Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Dhaka A |
Year: |
2003 |
Journal: |
J Neurosci |
Title: |
The RAS effector RIN1 modulates the formation of aversive memories. |
Volume: |
23 |
Issue: |
3 |
Pages: |
748-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dzudzor B |
Year: |
2010 |
Journal: |
Mol Cell Neurosci |
Title: |
Regulated expression of the Ras effector Rin1 in forebrain neurons. |
Volume: |
43 |
Issue: |
1 |
Pages: |
108-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bliss JM |
Year: |
2010 |
Journal: |
J Neurosci Res |
Title: |
Fear learning and extinction are linked to neuronal plasticity through Rin1 signaling. |
Volume: |
88 |
Issue: |
4 |
Pages: |
917-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deininger K |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. |
Volume: |
105 |
Issue: |
34 |
Pages: |
12539-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thai M |
Year: |
2011 |
Journal: |
Leukemia |
Title: |
ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1. |
Volume: |
25 |
Issue: |
2 |
Pages: |
290-300 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1777828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1777828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521248 |
|
Specimen Label: |
MRC Harwell_1521248 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1706828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521251 |
|
Specimen Label: |
MRC Harwell_1521251 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521248 |
|
Specimen Label: |
MRC Harwell_1521248 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521248 |
|
Specimen Label: |
MRC Harwell_1521248 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521250 |
|
Specimen Label: |
MRC Harwell_1521250 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521246 |
|
Specimen Label: |
MRC Harwell_1521246 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521248 |
|
Specimen Label: |
MRC Harwell_1521248 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521249 |
|
Specimen Label: |
MRC Harwell_1521249 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692563 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1521247 |
|
Specimen Label: |
MRC Harwell_1521247 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Napoles M |
Year: |
2004 |
Journal: |
Dev Cell |
Title: |
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. |
Volume: |
7 |
Issue: |
5 |
Pages: |
663-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
MGC Data curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Wang Y |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. |
Volume: |
22 |
Issue: |
3 |
Pages: |
916-26 |
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Publication |
First Author: |
Kong C |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. |
Volume: |
282 |
Issue: |
20 |
Pages: |
15294-301 |
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Publication |
First Author: |
Balaji K |
Year: |
2013 |
Journal: |
Commun Integr Biol |
Title: |
RIN1 regulates cell migration through RAB5 GTPases and ABL tyrosine kinases. |
Volume: |
6 |
Issue: |
5 |
Pages: |
e25421 |
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Interaction Experiment |
Description: |
Protein binding and signaling properties of RIN1 suggest a unique effector function. |
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Publication |
First Author: |
Han L |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Protein binding and signaling properties of RIN1 suggest a unique effector function. |
Volume: |
94 |
Issue: |
10 |
Pages: |
4954-9 |
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Protein Domain |
Type: |
Domain |
Description: |
RIN1, a member of the RIN (AKA Ras interaction/interference) family, have multifunctional domains including SH2 and proline-rich (PR) domains in the N-terminal region, and RIN-family homology (RH), VPS9 and Ras-association (RA) domains in the C-terminal region. RIN proteins function as Rab5-GEFs []. Previous studies showed that RIN1 interacts with EGF receptors via its SH2 domain and regulates trafficking and degradation of EGF receptors via its interaction with STAM, indicating a vital role for RIN1 in regulating endosomal trafficking of receptor tyrosine kinases (RTKs) []. RIN1 was first identified as a Ras-binding protein that suppresses the activated RAS2 allele in S. cerevisiae. RIN1 binds to the activated Ras through its carboxyl-terminal domain and this Ras-binding domain also binds to 14-3-3 proteins as Raf-1 does [].The SH2 domain of RIN1 are thought to interact with the phosphotyrosine-containing proteins, but the physiological partners for this domain are unknown. The proline-rich domain in RIN1 is similar to the consensus SH3 binding regions. |
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Publication |
First Author: |
Prag G |
Year: |
2003 |
Journal: |
Cell |
Title: |
Mechanism of ubiquitin recognition by the CUE domain of Vps9p. |
Volume: |
113 |
Issue: |
5 |
Pages: |
609-20 |
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Publication |
First Author: |
Burd CG |
Year: |
1996 |
Journal: |
Mol Cell Biol |
Title: |
A yeast protein related to a mammalian Ras-binding protein, Vps9p, is required for localization of vacuolar proteins. |
Volume: |
16 |
Issue: |
5 |
Pages: |
2369-77 |
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Protein Domain |
Type: |
Domain |
Description: |
Vps9 is a cytosolic yeast protein required for localization of vacuolar proteins, such as the soluble vacuolar hydrolases CPY and PrA []. It may bind and act as an effector of a Rab GTPase and plays a role in vacuolar protein sorting (VPS) pathway. Vps9 contains a region called GBH domain that is related to mammalian Ras-binding proteins, Rin1 and JC265, and may negatively regulate Ras-mediated signaling in yeast Saccharomyces cerevisiae. This entry represents the N-terminal CUE domain that interacts specifically with monoubiquitin and regulates intramolecular monoubiquitylation [, ]. |
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Publication |
First Author: |
Samant RS |
Year: |
2002 |
Journal: |
Int J Cancer |
Title: |
Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |
Volume: |
97 |
Issue: |
1 |
Pages: |
15-20 |
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Publication |
First Author: |
Sutcliffe MD |
Year: |
2021 |
Journal: |
Cancer Res |
Title: |
Premalignant Oligodendrocyte Precursor Cells Stall in a Heterogeneous State of Replication Stress Prior to Gliomagenesis. |
Volume: |
81 |
Issue: |
7 |
Pages: |
1868-1882 |
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Publication |
First Author: |
Wainszelbaum MJ |
Year: |
2006 |
Journal: |
Exp Cell Res |
Title: |
IL4/PGE2 induction of an enlarged early endosomal compartment in mouse macrophages is Rab5-dependent. |
Volume: |
312 |
Issue: |
12 |
Pages: |
2238-51 |
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Publication |
First Author: |
Shih SC |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. |
Volume: |
22 |
Issue: |
6 |
Pages: |
1273-81 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
763
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
774
 |
Fragment?: |
false |
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