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Search results 1 to 100 out of 447 for Relb

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Type Details Score
Gene
5971 | RELB
Type: gene
Organism: human
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Gene
714677 | RELB
Type: gene
Organism: macaque, rhesus
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Gene
522670 | RELB
Type: gene
Organism: cattle
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Gene
100360982 | Relb
Type: gene
Organism: rat
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Gene
484454 | RELB
Type: gene
Organism: dog, domestic
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Gene
456119 | RELB
Type: gene
Organism: chimpanzee
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Gene
795414 | relb
Type: gene
Organism: zebrafish
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Gene
100486410 | relb
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR030496 | RelB
Type: Family
Description: RelB is a component of the NF-kappa-B RelB-p50 complex and the RelB-p52 complex []. It is best known for its roles in lymphoid development and noncanonical signalling [], but it seems to be linked to many distinct processes. Among others, RelB may have a role in suppressing inflammation []and has been shown to negatively regulate osteoblast differentiation and bone formation [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].
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Protein Coding Gene
MGI:103289 | Relb
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24115294 | J:244086
First Author: Yao Z
Year: 2014
Journal: J Bone Miner Res
Title: NF-κB RelB negatively regulates osteoblast differentiation and bone formation.
Volume: 29
Issue: 4
Pages: 866-77
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Publication
16154093 | J:247386
First Author: Huang DB
Year: 2005
Journal: Structure
Title: NF-kappaB RelB forms an intertwined homodimer.
Volume: 13
Issue: 9
Pages: 1365-73
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Publication
25409035 | -
First Author: Labonté L
Year: 2014
Journal: PLoS One
Title: Alterations in the expression of the NF-κB family member RelB as a novel marker of cardiovascular outcomes during acute exacerbations of chronic obstructive pulmonary disease.
Volume: 9
Issue: 11
Pages: e112965
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Protein
A0A140LJD6
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
A0A140LI24
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
A0A140LI46
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
Q04863
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
Q8K220
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q4U109
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
Q4U112
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: false
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Protein
Q4U111
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
7845467 | J:23081
First Author: Burkly L
Year: 1995
Journal: Nature
Title: Expression of relB is required for the development of thymic medulla and dendritic cells.
Volume: 373
Issue: 6514
Pages: 531-6
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Publication
8441398 | J:24211
First Author: Dobrzanski P
Year: 1993
Journal: Mol Cell Biol
Title: Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif.
Volume: 13
Issue: 3
Pages: 1572-82
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Publication
19302050 | -
 
First Author: Vallabhapurapu S
Year: 2009
Journal: Annu Rev Immunol
Title: Regulation and function of NF-kappaB transcription factors in the immune system.
Volume: 27
Pages: 693-733
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Publication
17869269 | -
First Author: Moorthy AK
Year: 2007
Journal: J Mol Biol
Title: X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites.
Volume: 373
Issue: 3
Pages: 723-34
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Publication
22435556 | -
First Author: Smale ST
Year: 2012
Journal: Immunol Rev
Title: Dimer-specific regulatory mechanisms within the NF-κB family of transcription factors.
Volume: 246
Issue: 1
Pages: 193-204
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Publication
22302935 | -
First Author: Hayden MS
Year: 2012
Journal: Genes Dev
Title: NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Volume: 26
Issue: 3
Pages: 203-34
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Publication
30957303 | J:277920
First Author: Gupta AS
Year: 2019
Journal: Glia
Title: RelB controls adaptive responses of astrocytes during sterile inflammation.
Volume: 67
Issue: 8
Pages: 1449-1461
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Publication
22894897 | J:211236
First Author: Bellet MM
Year: 2012
Journal: Cell Cycle
Title: The RelB subunit of NFκB acts as a negative regulator of circadian gene expression.
Volume: 11
Issue: 17
Pages: 3304-11
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Publication
1732739 | J:22332
First Author: Ryseck RP
Year: 1992
Journal: Mol Cell Biol
Title: RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.
Volume: 12
Issue: 2
Pages: 674-84
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Publication
11753998 | J:73939
First Author: Guerin S
Year: 2002
Journal: Eur J Immunol
Title: RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation.
