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Search results 1 to 100 out of 470 for Sarm1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
23098 | SARM1
Type: gene
Organism: human
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Gene
779619 | sarm1
Type: gene
Organism: frog, western clawed
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Gene
287545 | Sarm1
Type: gene
Organism: rat
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Gene
491165 | SARM1
Type: gene
Organism: dog, domestic
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Gene
738203 | SARM1
Type: gene
Organism: chimpanzee
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Gene
536256 | SARM1
Type: gene
Organism: cattle
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Gene
417568 | SARM1
Type: gene
Organism: chicken
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Gene
403143 | sarm1
Type: gene
Organism: zebrafish
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Gene
715863 | SARM1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR039184 | SARM1
Type: Family
Description: SARM1 (sterile alpha and TIR motif-containing protein 1) is a TIR (Toll-interleukin 1 receptor) adaptor that downregulates Toll-like receptor signalling [, , ]. It plays a role in innate immunity []. It is also an essential mediator of axon degeneration know as Wallerian degeneration [, ]. A specific motif in its TIR domain is responsible for NAD+ loss and injury-induced SARM1 activation [, ].
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Protein Coding Gene
MGI:2136419 | Sarm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
A0PJL3
Organism: Mus musculus/domesticus
Length: 704  
Fragment?: true
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Protein
Q6PDS3
Organism: Mus musculus/domesticus
Length: 724  
Fragment?: false
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Publication
25908823 | -
First Author: Gerdts J
Year: 2015
Journal: Science
Title: SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.
Volume: 348
Issue: 6233
Pages: 453-7
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Publication
27671644 | -
First Author: Summers DW
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Volume: 113
Issue: 41
Pages: E6271-E6280
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Publication
25818290 | J:228171
First Author: Gilley J
Year: 2015
Journal: Cell Rep
Title: Absence of SARM1 rescues development and survival of NMNAT2-deficient axons.
Volume: 10
Issue: 12
Pages: 1974-81
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Publication
28334607 | J:256058
First Author: Essuman K
Year: 2017
Journal: Neuron
Title: The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.
Volume: 93
Issue: 6
Pages: 1334-1343.e5
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Publication
28978465 | J:252071
First Author: Gilley J
Year: 2017
Journal: Cell Rep
Title: Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy.
Volume: 21
Issue: 1
Pages: 10-16
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Publication
32584865 | J:294167
First Author: Viar K
Year: 2020
Journal: PLoS One
Title: Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis.
Volume: 15
Issue: 6
Pages: e0235110
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Publication
32312889 | J:302470
 
First Author: Ozaki E
Year: 2020
Journal: Life Sci Alliance
Title: SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration.
Volume: 3
Issue: 5
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Publication
33468661 | J:301532
 
First Author: Shen C
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Multiple domain interfaces mediate SARM1 autoinhibition.
Volume: 118
Issue: 4
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Publication
16964262 | -
First Author: Carty M
Year: 2006
Journal: Nat Immunol
Title: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.
Volume: 7
Issue: 10
Pages: 1074-81
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Publication
20306472 | -
First Author: Peng J
Year: 2010
Journal: Eur J Immunol
Title: SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.
Volume: 40
Issue: 6
Pages: 1738-47
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Publication
17980913 | -
First Author: Belinda LW
Year: 2008
Journal: Mol Immunol
Title: SARM: a novel Toll-like receptor adaptor, is functionally conserved from arthropod to human.
Volume: 45
Issue: 6
Pages: 1732-42
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Publication
38176648 | J:360281
First Author: Shanahan KA
Year: 2024
Journal: J Biol Chem
Title: SARM1 regulates NAD(+)-linked metabolism and select immune genes in macrophages.
Volume: 300
Issue: 2
Pages: 105620
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Publication
33107823 | J:298563
   
