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Search results 1 to 100 out of 605 for Ryr2

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: pig, domestic
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
GXD Expression
Probe: MGI:7493396
Assay Type: Immunohistochemistry
Annotation Date: 2023-06-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:7493448
Age: postnatal adult
Image: 4K RyR2
Note: Very slight enhanced expression in outer epicardial region.
Specimen Label: 4K RyR2
Detected: true
Specimen Num: 1
Publication
First Author: Lascano E
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Impact of RyR2 potentiation on myocardial function.
Volume: 312
Issue: 6
Pages: H1105-H1109
Publication
First Author: Respress JL
Year: 2012
Journal: Circ Res
Title: Role of RyR2 phosphorylation at S2814 during heart failure progression.
Volume: 110
Issue: 11
Pages: 1474-83
Publication
First Author: Pan X
Year: 2018
Journal: Circ Res
Title: In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.
Volume: 123
Issue: 8
Pages: 953-963
Publication      
First Author: Campbell HM
Year: 2020
Journal: Circulation
Title: Loss of SPEG Inhibitory Phosphorylation of RyR2 Promotes Atrial Fibrillation.
Publication
First Author: Fauconnier J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy.
Volume: 107
Issue: 4
Pages: 1559-64
Publication
First Author: Sarma S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Volume: 107
Issue: 29
Pages: 13165-70
Publication
First Author: Johnson JD
Year: 2004
Journal: J Biol Chem
Title: RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
Volume: 279
Issue: 23
Pages: 24794-802
Publication
First Author: Yao J
Year: 2020
Journal: Cell Rep
Title: Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.
Volume: 32
Issue: 12
Pages: 108169
Publication
First Author: Aiba I
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death.
Volume: 113
Issue: 33
Pages: E4895-903
Publication
First Author: Liu N
Year: 2006
Journal: Circ Res
Title: Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model.
Volume: 99
Issue: 3
Pages: 292-8
Publication
First Author: Roussel J
Year: 2015
Journal: Biochim Biophys Acta
Title: Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase.
Volume: 1852
Issue: 5
Pages: 749-58
Publication
First Author: Wang Q
Year: 2015
Journal: J Mol Cell Cardiol
Title: Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy.
Volume: 89
Issue: Pt B
Pages: 177-84
Publication
First Author: Kang G
Year: 2010
Journal: Circ Res
Title: Purkinje cells from RyR2 mutant mice are highly arrhythmogenic but responsive to targeted therapy.
Volume: 107
Issue: 4
Pages: 512-9
Publication
First Author: Fukuda M
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes.
Volume: 448
Issue: 1
Pages: 1-7
Publication
First Author: Ji G
Year: 2004
Journal: J Gen Physiol
Title: RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.
Volume: 123
Issue: 4
Pages: 377-86
Publication
First Author: Mazzocchi G
Year: 2016
Journal: J Physiol
Title: Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814.
Volume: 594
Issue: 11
Pages: 3005-30
Publication
First Author: Li N
Year: 2012
Journal: Circ Res
Title: Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.
Volume: 110
Issue: 3
Pages: 465-70
Publication
First Author: Brunello L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.
Volume: 110
Issue: 25
Pages: 10312-7
Publication
First Author: Sadredini M
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation.
Volume: 321
Issue: 2
Pages: H446-H460
Publication
First Author: Jiang D
Year: 2005
Journal: Circ Res
Title: Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death.
Volume: 97
Issue: 11
Pages: 1173-81
Publication
First Author: Okuda S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy.
Volume: 496
Issue: 4
Pages: 1250-1256
Allele
Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Masafumi Yano
Allele Type: Targeted
Attribute String: Humanized sequence
Protein
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
Publication  
First Author: Sun B
Year: 2021
Journal: Sci Transl Med
Title: Cardiac ryanodine receptor calcium release deficiency syndrome.
Volume: 13
Issue: 579
Publication      
First Author: Pontes R
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for arruda3.
Publication      
First Author: Teixeira S
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Arruda.
Publication      
First Author: Pontes R
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for arruda2.
Publication
First Author: Bertan F
Year: 2020
Journal: Cell Death Differ
Title: Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability.
Volume: 27
Issue: 12
Pages: 3354-3373
Publication
First Author: Min CK
Year: 2012
Journal: Biochem J
Title: Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart.
Volume: 447
Issue: 3
Pages: 371-9
Publication
First Author: Ziviani E
Year: 2011
Journal: EMBO J
Title: Ryanodine receptor-2 upregulation and nicotine-mediated plasticity.
Volume: 30
Issue: 1
Pages: 194-204
Publication
First Author: Wehrens XH
Year: 2003
Journal: Cell
Title: FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.
Volume: 113
Issue: 7
Pages: 829-40
Publication
First Author: Lehnart SE
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias.
Volume: 103
Issue: 20
Pages: 7906-10
Publication
First Author: Mei L
Year: 2020
Journal: Nat Commun
Title: Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway.