Volume: 32
Issue: 1
Pages: 1-9
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Publication
18321863 | J:136562
First Author: Fusco AJ
Year: 2008
Journal: J Biol Chem
Title: Stabilization of RelB requires multidomain interactions with p100/p52.
Volume: 283
Issue: 18
Pages: 12324-32
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Publication
32044112 | J:294539
 
First Author: Saha I
Year: 2020
Journal: Cell Immunol
Title: RelB suppresses type I Interferon signaling in dendritic cells.
Volume: 349
Pages: 104043
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Protein
Q3U0K7
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Publication
32145043 | J:292655
First Author: Engelmann C
Year: 2020
Journal: Dev Dyn
Title: Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice.
Volume: 249
Issue: 8
Pages: 983-997
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Publication
32552667 | J:326340
First Author: Zhou S
Year: 2020
Journal: BMC Immunol
Title: RelB regulates the homeostatic proliferation but not the function of Tregs.
Volume: 21
Issue: 1
Pages: 37
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Publication
31362762 | J:291686
First Author: Gupta AS
Year: 2019
Journal: J Neuroinflammation
Title: A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis.
Volume: 16
Issue: 1
Pages: 161
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Publication
21703398 | J:173687
First Author: McMillan DH
Year: 2011
Journal: Am J Pathol
Title: Lung-targeted overexpression of the NF-κB member RelB inhibits cigarette smoke-induced inflammation.
Volume: 179
Issue: 1
Pages: 125-33
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Publication
18413714 | J:133763
First Author: Puto LA
Year: 2008
Journal: Genes Dev
Title: Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
Volume: 22
Issue: 8
Pages: 998-1010
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Publication
16810633 | J:115794
First Author: Le Bon A
Year: 2006
Journal: Eur J Immunol
Title: A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming.
Volume: 36
Issue: 8
Pages: 2085-93
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Publication
32306539 | J:305745
First Author: Zhou D
Year: 2020
Journal: J Cell Mol Med
Title: RelB promotes liver fibrosis via inducing the release of injury-associated inflammatory cytokines.
Volume: 24
Issue: 11
Pages: 6008-6014
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Publication
10510387 | J:118966
First Author: Caamaño J
Year: 1999
Journal: J Immunol
Title: The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii.
Volume: 163
Issue: 8
Pages: 4453-61
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Publication
10940923 | J:63950
First Author: Barton D
Year: 2000
Journal: Eur J Immunol
Title: Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis.
Volume: 30
Issue: 8
Pages: 2323-32
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Publication
17327399 | J:145428
First Author: MacDonald KP
Year: 2007
Journal: Blood
Title: Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHD.
Volume: 109
Issue: 11
Pages: 5049-57
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Publication
8269849 | J:14704
First Author: Carrasco D
Year: 1993
Journal: Development
Title: Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells.
Volume: 118
Issue: 4
Pages: 1221-31
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Publication
29298831 | J:257627
First Author: Li J
Year: 2018
Journal: J Immunol
Title: Role of the NF-κB Family Member RelB in Regulation of Foxp3+ Regulatory T Cells In Vivo.
Volume: 200
Issue: 4
Pages: 1325-1334
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Publication
26773039 | J:232643
First Author: Almaden JV
Year: 2016
Journal: Blood
Title: B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.
Volume: 127
Issue: 10
Pages: 1276-86
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Publication
23665206 | J:202134
First Author: Luo L
Year: 2013
Journal: Cell Immunol
Title: Effects of tolerogenic dendritic cells generated by siRNA-mediated RelB silencing on immune defense and surveillance functions of T cells.
Volume: 282
Issue: 1
Pages: 28-37
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Publication
9881974 | J:110512
First Author: Wu L
Year: 1998
Journal: Immunity
Title: RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells.
Volume: 9
Issue: 6
Pages: 839-47
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Publication
23086447 | J:190685
First Author: Shih VF
Year: 2012
Journal: Nat Immunol
Title: Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways.
Volume: 13
Issue: 12
Pages: 1162-70
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Publication
18322009 | J:132757
First Author: Vaira S
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.
Volume: 105
Issue: 10
Pages: 3897-902
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Publication
28348230 | J:242023
First Author: Briseño CG
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Volume: 114
Issue: 15
Pages: 3957-3962
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Publication
31578269 | J:280918
First Author: Andreas N
Year: 2019
Journal: J Immunol
Title: RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells.