First Author: Sasaki Y
Year: 2020
Journal: Elife
Title: SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.
Volume: 9
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Publication
31439642 | J:280444
First Author: Cheng Y
Year: 2019
Journal: Diabetes
Title: Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice.
Volume: 68
Issue: 11
Pages: 2120-2130
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Publication
34793837 | J:337192
First Author: Doran CG
Year: 2021
Journal: J Biol Chem
Title: CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages.
Volume: 297
Issue: 6
Pages: 101417
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Publication
34686345 | J:323592
First Author: Wu T
Year: 2021
Journal: Cell Rep
Title: Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss.
Volume: 37
Issue: 3
Pages: 109872
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Publication
35334231 | J:352986
First Author: Shi Y
Year: 2022
Journal: Mol Cell
Title: Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Volume: 82
Issue: 9
Pages: 1643-1659.e10
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Publication
30842236 | J:275201
First Author: Zhu C
Year: 2019
Journal: J Exp Med
Title: SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.
Volume: 216
Issue: 4
Pages: 743-756
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Publication
36689294 | J:355531
First Author: Huang K
Year: 2023
Journal: ACS Sens
Title: Base-Exchange Enabling the Visualization of SARM1 Activities in Sciatic Nerve-Injured Mice.
Volume: 8
Issue: 2
Pages: 767-773
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Publication
38199568 | J:345666
First Author: Miyamoto T
Year: 2024
Journal: J Biol Chem
Title: SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
Volume: 300
Issue: 2
Pages: 105630
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Publication
35431772 | J:323923
 
First Author: Gibbons L
Year: 2022
Journal: Front Neurosci
Title: SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration.
Volume: 16
Pages: 852114
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Publication
34991663 | J:318733
First Author: Bloom AJ
Year: 2022
Journal: Mol Neurodegener
Title: Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.
Volume: 17
Issue: 1
Pages: 1
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Publication
38331947 | J:352328
First Author: Zeng H
Year: 2024
Journal: Acta Neuropathol Commun
Title: Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma.
Volume: 12
Issue: 1
Pages: 23
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Publication
31661035 | J:292932
First Author: White MA
Year: 2019
Journal: Acta Neuropathol Commun
Title: Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss.
Volume: 7
Issue: 1
Pages: 166
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Publication
32069324 | J:291775
First Author: Sundaramoorthy V
Year: 2020
Journal: PLoS Pathog
Title: Novel role of SARM1 mediated axonal degeneration in the pathogenesis of rabies.
Volume: 16
Issue: 2
Pages: e1008343
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Publication
38692735 | J:354314
 
First Author: Hinz FI
Year: 2024
Journal: J Neurosci
Title: Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons.
Volume: 44
Issue: 24
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Publication
36087583 | J:337138
First Author: Bratkowski M
Year: 2022
Journal: Neuron
Title: Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease.
Volume: 110
Issue: 22
Pages: 3711-3726.e16
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Publication
28485482 | J:274130
First Author: Turkiew E
Year: 2017
Journal: J Peripher Nerv Syst
Title: Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
Volume: 22
Issue: 3
Pages: 162-171
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Publication
33657413 | J:305613
First Author: Figley MD
Year: 2021
Journal: Neuron
Title: SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Volume: 109
Issue: 7
Pages: 1118-1136.e11
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Publication
32609299 | J:305854
 
First Author: Ko KW
Year: 2020
Journal: J Cell Biol
Title: SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.
Volume: 219
Issue: 8
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Publication
34910914 | J:320906
First Author: Gould SA
Year: 2021
Journal: Cell Rep
Title: Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration.
Volume: 37
Issue: 11
Pages: 110108
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Publication
31445042 | J:287827
 
First Author: Marion CM
Year: 2019
Journal: Exp Neurol
Title: Sarm1 deletion reduces axon damage, demyelination, and white matter atrophy after experimental traumatic brain injury.
Volume: 321
Pages: 113040
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Publication
31962129 | J:292731
 
