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Search results 1 to 100 out of 793 for Robo3

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0.055s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: The secreted Slit repellents and their Roundabout (Robo) receptors were originally identified as important axon guidance molecules. The SLIT-ROBO interaction has been found to be involved in the regulation of cell migration, cell death and angiogenesis and, as such, has a pivotal role during the development of other tissues such as the lung, kidney, liver and breast []. There are four Robo homologues in vertebrates (Robo1-4).Robo3 is a divergent member of the family that does not bind Slit proteins []. Robo3 exists in two splice isoforms with different intracellular domains: Robo3.1 is expressed on precrossing commissural axons and allows midline crossing (partly by inhibiting Slit signaling through Robo1/2), whereas Robo3.2 is expressed postcrossing and prevents midline recrossing []. NELL2 (neural epidermal growth factor-like-like 2) has been identified as a Robo3 ligand that repels commissural axons and helps steer them to the midline [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Chen Z
Year: 2008
Journal: Neuron
Title: Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.
Volume: 58
Issue: 3
Pages: 325-32
Publication
First Author: Jaworski A
Year: 2015
Journal: Science
Title: Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Volume: 350
Issue: 6263
Pages: 961-5
Publication
First Author: Camurri L
Year: 2005
Journal: Mol Cell Neurosci
Title: Evidence for the existence of two Robo3 isoforms with divergent biochemical properties.
Volume: 30
Issue: 4
Pages: 485-93
Publication  
First Author: Barber M
Year: 2009
Journal: Cereb Cortex
Title: The role of Robo3 in the development of cortical interneurons.
Volume: 19 Suppl 1
Pages: i22-31
Publication
First Author: Cariboni A
Year: 2012
Journal: Development
Title: Slit2 and Robo3 modulate the migration of GnRH-secreting neurons.
Volume: 139
Issue: 18
Pages: 3326-31
Publication
First Author: Zelina P
Year: 2014
Journal: Neuron
Title: Signaling switch of the axon guidance receptor Robo3 during vertebrate evolution.
Volume: 84
Issue: 6
Pages: 1258-72
Publication
First Author: Friocourt F
Year: 2019
Journal: J Comp Neurol
Title: Shared and differential features of Robo3 expression pattern in amniotes.
Volume: 527
Issue: 12
Pages: 2009-2029
Publication
First Author: Dickinson RE
Year: 2010
Journal: Reproduction
Title: The SLIT-ROBO pathway: a regulator of cell function with implications for the reproductive system.
Volume: 139
Issue: 4
Pages: 697-704
Publication  
First Author: Taroc EZM
Year: 2019
Journal: Front Cell Neurosci
Title: GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling.
Volume: 13
Pages: 70
Protein
Organism: Mus musculus/domesticus
Length: 1366  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1345  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1380  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1402  
Fragment?: false
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191220
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Robo3
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191220
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Robo3
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191220
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Robo3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191220
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Robo3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191220
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Robo3
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191220
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Robo3
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6182410
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191220
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Robo3
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:5752618
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747020
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5752742
Age: embryonic day 12.5
Note: Robo1 and Robo3 showed similar patterns of expression both within the lateral and medial ganglionic eminences, and overlapped in regions where Robo1 protein was most robustly localized.
Specimen Label: S1F
Detected: true
Specimen Num: 14
GXD Expression  
Probe: MGI:5752618
Assay Type: Immunohistochemistry
Annotation Date: 2016-03-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3747120
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:5752742
Age: embryonic day 12.5
Note: Robo1 and Robo3 showed similar patterns of expression both within the lateral and medial ganglionic eminences, and overlapped in regions where Robo1 protein was most robustly localized.
Specimen Label: S1F
Detected: true
Specimen Num: 14
Publication
First Author: Pak JS
Year: 2020
Journal: Nat Commun
Title: NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Volume: 11
Issue: 1
Pages: 1489
Publication
First Author: Kuwako K
Year: 2010
Journal: Neuron
Title: Neural RNA-binding protein Musashi1 controls midline crossing of precerebellar neurons through posttranscriptional regulation of Robo3/Rig-1 expression.
Volume: 67
Issue: 3
Pages: 407-21
Publication
First Author: Dailey-Krempel B
Year: 2023
Journal: Cell Rep
Title: A tug of war between DCC and ROBO1 signaling during commissural axon guidance.
Volume: 42
Issue: 5
Pages: 112455
Publication
First Author: Moreno-Bravo JA
Year: 2022
Journal: J Comp Neurol
Title: Uncoupling axon guidance and neuronal migration in Robo3-deficient inferior olivary neurons.
Volume: 530
Issue: 16
Pages: 2868-2880
Publication
First Author: Junge HJ
Year: 2016
Journal: Neural Dev
Title: Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord.
Volume: 11
Issue: 1
Pages: 19
Publication
First Author: Jaworski A
Year: 2010
Journal: J Neurosci
Title: Collaborative and specialized functions of Robo1 and Robo2 in spinal commissural axon guidance.
Volume: 30
Issue: 28
Pages: 9445-53
Publication
First Author: Tulloch AJ
Year: 2019
Journal: J Comp Neurol
Title: Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse.
Volume: 527
Issue: 18
Pages: 2948-2972
Publication
First Author: Di Meglio T
Year: 2008
Journal: J Neurosci
Title: Molecular mechanisms controlling midline crossing by precerebellar neurons.
