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Search results 1 to 100 out of 315 for S100a8

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Hits by Pathway

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Type Details Score
Gene
6279 | S100A8
Type: gene
Organism: human
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Gene
457319 | S100A8
Type: gene
Organism: chimpanzee
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Gene
616818 | S100A8
Type: gene
Organism: cattle
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Gene
714740 | S100A8
Type: gene
Organism: macaque, rhesus
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Gene
116547 | S100a8
Type: gene
Organism: rat
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Gene
490461 | S100A8
Type: gene
Organism: dog, domestic
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Protein Domain
IPR028474 | S100A8
Type: Family
Description: S100-A8 (also known as calgranulin A) belongs to the S100 calcium-binding family and plays a prominent role in the regulation of inflammatory processes and immune response []. S100A8 forms a heterocomplex with S100A9, termed S100A8/A9 or calprotectin. The intracellular functions of S100A8/A9 include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase [, , , ]. The extracellular functions of S100A8/A9 involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities [, ]. S100A8 and S100A9 may also have distinct functions and are regulated in part by different mechanisms [].
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Protein Coding Gene
MGI:88244 | S100a8
Type: protein_coding_gene
Organism: mouse, laboratory
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GO Term
GO:1990661 | S100A8 complex
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Publication
22095980 | -
First Author: Averill MM
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: S100A8 and S100A9 in cardiovascular biology and disease.
Volume: 32
Issue: 2
Pages: 223-9
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Publication
22489132 | -
First Author: Vogl T
Year: 2012
Journal: Int J Mol Sci
Title: Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes.
Volume: 13
Issue: 3
Pages: 2893-917
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Publication
15642721 | J:105177
First Author: Kerkhoff C
Year: 2005
Journal: FASEB J
Title: The arachidonic acid-binding protein S100A8/A9 promotes NADPH oxidase activation by interaction with p67phox and Rac-2.
Volume: 19
Issue: 3
Pages: 467-9
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Publication
29158436 | J:276196
 
First Author: Müller I
Year: 2017
Journal: Circ Heart Fail
Title: Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis.
Volume: 10
Issue: 11
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Publication
24532576 | J:209911
First Author: Hiroshima Y
Year: 2014
Journal: J Immunol
Title: S100A8 induces IL-10 and protects against acute lung injury.
Volume: 192
Issue: 6
Pages: 2800-11
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Publication
25848057 | J:220959
First Author: Sekimoto R
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Visualized macrophage dynamics and significance of S100A8 in obese fat.
Volume: 112
Issue: 16
Pages: E2058-66
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Publication
12626582 | -
First Author: Ryckman C
Year: 2003
Journal: J Immunol
Title: Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion.
Volume: 170
Issue: 6
Pages: 3233-42
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Publication
19935766 | -
First Author: Perera C
Year: 2010
Journal: Immunol Cell Biol
Title: S100 Calgranulins in inflammatory arthritis.
Volume: 88
Issue: 1
Pages: 41-9
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Publication
16258195 | -
First Author: Nakatani Y
Year: 2005
Journal: Mediators Inflamm
Title: Regulation of S100A8/A9 (calprotectin) binding to tumor cells by zinc ion and its implication for apoptosis-inducing activity.
Volume: 2005
Issue: 5
Pages: 280-92
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Publication
8423249 | -
First Author: Miyasaki KT
Year: 1993
Journal: J Dent Res
Title: In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena.
Volume: 72
Issue: 2
Pages: 517-23
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Publication
22768176 | J:187906
First Author: González-López A
Year: 2012
Journal: PLoS One
Title: MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
Volume: 7
Issue: 6
Pages: e39940
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Publication
18292562 | J:131569
First Author: Raquil MA
Year: 2008
Journal: J Immunol
Title: Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia.
Volume: 180
Issue: 5
Pages: 3366-74
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Publication
22016186 | J:177483
First Author: Baker JR
Year: 2011
Journal: Dev Dyn
Title: Distinct roles for S100a8 in early embryo development and in the maternal deciduum.
