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Search results 1 to 100 out of 305 for Rheb

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
6009 | RHEB
Type: gene
Organism: human
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Gene
528204 | RHEB
Type: gene
Organism: cattle
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Gene
420434 | RHEB
Type: gene
Organism: chicken
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Gene
393702 | rheb
Type: gene
Organism: zebrafish
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Gene
715378 | RHEB
Type: gene
Organism: macaque, rhesus
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Gene
548676 | rheb
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR037586 | RHEB
Type: Family
Description: Rheb is a Ras-like small GTPase essential for TORC1 activity in mammals []. Rheb activates the protein kinase activity of mTORC1 (rapamycin), and in turn stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling [, , ]. Rheb alternates between an inactive form bound to GDP and an active form bound to GTP. It is inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2 []. The mechanism of action of Rheb has been determined from the tertiary structure [].
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Gene
26954 | Rheb
Type: gene
Organism: rat
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Gene
475545 | RHEB
Type: gene
Organism: dog, domestic
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Gene
463880 | RHEB
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:97912 | Rheb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9ESR1
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
15854902 | -
First Author: Long X
Year: 2005
Journal: Curr Biol
Title: Rheb binds and regulates the mTOR kinase.
Volume: 15
Issue: 8
Pages: 702-13
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Publication
16098514 | -
First Author: Tee AR
Year: 2005
Journal: FEBS Lett
Title: Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
Volume: 579
Issue: 21
Pages: 4763-8
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Publication
12869586 | -
First Author: Inoki K
Year: 2003
Journal: Genes Dev
Title: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Volume: 17
Issue: 15
Pages: 1829-34
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Protein
Q921J2
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
15728574 | -
First Author: Yu Y
Year: 2005
Journal: J Biol Chem
Title: Structural basis for the unique biological function of small GTPase RHEB.
Volume: 280
Issue: 17
Pages: 17093-100
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Publication
29104218 | -
 
First Author: Tatebe H
Year: 2017
Journal: Biomolecules
Title: Evolutionary Conservation of the Components in the TOR Signaling Pathways.
Volume: 7
Issue: 4
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Gene
121268 | RHEBL1
Type: gene
Organism: human
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Gene
6008 | RHEBP1
Type: gene
Organism: human
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Gene
692231 | RHEBP3
Type: gene
Organism: human
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Gene
101060032 | RHEBP2
Type: gene
Organism: human
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Publication
21336308 | J:180541
First Author: Zheng M
Year: 2011
Journal: Nat Cell Biol
Title: Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Volume: 13
Issue: 3
Pages: 263-72
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Publication
21321084 | J:170999
First Author: Goorden SM
Year: 2011
Journal: Mol Cell Biol
Title: Rheb is essential for murine development.
Volume: 31
Issue: 8
Pages: 1672-8
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Protein
Q540E6
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Publication
33725483 | J:303709
First Author: Yang W
Year: 2021
Journal: Dev Cell
Title: Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Volume: 56
Issue: 6
Pages: 811-825.e6
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Publication
18708578 | J:138980
First Author: Mavrakis KJ
Year: 2008
Journal: Genes Dev
Title: Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
Volume: 22
Issue: 16
Pages: 2178-88
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Publication
35372326 | J:329059
 
First Author: Du C
Year: 2022
Journal: Front Cell Dev Biol
Title: Rheb Promotes Triglyceride Secretion and Ameliorates Diet-Induced Steatosis in the Liver.
Volume: 10
Pages: 808140
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Publication
30514904 | J:298778
First Author: Deng L
Year: 2019
Journal: Cell Res
Title: Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.
Volume: 29
Issue: 2
Pages: 136-150
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Publication
- | J:70528
   
First Author: Watanabe S
Year: 2000
Journal: GenBank Submission
Title: Mus musculus rheb mRNA for Ras homolog, complete cds
Pages: AB039919
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Publication
27960107 | J:239839
 
