|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 355 for Rgs2

<< First    < Previous  |  Next >    Last >>
0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: RGS2 is a member of B/R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signaling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS2 blocks Gq-alpha mediated signalling []. It lacks Gs-alpha GAP activity, but can directly inhibit the activity of several adenylyl cyclase isoforms []. RGS2 is involved in the regulation of multiple G-protein linked signaling pathways. It plays a crucial role in the pathogenesis of cardiovascular diseases [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Le TH
Year: 2003
Journal: J Clin Invest
Title: RGS2: a "turn-off" in hypertension.
Volume: 111
Issue: 4
Pages: 441-3
Protein
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
Publication  
First Author: Tsang S
Year: 2010
Journal: Front Biosci (Schol Ed)
Title: Deregulation of RGS2 in cardiovascular diseases.
Volume: 2
Pages: 547-57
Publication
First Author: Schoeber JP
Year: 2006
Journal: J Biol Chem
Title: RGS2 inhibits the epithelial Ca2+ channel TRPV6.
Volume: 281
Issue: 40
Pages: 29669-74
Publication
First Author: Gurley SB
Year: 2010
Journal: J Am Soc Nephrol
Title: Renal actions of RGS2 control blood pressure.
Volume: 21
Issue: 11
Pages: 1847-51
Publication  
First Author: Deng Y
Year: 2022
Journal: Mol Metab
Title: Elucidating the role of Rgs2 expression in the PVN for metabolic homeostasis in mice.
Volume: 66
Pages: 101622
Publication  
First Author: Mark MD
Year: 2019
Journal: Commun Biol
Title: RGS2 drives male aggression in mice via the serotonergic system.
Volume: 2
Pages: 373
Publication
First Author: Tang C
Year: 2023
Journal: Exp Mol Med
Title: RGS2 promotes estradiol biosynthesis by trophoblasts during human pregnancy.
Volume: 55
Issue: 1
Pages: 240-252
Publication
First Author: Kimple AJ
Year: 2009
Journal: J Biol Chem
Title: Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Volume: 284
Issue: 29
Pages: 19402-11
Publication
First Author: Chakir K
Year: 2011
Journal: J Mol Cell Cardiol
Title: RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
Volume: 50
Issue: 6
Pages: 1000-7
Protein
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
Publication
First Author: Kehrl JH
Year: 2002
Journal: Int J Biochem Cell Biol
Title: RGS2: a multifunctional regulator of G-protein signaling.
Volume: 34
Issue: 5
Pages: 432-8
Publication
First Author: Sjögren B
Year: 2015
Journal: PLoS One
Title: FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.
Volume: 10
Issue: 5
Pages: e0123581
Publication
First Author: Han J
Year: 2006
Journal: Neuron
Title: RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels.
Volume: 51
Issue: 5
Pages: 575-86
Publication
First Author: George T
Year: 2017
Journal: PLoS One
Title: Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.
Volume: 12
Issue: 1
Pages: e0170269
Publication
First Author: Roy AA
Year: 2006
Journal: J Biol Chem
Title: Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.
Volume: 281
Issue: 43
Pages: 32684-93
Publication
First Author: Sun X
Year: 2005
Journal: Mol Pharmacol
Title: RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.
Volume: 67
Issue: 3
Pages: 631-9
Publication
First Author: Miles RR
Year: 2000
Journal: Endocrinology
Title: Dynamic regulation of RGS2 in bone: potential new insights into parathyroid hormone signaling mechanisms.
Volume: 141
Issue: 1
Pages: 28-36
Publication
First Author: Yalcin B
Year: 2004
Journal: Nat Genet
Title: Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
Volume: 36
Issue: 11
Pages: 1197-202
Publication
First Author: Jiang M
Year: 2019
Journal: Mol Reprod Dev
Title: Uterine RGS2 expression is regulated by exogenous estrogen and progesterone in ovariectomized mice, and downregulation of RGS2 expression in artificial decidualized ESCs inhibits trophoblast spreading in vitro.
Volume: 86
Issue: 1
Pages: 88-99
Publication  
First Author: Zhu C
Year: 2020
Journal: Brain Res
Title: Silencing of RGS2 enhances hippocampal neuron regeneration and rescues depression-like behavioral impairments through activation of cAMP pathway.
Volume: 1746
Pages: 147018
Publication
First Author: Boelte KC
Year: 2011
Journal: PLoS One
Title: Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1.
Volume: 6
Issue: 4
Pages: e18534
Protein
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
Publication
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume: 18
Issue: 5
Pages: 579-91
Publication
First Author: Perschbacher KJ
Year: 2020
Journal: Hypertension
Title: Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
Volume: 75
Issue: 2
Pages: 569-579
Publication
First Author: Jiang MX
Year: 2016
Journal: PLoS One
Title: Inhibition of the Binding between RGS2 and β-Tubulin Interferes with Spindle Formation and Chromosome Segregation during Mouse Oocyte Maturation In Vitro.
Volume: 11
Issue: 7
Pages: e0159535
Publication
First Author: Labouèbe G
Year: 2007
Journal: Nat Neurosci
Title: RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.
Volume: 10
Issue: 12
Pages: 1559-68
GXD Expression    
Probe: MGI:6363247
Assay Type: Western blot
Annotation Date: 2019-10-11
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6363357
Age: postnatal adult
Image: 4
Specimen Label: Rgs2 KO
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6363247
Assay Type: Western blot
Annotation Date: 2019-10-11
Strength: Present
Sex: Female
Emaps: EMAPS:3575528
Stage: TS28
Assay Id: MGI:6363357
Age: postnatal adult
Image: 4
Specimen Label: Rgs2 KO
Detected: true
Specimen Num: 4
Publication
First Author: Oliveira-Dos-Santos AJ
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Regulation of T cell activation, anxiety, and male aggression by RGS2.
