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Search results 1 to 100 out of 897 for Rgs4

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: RGS4 is a memberof R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS4 is expressed widely in brain and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling []. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia [, , ]. RGS4 also is up-regulated in the failing human heart []. RGS4 interacts with many binding partners outside of GPCR pathways, including PIP, calcium/CaM, PA and 14-3-3 [, ].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
Publication
First Author: Lerner TN
Year: 2012
Journal: Neuron
Title: RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits.
Volume: 73
Issue: 2
Pages: 347-59
Publication
First Author: Madigan LA
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.
Volume: 58
Issue: 1
Pages: 89-98
Publication
First Author: Owen VJ
Year: 2001
Journal: Eur Heart J
Title: Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure.
Volume: 22
Issue: 12
Pages: 1015-20
Publication
First Author: Grillet N
Year: 2005
Journal: Mol Cell Biol
Title: Generation and characterization of Rgs4 mutant mice.
Volume: 25
Issue: 10
Pages: 4221-8
Publication
First Author: Joshi IV
Year: 2024
Journal: J Biol Chem
Title: RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.
Volume: 300
Issue: 4
Pages: 107127
Publication
First Author: Avrampou K
Year: 2019
Journal: J Neurosci
Title: RGS4 Maintains Chronic Pain Symptoms in Rodent Models.
Volume: 39
Issue: 42
Pages: 8291-8304
Publication
First Author: Bowden NA
Year: 2007
Journal: Schizophr Res
Title: Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia.
Volume: 89
Issue: 1-3
Pages: 165-8
Publication
First Author: Hooks SB
Year: 2008
Journal: Biochem Pharmacol
Title: A role of RGS proteins in drug addiction.
Volume: 75
Issue: 1
Pages: 76-84
Publication
First Author: Riddle EL
Year: 2005
Journal: Circ Res
Title: Multi-tasking RGS proteins in the heart: the next therapeutic target?
Volume: 96
Issue: 4
Pages: 401-11
Publication
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: Modulation of subfamily B/R4 RGS protein function by 14-3-3 proteins.
Volume: 18
Issue: 12
Pages: 2209-22
Publication
First Author: Siedlecki A
Year: 2010
Journal: Am J Transplant
Title: RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity.
Volume: 10
Issue: 2
Pages: 231-41
Publication
First Author: Jaba IM
Year: 2013
Journal: J Clin Invest
Title: NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth.
Volume: 123
Issue: 4
Pages: 1718-31
Publication
First Author: Bansal G
Year: 2007
Journal: Pharmacol Ther
Title: R4 RGS proteins: regulation of G-protein signaling and beyond.
Volume: 116
Issue: 3
Pages: 473-95
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
Publication
First Author: Cifelli C
Year: 2008
Journal: Circ Res
Title: RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.
Volume: 103
Issue: 5
Pages: 527-35
Publication
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume: 18
Issue: 5
Pages: 579-91
Publication  
First Author: Bastin G
Year: 2020
Journal: J Cell Sci
Title: RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
Volume: 133
Issue: 12
Publication
First Author: Pang P
Year: 2015
Journal: Kidney Int
Title: RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm.
Volume: 87
Issue: 4
Pages: 771-83
Publication
First Author: Wong GS
Year: 2020
Journal: J Allergy Clin Immunol
Title: RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
Volume: 146
Issue: 5
Pages: 1152-1164.e13
Publication
First Author: Nomoto S
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Distribution of RGS4 mRNA in mouse brain shown by in situ hybridization.
Volume: 241
Issue: 2
Pages: 281-7
Publication
First Author: Chen Y
Year: 2012
Journal: J Neurosci
Title: Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine.
Volume: 32
Issue: 8
Pages: 2683-95
Publication
First Author: Song KS
Year: 2009
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway.
Volume: 296
Issue: 4
Pages: L684-92
Publication  
First Author: Pallaki P
Year: 2017
Journal: Neuropharmacology
Title: A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation.
Volume: 117
Pages: 408-421
Publication
First Author: Wang Q
Year: 2009
Journal: J Biol Chem
Title: Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.
Volume: 284
Issue: 27
Pages: 18357-67
Publication
First Author: Ruiz de Azua I
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.
Volume: 107
Issue: 17
Pages: 7999-8004
Publication
First Author: Lee MJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Volume: 102
Issue: 42
Pages: 15030-5
Publication
First Author: Ding L
Year: 2007
Journal: Gene
Title: Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain.
Volume: 401
Issue: 1-2
Pages: 46-60
Publication
First Author: McOmish CE
Year: 2008
Journal: Hippocampus
Title: PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression.
