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Search results 1 to 95 out of 95 for Rnf170

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
81790 | RNF170
Type: gene
Organism: human
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Gene
738443 | RNF170
Type: gene
Organism: chimpanzee
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Gene
475568 | RNF170
Type: gene
Organism: dog, domestic
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Gene
617379 | RNF170
Type: gene
Organism: cattle
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Gene
427296 | RNF170
Type: gene
Organism: chicken
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Gene
406612 | rnf170
Type: gene
Organism: zebrafish
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Gene
712606 | RNF170
Type: gene
Organism: macaque, rhesus
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Gene
549626 | rnf170
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR038896 | RNF170
Type: Family
Description: RNF170 is an endoplasmic reticulum membrane ubiquitin ligase that contributes to the ubiquitination of activated inositol 1,4,5-trisphosphate (IP3) receptors []. When point mutated (arginine to cysteine at position 199), it causes autosomal dominant sensory ataxia (ADSA), a disease characterised by neurodegeneration in the posterior columns of the spinal cord [].
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Gene
364654 | Rnf170
Type: gene
Organism: rat
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Protein Coding Gene
MGI:1924983 | Rnf170
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8CBG9
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
D3Z7W3
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
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Protein
E9PUJ5
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: false
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Protein
F6UDR6
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Publication
21610068 | -
First Author: Lu JP
Year: 2011
Journal: J Biol Chem
Title: RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.
Volume: 286
Issue: 27
Pages: 24426-33
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Publication
25882839 | -
First Author: Wright FA
Year: 2015
Journal: J Biol Chem
Title: A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+ Signaling.
Volume: 290
Issue: 22
Pages: 13948-57
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Protein
A0A1B0GR51
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
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Publication
26433933 | J:226836
First Author: Kim Y
Year: 2015
Journal: Hum Mol Genet
Title: Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia.
Volume: 24
Issue: 25
Pages: 7196-206
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Publication
31076723 | J:315640
First Author: Song X
Year: 2020
Journal: Cell Mol Immunol
Title: E3 ubiquitin ligase RNF170 inhibits innate immune responses by targeting and degrading TLR3 in murine cells.
Volume: 17
Issue: 8
Pages: 865-874
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Protein
D3Z0A0
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0030938 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033401 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033186 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1924983 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033988 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032512 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033161 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033316 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033260 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032628 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021408 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032057 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Protein
Q8CBG9-4
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
Q8CBG9-5
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
Q8CBG9-2
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
Q8CBG9-3
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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UniProt Feature
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase RNF170
Type: chain
End: 286
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Interaction Experiment
Lu JP (2011)
Description: RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation.
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DO Term
DOID:0112345 | hereditary spastic paraplegia 85
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DO Term
DOID:0111170 | autosomal dominant sensory ataxia 1
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Protein Domain
IPR010652 | DUF1232
Type: Domain
Description: This domain can be found in RNF170 from eukaryotes and some uncharacterised proteins from bacteria and archaea. RNF170 is an E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway [].
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Publication
17502376 | J:123599
First Author: Pearce MM
Year: 2007
Journal: J Biol Chem
Title: SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells.
Volume: 282
Issue: 28
Pages: 20104-15
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Protein
F6Z6D6
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
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Protein
E9PZB0
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Publication
19240031 | J:149249
First Author: Pearce MM
Year: 2009
Journal: J Biol Chem
Title: An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
Volume: 284
Issue: 16
Pages: 10433-45
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Publication
19751772 | -
First Author: Wang Y
Year: 2009
Journal: Biochim Biophys Acta
Title: SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells.
Volume: 1793
Issue: 11
Pages: 1710-8
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Publication
22269071 | -
 
First Author: Hoegg MB
Year: 2012
Journal: BMC Cell Biol
Title: Characterization of the C. elegans erlin homologue.
Volume: 13
Pages: 2
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Protein Domain
IPR033294 | Erlin1/2
Type: Family
Description: This entry includes Erlin1/2 (also known as SPFH1/2) from animals and their homologues from plants. Mammalian Erlin1 and Erlin2 form a complex that mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 [, , ]. The Erlin1/2 complex may recruit RNF170 (an E3 ubiquitin-protein ligase) to activated IP(3) receptors where it mediates IP(3) receptor ubiquitination [].Interestingly, C. elegans erlin homologue, ERL-1, does not play an essential role in the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-triphosphate receptors (IP3Rs) [].
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Protein
A0A1B0GRG7
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
A0A1B0GT43
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
A0A1B0GRQ1
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
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Protein
A0A1B0GT70
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Protein
Q8BFZ9
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Protein
Q91X78
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
E9PUH5
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: true
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Protein
A0A1B0GQZ0
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: true
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Protein
A0A1B0GSD8
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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