Volume: 240
Issue: 9
Pages: 2194-203
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Publication
26608915 | J:251653
First Author: Mukai K
Year: 2016
Journal: J Immunol
Title: S100A8 Production in CXCR2-Expressing CD11b+Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol Diet.
Volume: 196
Issue: 1
Pages: 395-406
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Publication
36505926 | J:334321
First Author: Miyashita D
Year: 2022
Journal: iScience
Title: Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.
Volume: 25
Issue: 12
Pages: 105662
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Publication
18403730 | J:149024
First Author: Boyd JH
Year: 2008
Journal: Circ Res
Title: S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products.
Volume: 102
Issue: 10
Pages: 1239-46
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Publication
10438963 | J:56750
First Author: Passey RJ
Year: 1999
Journal: J Immunol
Title: A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo.
Volume: 163
Issue: 4
Pages: 2209-16
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Publication
27388991 | J:238126
First Author: Sakaguchi M
Year: 2016
Journal: J Invest Dermatol
Title: Identification of an S100A8 Receptor Neuroplastin-β and its Heterodimer Formation with EMMPRIN.
Volume: 136
Issue: 11
Pages: 2240-2250
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Publication
26878232 | J:233322
First Author: Schneider RK
Year: 2016
Journal: Nat Med
Title: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.
Volume: 22
Issue: 3
Pages: 288-97
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Publication
30232010 | J:270895
First Author: Fujita Y
Year: 2018
Journal: Cell Rep
Title: Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis.
Volume: 24
Issue: 12
Pages: 3296-3311.e6
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Publication
21233451 | J:184170
First Author: Hiuge-Shimizu A
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone.
Volume: 31
Issue: 4
Pages: 792-9
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Publication
31605018 | J:284072
First Author: Maekawa S
Year: 2019
Journal: Sci Rep
Title: RNA sequencing for ligature induced periodontitis in mice revealed important role of S100A8 and S100A9 for periodontal destruction.
Volume: 9
Issue: 1
Pages: 14663
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Publication
12082614 | J:77140
First Author: Gebhardt C
Year: 2002
Journal: Oncogene
Title: Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis.
Volume: 21
Issue: 27
Pages: 4266-76
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Publication
32805279 | J:305340
First Author: Willers M
Year: 2020
Journal: Gastroenterology
Title: S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Volume: 159
Issue: 6
Pages: 2130-2145.e5
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Protein
P27005
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Protein
Q53X15
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: false
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Gene
101929559 | PIRAT1
Type: gene
Organism: human
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Publication
35543413 | J:325051
   
First Author: Jauch-Speer SL
Year: 2022
Journal: Elife
Title: C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9.
Volume: 11
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Publication
33361205 | J:303887
First Author: Defrêne J
Year: 2021
Journal: J Immunol
Title: Deletion of S100a8 and S100a9 Enhances Skin Hyperplasia and Promotes the Th17 Response in Imiquimod-Induced Psoriasis.
Volume: 206
Issue: 3
Pages: 505-514
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Publication
28459433 | J:258926
First Author: Ulas T
Year: 2017
Journal: Nat Immunol
Title: S100-alarmin-induced innate immune programming protects newborn infants from sepsis.
Volume: 18
Issue: 6
Pages: 622-632
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Publication
32107497 | J:291711
First Author: Frohberger SJ
Year: 2020
Journal: PLoS Negl Trop Dis
Title: S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.
Volume: 14
Issue: 2
Pages: e0008119
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Publication
23874727 | J:204401
First Author: Kuipers MT
Year: 2013
Journal: PLoS One
Title: High levels of S100A8/A9 proteins aggravate ventilator-induced lung injury via TLR4 signaling.
Volume: 8
Issue: 7
Pages: e68694
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Publication
23132931 | J:200244
First Author: Roth W
Year: 2012
Journal: J Cell Sci
Title: Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.
Volume: 125
Issue: Pt 22
Pages: 5269-79
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Publication
25759267 | J:220687
First Author: Pepper RJ
Year: 2015
Journal: Am J Pathol
Title: S100A8/A9 (calprotectin) is critical for development of glomerulonephritis and promotes inflammatory leukocyte-renal cell interactions.
