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Search results 1 to 100 out of 697 for Rgs5

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0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: RGS5 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) []. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).RGS5 may have a role in pericyte (peri-endothelial cell) and vascular smooth muscle cell development and function [, , ]. It is also expressed is the heart, where it is upregulated by beta-adrenergic mediated induction [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Bondjers C
Year: 2003
Journal: Am J Pathol
Title: Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells.
Volume: 162
Issue: 3
Pages: 721-9
GXD Expression  
Probe: MGI:938976
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2622022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825696
Age: embryonic day 14.5
Image: Additional file 4 Rgs5
Specimen Label: Additional file 4 Rgs5
Detected: true
Specimen Num: 1
Gene
Type: gene
Organism: human
Protein
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
GXD Expression
Probe: MGI:7439083
Assay Type: RNA in situ
Annotation Date: 2023-02-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3187615
Pattern: Single cells
Stage: TS15
Assay Id: MGI:7439163
Age: embryonic day 9.5
Image: 3 - Rgs5 - +/+
Note: Expression is seen in spiral artery-associated trophoblast giant cells (SpA-TGCs).
Specimen Label: 3 - Rgs5 - +/+
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7439083
Assay Type: RNA in situ
Annotation Date: 2023-02-28
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3187615
Stage: TS15
Assay Id: MGI:7439163
Age: embryonic day 9.5
Image: 3 - Rgs5 - -/-
Note: The spiral artery-associated trophoblast giant cells (SpA-TGCs) are absent from the mutant.
Specimen Label: 3 - Rgs5 - -/-
Detected: false
Specimen Num: 2
Publication
First Author: Arnold C
Year: 2014
Journal: EMBO Mol Med
Title: RGS5 promotes arterial growth during arteriogenesis.
Volume: 6
Issue: 8
Pages: 1075-89
Publication
First Author: Nisancioglu MH
Year: 2008
Journal: Mol Cell Biol
Title: Generation and characterization of rgs5 mutant mice.
Volume: 28
Issue: 7
Pages: 2324-31
Publication
First Author: Cho H
Year: 2003
Journal: FASEB J
Title: Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation.
Volume: 17
Issue: 3
Pages: 440-2
Publication
First Author: Berger M
Year: 2005
Journal: Blood
Title: Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization.
Volume: 105
Issue: 3
Pages: 1094-101
Publication
First Author: Jean-Baptiste G
Year: 2005
Journal: Life Sci
Title: Beta adrenergic receptor-mediated atrial specific up-regulation of RGS5.
Volume: 76
Issue: 13
Pages: 1533-45
Publication
First Author: Zhang H
Year: 2012
Journal: FASEB J
Title: Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression.
Volume: 26
Issue: 1
Pages: 181-91
Protein
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
Publication  
First Author: Demirel E
Year: 2021
Journal: Cells
Title: RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells.
Volume: 10
Issue: 7
Publication
First Author: Cho H
Year: 2008
Journal: Mol Cell Biol
Title: Rgs5 targeting leads to chronic low blood pressure and a lean body habitus.
Volume: 28
Issue: 8
Pages: 2590-7
Publication
First Author: Qin M
Year: 2012
Journal: J Mol Cell Cardiol
Title: Absence of Rgs5 prolongs cardiac repolarization and predisposes to ventricular tachyarrhythmia in mice.
Volume: 53
Issue: 6
Pages: 880-90
Publication  
First Author: Song ZL
Year: 2021
Journal: Front Physiol
Title: Absence of Rgs5 Influences the Spatial and Temporal Fluctuation of Cardiac Repolarization in Mice.
Volume: 12
Pages: 622084
Publication
First Author: Abramow-Newerly M
Year: 2006
Journal: Cell Signal
Title: RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.
Volume: 18
Issue: 5
Pages: 579-91
Publication
First Author: Lee MJ
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Volume: 102
Issue: 42
Pages: 15030-5
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Ding HS
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Regulator of G-protein signalling 5 deficiency impairs ventricular remodelling after myocardial infarction by promoting NF-κB and MAPK signalling in mice.
Volume: 499
Issue: 2
Pages: 143-149
Publication
First Author: Holobotovskyy V
Year: 2015
Journal: Sci Transl Med
Title: Regulator of G protein signaling 5 is a determinant of gestational hypertension and preeclampsia.
Volume: 7
Issue: 290
Pages: 290ra88
Publication  
First Author: Liu C
Year: 2017
Journal: Mol Cell Neurosci
Title: Regulator of G protein signaling 5 (RGS5) inhibits sonic hedgehog function in mouse cortical neurons.
Volume: 83
Pages: 65-73
Publication
First Author: Hamzah J
Year: 2008
Journal: Nature
Title: Vascular normalization in Rgs5-deficient tumours promotes immune destruction.
