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Search results 1 to 100 out of 370 for Rgs2

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
5997 | RGS2
Type: gene
Organism: human
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Gene
595010 | rgs2
Type: gene
Organism: frog, western clawed
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Gene
84583 | Rgs2
Type: gene
Organism: rat
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Gene
488584 | RGS2
Type: gene
Organism: dog, domestic
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Gene
469623 | RGS2
Type: gene
Organism: chimpanzee
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Gene
100848920 | RGS2
Type: gene
Organism: cattle
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Gene
378912 | RGS2
Type: gene
Organism: chicken
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Gene
436935 | rgs2
Type: gene
Organism: zebrafish
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Gene
712617 | RGS2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR034947 | RGS2
Type: Family
Description: RGS2 is a member of B/R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signaling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS2 blocks Gq-alpha mediated signalling []. It lacks Gs-alpha GAP activity, but can directly inhibit the activity of several adenylyl cyclase isoforms []. RGS2 is involved in the regulation of multiple G-protein linked signaling pathways. It plays a crucial role in the pathogenesis of cardiovascular diseases [, ].
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Protein Coding Gene
MGI:1098271 | Rgs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12588881 | J:89314
First Author: Le TH
Year: 2003
Journal: J Clin Invest
Title: RGS2: a "turn-off" in hypertension.
Volume: 111
Issue: 4
Pages: 441-3
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Protein
O08849
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Publication
20036967 | -
 
First Author: Tsang S
Year: 2010
Journal: Front Biosci (Schol Ed)
Title: Deregulation of RGS2 in cardiovascular diseases.
Volume: 2
Pages: 547-57
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Publication
16895908 | J:117181
First Author: Schoeber JP
Year: 2006
Journal: J Biol Chem
Title: RGS2 inhibits the epithelial Ca2+ channel TRPV6.
Volume: 281
Issue: 40
Pages: 29669-74
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Publication
20847141 | J:185902
First Author: Gurley SB
Year: 2010
Journal: J Am Soc Nephrol
Title: Renal actions of RGS2 control blood pressure.
Volume: 21
Issue: 11
Pages: 1847-51
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Publication
36307046 | J:330964
 
First Author: Deng Y
Year: 2022
Journal: Mol Metab
Title: Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.
Volume: 66
Pages: 101622
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Publication
19478087 | J:228415
First Author: Kimple AJ
Year: 2009
Journal: J Biol Chem
Title: Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Volume: 284
Issue: 29
Pages: 19402-11
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Publication
31633064 | J:288819
 
First Author: Mark MD
Year: 2019
Journal: Commun Biol
Title: RGS2 drives male aggression in mice via the serotonergic system.
Volume: 2
Pages: 373
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Publication
36653442 | J:340142
First Author: Tang C
Year: 2023
Journal: Exp Mol Med
Title: RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy.
Volume: 55
Issue: 1
Pages: 240-252
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Publication
21291891 | J:172850
First Author: Chakir K
Year: 2011
Journal: J Mol Cell Cardiol
Title: RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
Volume: 50
Issue: 6
Pages: 1000-7
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Protein
A0A087WPY2
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Publication
11906816 | -
First Author: Kehrl JH
Year: 2002
Journal: Int J Biochem Cell Biol
Title: RGS2: a multifunctional regulator of G-protein signaling.
Volume: 34
Issue: 5
Pages: 432-8
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Publication
25970626 | J:235324
First Author: Sjögren B
Year: 2015
Journal: PLoS One
Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Volume: 10
Issue: 5
Pages: e0123581
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Publication
16950156 | J:122966
First Author: Han J
Year: 2006
Journal: Neuron
Title: RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels.
Volume: 51
Issue: 5
Pages: 575-86
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Publication
22080612 | J:351718
First Author: Holden NS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.
Volume: 108
Issue: 49
Pages: 19713-8
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Publication
28107494 | J:245715
First Author: George T
Year: 2017
Journal: PLoS One
Title: Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.
Volume: 12
Issue: 1
Pages: e0170269
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Publication
37848733 | J:350107
First Author: Gumusoglu SB
Year: 2024
Journal: Neuropsychopharmacology
Title: Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk.
Volume: 49
Issue: 5
Pages: 864-875
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Publication
16950788 | J:117382
First Author: Roy AA
Year: 2006
Journal: J Biol Chem
Title: Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.
Volume: 281
Issue: 43
Pages: 32684-93
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Publication
15563583 | J:114286
First Author: Sun X
Year: 2005
Journal: Mol Pharmacol
Title: RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.
Volume: 67
Issue: 3
Pages: 631-9
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Publication
26811058 | J:351720
 