Volume: 11
Issue: 1
Pages: 3527
Publication
First Author: Mori F
Year: 2000
Journal: Neurosci Lett
Title: Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.
Volume: 285
Issue: 1
Pages: 57-60
Publication
First Author: van Oort RJ
Year: 2010
Journal: Circulation
Title: Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.
Volume: 122
Issue: 25
Pages: 2669-79
Publication
First Author: Said M
Year: 2011
Journal: J Mol Cell Cardiol
Title: Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias.
Volume: 51
Issue: 6
Pages: 936-44
Publication
First Author: Chakraborty A
Year: 2014
Journal: PLoS One
Title: Inhibition of CaMKII does not attenuate cardiac hypertrophy in mice with dysfunctional ryanodine receptor.
Volume: 9
Issue: 8
Pages: e104338
Publication
First Author: Zhao YT
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function.
Volume: 112
Issue: 13
Pages: E1669-77
Publication
First Author: Lavorato M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges.
Volume: 114
Issue: 5
Pages: E849-E858
Publication
First Author: Hiess F
Year: 2015
Journal: J Biol Chem
Title: Distribution and Function of Cardiac Ryanodine Receptor Clusters in Live Ventricular Myocytes.
Volume: 290
Issue: 33
Pages: 20477-87
Publication
First Author: Kannankeril PJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.
Volume: 103
Issue: 32
Pages: 12179-84
Publication
First Author: van Oort RJ
Year: 2010
Journal: Hypertension
Title: Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.
Volume: 55
Issue: 4
Pages: 932-8
Publication
First Author: Mathur N
Year: 2009
Journal: Circ Arrhythm Electrophysiol
Title: Sudden infant death syndrome in mice with an inherited mutation in RyR2.
Volume: 2
Issue: 6
Pages: 677-85
Publication  
First Author: Nakamura Y
Year: 2019
Journal: JCI Insight
Title: Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia.
Volume: 4
Issue: 11
Publication
First Author: Zhong X
Year: 2018
Journal: Biochem J
Title: Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans.
Volume: 475
Issue: 1
Pages: 169-183
Publication
First Author: Hotta S
Year: 2007
Journal: J Physiol
Title: Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle.
Volume: 582
Issue: Pt 2
Pages: 489-506
Publication
First Author: Becerra R
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.
Volume: 311
Issue: 3
Pages: H713-24
Publication
First Author: Zhong X
Year: 2016
Journal: Biochem J
Title: Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.
Volume: 473
Issue: 21
Pages: 3951-3964
Publication
First Author: Chen W
Year: 2014
Journal: Nat Med
Title: The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
Volume: 20
Issue: 2
Pages: 184-92
Publication
First Author: Cerrone M
Year: 2005
Journal: Circ Res
Title: Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.
Volume: 96
Issue: 10
Pages: e77-82
Publication
First Author: Lehnart SE
Year: 2008
Journal: J Clin Invest
Title: Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice.
Volume: 118
Issue: 6
Pages: 2230-45
Publication
First Author: Goddard CA
Year: 2008
Journal: Acta Physiol (Oxf)
Title: Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts.
Volume: 194
Issue: 2
Pages: 123-40
Publication
First Author: Shan J
Year: 2010
Journal: J Clin Invest
Title: Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.
Volume: 120
Issue: 12
Pages: 4388-98
Publication
First Author: Shan J
Year: 2010
Journal: J Clin Invest
Title: Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice.
Volume: 120
Issue: 12
Pages: 4375-87
Publication
First Author: Wehrens XH
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Volume: 103
Issue: 3
Pages: 511-8
Publication  
First Author: Wegener JW
Year: 2021
Journal: Front Physiol
Title: The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool.
Volume: 12
Pages: 777770
Publication  
First Author: Mohamed BA
Year: 2018
Journal: Sci Transl Med
Title: Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression.
Volume: 10
Issue: 458
Publication
First Author: Manotheepan R
Year: 2016
Journal: Cardiovasc Res
Title: Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release.
Volume: 111
Issue: 3
Pages: 295-306
Publication  
First Author: Wegener JW
Year: 2024
Journal: Life Sci Alliance
Title: A dual-targeted drug inhibits cardiac ryanodine receptor Ca(2+) leak but activates SERCA2a Ca(2+) uptake.
Volume: 7
Issue: 2
Publication
First Author: Sedej S
Year: 2010
Journal: Cardiovasc Res
Title: Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Volume: 87
Issue: 1
Pages: 50-9
Publication
First Author: Kashimura T
Year: 2010
Journal: Circ Res
Title: In the RyR2(R4496C) mouse model of CPVT, β-adrenergic stimulation induces Ca waves by increasing SR Ca content and not by decreasing the threshold for Ca waves.
Volume: 107
Issue: 12
Pages: 1483-9
Publication
First Author: Fernández-Velasco M
Year: 2009
Journal: Circ Res
Title: Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardia.
