Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
RSPO3 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. RSPO3 promotes angioblast and vascular development []. It has been shown to promote bladder cancer progression via mediating the Wnt/beta-catenin and Hedgehog signaling pathways []. The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Kazanskaya O |
Year: |
2008 |
Journal: |
Development |
Title: |
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. |
Volume: |
135 |
Issue: |
22 |
Pages: |
3655-64 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5811467 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-02-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:5823704 |
Age: |
embryonic day 11.5 |
Image: |
S1A - Rspo3 - E11.5 |
Note: |
This gene exhibits category 2 expression: staining is observed in the central limb bud. |
Specimen Label: |
S1A - Rspo3 - E11.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5811467 |
Assay Type: |
RNA in situ |
Annotation Date: |
2017-02-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640617 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:5823704 |
Age: |
embryonic day 10.5 |
Image: |
S1A - Rspo3 - E10.5 |
Note: |
This gene exhibits category 2 expression: staining is observed in the central limb bud. |
Specimen Label: |
S1A - Rspo3 - E10.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Z |
Year: |
2019 |
Journal: |
Carcinogenesis |
Title: |
RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways. |
Volume: |
40 |
Issue: |
2 |
Pages: |
360-369 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lebensohn AM |
Year: |
2018 |
Journal: |
Elife |
Title: |
R-spondins can potentiate WNT signaling without LGRs. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hilkens J |
Year: |
2017 |
Journal: |
Gut |
Title: |
RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. |
Volume: |
66 |
Issue: |
6 |
Pages: |
1095-1105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scholz B |
Year: |
2016 |
Journal: |
Dev Cell |
Title: |
Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling. |
Volume: |
36 |
Issue: |
1 |
Pages: |
79-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang D |
Year: |
2013 |
Journal: |
Genes Dev |
Title: |
Structural basis for R-spondin recognition by LGR4/5/6 receptors. |
Volume: |
27 |
Issue: |
12 |
Pages: |
1339-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilsson KH |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
RSPO3 is important for trabecular bone and fracture risk in mice and humans. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4923 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
277
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
186
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Neufeld S |
Year: |
2012 |
Journal: |
Genesis |
Title: |
A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development. |
Volume: |
50 |
Issue: |
10 |
Pages: |
741-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilsson KH |
Year: |
2022 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Estradiol and RSPO3 regulate vertebral trabecular bone mass independent of each other. |
Volume: |
322 |
Issue: |
3 |
Pages: |
E211-E218 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinozuka T |
Year: |
2024 |
Journal: |
Dev Dyn |
Title: |
Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos. |
Volume: |
253 |
Issue: |
4 |
Pages: |
435-446 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191233 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Rspo3 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191233 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Rspo3 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191233 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Rspo3 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191233 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Rspo3 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191233 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Rspo3 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191233 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Rspo3 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6182626 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191233 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Rspo3 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640619 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6158433 |
Age: |
embryonic day 11.5 |
Image: |
2L |
Note: |
Expression in limbs was different from pattern of expression of Rspo3 mRNA (assay MGI:6158432). |
Specimen Label: |
2L |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3187313 |
Pattern: |
Regionally restricted |
Stage: |
TS13 |
Assay Id: |
MGI:6158432 |
Age: |
embryonic day 8.5 |
Image: |
3J |
Note: |
Authors report expression coincided with Rspo3 reporter gene expression (assay MGI:6158433). |
Specimen Label: |
3J |
Detected: |
true |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3187317 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:6158432 |
Age: |
embryonic day 10.5 |
Image: |
3L |
Note: |
Authors report expression coincided with Rspo3 reporter gene expression (assay MGI:6158433). |
Specimen Label: |
3L |
Detected: |
true |
Specimen Num: |
13 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-25 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1611212 |
Pattern: |
Not Specified |
Stage: |
TS12 |
Assay Id: |
MGI:6158432 |
Age: |
embryonic day 8.0 |
Image: |
3I |
Note: |
Authors report expression coincided with Rspo3 reporter gene expression (assay MGI:6158433). |
Specimen Label: |
3I |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158424 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-25 |
Strength: |
Trace |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610712 |
Pattern: |
Not Specified |
Stage: |
TS12 |
Assay Id: |
MGI:6158432 |
Age: |
embryonic day 8.0 |
Image: |
3I |
Note: |
Authors report expression coincided with Rspo3 reporter gene expression (assay MGI:6158433). |
Specimen Label: |
3I |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1677919 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6158433 |
Age: |
embryonic day 11.5 |
Image: |
2L |
Note: |
Expression in limbs was different from pattern of expression of Rspo3 mRNA (assay MGI:6158432). |
Specimen Label: |
2L |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741220 |
Pattern: |
Regionally restricted |
Stage: |
TS20 |
Assay Id: |
MGI:6158433 |
Age: |
embryonic day 12.5 |
Image: |
2M |
Note: |
Expression in limbs was different from pattern of expression of Rspo3 mRNA (assay MGI:6158432). |
Specimen Label: |
2M |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ter Steege EJ |
Year: |
2023 |
Journal: |
Cancer Lett |
Title: |
R-spondin-3 promotes proliferation and invasion of breast cancer cells independently of Wnt signaling. |
Volume: |
568 |
|
Pages: |
216301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sigal M |
Year: |
2019 |
Journal: |
Nat Cell Biol |
Title: |
R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach. |
Volume: |
21 |
Issue: |
7 |
Pages: |
812-823 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goto N |
Year: |
2022 |
Journal: |
Cell Stem Cell |
Title: |
Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury. |
Volume: |
29 |
Issue: |
8 |
Pages: |
1246-1261.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harnack C |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4368 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han T |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine. |