First Author: Jie L
Year: 2016
Journal: Physiol Rep
Title: RGS2 squelches vascular Gi/o and Gq signaling to modulate myogenic tone and promote uterine blood flow.
Volume: 4
Issue: 2
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Publication
10614620 | J:59152
First Author: Miles RR
Year: 2000
Journal: Endocrinology
Title: Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms.
Volume: 141
Issue: 1
Pages: 28-36
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Publication
30305828 | J:353448
 
First Author: George T
Year: 2018
Journal: Allergy Asthma Clin Immunol
Title: A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation.
Volume: 14
Pages: 40
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Publication
15489855 | J:93903
First Author: Yalcin B
Year: 2004
Journal: Nat Genet
Title: Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
Volume: 36
Issue: 11
Pages: 1197-202
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Publication
30412338 | J:309446
First Author: Jiang M
Year: 2019
Journal: Mol Reprod Dev
Title: Uterine RGS2 expression is regulated by exogenous estrogen and progesterone in ovariectomized mice, and downregulation of RGS2 expression in artificial decidualized ESCs inhibits trophoblast spreading in vitro.
Volume: 86
Issue: 1
Pages: 88-99
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Protein
A0A087WRB0
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Publication
16226429 | -
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume: 18
Issue: 5
Pages: 579-91
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Publication
32679115 | J:300831
 
First Author: Zhu C
Year: 2020
Journal: Brain Res
Title: Silencing of RGS2 enhances hippocampal neuron regeneration and rescues depression-like behavioral impairments through activation of cAMP pathway.
Volume: 1746
Pages: 147018
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Publication
21982117 | J:351715
First Author: Greenbaum L
Year: 2012
Journal: Eur Neuropsychopharmacol
Title: Alteration in RGS2 expression level is associated with changes in haloperidol induced extrapyramidal features in a mutant mouse model.
Volume: 22
Issue: 5
Pages: 379-86
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Publication
22040681 | J:351803
First Author: Lifschytz T
Year: 2012
Journal: Int J Neuropsychopharmacol
Title: Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement.
Volume: 15
Issue: 9
Pages: 1307-18
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Publication
21494556 | J:172225
First Author: Boelte KC
Year: 2011
Journal: PLoS One
Title: Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1.
Volume: 6
Issue: 4
Pages: e18534
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Publication
31865781 | J:287237
First Author: Perschbacher KJ
Year: 2020
Journal: Hypertension
Title: Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
Volume: 75
Issue: 2
Pages: 569-579
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Publication
27463806 | J:248952
First Author: Jiang MX
Year: 2016
Journal: PLoS One
Title: Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro.
Volume: 11
Issue: 7
Pages: e0159535
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Publication
17965710 | J:130787
First Author: Labouèbe G
Year: 2007
Journal: Nat Neurosci
Title: RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.
Volume: 10
Issue: 12
Pages: 1559-68
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Publication
36259376 | J:352970
First Author: Ritter ML
Year: 2022
Journal: Hypertension
Title: Cardiometabolic Consequences of Deleting the Regulator of G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.
Volume: 79
Issue: 12
Pages: 2843-2853
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GXD Expression
GXD Expression
   
Probe: MGI:6363247
Assay Type: Western blot
Annotation Date: 2019-10-11
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6363357
Age: postnatal adult
Image: 4
Specimen Label: Rgs2 KO
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6363247
Assay Type: Western blot
Annotation Date: 2019-10-11
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6363357
Age: postnatal adult
Image: 4
Specimen Label: Rgs2 KO
Detected: true
Specimen Num: 4
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Publication
11027316 | J:77273
First Author: Oliveira-Dos-Santos AJ
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Regulation of T cell activation, anxiety, and male aggression by RGS2.
Volume: 97
Issue: 22
Pages: 12272-7
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Publication
19736320 | J:153836
First Author: Nguyen CH
Year: 2009
Journal: J Cell Biol
Title: Translational control by RGS2.
Volume: 186
Issue: 5
Pages: 755-65
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Publication
12588882 | J:81893
First Author: Heximer SP
Year: 2003
Journal: J Clin Invest
Title: Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
Volume: 111
Issue: 4
Pages: 445-52
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Publication
24973550 | J:218502
First Author: Jang HS
Year: 2014
Journal: Biochim Biophys Acta
Title: Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis.
Volume: 1842
Issue: 9
Pages: 1733-41
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Publication
22354966 | J:184284
First Author: Osei-Owusu P
Year: 2012
Journal: J Biol Chem
Title: Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Volume: 287
Issue: 15
Pages: 12541-9
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Publication
19262744 | J:152507
 