Volume: 18
Issue: 8
Pages: 824-34
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191205
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rgs4
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191205
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rgs4
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191205
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rgs4
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191205
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rgs4
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191205
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rgs4
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191205
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rgs4
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6182186
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191205
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rgs4
Detected: true
Specimen Num: 5
Publication
First Author: Grillet N
Year: 2003
Journal: J Neurosci
Title: Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.
Volume: 23
Issue: 33
Pages: 10613-21
Publication
First Author: Ebert PJ
Year: 2006
Journal: Neuroscience
Title: Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortex.
Volume: 142
Issue: 4
Pages: 1145-61
Publication
First Author: Hoekstra EJ
Year: 2013
Journal: Eur J Neurosci
Title: Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
Volume: 37
Issue: 1
Pages: 23-32
GXD Expression
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1630117
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 1C
Note: Expressed in the ventral region, which had already undergone their last S phase. The more superficially located, thus presumably older postmitotic precursors, had already lost Rgs4 expression.
Specimen Label: 1C
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:1278286
Assay Type: RNA in situ
Annotation Date: 2024-06-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679517
Pattern: Regionally restricted
Stage: TS17
Assay Id: MGI:7645412
Age: embryonic day 10.5
Image: 4C
Note: Phox2a+ cells delaminated from the glossopharyngeal placode (pIX) and switched on Rgs4 as they aggregated to form the ganglion anlage (gIX).
Specimen Label: 4C
Detected: true
Specimen Num: 20
Publication
First Author: Iankova I
Year: 2008
Journal: Endocrinology
Title: Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.
Volume: 149
Issue: 11
Pages: 5706-12
Publication  
First Author: Ashrafi A
Year: 2017
Journal: Neurobiol Aging
Title: Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease.
Volume: 58
Pages: 30-33
Publication
First Author: Opel A
Year: 2015
Journal: J Biol Chem
Title: Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.
Volume: 290
Issue: 31
Pages: 19233-44
Publication
First Author: Siedlecki AM
Year: 2011
Journal: Kidney Int
Title: RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.
Volume: 80
Issue: 3
Pages: 263-71
Publication
First Author: Dripps IJ
Year: 2017
Journal: Psychopharmacology (Berl)
Title: The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors.
Volume: 234
Issue: 1
Pages: 29-39
Publication
First Author: Stratinaki M
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.
Volume: 110
Issue: 20
Pages: 8254-9
Publication
First Author: Han MH
Year: 2010
Journal: Biol Psychiatry
Title: Brain region specific actions of regulator of G protein signaling 4 oppose morphine reward and dependence but promote analgesia.
Volume: 67
Issue: 8
Pages: 761-9
Publication
First Author: Pisanò CA
Year: 2023
Journal: Br J Pharmacol
Title: Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
Volume: 180
Issue: 7
Pages: 927-942
Publication
First Author: Tokudome T
Year: 2008
Journal: Circulation
Title: Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
Volume: 117
Issue: 18
Pages: 2329-39
Publication  
First Author: Rorabaugh BR
Year: 2018
Journal: Physiol Behav
Title: Regulators of G-protein signaling 2 and 4 differentially regulate cocaine-induced rewarding effects.
Volume: 195
Pages: 9-19
Publication
First Author: Wydeven N
Year: 2014
Journal: J Biol Chem
Title: RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.
Volume: 289
Issue: 4
Pages: 2440-9
Publication
First Author: Harris IS
Year: 2004
Journal: Diabetes
Title: G-protein signaling participates in the development of diabetic cardiomyopathy.
Volume: 53
Issue: 12
Pages: 3082-90
Publication
First Author: Harder S
Year: 2001
Journal: Endocrinology
Title: Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2).
Volume: 142
Issue: 3
Pages: 1188-94
Publication
First Author: Pacey LK
Year: 2011
Journal: Mol Cell Neurosci
Title: Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.
Volume: 46
Issue: 3
Pages: 563-72
Publication  
First Author: Winden KD
Year: 2009
Journal: Mol Syst Biol
Title: The organization of the transcriptional network in specific neuronal classes.
Volume: 5
Pages: 291
Publication
First Author: Samadi M
Year: 2023
Journal: Hippocampus
Title: Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
Volume: 33
Issue: 6
Pages: 730-744
Publication
First Author: Serafimidis I
Year: 2011
Journal: Mol Cell Biol
Title: G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis.
Volume: 31
Issue: 22
Pages: 4442-53
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: brain - total
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: cortex
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: brain medulla
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: cerebellum
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: brainstem
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: olfactory bulb
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: spinal cord
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: eye
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: harderian gland
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: heart
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3624990
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3624991
Age: postnatal
Specimen Label: lung
Detected: true
Specimen Num: 11