Volume: 28
Issue: 25
Pages: 6285-94
Publication
First Author: Belle M
Year: 2014
Journal: Cell Rep
Title: A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system.
Volume: 9
Issue: 4
Pages: 1191-201
Publication
First Author: Marillat V
Year: 2004
Journal: Neuron
Title: The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.
Volume: 43
Issue: 1
Pages: 69-79
Publication
First Author: Renier N
Year: 2010
Journal: PLoS Biol
Title: Genetic dissection of the function of hindbrain axonal commissures.
Volume: 8
Issue: 3
Pages: e1000325
Publication
First Author: Michalski N
Year: 2013
Journal: Neuron
Title: Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.
Volume: 78
Issue: 5
Pages: 855-68
Publication  
First Author: Comer JD
Year: 2015
Journal: Front Neural Circuits
Title: Sensory and spinal inhibitory dorsal midline crossing is independent of Robo3.
Volume: 9
Pages: 36
Publication    
First Author: Renier N
Year: 2017
Journal: Elife
Title: A mutant with bilateral whisker to barrel inputs unveils somatosensory mapping rules in the cerebral cortex.
Volume: 6
Publication  
First Author: Tamada A
Year: 2008
Journal: Neural Dev
Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
Volume: 3
Pages: 29
Publication
First Author: Rafipay A
Year: 2021
Journal: Dev Dyn
Title: Knockdown of slit signaling during limb development leads to a reduction in humerus length.
Volume: 250
Issue: 9
Pages: 1340-1357
Publication  
First Author: Laumonnerie C
Year: 2015
Journal: Nat Commun
Title: Commissural axonal corridors instruct neuronal migration in the mouse spinal cord.
Volume: 6
Pages: 7028
Publication
First Author: Escalante A
Year: 2013
Journal: Neuron
Title: Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS.
Volume: 80
Issue: 6
Pages: 1392-406
Publication
First Author: Badura A
Year: 2013
Journal: Neuron
Title: Climbing fiber input shapes reciprocity of Purkinje cell firing.
Volume: 78
Issue: 4
Pages: 700-13
Publication
First Author: Tsytsarev V
Year: 2017
Journal: J Neurosci
Title: Behavioral Consequences of a Bifacial Map in the Mouse Somatosensory Cortex.
Volume: 37
Issue: 30
Pages: 7209-7218
Publication  
First Author: Wurmser M
Year: 2021
Journal: Front Cell Dev Biol
Title: Robo2 Receptor Gates the Anatomical Divergence of Neurons Derived From a Common Precursor Origin.
Volume: 9
Pages: 668175
Publication
First Author: Sabatier C
Year: 2004
Journal: Cell
Title: The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Volume: 117
Issue: 2
Pages: 157-69
Publication
First Author: Inamata Y
Year: 2014
Journal: Development
Title: Dbx1 triggers crucial molecular programs required for midline crossing by midbrain commissural axons.
Volume: 141
Issue: 6
Pages: 1260-71
Publication    
First Author: Johnson V
Year: 2019
Journal: Elife
Title: Temporal regulation of axonal repulsion by alternative splicing of a conserved microexon in mammalian Robo1 and Robo2.
Volume: 8
Publication
First Author: Wilson SI
Year: 2008
Journal: Neuron
Title: A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.
Volume: 59
Issue: 3
Pages: 413-24
Publication
First Author: Bouvier J
Year: 2010
Journal: Nat Neurosci
Title: Hindbrain interneurons and axon guidance signaling critical for breathing.
Volume: 13
Issue: 9
Pages: 1066-74
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication      
First Author: Karst SY
Year: 2011
Journal: MGI Direct Data Submission
Title: A Spontaneous Point Mutation in the Mouse Gene Roundabout Homolog 3 Results in Impaired Balance
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1343370
Age: embryonic day 10.5
Image: 3
Specimen Label: E10.5 +/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:1343370
Age: embryonic day 10.5
Image: 3
Specimen Label: E10.5 -/-
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:1343370
Age: embryonic day 11.5
Image: 3
Specimen Label: E11.5 +/+
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:1343370
Age: embryonic day 11.5
Image: 3
Specimen Label: E11.5 -/-
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:1343370
Age: embryonic day 12.5
Image: 3
Specimen Label: E12.5 +/+
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:1343370
Age: embryonic day 12.5
Image: 3
Specimen Label: E12.5 -/-
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:1343370
Age: embryonic day 13.5
Image: 3
Specimen Label: E13.5 +/+
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:1343346
Assay Type: Northern blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:1343370
Age: embryonic day 13.5
Image: 3
Specimen Label: E13.5 -/-
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343382
Age: embryonic day 11.5
Image: 5
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:1343382
Age: embryonic day 11.5
Image: 5
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343382
Age: embryonic day 11.5
Image: 5
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:1343382
Age: embryonic day 11.5
Image: 5
Specimen Label: 3
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 9
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1343358
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Stage: TS19
Assay Id: MGI:1343383
Age: embryonic day 11.5
Image: 5
Specimen Label: 9
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691617
Stage: TS17
Assay Id: MGI:1343389
Age: embryonic day 10.5
Image: 7
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609217
Stage: TS17
Assay Id: MGI:1343389
Age: embryonic day 10.5
Image: 7
Specimen Label: 1
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:1343356
Assay Type: Western blot
Annotation Date: 1999-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Stage: TS19
Assay Id: MGI:1343389
Age: embryonic day 11.5
Image: 7
Specimen Label: 2
Detected: true
Specimen Num: 2