Volume: 185
Issue: 5
Pages: 1264-74
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Publication
21228116 | J:205229
First Author: Ichikawa M
Year: 2011
Journal: Mol Cancer Res
Title: S100A8/A9 activate key genes and pathways in colon tumor progression.
Volume: 9
Issue: 2
Pages: 133-48
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Publication
23133376 | J:195364
First Author: Achouiti A
Year: 2012
Journal: PLoS Pathog
Title: Myeloid-related protein-14 contributes to protective immunity in gram-negative pneumonia derived sepsis.
Volume: 8
Issue: 10
Pages: e1002987
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Publication
24478092 | J:209808
First Author: Yano J
Year: 2014
Journal: Infect Immun
Title: Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis.
Volume: 82
Issue: 2
Pages: 783-92
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Publication
23188082 | J:193123
First Author: Petersen B
Year: 2013
Journal: EMBO J
Title: The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
Volume: 32
Issue: 1
Pages: 100-11
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Publication
29563178 | J:261459
First Author: Denstaedt SJ
Year: 2018
Journal: J Immunol
Title: S100A8/A9 Drives Neuroinflammatory Priming and Protects against Anxiety-like Behavior after Sepsis.
Volume: 200
Issue: 9
Pages: 3188-3200
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Publication
10534107 | J:58109
First Author: Passey RJ
Year: 1999
Journal: J Leukoc Biol
Title: S100A8: emerging functions and regulation.
Volume: 66
Issue: 4
Pages: 549-56
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Publication
17767165 | J:125179
First Author: Vogl T
Year: 2007
Journal: Nat Med
Title: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
Volume: 13
Issue: 9
Pages: 1042-9
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Publication
28504650 | J:244015
First Author: Kraakman MJ
Year: 2017
Journal: J Clin Invest
Title: Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes.
Volume: 127
Issue: 6
Pages: 2133-2147
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Publication
26404752 | J:226627
First Author: De Ponti A
Year: 2015
Journal: Cancer Lett
Title: A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma.
Volume: 369
Issue: 2
Pages: 396-404
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Publication
37610870 | J:340473
First Author: von Wulffen M
Year: 2023
Journal: Cell Rep
Title: S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis.
Volume: 42
Issue: 8
Pages: 113006
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Publication
31437241 | J:283601
First Author: Cesaro A
Year: 2019
Journal: PLoS One
Title: Enhanced myelopoiesis and aggravated arthritis in S100a8-deficient mice.
Volume: 14
Issue: 8
Pages: e0221528
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Publication
18714033 | J:138938
First Author: Pouliot P
Year: 2008
Journal: J Immunol
Title: Myeloid-related proteins rapidly modulate macrophage nitric oxide production during innate immune response.
Volume: 181
Issue: 5
Pages: 3595-601
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Publication
18832721 | J:140757
First Author: Lim SY
Year: 2008
Journal: J Immunol
Title: S-nitrosylated S100A8: novel anti-inflammatory properties.
Volume: 181
Issue: 8
Pages: 5627-36
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Publication
25597447 | J:343391
First Author: Gagnon DM
Year: 2015
Journal: J Am Chem Soc
Title: Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis.
Volume: 137
Issue: 8
Pages: 3004-16
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Publication
25820336 | J:234318
First Author: Wei X
Year: 2015
Journal: Circulation
Title: Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9.
Volume: 131
Issue: 17
Pages: 1506-17; discussion 1517
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Publication
18689872 | J:140328
First Author: Turovskaya O
Year: 2008
Journal: Carcinogenesis
Title: RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.
Volume: 29
Issue: 10
Pages: 2035-43
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Publication
28137827 | J:241074
First Author: Laouedj M
Year: 2017
Journal: Blood
Title: S100A9 induces differentiation of acute myeloid leukemia cells through TLR4.
Volume: 129
Issue: 14
Pages: 1980-1990
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Publication
20473308 | J:161530
First Author: Loser K
Year: 2010
Journal: Nat Med
Title: The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells.
