Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds A |
Year: |
2013 |
Journal: |
Nat Genet |
Title: |
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. |
Volume: |
45 |
Issue: |
3 |
Pages: |
269-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiao H |
Year: |
2014 |
Journal: |
Nat Genet |
Title: |
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. |
Volume: |
46 |
Issue: |
2 |
Pages: |
194-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujiwara Y |
Year: |
2015 |
Journal: |
Reproduction |
Title: |
An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility. |
Volume: |
149 |
Issue: |
1 |
Pages: |
67-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiao H |
Year: |
2018 |
Journal: |
Mol Cell |
Title: |
Impeding DNA Break Repair Enables Oocyte Quality Control. |
Volume: |
72 |
Issue: |
2 |
Pages: |
211-221.e3 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiao H |
Year: |
2012 |
Journal: |
PLoS Genet |
Title: |
Interplay between synaptonemal complex, homologous recombination, and centromeres during mammalian meiosis. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e1002790 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang RJ |
Year: |
2017 |
Journal: |
Genetics |
Title: |
Genetics of Genome-Wide Recombination Rate Evolution in Mice from an Isolated Island. |
Volume: |
206 |
Issue: |
4 |
Pages: |
1841-1852 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bondarieva A |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. |
Volume: |
11 |
Issue: |
1 |
Pages: |
3101 |
|
•
•
•
•
•
|
Publication |
First Author: |
JAX Reproductive Mutagenesis Program |
Year: |
2004 |
Journal: |
MGI Direct Data Submission |
Title: |
Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Schimenti JC |
Year: |
2018 |
Journal: |
Biol Reprod |
Title: |
Unpackaging the genetics of mammalian fertility: strategies to identify the "reproductive genome". |
Volume: |
99 |
Issue: |
6 |
Pages: |
1119-1128 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito M |
Year: |
2025 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis. |
Volume: |
122 |
Issue: |
2 |
Pages: |
e2412961121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Felipe-Medina N |
Year: |
2020 |
Journal: |
Elife |
Title: |
A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ni L |
Year: |
2016 |
Journal: |
Mol Reprod Dev |
Title: |
Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. |
Volume: |
83 |
Issue: |
12 |
Pages: |
1060-1069 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mutant Mouse Regional Resource Centers |
Year: |
2004 |
Journal: |
Unpublished |
Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniPathway vocabulary mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
307
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
99
 |
Fragment?: |
false |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Probable E3 SUMO-protein ligase RNF212 |
Type: |
chain |
End: |
307 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
95
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
179
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
60
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kong A |
Year: |
2008 |
Journal: |
Science |
Title: |
Sequence variants in the RNF212 gene associate with genome-wide recombination rate. |
Volume: |
319 |
Issue: |
5868 |
Pages: |
1398-401 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Holloway JK |
Year: |
2014 |
Journal: |
J Cell Biol |
Title: |
Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. |
Volume: |
205 |
Issue: |
5 |
Pages: |
633-41 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
161
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng CH |
Year: |
2006 |
Journal: |
Genes Dev |
Title: |
SUMO modifications control assembly of synaptonemal complex and polycomplex in meiosis of Saccharomyces cerevisiae. |
Volume: |
20 |
Issue: |
15 |
Pages: |
2067-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lake CM |
Year: |
2019 |
Journal: |
PLoS Genet |
Title: |
Narya, a RING finger domain-containing protein, is required for meiotic DNA double-strand break formation and crossover maturation in Drosophila melanogaster. |
Volume: |
15 |
Issue: |
1 |
Pages: |
e1007886 |
|
•
•
•
•
•
|
Publication |
First Author: |
Serrentino ME |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination. |
Volume: |
9 |
Issue: |
4 |
Pages: |
e1003416 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2018 |
Journal: |
Elife |
Title: |
A compartmentalized signaling network mediates crossover control in meiosis. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents budding yeast Zip3 (also known as Cst9) and its homologues including Vilya/Nenya/narya from Drosophila melanogaster, RNF212/RNF212B from animals and Zip homologous proteins 1, 2, 3 and 4 from Caenorhabditis elegans. In budding yeasts, Zip3 is a SUMO E3 ligase and a component of the synapsis initiation complex (SIC) required for synaptonemal complex formation. Zip3 possesses a C3H2C3 RING finger motif, which is required for its E3 SUMO ligase activity in vitro [].The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates synapsis between homologous chromosomes during meiotic prophase []. A number of chromosomal crossover factors and DNA damage repair components have been found to associate with both synaptonemal complexes and multiple synaptonemal complexes (polycomplexes). These include Zip3 (Cst9) from budding yeast, which localizes throughout the body of polycomplexes []. The presence of several Zip3-related proteins within the same organism, for instance the mammalian RNF212 ortholog (RNF212B), expands recombination control by E3-ligase activities []. Mouse RNF212 acts as a regulator of crossing-over during meiosis [].The Caenorhabditis elegans genome encodes at least four RING finger E3 ligase proteins, ZHP-1, ZHP-2, ZHP-3 and ZHP-4 that act together to promote a spatio-temporal accumulation of pro-crossover factors [].Drosophila melanogaster contain three Zip3-related proteins Vilya, Nenya and Narya which function in the formation of meiotic DNA DSBs and in the process of crossing over []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Condezo YB |
Year: |
2024 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. |
Volume: |
121 |
Issue: |
25 |
Pages: |
e2320995121 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
297
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
212
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
57
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
53
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|