Volume: 453
Issue: 7193
Pages: 410-4
Publication
First Author: Chan EC
Year: 2018
Journal: J Biol Chem
Title: Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking.
Volume: 293
Issue: 33
Pages: 12690-12702
Publication
First Author: Li H
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload.
Volume: 107
Issue: 31
Pages: 13818-23
Publication
First Author: Deng W
Year: 2012
Journal: PLoS One
Title: Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.
Volume: 7
Issue: 1
Pages: e30256
Publication
First Author: Qin M
Year: 2012
Journal: PLoS One
Title: Atrial tachyarrhythmia in Rgs5-null mice.
Volume: 7
Issue: 11
Pages: e46856
Publication
First Author: Arnold C
Year: 2018
Journal: FASEB J
Title: Hypertension-evoked RhoA activity in vascular smooth muscle cells requires RGS5.
Volume: 32
Issue: 4
Pages: 2021-2035
Publication
First Author: Wang Z
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Regulator of G-protein signaling 5 protects cardiomyocytes against apoptosis during in vitro cardiac ischemia-reperfusion in mice by inhibiting both JNK1/2 and P38 signaling pathways.
Volume: 473
Issue: 2
Pages: 551-7
Publication
First Author: Bahrami AJ
Year: 2014
Journal: PLoS One
Title: Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.
Volume: 9
Issue: 10
Pages: e108505
Publication
First Author: Roth M
Year: 2019
Journal: FASEB J
Title: Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke.
Volume: 33
Issue: 8
Pages: 8990-8998
Publication
First Author: Özen I
Year: 2018
Journal: Stroke
Title: Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke.
Volume: 49
Issue: 9
Pages: 2182-2190
Publication
First Author: Svensson A
Year: 2015
Journal: PLoS One
Title: Endogenous brain pericytes are widely activated and contribute to mouse glioma microvasculature.
Volume: 10
Issue: 4
Pages: e0123553
Publication
First Author: Holobotovskyy V
Year: 2013
Journal: Circ Res
Title: Regulator of G-protein signaling 5 controls blood pressure homeostasis and vessel wall remodeling.
Volume: 112
Issue: 5
Pages: 781-91
Publication
First Author: Balenga N
Year: 2019
Journal: J Bone Miner Res
Title: Parathyroid-Targeted Overexpression of Regulator of G-Protein Signaling 5 (RGS5) Causes Hyperparathyroidism in Transgenic Mice.
Volume: 34
Issue: 5
Pages: 955-963
Publication
First Author: Sladojevic N
Year: 2020
Journal: J Am Heart Assoc
Title: Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
Volume: 9
Issue: 18
Pages: e017533
Publication
First Author: Balenga NA
Year: 2014
Journal: J Allergy Clin Immunol
Title: Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation.
Volume: 134
Issue: 2
Pages: 451-9
Publication
First Author: Daniel JM
Year: 2016
Journal: Arterioscler Thromb Vasc Biol
Title: Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation.
Volume: 36
Issue: 2
Pages: 317-27
Publication
First Author: Chen C
Year: 1997
Journal: J Biol Chem
Title: Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast.
Volume: 272
Issue: 13
Pages: 8679-85
Publication
First Author: Ketsawatsomkron P
Year: 2012
Journal: Circ Res
Title: PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.
Volume: 111
Issue: 11
Pages: 1446-58
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Roth M
Year: 2020
Journal: J Neurosci Res
Title: Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice.
Volume: 98
Issue: 5
Pages: 826-842
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: brain - total
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: cortex
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: brain medulla
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: cerebellum
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: brainstem
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: olfactory bulb
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: spinal cord
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: eye
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: harderian gland
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: heart
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: lung
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: liver
Detected: true
Specimen Num: 12
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: pancreas
Detected: true
Specimen Num: 13
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: kidney
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: spleen
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: thymus
Detected: true
Specimen Num: 16
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: lymph nodes
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: bone marrow
Detected: true
Specimen Num: 18
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1752528
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: skin
Detected: true
Specimen Num: 19
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: gallbladder
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: urinary bladder
Detected: true
Specimen Num: 21
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: pituitary gland
Detected: true
Specimen Num: 22
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: adrenal gland
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775128
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: salivary gland
Detected: true
Specimen Num: 24
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: skeletal muscle
Detected: true
Specimen Num: 25
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718528
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: tongue
Detected: true
Specimen Num: 26
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: stomach
Detected: true
Specimen Num: 27
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: small intestine
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:3624859
Assay Type: RT-PCR
Annotation Date: 2006-06-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925228
Stage: TS28
Assay Id: MGI:3624979
Age: postnatal
Specimen Label: large intestine
Detected: true
Specimen Num: 29