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Search results 1 to 100 out of 557 for Rhog

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
391 | RHOG
Type: gene
Organism: human
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Gene
748092 | RHOG
Type: gene
Organism: chimpanzee
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Gene
538559 | RHOG
Type: gene
Organism: cattle
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Gene
100859599 | RHOG
Type: gene
Organism: chicken
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Gene
718113 | RHOG
Type: gene
Organism: macaque, rhesus
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Gene
100489878 | rhog
Type: gene
Organism: frog, western clawed
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Gene
308875 | Rhog
Type: gene
Organism: rat
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Gene
485217 | RHOG
Type: gene
Organism: dog, domestic
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Protein Domain
IPR042734 | RhoG
Type: Family
Description: RhoG is a GTPase with high sequence similarity to members of the Rac subfamily, including the regions involved in effector recognition and binding. However, RhoG does not bind to known Rac1 and Cdc42 effectors, including proteins containing a Cdc42/Rac interacting binding (CRIB) motif. Instead, RhoG interacts directly with Elmo, an upstream regulator of Rac1, in a GTP-dependent manner and forms a ternary complex with Dock180 to induce activation of Rac1 []. The RhoG-Elmo-Dock180 pathway is required for activation of Rac1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Thus RhoG activates Rac1 through Elmo and Dock180 to control cell morphology []. RhoG has also been shown to play a role in caveolar trafficking []and has a novel role in signaling the neutrophil respiratory burst stimulated by G protein-coupled receptor (GPCR) agonists []. Most Rho proteins contain a lipid modification site at the C terminus, with a typical sequence motif CaaX, where a = an aliphatic amino acid and X = any amino acid. Lipid binding is essential for membrane attachment, a key feature of most Rho proteins.
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Protein Coding Gene
MGI:1928370 | Rhog
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16621998 | J:131659
First Author: Condliffe AM
Year: 2006
Journal: J Immunol
Title: RhoG regulates the neutrophil NADPH oxidase.
Volume: 176
Issue: 9
Pages: 5314-20
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Publication
16568096 | -
First Author: Prieto-Sánchez RM
Year: 2006
Journal: Oncogene
Title: Involvement of the Rho/Rac family member RhoG in caveolar endocytosis.
Volume: 25
Issue: 21
Pages: 2961-73
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Publication
12879077 | -
First Author: Katoh H
Year: 2003
Journal: Nature
Title: RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Volume: 424
Issue: 6947
Pages: 461-4
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Publication
12805377 | -
First Author: Prieto-Sánchez RM
Year: 2003
Journal: J Biol Chem
Title: Structural basis for the signaling specificity of RhoG and Rac1 GTPases.
Volume: 278
Issue: 39
Pages: 37916-25
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Protein
P84096
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Publication
24106270 | J:204982
First Author: Goggs R
Year: 2013
Journal: J Biol Chem
Title: RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Volume: 288
Issue: 47
Pages: 34217-29
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Publication
22588079 | J:187014
First Author: Franke K
Year: 2012
Journal: EMBO J
Title: miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling.
Volume: 31
Issue: 13
Pages: 2908-21
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Publication
21820331 | J:175846
First Author: Martínez-Martín N
Year: 2011
Journal: Immunity
Title: T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.
Volume: 35
Issue: 2
Pages: 208-22
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Publication
18505794 | J:139771
First Author: Meller J
Year: 2008
Journal: J Cell Sci
Title: Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.
Volume: 121
Issue: Pt 12
Pages: 1981-9
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Protein
Q3UDZ1
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: false
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Publication
24106269 | J:204983
First Author: Kim S
Year: 2013
Journal: J Biol Chem
Title: RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.
Volume: 288
Issue: 47
Pages: 34230-8
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Publication
24659802 | J:214692
First Author: Damoulakis G
Year: 2014
Journal: J Cell Sci
Title: P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
Volume: 127
Issue: Pt 11
Pages: 2589-600
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Publication
19581409 | J:150407
First Author: Elfenbein A
Year: 2009
Journal: J Cell Biol
Title: Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
Volume: 186
Issue: 1
Pages: 75-83
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Gene
392489 | RHOG2P
Type: gene
Organism: human
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Gene
9710 | GARRE1
Type: gene
Organism: human
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Publication
14701744 | J:87580
First Author: Vigorito E
Year: 2004
Journal: Mol Cell Biol
Title: Immunological function in mice lacking the Rac-related GTPase RhoG.
Volume: 24
Issue: 2
Pages: 719-29
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Publication
21982645 | J:181008
First Author: Bass MD
Year: 2011
Journal: Dev Cell
Title: A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.
Volume: 21
Issue: 4
Pages: 681-93
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Publication
22734669 | J:213976
First Author: Namekata K
Year: 2012
Journal: Genes Cells
Title: Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG.
Volume: 17
Issue: 8
Pages: 688-97
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Publication
23372835 | J:195919
First Author: Samson T
Year: 2013
Journal: PLoS One
Title: The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis.
Volume: 8
Issue: 1
Pages: e55202
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Publication
25995380 | J:311754
First Author: Jackson BC
Year: 2015
Journal: Mol Biol Cell
Title: An ELMO2-RhoG-ILK network modulates microtubule dynamics.
Volume: 26
Issue: 14
Pages: 2712-25
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Publication
19273601 | J:149158
First Author: Monypenny J
Year: 2009
Journal: Mol Cell Biol
Title: Cdc42 and Rac family GTPases regulate mode and speed but not direction of primary fibroblast migration during platelet-derived growth factor-dependent chemotaxis.
Volume: 29
Issue: 10
Pages: 2730-47
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Publication
19439446 | J:164415
First Author: Ho E
Year: 2009
Journal: Mol Biol Cell
Title: Integrin-linked kinase interactions with ELMO2 modulate cell polarity.
Volume: 20
Issue: 13
Pages: 3033-43
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Publication
17898204 | J:125289
First Author: Backer S
Year: 2007
Journal: J Neurosci
Title: Trio controls the mature organization of neuronal clusters in the hindbrain.
Volume: 27
Issue: 39
Pages: 10323-32
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
8939998 | J:36812
First Author: Zalcman G
Year: 1996
Journal: J Biol Chem
Title: RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.
Volume: 271
Issue: 48
Pages: 30366-74
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Protein Coding Gene
MGP_CAROLIEiJ_G0030084 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0032606 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0032582 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0032518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0032593 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1928370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0031633 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032273 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032425 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032381 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0032514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033112 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031351 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0031750 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013305 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031195 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
29987136 | J:265194
 