Volume: 16
Issue: 6
Pages: 713-7
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Publication
18820689 | J:145634
First Author: Hiratsuka S
Year: 2008
Journal: Nat Cell Biol
Title: The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase.
Volume: 10
Issue: 11
Pages: 1349-55
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Publication
22577135 | J:188377
First Author: Ryu MJ
Year: 2012
Journal: J Biol Chem
Title: Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis.
Volume: 287
Issue: 27
Pages: 22948-58
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Publication
21536666 | J:174810
First Author: Farris SD
Year: 2011
Journal: J Biol Chem
Title: Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins.
Volume: 286
Issue: 25
Pages: 22665-77
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Publication
26165843 | J:234214
First Author: Deguchi A
Year: 2016
Journal: Oncogene
Title: Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.
Volume: 35
Issue: 11
Pages: 1445-56
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Publication
15203200 | J:90621
First Author: Ravasi T
Year: 2004
Journal: Genomics
Title: Probing the S100 protein family through genomic and functional analysis.
Volume: 84
Issue: 1
Pages: 10-22
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Publication
10381505 | J:56240
First Author: Lichanska AM
Year: 1999
Journal: Blood
Title: Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.
Volume: 94
Issue: 1
Pages: 127-38
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Protein Coding Gene
MGP_CAROLIEiJ_G0025251 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027479 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027443 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027408 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027452 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027194 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026640 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027306 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027274 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027415 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027295 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026695 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026194 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8454868 | J:17391
First Author: Lackmann M
Year: 1993
Journal: J Immunol
Title: Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10.
Volume: 150
Issue: 7
Pages: 2981-91
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Publication
8611640 | J:31265
First Author: Nacken W
Year: 1996
Journal: Biochim Biophys Acta
Title: Molecular characterisation of the genomic locus of the mouse MRP8 gene.
Volume: 1315
Issue: 1
Pages: 1-5
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Publication
8179823 | J:17216
First Author: Iismaa SE
Year: 1994
Journal: DNA Cell Biol
Title: Recombinant and cellular expression of the murine chemotactic protein, CP-10.
Volume: 13
Issue: 2
Pages: 183-92
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Publication
23817615 | J:199826
First Author: Kehl-Fie TE
Year: 2013
Journal: Infect Immun
Title: MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese.
Volume: 81
Issue: 9
Pages: 3395-405
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Publication
32080297 | J:297864
First Author: Hata Y
Year: 2020
Journal: Sci Rep
Title: Ablation of Myeloid Cell MRP8 Ameliorates Nephrotoxic Serum-induced Glomerulonephritis by Affecting Macrophage Characterization through Intraglomerular Crosstalk.
Volume: 10
Issue: 1
Pages: 3056
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GXD Expression
GXD Expression
     
Probe: MGI:3513260
Assay Type: RT-PCR
Annotation Date: 2005-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:3513267
Age: embryonic day 11.5
Specimen Label: E11.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3513260
Assay Type: RT-PCR
Annotation Date: 2005-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603921
Stage: TS21
Assay Id: MGI:3513267
Age: embryonic day 13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3513260
Assay Type: RT-PCR
Annotation Date: 2005-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2576527
Stage: TS27
Assay Id: MGI:3513267
Age: postnatal day 1
Specimen Label: P1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:5577122
Age: postnatal
Image: 4
Specimen Label: Bone Marrow
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:5577122
Age: embryonic day 8.5
Image: 4
Specimen Label: E8.5
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:5577122
Age: embryonic day 10.5
Image: 4
Specimen Label: E10.5
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:5577122
Age: embryonic day 12.5
Image: 4
Specimen Label: E12.5
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:5577122
Age: embryonic day 8.5
Image: 4
Specimen Label: E8.5
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5577120
Assay Type: RT-PCR
Annotation Date: 2014-08-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3526928
Stage: TS28
Assay Id: MGI:5577122
Age: embryonic day 10.5
Image: 4
Specimen Label: E10.5
Detected: true
Specimen Num: 6
•
•
•
•
•




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