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Search results 1 to 100 out of 113 for Rgs18

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: RGS18 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signaling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS18 is expressed predominantly in osteoclasts where it acts as a negative regulator of the acidosis-induced osteoclastogenic OGR1/NFAT signaling pathway. RANKL (receptor activator of nuclear factor B ligand) stimulates osteoclastogenesis by inhibiting expression of RGS18 []. RGS18 is also highly expressed in megakaryocytes, platelet, and leukocyte cell lines [, ].
Publication
First Author: Yowe D
Year: 2001
Journal: Biochem J
Title: RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes.
Volume: 359
Issue: Pt 1
Pages: 109-18
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
Publication
First Author: Iwai K
Year: 2007
Journal: J Bone Miner Res
Title: RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
Volume: 22
Issue: 10
Pages: 1612-20
Publication
First Author: Ma P
Year: 2015
Journal: Blood
Title: Modulating platelet reactivity through control of RGS18 availability.
Volume: 126
Issue: 24
Pages: 2611-20
Publication
First Author: Sengupta A
Year: 2016
Journal: J Cell Sci
Title: Reciprocal regulation of alternative lineages by Rgs18 and its transcriptional repressor Gfi1b.
Volume: 129
Issue: 1
Pages: 145-54
Publication
First Author: DeHelian D
Year: 2020
Journal: Blood
Title: RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival.
Volume: 136
Issue: 15
Pages: 1773-1782
Publication
First Author: Gagnon AW
Year: 2002
Journal: Cell Signal
Title: Cloning and characterization of a novel regulator of G protein signalling in human platelets.
Volume: 14
Issue: 7
Pages: 595-606
Protein
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
Publication
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume: 18
Issue: 5
Pages: 579-91
Publication
First Author: Park IK
Year: 2001
Journal: J Biol Chem
Title: Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.
Volume: 276
Issue: 2
Pages: 915-23
Publication
First Author: Delesque-Touchard N
Year: 2014
Journal: PLoS One
Title: Regulator of G-protein signaling 18 controls both platelet generation and function.
Volume: 9
Issue: 11
Pages: e113215
Publication
First Author: Alshbool FZ
Year: 2015
Journal: Biochem Biophys Res Commun
Title: The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.
Volume: 462
Issue: 4
Pages: 378-82
Publication
First Author: Nagata Y
Year: 2001
Journal: Blood
Title: A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.
Volume: 97
Issue: 10
Pages: 3051-60
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: 1. Liver 1
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: 3. Liver 2
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: 5. Liver 3
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738122
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619222
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1774322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 1
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738122
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619222
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1774322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 2
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1624622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752422
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1640522
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1646922
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738122
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672722
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619222
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3036123
Assay Type: Northern blot
Annotation Date: 2004-04-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1774322
Stage: TS22
Assay Id: MGI:3036754
Age: embryonic day 14.0
Specimen Label: (-liver) 3
Detected: false
Specimen Num: 6
Publication
First Author: Yalcin B
Year: 2004
Journal: Nat Genet
Title: Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
Volume: 36
Issue: 11
Pages: 1197-202
Publication
First Author: Sierra DA
Year: 2002
Journal: Genomics
Title: Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Volume: 79
Issue: 2
Pages: 177-85
Publication      
First Author: MouseBookTM
Year: 2005
Journal: Unpublished
Title: Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK.
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database