First Author: Shahani N
Year: 2017
Journal: Neurobiol Aging
Title: Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Volume: 50
Pages: 134-143
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Publication
31220300 | J:294498
First Author: Meng W
Year: 2019
Journal: J Mol Cell Biol
Title: Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway.
Volume: 11
Issue: 9
Pages: 781-790
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Publication
16631613 | J:338254
First Author: Buerger C
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Localization of Rheb to the endomembrane is critical for its signaling function.
Volume: 344
Issue: 3
Pages: 869-80
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Publication
29222112 | J:257623
 
First Author: Hao F
Year: 2018
Journal: J Cell Sci
Title: Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site.
Volume: 131
Issue: 3
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Publication
28242620 | J:246940
First Author: Meng W
Year: 2017
Journal: Diabetes
Title: Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway.
Volume: 66
Issue: 5
Pages: 1198-1213
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Publication
24713393 | J:213136
First Author: Baker MD
Year: 2014
Journal: Reproduction
Title: The small GTPase Rheb is required for spermatogenesis but not oogenesis.
Volume: 147
Issue: 5
Pages: 615-25
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Publication
25880340 | J:222712
 
First Author: Sugiura H
Year: 2015
Journal: Nat Commun
Title: Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.
Volume: 6
Pages: 6842
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Publication
37463107 | J:345123
First Author: Huang H
Year: 2023
Journal: Cell Rep
Title: Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis.
Volume: 42
Issue: 7
Pages: 112801
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191206
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rheb
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191206
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rheb
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191206
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rheb
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191206
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rheb
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191206
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rheb
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191206
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rheb
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6182208
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191206
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rheb
Detected: true
Specimen Num: 7
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Publication
22294621 | J:196624
First Author: Sciarretta S
Year: 2012
Journal: Circulation
Title: Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.
Volume: 125
Issue: 9
Pages: 1134-46
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Publication
29175333 | J:272444
First Author: Peng H
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.
Volume: 495
Issue: 1
Pages: 1129-1135
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Publication
31315433 | J:327125
First Author: Zhang Q
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Rheb (Ras Homolog Enriched in Brain 1) Deficiency in Mature Macrophages Prevents Atherosclerosis by Repressing Macrophage Proliferation, Inflammation, and Lipid Uptake.
Volume: 39
Issue: 9
Pages: 1787-1801
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Publication
20388784 | J:158945
First Author: Lu ZH
Year: 2010
Journal: Cancer Res
Title: Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Volume: 70
Issue: 8
Pages: 3287-98
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Publication
17942919 | J:125965
First Author: Finlay GA
Year: 2007
Journal: Cancer Res
Title: Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Volume: 67
Issue: 20
Pages: 9878-86
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Publication
23426372 | J:197831
First Author: Tamai T
Year: 2013
Journal: J Biol Chem
Title: Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
Volume: 288
Issue: 14
Pages: 10176-87
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Publication
32920594 | J:340198
First Author: Ma X
Year: 2020
Journal: Cell Death Dis
Title: Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.
Volume: 11
Issue: 9
Pages: 747
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Publication
21896734 | J:176586
First Author: Banerjee S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.
Volume: 108
Issue: 38
Pages: 15996-6001
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Publication
34619097 | J:314132
First Author: Jia L
Year: 2021
Journal: Dev Cell
Title: Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability.
Volume: 56
Issue: 21
Pages: 2980-2994.e6
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Publication
24303063 | J:209763
First Author: Groenewoud MJ
Year: 2013
Journal: PLoS One
Title: Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.
Volume: 8
Issue: 11
Pages: e81649
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Publication
24130493 | J:246768
First Author: Wang J
Year: 2013
Journal: PLoS Pathog
Title: MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb.
Volume: 9
Issue: 10
Pages: e1003697
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Publication
30262562 | J:295707
First Author: Wang X
Year: 2019
Journal: Haematologica
Title: Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo.
Volume: 104
Issue: 2
Pages: 245-255
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Publication
12820960 | J:338163
First Author: Garami A
Year: 2003
Journal: Mol Cell
Title: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2.
Volume: 11
Issue: 6
Pages: 1457-66
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Publication
21513702 | J:172202
First Author: Sasaki H
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Acceleration of autoimmune diabetes in Rheb-congenic NOD mice with β-cell-specific mTORC1 activation.
Volume: 408
Issue: 2
Pages: 306-11
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Publication
18650380 | J:139022
First Author: Schewe DM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo.
Volume: 105
Issue: 30
Pages: 10519-24
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Publication
19258434 | J:154349
First Author: Hamada S
Year: 2009
Journal: Diabetes
Title: Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia.
Volume: 58
Issue: 6
Pages: 1321-32
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Publication
28225024 | J:271919
 