Volume: 97
Issue: 22
Pages: 12272-7
Publication
First Author: Nguyen CH
Year: 2009
Journal: J Cell Biol
Title: Translational control by RGS2.
Volume: 186
Issue: 5
Pages: 755-65
Publication
First Author: Osei-Owusu P
Year: 2012
Journal: J Biol Chem
Title: Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Volume: 287
Issue: 15
Pages: 12541-9
Publication
First Author: Heximer SP
Year: 2003
Journal: J Clin Invest
Title: Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.
Volume: 111
Issue: 4
Pages: 445-52
Publication
First Author: Wolff DW
Year: 2012
Journal: Int J Cancer
Title: Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth.
Volume: 130
Issue: 7
Pages: 1521-31
Publication
First Author: Kanai SM
Year: 2017
Journal: J Biol Chem
Title: Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction.
Volume: 292
Issue: 47
Pages: 19266-19278
Publication
First Author: Jang HS
Year: 2014
Journal: Biochim Biophys Acta
Title: Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis.
Volume: 1842
Issue: 9
Pages: 1733-41
Publication  
First Author: Inoue-Mochita M
Year: 2009
Journal: Mol Vis
Title: RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival.
Volume: 15
Pages: 495-504
Publication
First Author: Obst M
Year: 2006
Journal: Am J Physiol Regul Integr Comp Physiol
Title: NO-dependent blood pressure regulation in RGS2-deficient mice.
Volume: 290
Issue: 4
Pages: R1012-9
Publication
First Author: Huang ZP
Year: 2003
Journal: Reproduction
Title: Expression of regulator of G-protein signalling protein 2 (RGS2) in the mouse uterus at implantation sites.
Volume: 126
Issue: 3
Pages: 309-16
Publication  
First Author: Lee KN
Year: 2017
Journal: J Mol Cell Cardiol
Title: Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice.
Volume: 108
Pages: 194-202
Publication
First Author: Xie Y
Year: 2016
Journal: Respir Res
Title: Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.
Volume: 17
Issue: 1
Pages: 103
Publication
First Author: Zuber AM
Year: 2007
Journal: J Am Soc Nephrol
Title: Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.
Volume: 18
Issue: 6
Pages: 1672-8
Publication
First Author: Osei-Owusu P
Year: 2015
Journal: PLoS One
Title: Regulation of Renal Hemodynamics and Function by RGS2.
Volume: 10
Issue: 7
Pages: e0132594
Publication
First Author: Gross V
Year: 2005
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.
Volume: 288
Issue: 5
Pages: R1134-42
Publication
First Author: Wang X
Year: 2004
Journal: J Biol Chem
Title: Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells.
Volume: 279
Issue: 40
Pages: 41642-9
Publication
First Author: Park-Windhol C
Year: 2012
Journal: PLoS One
Title: Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2.
Volume: 7
Issue: 7
Pages: e40048
Publication
First Author: Xie Z
Year: 2007
Journal: J Biol Chem
Title: Group VIA phospholipase A2 (iPLA2beta) participates in angiotensin II-induced transcriptional up-regulation of regulator of g-protein signaling-2 in vascular smooth muscle cells.
Volume: 282
Issue: 35
Pages: 25278-89
Publication
First Author: Chen C
Year: 1997
Journal: J Biol Chem
Title: Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.
Volume: 272
Issue: 13
Pages: 8679-85
Publication
First Author: Narla C
Year: 2016
Journal: Sci Signal
Title: A switch in G protein coupling for type 1 corticotropin-releasing factor receptors promotes excitability in epileptic brains.
Volume: 9
Issue: 432
Pages: ra60
Publication
First Author: Takimoto E
Year: 2009
Journal: J Clin Invest
Title: Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Volume: 119
Issue: 2
Pages: 408-20
Publication
First Author: Bernhardt ML
Year: 2015
Journal: Development
Title: Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs.
Volume: 142
Issue: 15
Pages: 2633-40
Publication
First Author: Wang X
Year: 2007
Journal: EMBO J
Title: Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors.
Volume: 26
Issue: 11
Pages: 2768-76
Publication
First Author: Tuomi JM
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse.
Volume: 298
Issue: 2
Pages: H554-61
Publication
First Author: Wilson LD
Year: 2005
Journal: Gene Expr Patterns
Title: Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary.
Volume: 5
Issue: 3
Pages: 305-11
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tang KM
Year: 2003
Journal: Nat Med
Title: Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Volume: 9
Issue: 12
Pages: 1506-12
Publication
First Author: Tank J
Year: 2007
Journal: Auton Neurosci
Title: Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.
Volume: 136
Issue: 1-2
Pages: 52-7
Publication
First Author: Mederos y Schnitzler M
Year: 2008
Journal: EMBO J
Title: Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction.
Volume: 27
Issue: 23
Pages: 3092-103
Publication
First Author: Yalcin B
Year: 2005
Journal: Genetics
Title: Using progenitor strain information to identify quantitative trait nucleotides in outbred mice.
Volume: 171
Issue: 2
Pages: 673-81
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: whole brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: cortex
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: subcortical region
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: cerebellum
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: brainstem
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: olfactory bulb
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: spinal cord
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: eyes
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: harderian gland
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: heart
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: lung
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3624983
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3624985
Age: postnatal
Image: Gene 460 RT-PCR
Specimen Label: liver
Detected: true
Specimen Num: 12