Volume: 104
Issue: 2
Pages: 201-9, 12p following 209
Publication
First Author: Sedej S
Year: 2014
Journal: J Am Coll Cardiol
Title: Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
Volume: 63
Issue: 15
Pages: 1569-79
Publication
First Author: Nishio H
Year: 2014
Journal: Leg Med (Tokyo)
Title: Hypertrophy of lymphoid organs is a possible phenotypic characteristic of R420W mutation of the cardiac ryanodine receptor gene: a study using a knock-in mouse model.
Volume: 16
Issue: 6
Pages: 326-32
Publication
First Author: Yamaguchi N
Year: 2013
Journal: Am J Physiol Heart Circ Physiol
Title: Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1.
Volume: 305
Issue: 1
Pages: H86-94
Publication
First Author: Yang HT
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The ryanodine receptor modulates the spontaneous beating rate of cardiomyocytes during development.
Volume: 99
Issue: 14
Pages: 9225-30
Publication
First Author: Fu JD
Year: 2006
Journal: FASEB J
Title: Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells.
Volume: 20
Issue: 1
Pages: 181-3
Publication
First Author: Benkusky NA
Year: 2007
Journal: Circ Res
Title: Intact beta-adrenergic response and unmodified progression toward heart failure in mice with genetic ablation of a major protein kinase A phosphorylation site in the cardiac ryanodine receptor.
Volume: 101
Issue: 8
Pages: 819-29
Publication
First Author: Zhang H
Year: 2012
Journal: Circ Res
Title: Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction.
Volume: 110
Issue: 6
Pages: 831-40
Publication
First Author: Zhang J
Year: 2015
Journal: Biochem J
Title: Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.
Volume: 470
Issue: 2
Pages: 233-42
Publication
First Author: Tan Z
Year: 2016
Journal: Biochem J
Title: Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.
Volume: 473
Issue: 22
Pages: 4159-4172
Publication
First Author: Arnáiz-Cot JJ
Year: 2013
Journal: J Physiol
Title: Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor.
Volume: 591
Issue: 17
Pages: 4287-99
Publication
First Author: Yang Y
Year: 2014
Journal: Circ Res
Title: Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.
Volume: 114
Issue: 2
Pages: 295-306
Publication  
First Author: Salvage SC
Year: 2019
Journal: J Cell Sci
Title: Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.
Volume: 132
Issue: 10
Publication
First Author: Chiang DY
Year: 2014
Journal: Circ Arrhythm Electrophysiol
Title: Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.
Volume: 7
Issue: 6
Pages: 1214-22
Publication
First Author: Wang R
Year: 2004
Journal: J Biol Chem
Title: The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gating.
Volume: 279
Issue: 5
Pages: 3635-42
Publication
First Author: George CH
Year: 2003
Journal: Circ Res
Title: Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes.
Volume: 93
Issue: 6
Pages: 531-40
Publication
First Author: Liu Z
Year: 2002
Journal: J Biol Chem
Title: Three-dimensional reconstruction of the recombinant type 2 ryanodine receptor and localization of its divergent region 1.
Volume: 277
Issue: 48
Pages: 46712-9
Publication
First Author: Liu Z
Year: 2010
Journal: J Cell Sci
Title: Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor.
Volume: 123
Issue: Pt 10
Pages: 1775-84
Publication
First Author: Li P
Year: 2001
Journal: J Gen Physiol
Title: Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor).
Volume: 118
Issue: 1
Pages: 33-44
Publication
First Author: George CH
Year: 2007
Journal: Circ Res
Title: Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis.
Volume: 100
Issue: 6
Pages: 874-83
Publication  
First Author: Xiong J
Year: 2018
Journal: J Mol Cell Cardiol
Title: Pathogenic mechanism of a catecholaminergic polymorphic ventricular tachycardia causing-mutation in cardiac calcium release channel RyR2.
Volume: 117
Pages: 26-35
Publication
First Author: Kaßmann M
Year: 2019
Journal: J Am Heart Assoc
Title: Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses.
Volume: 8
Issue: 9
Pages: e010090
Publication    
First Author: Alvarado FJ
Year: 2019
Journal: JCI Insight
Title: Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.
Volume: 5
Publication
First Author: Hiess F
Year: 2022
Journal: Commun Biol
Title: Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory.
Volume: 5
Issue: 1
Pages: 183
Publication
First Author: Lehnart SE
Year: 2005
Journal: Cell
Title: Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Volume: 123
Issue: 1
Pages: 25-35
Publication
First Author: Liu X
Year: 2012
Journal: Cell
Title: Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.
Volume: 150
Issue: 5
Pages: 1055-67
Publication
First Author: Savio-Galimberti E
Year: 2015
Journal: PLoS One
Title: Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes.
Volume: 10
Issue: 6
Pages: e0131179
Publication
First Author: Zhang J
Year: 2014
Journal: Biochem J
Title: The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.
Volume: 461
Issue: 1
Pages: 99-106
Publication
First Author: De Waard S
Year: 2020
Journal: Biochem J
Title: Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes.
Volume: 477
Issue: 20
Pages: 3985-3999