First Author: Martínez-Riaño A
Year: 2018
Journal: EMBO Rep
Title: Antigen phagocytosis by B cells is required for a potent humoral response.
Volume: 19
Issue: 9
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GXD Expression
GXD Expression
   
Probe: MGI:6119733
Assay Type: RT-PCR
Annotation Date: 2018-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6119736
Age: postnatal
Image: S6
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6119733
Assay Type: RT-PCR
Annotation Date: 2018-03-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:6119736
Age: postnatal
Image: S6
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1831460
Assay Type: RNA in situ
Annotation Date: 2024-04-19
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3266022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7621790
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1831460
Assay Type: RNA in situ
Annotation Date: 2024-04-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7621790
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
- | J:66347
   
First Author: Seki N
Year: 1999
Journal: GenBank Submission
Title: Mus musculus mRNA for Sid10750p, complete cds
Pages: AB025943
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Publication
33730591 | J:304274
First Author: Boccasavia VL
Year: 2021
Journal: Cell Rep
Title: Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen.
Volume: 34
Issue: 11
Pages: 108861
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Protein
Q8C5X1
Organism: Mus musculus/domesticus
Length: 1059  
Fragment?: false
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Publication
8464478 | J:4309
First Author: Miki T
Year: 1993
Journal: Nature
Title: Oncogene ect2 is related to regulators of small GTP-binding proteins.
Volume: 362
Issue: 6419
Pages: 462-5
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Publication
27023172 | J:250078
 
First Author: Fujiwara K
Year: 2016
Journal: Transl Psychiatry
Title: Deletion of JMJD2B in neurons leads to defective spine maturation, hyperactive behavior and memory deficits in mouse.
Volume: 6
Pages: e766
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Publication
23706742 | J:198414
First Author: Fritsch R
Year: 2013
Journal: Cell
Title: RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.
Volume: 153
Issue: 5
Pages: 1050-63
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Publication
19723774 | J:155773
First Author: Tkatchenko TV
Year: 2009
Journal: Physiol Genomics
Title: Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
Volume: 39
Issue: 3
Pages: 160-8
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Protein
A0A0U1RPA2
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: true
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Protein
A0A0U1RNZ3
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Protein Coding Gene
MGI:1924311 | Garre1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
491949 | RHOG2
Type: gene
Organism: dog, domestic
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Gene
531038 | RHOG2
Type: gene
Organism: cattle
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom