos.
Volume: 60
Issue: 6
Pages: 1536-41
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Publication
30612857 | J:295255
 
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Journal: Cell
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