First Author: Inoue-Mochita M
Year: 2009
Journal: Mol Vis
Title: RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.
Volume: 15
Pages: 495-504
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Publication
28974581 | J:253137
First Author: Kanai SM
Year: 2017
Journal: J Biol Chem
Title: Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction.
Volume: 292
Issue: 47
Pages: 19266-19278
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Publication
22704538 | J:351716
First Author: Xie Y
Year: 2012
Journal: J Allergy Clin Immunol
Title: Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness.
Volume: 130
Issue: 4
Pages: 968-76.e3
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Publication
28542139 | J:351717
First Author: Dong H
Year: 2017
Journal: Cell Death Dis
Title: Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function.
Volume: 8
Issue: 5
Pages: e2821
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Publication
16269576 | J:115763
First Author: Obst M
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: NO-dependent blood pressure regulation in RGS2-deficient mice.
Volume: 290
Issue: 4
Pages: R1012-9
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Publication
22158566 | J:351802
First Author: Kim DH
Year: 2012
Journal: J Infect Dis
Title: RGS2-mediated intracellular Ca2+ level plays a key role in the intracellular replication of Brucella abortus within phagocytes.
Volume: 205
Issue: 3
Pages: 445-52
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Publication
21500190 | J:181080
First Author: Wolff DW
Year: 2012
Journal: Int J Cancer
Title: Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth.
Volume: 130
Issue: 7
Pages: 1521-31
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Publication
27549302 | J:318384
First Author: Xie Y
Year: 2016
Journal: Respir Res
Title: Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.
Volume: 17
Issue: 1
Pages: 103
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Publication
25368964 | J:351719
First Author: Jiang H
Year: 2015
Journal: Am J Respir Cell Mol Biol
Title: Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma.
Volume: 53
Issue: 1
Pages: 42-9
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Publication
12968938 | J:85617
First Author: Huang ZP
Year: 2003
Journal: Reproduction
Title: Expression of regulator of G-protein signalling protein 2 (RGS2) in the mouse uterus at implantation sites.
Volume: 126
Issue: 3
Pages: 309-16
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Publication
28641980 | J:253730
 
First Author: Lee KN
Year: 2017
Journal: J Mol Cell Cardiol
Title: Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice.
Volume: 108
Pages: 194-202
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Publication
17475820 | J:150246
First Author: Zuber AM
Year: 2007
Journal: J Am Soc Nephrol
Title: Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.
Volume: 18
Issue: 6
Pages: 1672-8
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Publication
15661972 | J:97731
First Author: Gross V
Year: 2005
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
Volume: 288
Issue: 5
Pages: R1134-42
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Publication
26193676 | J:301937
First Author: Osei-Owusu P
Year: 2015
Journal: PLoS One
Title: Regulation of Renal Hemodynamics and Function by RGS2.
Volume: 10
Issue: 7
Pages: e0132594
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Publication
15292238 | J:93456
First Author: Wang X
Year: 2004
Journal: J Biol Chem
Title: Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells.
Volume: 279
Issue: 40
Pages: 41642-9
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Publication
22802950 | J:189638
First Author: Park-Windhol C
Year: 2012
Journal: PLoS One
Title: Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2.
Volume: 7
Issue: 7
Pages: e40048
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Publication
17613534 | J:124654
First Author: Xie Z
Year: 2007
Journal: J Biol Chem
Title: Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
Volume: 282
Issue: 35
Pages: 25278-89
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Publication
9079700 | J:39294
First Author: Chen C
Year: 1997
Journal: J Biol Chem
Title: Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.
Volume: 272
Issue: 13
Pages: 8679-85
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Publication
30036561 | J:359334
 
First Author: Rorabaugh BR
Year: 2018
Journal: Physiol Behav
Title: Regulators of G-protein signaling 2 and 4 differentially regulate cocaine-induced rewarding effects.
Volume: 195
Pages: 9-19
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Publication
27303056 | J:261275
First Author: Narla C
Year: 2016
Journal: Sci Signal
Title: A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains.
Volume: 9
Issue: 432
Pages: ra60
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Publication
26160904 | J:239803
First Author: Bernhardt ML
Year: 2015
Journal: Development
Title: Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs.
Volume: 142
Issue: 15
Pages: 2633-40
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Publication
19127022 | J:146192
First Author: Takimoto E
Year: 2009
Journal: J Clin Invest
Title: Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Volume: 119
Issue: 2
Pages: 408-20
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Publication
17464283 | J:154724
First Author: Wang X
Year: 2007
Journal: EMBO J
Title: Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors.
Volume: 26
Issue: 11
Pages: 2768-76
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Publication
19966055 | J:158454
First Author: Tuomi JM
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse.
Volume: 298
Issue: 2
Pages: H554-61
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Publication
15661635 | J:95375
First Author: Wilson LD
Year: 2005
Journal: Gene Expr Patterns
Title: Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary.
Volume: 5
Issue: 3
Pages: 305-11
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Protein Coding Gene
MGP_CAROLIEiJ_G0014678 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0016565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0016548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0016513 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0016508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1098271 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016969 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016413 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016411 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016484 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016437 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017005 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015698 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027914 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015485 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14608379 | J:86774
First Author: Tang KM
Year: 2003
Journal: Nat Med
Title: Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Volume: 9
Issue: 12
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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