Volume: |
8 |
|
Pages: |
15945 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nagano K |
Year: |
2022 |
Journal: |
Elife |
Title: |
R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mita Y |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
R-spondin3 is a myokine that differentiates myoblasts to type I fibres. |
Volume: |
12 |
Issue: |
1 |
Pages: |
13020 |
|
•
•
•
•
•
|
Publication |
First Author: |
Palikuqi B |
Year: |
2022 |
Journal: |
Cell Stem Cell |
Title: |
Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. |
Volume: |
29 |
Issue: |
8 |
Pages: |
1262-1272.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vidal V |
Year: |
2016 |
Journal: |
Genes Dev |
Title: |
The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3. |
Volume: |
30 |
Issue: |
12 |
Pages: |
1389-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoki M |
Year: |
2007 |
Journal: |
Dev Biol |
Title: |
R-spondin3 is required for mouse placental development. |
Volume: |
301 |
Issue: |
1 |
Pages: |
218-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarmas AE |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis. |
Volume: |
12 |
Issue: |
1 |
Pages: |
6332 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fischer AS |
Year: |
2022 |
Journal: |
J Clin Invest |
Title: |
R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice. |
Volume: |
132 |
Issue: |
21 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Rocha AS |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation. |
Volume: |
13 |
Issue: |
9 |
Pages: |
1757-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Da Silva F |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
Coronary Artery Formation Is Driven by Localized Expression of R-spondin3. |
Volume: |
20 |
Issue: |
8 |
Pages: |
1745-1754 |
|
•
•
•
•
•
|
Publication |
First Author: |
Da Silva F |
Year: |
2018 |
Journal: |
Dev Biol |
Title: |
Myocardial-specific R-spondin3 drives proliferation of the coronary stems primarily through the Leucine Rich Repeat G Protein coupled receptor LGR4. |
Volume: |
441 |
Issue: |
1 |
Pages: |
42-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vidal VP |
Year: |
2020 |
Journal: |
Elife |
Title: |
R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mehta V |
Year: |
2011 |
Journal: |
Dev Dyn |
Title: |
Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract. |
Volume: |
240 |
Issue: |
11 |
Pages: |
2548-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alhazmi N |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. |
Volume: |
11 |
Issue: |
1 |
Pages: |
5871 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dasgupta K |
Year: |
2021 |
Journal: |
J Dev Biol |
Title: |
R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development. |
Volume: |
9 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chen F |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts. |
Volume: |
9 |
|
Pages: |
651655 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cambier L |
Year: |
2014 |
Journal: |
Development |
Title: |
Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. |
Volume: |
141 |
Issue: |
15 |
Pages: |
2959-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olczak A |
Year: |
2024 |
Journal: |
Front Physiol |
Title: |
The overexpression of R-spondin 3 affects hair morphogenesis and hair development along with the formation and maturation of the hair follicle stem cells. |
Volume: |
15 |
|
Pages: |
1424077 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Kannan L |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. |
Volume: |
110 |
Issue: |
35 |
Pages: |
14348-53 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-03-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603910 |
|
Stage: |
TS10 |
Assay Id: |
MGI:3698264 |
Age: |
embryonic day 7.0 |
Image: |
1 |
|
Specimen Label: |
E7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-03-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603918 |
|
Stage: |
TS18 |
Assay Id: |
MGI:3698264 |
Age: |
embryonic day 11.0 |
Image: |
1 |
|
Specimen Label: |
E11 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-03-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603923 |
|
Stage: |
TS23 |
Assay Id: |
MGI:3698264 |
Age: |
embryonic day 15.0 |
Image: |
1 |
|
Specimen Label: |
E15 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2007-03-01 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603925 |
|
Stage: |
TS25 |
Assay Id: |
MGI:3698264 |
Age: |
embryonic day 17.0 |
Image: |
1 |
|
Specimen Label: |
E17 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5810913 |
Assay Type: |
RT-PCR |
Annotation Date: |
2016-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640617 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5812459 |
Age: |
embryonic day 10.5 |
Image: |
3 |
|
Specimen Label: |
Wild-type |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5810913 |
Assay Type: |
RT-PCR |
Annotation Date: |
2016-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1640617 |
|
Stage: |
TS17 |
Assay Id: |
MGI:5812459 |
Age: |
embryonic day 10.5 |
Image: |
3 |
|
Specimen Label: |
Shh-/-;Gli3-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158416 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158419 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158416 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158419 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
-/- |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158417 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158420 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158417 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158420 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158418 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158421 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
+/+ |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6158418 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-05-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1603917 |
|
Stage: |
TS17 |
Assay Id: |
MGI:6158421 |
Age: |
embryonic day 10.5 |
Image: |
1 |
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1737322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6241533 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 kidney |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:6241533 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
E14.5 lung |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759723 |
|
Stage: |
TS23 |
Assay Id: |
MGI:6241533 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
E15.5 cochlea |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759725 |
|
Stage: |
TS25 |
Assay Id: |
MGI:6241533 |
Age: |
embryonic day 17.5 |
|
|
Specimen Label: |
E17.5 cochlea |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:6241533 |
Age: |
postnatal day 0 |
|
|
Specimen Label: |
P0 cochlea |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-11-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1759721 |
|
Stage: |
TS21 |
Assay Id: |
MGI:6241533 |
Age: |
embryonic day 13.25 |
|
|
Specimen Label: |
E13.25 cochlea |
Detected: |
false |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3687284 |
Assay Type: |
RT-PCR |
Annotation Date: |
2006-11-13 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3185715 |
|
Stage: |
TS15 |
Assay Id: |
MGI:3687321 |
Age: |
embryonic day 9.5 |
Image: |
1 |
|
Specimen Label: |
-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|