First Author: Maynard ME
Year: 2020
Journal: Exp Neurol
Title: Sarm1 loss reduces axonal damage and improves cognitive outcome after repetitive mild closed head injury.
Volume: 327
Pages: 113207
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Publication
31439792 | -
First Author: Horsefield S
Year: 2019
Journal: Science
Title: NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Volume: 365
Issue: 6455
Pages: 793-799
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Publication
33754056 | J:322144
First Author: Liu H
Year: 2021
Journal: Theranostics
Title: SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling.
Volume: 11
Issue: 9
Pages: 4187-4206
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Publication
29526794 | J:280442
 
First Author: Fernandes KA
Year: 2018
Journal: Exp Eye Res
Title: Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.
Volume: 171
Pages: 54-61
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Publication
23751821 | J:317376
First Author: Lin CW
Year: 2014
Journal: Innate Immun
Title: Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains.
Volume: 20
Issue: 2
Pages: 161-72
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Publication
33406435 | J:337026
First Author: Hughes RO
Year: 2021
Journal: Cell Rep
Title: Small Molecule SARM1 Inhibitors Recapitulate the SARM1(-/-) Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.
Volume: 34
Issue: 1
Pages: 108588
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Publication
35947948 | J:337181
First Author: Feriotti C
Year: 2022
Journal: Cell Rep
Title: Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.
Volume: 40
Issue: 6
Pages: 111167
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Publication
36055989 | J:328328
First Author: Jin L
Year: 2022
Journal: Cell Death Dis
Title: Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling.
Volume: 13
Issue: 9
Pages: 759
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Publication
35869039 | J:327344
First Author: Xiang L
Year: 2022
Journal: Cell Death Dis
Title: SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice.
Volume: 13
Issue: 7
Pages: 638
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Publication
32087251 | J:297605
 
First Author: Sasaki Y
Year: 2020
Journal: Exp Neurol
Title: cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.
Volume: 329
Pages: 113252
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Publication
30010873 | J:266573
First Author: Peters OM
Year: 2018
Journal: Hum Mol Genet
Title: Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
Volume: 27
Issue: 21
Pages: 3761-3771
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Publication
29454967 | J:270665
First Author: Pan ZG
Year: 2018
Journal: Biochem Biophys Res Commun
Title: SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation.
Volume: 498
Issue: 3
Pages: 416-423
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Publication
37091921 | J:335222
 
First Author: Fazal SV
Year: 2023
Journal: Front Cell Neurosci
Title: SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.
Volume: 17
Pages: 1158388
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Publication
36680758 | J:351555
First Author: Alexandris AS
Year: 2023
Journal: J Neurotrauma
Title: Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy.
Volume: 40
Issue: 15-16
Pages: 1743-1761
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Publication
38124145 | J:350853
First Author: Dogan EO
Year: 2023
Journal: Acta Neuropathol Commun
Title: Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
Volume: 11
Issue: 1
Pages: 206
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Publication
35163535 | J:325888
 
First Author: Finnegan LK
Year: 2022
Journal: Int J Mol Sci
Title: SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration.
Volume: 23
Issue: 3
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Publication
34001261 | J:323316
First Author: Bradshaw DV Jr
Year: 2021
Journal: Acta Neuropathol Commun
Title: Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures.
Volume: 9
Issue: 1
Pages: 89
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Publication
35507602 | J:325621
First Author: Ward A
Year: 2022
Journal: PLoS One
Title: Lack of the immune adaptor molecule SARM1 accelerates disease in prion infected mice and is associated with increased mitochondrial respiration and decreased expression of NRF2.
Volume: 17
Issue: 5
Pages: e0267720
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Publication
35863521 | J:328355
 