Volume: 203
Issue: 10
Pages: 2602-2613
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Publication
21419662 | J:169863
First Author: Powolny-Budnicka I
Year: 2011
Journal: Immunity
Title: RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.
Volume: 34
Issue: 3
Pages: 364-74
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Protein
Q4U110
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: false
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Publication
11489970 | J:70818
First Author: Weih DS
Year: 2001
Journal: J Immunol
Title: Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines.
Volume: 167
Issue: 4
Pages: 1909-19
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Publication
31476634 | J:290501
 
First Author: Pareek S
Year: 2019
Journal: Mol Immunol
Title: Pulmonary neutrophilia caused by absence of the NF-κB member RelB is dampened by exposure to cigarette smoke.
Volume: 114
Pages: 395-409
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Publication
17446175 | J:122998
First Author: Mineva ND
Year: 2007
Journal: J Biol Chem
Title: CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis.
Volume: 282
Issue: 24
Pages: 17475-85
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Publication
26115685 | J:297199
First Author: Seki T
Year: 2015
Journal: J Biochem
Title: Visualization of RelB expression and activation at the single-cell level during dendritic cell maturation in Relb-Venus knock-in mice.
Volume: 158
Issue: 6
Pages: 485-95
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Publication
22565310 | J:188293
First Author: Hamidi T
Year: 2012
Journal: J Clin Invest
Title: Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
Volume: 122
Issue: 6
Pages: 2092-103
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Publication
12505990 | J:81255
First Author: Yilmaz ZB
Year: 2003
Journal: EMBO J
Title: RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF.
Volume: 22
Issue: 1
Pages: 121-30
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Publication
17023558 | J:117261
First Author: Martucci C
Year: 2007
Journal: J Leukoc Biol
Title: Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes.
Volume: 81
Issue: 1
Pages: 344-54
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Publication
11529676 | J:71982
First Author: Piffat KA
Year: 2001
Journal: Mol Cell Biol Res Commun
Title: The chicken RelB transcription factor has transactivation sequences and a tissue-specific expression pattern that are distinct from mammalian RelB.
Volume: 4
Issue: 5
Pages: 266-75
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Publication
12810685 | J:120659
First Author: Elewaut D
Year: 2003
Journal: J Exp Med
Title: NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells.
Volume: 197
Issue: 12
Pages: 1623-33
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Publication
16081776 | J:107516
First Author: Corn RA
Year: 2005
Journal: J Immunol
Title: Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.
Volume: 175
Issue: 4
Pages: 2102-10
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Publication
25267645 | J:216442
First Author: Authier H
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: IKK phosphorylates RelB to modulate its promoter specificity and promote fibroblast migration downstream of TNF receptors.
Volume: 111
Issue: 41
Pages: 14794-9
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Publication
30445013 | J:294541
First Author: Elßner C
Year: 2019
Journal: Gastroenterology
Title: Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Volume: 156
Issue: 4
Pages: 1190-1205.e14
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Publication
26806881 | J:246876
First Author: Baik S
Year: 2016
Journal: Eur J Immunol
Title: Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors.
Volume: 46
Issue: 4
Pages: 857-62
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Publication
30037996 | J:264370
First Author: Sima J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.
Volume: 115
Issue: 32
Pages: 8173-8178
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Publication
22172711 | J:181370
First Author: Luo L
Year: 2012
Journal: Cell Immunol
Title: Dendritic cells transduced with lentiviral vector targeting RelB gene using RNA interference induce hyporesponsiveness in memory CD4(+) T cells and naïve CD4(+) T cells.
Volume: 273
Issue: 1
Pages: 85-93
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Publication
8879226 | J:110747
First Author: Snapper CM
Year: 1996
Journal: J Exp Med
Title: B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching.
Volume: 184
Issue: 4
Pages: 1537-41
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Publication
10523657 | J:119904
First Author: Xia Y
Year: 1999
Journal: Mol Cell Biol
Title: RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts.
