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Search results 1 to 100 out of 830 for Rspo1

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0.064s
Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: RSPO1 is a secreted protein that belongs to the R-spondin (RSPO) family. It regulates Wnt signalling by inhibiting internalization of LRP6 []. It also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signalling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signalling pathway []. The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression  
Probe: MGI:7466954
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7467156
Age: embryonic day 13.5
Image: 8A Rspo1
Specimen Label: 8A Rspo1
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7466954
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796321
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:7467156
Age: embryonic day 13.5
Image: 8C Rspo1
Specimen Label: 8C Rspo1
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:7466954
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Widespread
Stage: TS21
Assay Id: MGI:7467156
Age: embryonic day 13.5
Image: 8A Rspo1
Specimen Label: 8A Rspo1
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:7466954
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Widespread
Stage: TS21
Assay Id: MGI:7467156
Age: embryonic day 13.5
Image: 8C Rspo1
Specimen Label: 8C Rspo1
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:7466932
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467160
Age: embryonic day 13.5
Image: 8A Rspo1
Note: Expression is seen in somatic cells.
Specimen Label: 8A Rspo1
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:7466932
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467160
Age: embryonic day 13.5
Image: 8C Rspo1
Note: Expression is seen in somatic cells.
Specimen Label: 8C Rspo1
Detected: true
Specimen Num: 7
Publication
First Author: Binnerts ME
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
Volume: 104
Issue: 37
Pages: 14700-5
Publication
First Author: Warr N
Year: 2022
Journal: Reproduction
Title: Gadd45g is required for timely Sry expression independently of RSPO1 activity.
Volume: 163
Issue: 6
Pages: 333-340
Publication
First Author: Hao HX
Year: 2012
Journal: Nature
Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Volume: 485
Issue: 7397
Pages: 195-200
Publication
First Author: Wang D
Year: 2013
Journal: Genes Dev
Title: Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Volume: 27
Issue: 12
Pages: 1339-44
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
Publication
First Author: Chassot AA
Year: 2008
Journal: Hum Mol Genet
Title: Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary.
Volume: 17
Issue: 9
Pages: 1264-77
Publication
First Author: Chassot AA
Year: 2012
Journal: Development
Title: WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.
Volume: 139
Issue: 23
Pages: 4461-72
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191231
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Rspo1
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191231
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Rspo1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191231
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Rspo1
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191231
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Rspo1
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191231
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Rspo1
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191231
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Rspo1
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6182624
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191231
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Rspo1
Detected: true
Specimen Num: 7
Publication
First Author: Chadi S
Year: 2009
Journal: Biochem Biophys Res Commun
Title: R-spondin1 is required for normal epithelial morphogenesis during mammary gland development.
Volume: 390
Issue: 3
Pages: 1040-3
Publication
First Author: Lacour F
Year: 2017
Journal: Cell Rep
Title: R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways.
Volume: 18
Issue: 10
Pages: 2320-2330
Publication
First Author: Cai C
Year: 2014
Journal: Genes Dev
Title: R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal.
Volume: 28
Issue: 20
Pages: 2205-18
Publication
First Author: Lu W
Year: 2008
Journal: FEBS Lett
Title: R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression.
Volume: 582
Issue: 5
Pages: 643-50
Publication
First Author: Peng WC
Year: 2013
Journal: PLoS One
Title: Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
Volume: 8
Issue: 12
Pages: e83110
Publication    
First Author: Geng A
Year: 2020
Journal: Elife
Title: A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
Volume: 9
Publication
First Author: Wong VS
Year: 2011
Journal: Diabetologia
Title: R-spondin1 deficiency in mice improves glycaemic control in association with increased beta cell mass.
Volume: 54
Issue: 7
Pages: 1726-34
Publication  
First Author: Liu F
Year: 2017
Journal: Mol Med
Title: Sirtuin-6 preserves R-spondin-1 expression and increases resistance of intestinal epithelium to injury in mice.
Volume: 23
Pages: 272-284
Publication
First Author: Auguste A
Year: 2011
Journal: Sex Dev
Title: Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice.
Volume: 5
Issue: 6
Pages: 304-17
Publication
First Author: De Cian MC
Year: 2017
Journal: Oncogene
Title: Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary.
Volume: 36
Issue: 2
Pages: 208-218
Publication
First Author: Rocha AS
Year: 2015
Journal: Cell Rep
Title: The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Volume: 13
Issue: 9
Pages: 1757-64
Publication    
First Author: Richardson N
Year: 2020
Journal: Elife
Title: Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals.