First Author: Collins JM
Year: 2022
Journal: Neurobiol Dis
Title: Sarm1 knockout modifies biomarkers of neurodegeneration and spinal cord circuitry but not disease progression in the mSOD1G93A mouse model of ALS.
Volume: 172
Pages: 105821
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Publication
22678360 | J:185791
First Author: Osterloh JM
Year: 2012
Journal: Science
Title: dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Volume: 337
Issue: 6093
Pages: 481-4
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Publication
21555464 | J:172355
First Author: Chen CY
Year: 2011
Journal: J Cell Biol
Title: Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology.
Volume: 193
Issue: 4
Pages: 769-84
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Publication
19587044 | J:200140
First Author: Szretter KJ
Year: 2009
Journal: J Virol
Title: The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis.
Volume: 83
Issue: 18
Pages: 9329-38
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Publication
27735788 | J:269726
   
First Author: Sasaki Y
Year: 2016
Journal: Elife
Title: NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.
Volume: 5
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Publication
17724133 | J:126083
First Author: Kim Y
Year: 2007
Journal: J Exp Med
Title: MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival.
Volume: 204
Issue: 9
Pages: 2063-74
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Publication
34870595 | J:317828
   
First Author: Loreto A
Year: 2021
Journal: Elife
Title: Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Volume: 10
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Publication
33871822 | J:350405
First Author: Sun Y
Year: 2021
Journal: Protein Cell
Title: Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.
Volume: 12
Issue: 8
Pages: 621-638
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Publication
32268088 | J:300476
First Author: Uccellini MB
Year: 2020
Journal: Cell Rep
Title: Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice.
Volume: 31
Issue: 1
Pages: 107498
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Publication
33053563 | J:300326
First Author: Jiang Y
Year: 2020
Journal: Nature
Title: The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Volume: 588
Issue: 7839
Pages: 658-663
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Publication
28095293 | J:240612
   
First Author: Walker LJ
Year: 2017
Journal: Elife
Title: MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.
Volume: 6
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Publication
24321214 | J:318802
 
First Author: Lin CW
Year: 2014
Journal: Brain Behav Immun
Title: Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice.
Volume: 37
Pages: 142-51
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Publication
31484833 | J:298143
 
First Author: Geisler S
Year: 2019
Journal: JCI Insight
Title: Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.
Volume: 4
Issue: 17
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Publication
25009267 | J:215305
First Author: Summers DW
Year: 2014
Journal: J Neurosci
Title: Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.
Volume: 34
Issue: 28
Pages: 9338-50
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Publication
33460644 | J:307743
 
First Author: Gould SA
Year: 2021
Journal: Exp Neurol
Title: Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1-/- mice.
Volume: 338
Pages: 113607
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Publication
33892050 | J:322256
 
First Author: Peters OM
Year: 2021
Journal: Neurobiol Dis
Title: Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease.
Volume: 155
Pages: 105368
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Publication
23946415 | J:200987
First Author: Gerdts J
Year: 2013
Journal: J Neurosci
Title: Sarm1-mediated axon degeneration requires both SAM and TIR interactions.
Volume: 33
Issue: 33
Pages: 13569-80
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Publication
30191480 | J:321855
First Author: Killackey SA
Year: 2019
Journal: Mol Cell Biochem
Title: The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1.
Volume: 453
Issue: 1-2
Pages: 187-196
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Publication
33545051 | J:303733
First Author: Liu K
Year: 2021
Journal: Cell Metab
Title: Metabolic stress drives sympathetic neuropathy within the liver.
Volume: 33
Issue: 3
Pages: 666-675.e4
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Publication
29567804 | J:261220
First Author: Ziogas NK
Year: 2018
Journal: J Neurosci
Title: Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods.
Volume: 38
Issue: 16
Pages: 4031-4047
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Publication
17804407 | J:126955
First Author: Molday LL
Year: 2007
Journal: J Biol Chem
Title: Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex.
Volume: 282
Issue: 45
Pages: 32792-801
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Protein
Q6PDS3-2
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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Protein
Q6PDS3-4
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Protein
Q6PDS3-3
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0016807 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0018781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0018747 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0018717 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0018721 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0018534 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2136419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019172 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018088 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0018505 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0018613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0018603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0018684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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