Volume: 19
Issue: 11
Pages: 7688-96
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Publication
24752502 | J:212832
First Author: de Souza AR
Year: 2014
Journal: Toxicol Sci
Title: Aryl hydrocarbon receptor (AhR) attenuation of subchronic cigarette smoke-induced pulmonary neutrophilia is associated with retention of nuclear RelB and suppression of intercellular adhesion molecule-1 (ICAM-1).
Volume: 140
Issue: 1
Pages: 204-23
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Publication
26851215 | J:233743
First Author: De Silva NS
Year: 2016
Journal: J Immunol
Title: Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells.
Volume: 196
Issue: 6
Pages: 2591-601
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Publication
29485182 | J:263501
First Author: Andreas N
Year: 2018
Journal: Eur J Immunol
Title: A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.
Volume: 48
Issue: 6
Pages: 923-936
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Publication
11931770 | J:75807
First Author: Fiorini E
Year: 2002
Journal: Mol Cell
Title: Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.
Volume: 9
Issue: 3
Pages: 637-48
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Publication
28385374 | J:270571
 
First Author: Riemann M
Year: 2017
Journal: J Autoimmun
Title: Central immune tolerance depends on crosstalk between the classical and alternative NF-κB pathways in medullary thymic epithelial cells.
Volume: 81
Pages: 56-67
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Publication
24928446 | J:213568
First Author: Manecka DL
Year: 2014
Journal: FEBS Lett
Title: Inhibition of constitutive TNF production is associated with PACAP-mediated differentiation in PC12 cells.
Volume: 588
Issue: 17
Pages: 3008-14
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Publication
26555174 | J:226752
First Author: Kondylis V
Year: 2015
Journal: Cancer Cell
Title: NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.
Volume: 28
Issue: 5
Pages: 582-598
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Publication
26982364 | J:254667
First Author: Vlantis K
Year: 2016
Journal: Immunity
Title: NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.
Volume: 44
Issue: 3
Pages: 553-567
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Publication
34877491 | J:317727
First Author: Zhao J
Year: 2021
Journal: iScience
Title: TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.
Volume: 24
Issue: 12
Pages: 103425
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Publication
9058787 | J:107546
First Author: DeKoning J
Year: 1997
Journal: J Immunol
Title: Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient mice.
Volume: 158
Issue: 6
Pages: 2558-66
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Publication
28960101 | J:271488
First Author: Nair PM
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation.
Volume: 58
Issue: 3
Pages: 352-365
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Publication
9164938 | J:40630
First Author: Weih F
Year: 1997
Journal: J Immunol
Title: Multifocal defects in immune responses in RelB-deficient mice.
Volume: 158
Issue: 11
Pages: 5211-8
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Publication
8892630 | J:110829
First Author: Weih F
Year: 1996
Journal: J Immunol
Title: Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.
Volume: 157
Issue: 9
Pages: 3974-9
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Publication
7834753 | J:22675
First Author: Weih F
Year: 1995
Journal: Cell
Title: Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family.
Volume: 80
Issue: 2
Pages: 331-40
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Publication
16982744 | J:112934
First Author: Croxton R
Year: 2006
Journal: Cancer Res
Title: Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
Volume: 66
Issue: 18
Pages: 9026-35
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Publication
11274135 | -
First Author: Galvani C
Year: 2001
Journal: J Bacteriol
Title: Purification of the RelB and RelE proteins of Escherichia coli: RelE binds to RelB and to ribosomes.
Volume: 183
Issue: 8
Pages: 2700-3
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Publication
15470505 | J:93302
First Author: Bonizzi G
Year: 2004
Journal: EMBO J
Title: Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
Volume: 23
Issue: 21
Pages: 4202-10
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Publication
21900177 | J:179324
First Author: O'Sullivan BJ
Year: 2011
Journal: J Immunol
Title: Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.
Volume: 187
Issue: 8
Pages: 4018-30
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Publication
12556537 | J:82779
First Author: Müller JR
Year: 2003
Journal: J Biol Chem
Title: Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways.
Volume: 278
Issue: 14
Pages: 12006-12
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Publication
17889723 | J:126347
First Author: Tan JK
Year: 2007
Journal: Exp Hematol
Title: Hematopoiesis of immature myeloid dendritic cells in stroma-dependent spleen long-term cultures occurs independently of NF-KB/RelB function.
Volume: 35
Issue: 10
Pages: 1580-93
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