Volume: 9
Publication
First Author: Liu S
Year: 2020
Journal: FASEB J
Title: Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Volume: 34
Issue: 11
Pages: 14946-14959
Publication    
First Author: Vidal VP
Year: 2020
Journal: Elife
Title: R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.
Volume: 9
Publication
First Author: Zhao J
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway.
Volume: 106
Issue: 7
Pages: 2331-6
Publication  
First Author: Smith CA
Year: 2008
Journal: BMC Dev Biol
Title: Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development.
Volume: 8
Pages: 72
Publication
First Author: Liu CF
Year: 2009
Journal: Hum Mol Genet
Title: Sex-specific roles of beta-catenin in mouse gonadal development.
Volume: 18
Issue: 3
Pages: 405-17
Publication
First Author: Tomizuka K
Year: 2008
Journal: Hum Mol Genet
Title: R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling.
Volume: 17
Issue: 9
Pages: 1278-91
Publication
First Author: Maatouk DM
Year: 2013
Journal: Dev Biol
Title: Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
Volume: 383
Issue: 2
Pages: 295-306
Publication
First Author: Lavery R
Year: 2012
Journal: PLoS Genet
Title: Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.
Volume: 8
Issue: 12
Pages: e1003170
Publication
First Author: Chassot AA
Year: 2011
Journal: PLoS One
Title: RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.
Volume: 6
Issue: 10
Pages: e25641
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Spinal Cord
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691028
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Cerebrum
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Heart
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Lung
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3604101
Age: postnatal adult
Specimen Label: Cerebellum
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:3604102
Age: embryonic day 8.0
Specimen Label: 8 dpc
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603914
Stage: TS14
Assay Id: MGI:3604102
Age: embryonic day 9.0
Specimen Label: 9 dpc
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1664016
Stage: TS16
Assay Id: MGI:3604102
Age: embryonic day 10.0
Specimen Label: 10 dpc
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689518
Stage: TS18
Assay Id: MGI:3604102
Age: embryonic day 11.0
Specimen Label: 11 dpc
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689520
Stage: TS20
Assay Id: MGI:3604102
Age: embryonic day 12.0
Specimen Label: 12 dpc
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689521
Stage: TS21
Assay Id: MGI:3604102
Age: embryonic day 13.0
Specimen Label: 13 dpc
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689522
Stage: TS22
Assay Id: MGI:3604102
Age: embryonic day 14.0
Specimen Label: 14 dpc
Detected: true
Specimen Num: 9
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689523
Stage: TS23
Assay Id: MGI:3604102
Age: embryonic day 15.0
Specimen Label: 15 dpc
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3604098
Assay Type: Northern blot
Annotation Date: 2005-11-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689527
Stage: TS27
Assay Id: MGI:3604102
Age: postnatal day 0
Specimen Label: P0
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2007-03-01
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603910
Stage: TS10
Assay Id: MGI:3698261
Age: embryonic day 7.0
Image: 1
Specimen Label: E7
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2007-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:3698261
Age: embryonic day 11.0
Image: 1
Specimen Label: E11
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2007-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:3698261
Age: embryonic day 15.0
Image: 1
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2007-03-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603925
Stage: TS25
Assay Id: MGI:3698261
Age: embryonic day 17.0
Image: 1
Specimen Label: E17
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3768097
Assay Type: RT-PCR
Annotation Date: 2008-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185817
Stage: TS17
Assay Id: MGI:3768153
Age: embryonic day 10.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:6241499
Age: embryonic day 14.5
Specimen Label: E14.5 kidney
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672822
Stage: TS22
Assay Id: MGI:6241499
Age: embryonic day 14.5
Specimen Label: E14.5 lung
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759723
Stage: TS23
Assay Id: MGI:6241499
Age: embryonic day 15.5
Specimen Label: E15.5 cochlea
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759725
Stage: TS25
Assay Id: MGI:6241499
Age: embryonic day 17.5
Specimen Label: E17.5 cochlea
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759727
Stage: TS27
Assay Id: MGI:6241499
Age: postnatal day 0
Specimen Label: P0 cochlea
Detected: false
Specimen Num: 6
GXD Expression      
Probe: MGI:3698258
Assay Type: RT-PCR
Annotation Date: 2018-11-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1759721
Stage: TS21
Assay Id: MGI:6241499
Age: embryonic day 13.25
Specimen Label: E13.25 cochlea
Detected: false
Specimen Num: 3