First Author: Li K
Year: 2017
Journal: Sci Rep
Title: Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.
Volume: 7
Pages: 42655
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Publication
19451232 | J:150143
First Author: Lee MN
Year: 2009
Journal: Mol Cell Biol
Title: Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.
Volume: 29
Issue: 14
Pages: 3991-4001
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Publication
28945203 | J:255466
First Author: Asrani K
Year: 2017
Journal: J Clin Invest
Title: mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation.
Volume: 127
Issue: 11
Pages: 4001-4017
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Publication
29961810 | J:268375
First Author: Xiong Z
Year: 2018
Journal: Biol Reprod
Title: Raptor directs Sertoli cell cytoskeletal organization and polarity in the mouse testis.
Volume: 99
Issue: 6
Pages: 1289-1302
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Publication
26026060 | J:325030
First Author: Guan Y
Year: 2015
Journal: J Immunol
Title: Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models.
Volume: 195
Issue: 1
Pages: 339-46
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Publication
24648513 | -
First Author: Mazhab-Jafari MT
Year: 2014
Journal: J Biol Chem
Title: Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Volume: 289
Issue: 18
Pages: 12195-201
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Publication
28424242 | J:247857
First Author: Chornoguz O
Year: 2017
Journal: J Immunol
Title: mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation.
Volume: 198
Issue: 10
Pages: 3939-3948
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Publication
28289099 | J:242501
First Author: Jacobs BL
Year: 2017
Journal: J Biol Chem
Title: Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.
Volume: 292
Issue: 17
Pages: 6987-6997
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Publication
27374985 | J:253765
 
First Author: Diao F
Year: 2016
Journal: Sci Rep
Title: Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.
Volume: 6
Pages: 28917
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Publication
30582446 | J:292335
First Author: Blackwood EA
Year: 2019
Journal: Circ Res
Title: ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Volume: 124
Issue: 1
Pages: 79-93
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Gene
359959 | Rhebl1
Type: gene
Organism: rat
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Gene
608884 | RHEBL1
Type: gene
Organism: dog, domestic
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Gene
742542 | RHEBL1
Type: gene
Organism: chimpanzee
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Gene
353300 | RHEBL1
Type: gene
Organism: cattle
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Gene
709384 | RHEBL1
Type: gene
Organism: macaque, rhesus
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Gene
394534 | rhebl1
Type: gene
Organism: frog, western clawed
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Publication
24282297 | J:205513
First Author: Wang Y
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells.
Volume: 110
Issue: 50
Pages: E4894-903
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Publication
20668162 | J:182841
First Author: Goodman CA
Year: 2010
Journal: Mol Biol Cell
Title: A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy.
Volume: 21
Issue: 18
Pages: 3258-68
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Publication
21238928 | J:168571
First Author: Zou J
Year: 2011
Journal: Dev Cell
Title: Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Volume: 20
Issue: 1
Pages: 97-108
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Protein Coding Gene
MGP_CAROLIEiJ_G0027024 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029356 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029322 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029053 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97912 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029786 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028465 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029020 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029158 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029820 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021797 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028020 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
25759467 | J:221351
First Author: Goorden SM
Year: 2015
Journal: Hum Mol Genet
Title: Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments.
Volume: 24
Issue: 12
Pages: 3390-8
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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