Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
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•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
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•
•
•
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Regulatory solute carrier protein family 1 member 1 (RSC1A1, also known as RS1) has been shown to induce downregulation of the sodium-D-glucose cotransporter 1 (SGLT1) and of the concentrative nucleoside transporter 1 (CNT1) in the plasma membrane by blocking exocytosis at the Golgi [].SGLT1 is rate-limiting for glucose absorption in the small intestine. RSC1A1 regulates SGLT1 by inhibiting the release of vesicles from the trans-Golgi network. RSC1A1 is also involved in glucose dependent down-regulation of SGLT1 transcription []. |
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•
•
•
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•
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Publication |
First Author: |
Osswald C |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. |
Volume: |
25 |
Issue: |
1 |
Pages: |
78-87 |
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•
•
•
•
•
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Publication |
First Author: |
Veyhl-Wichmann M |
Year: |
2016 |
Journal: |
Mol Pharmacol |
Title: |
Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption. |
Volume: |
89 |
Issue: |
1 |
Pages: |
118-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song P |
Year: |
2016 |
Journal: |
Expert Opin Ther Targets |
Title: |
Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus. |
Volume: |
20 |
Issue: |
9 |
Pages: |
1109-25 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
582
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Lai E |
Year: |
1989 |
Journal: |
Adv Immunol |
Title: |
Physical maps of the mouse and human immunoglobulin-like loci. |
Volume: |
46 |
|
Pages: |
1-59 |
|
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•
•
•
•
|
Publication |
First Author: |
Errasti-Murugarren E |
Year: |
2012 |
Journal: |
Mol Pharmacol |
Title: |
Role of the transporter regulator protein (RS1) in the modulation of concentrative nucleoside transporters (CNTs) in epithelia. |
Volume: |
82 |
Issue: |
1 |
Pages: |
59-67 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sebastiani A |
Year: |
2018 |
Journal: |
J Neurochem |
Title: |
RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays brain damage after experimental traumatic brain injury. |
Volume: |
147 |
Issue: |
2 |
Pages: |
190-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang W |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. |
Volume: |
25 |
Issue: |
15 |
Pages: |
6496-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and VEGA Genome Database Project |
Year: |
2006 |
Journal: |
Database Release |
Title: |
Collaboration to Associate VEGA (Vertebrate Genome Annotation) Mouse Gene Models with MGI Markers |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientfic Curators |
Year: |
2013 |
|
Title: |
Curated associations of genes in MGI and UniProt sequence records |
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|
|
•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
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•
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•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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