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Search results 1 to 100 out of 413 for Sars

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Hits by Pathway

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Hits by Category

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6362700
Age: postnatal
Image: Sars
Specimen Label: oocyte
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6362700
Age: embryonic day 0.5
Image: Sars
Specimen Label: zygote
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6362700
Age: embryonic day 1.0
Image: Sars
Specimen Label: 2-cell
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6362700
Age: embryonic day 3.0
Image: Sars
Specimen Label: 16-cell
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6362700
Age: embryonic day 3.5
Image: Sars
Specimen Label: blastocyst
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160429
Stage: TS09
Assay Id: MGI:6362700
Age: embryonic day 6.5
Image: Sars
Specimen Label: extraembryonic
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Stage: TS09
Assay Id: MGI:6362700
Age: embryonic day 6.5
Image: Sars
Specimen Label: visceral endoderm
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:6362700
Age: embryonic day 6.5
Image: Sars
Specimen Label: epiblast
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:6362700
Age: embryonic day 7.5
Image: Sars
Specimen Label: extraembryonic
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:6362700
Age: embryonic day 8.5
Image: Sars
Specimen Label: yolk sac
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6362700
Age: embryonic day 8.5
Image: Sars
Specimen Label: embryonic
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362700
Age: postnatal
Image: Sars
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362700
Age: postnatal
Image: Sars
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
   
Probe: MGI:6361735
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:6362700
Age: embryonic day 7.5
Image: Sars
Specimen Label: embryonic
Detected: true
Specimen Num: 12
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Author
de Sars V
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Publication
15324552 | J:286327
First Author: Wentworth DE
Year: 2004
Journal: Emerg Infect Dis
Title: Mice susceptible to SARS coronavirus.
Volume: 10
Issue: 7
Pages: 1293-6
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QTL
MGI:6403753 | Hrsq3
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404136 | Hrsq12
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6403752 | Hrsq2
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404133 | Hrsq9
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765462 | Hrsq27
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765460 | Hrsq25
Type: QTL
Organism: mouse, laboratory
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Publication
26184451 | J:284000
 
First Author: Gretebeck LM
Year: 2015
Journal: Curr Opin Virol
Title: Animal models for SARS and MERS coronaviruses.
Volume: 13
Pages: 123-9
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Publication
- | J:308670
     
First Author: Dangi T
Year: 2021
Journal: bioRxiv
Title: SARS coronavirus vaccines protect against different coronaviruses.
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QTL
MGI:6404134 | Hrsq10
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404131 | Hrsq7
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404135 | Hrsq11
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6403751 | Hrsq1
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404130 | Hrsq6
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404129 | Hrsq5
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6403754 | Hrsq4
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6404132 | Hrsq8
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765405 | Hrsq18
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765464 | Hrsq29
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765470 | Hrsq35
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765396 | Hrsq14
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765393 | Hrsq13
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765469 | Hrsq34
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765402 | Hrsq17
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765463 | Hrsq28
Type: QTL
Organism: mouse, laboratory
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Protein Domain
IPR044393 | ORF8_bat_SARS-CoV_HKU3-1-like
Type: Family
Description: This entry includes the ORF8 immunoglobulin (Ig) domain proteins of Bat SARS coronavirus HKU3-1, which have been classified previously as type III ORF8's.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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DO Term
DOID:2945 | severe acute respiratory syndrome
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Publication
22536382 | J:291628
First Author: Tseng CT
Year: 2012
Journal: PLoS One
Title: Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus.
Volume: 7
Issue: 4
Pages: e35421
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Publication
- | J:296690
     
First Author: Mazumder S
Year: 2020
Journal: bioRxiv
Title: PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2.
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QTL
MGI:6765406 | Hrsq19
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765468 | Hrsq33
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765417 | Hrsq22
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765398 | Hrsq15
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765465 | Hrsq30
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765408 | Hrsq20
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765420 | Hrsq23
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765409 | Hrsq21
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765471 | Hrsq36
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765400 | Hrsq16
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765466 | Hrsq31
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765467 | Hrsq32
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765461 | Hrsq26
Type: QTL
Organism: mouse, laboratory
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QTL
MGI:6765421 | Hrsq24
Type: QTL
Organism: mouse, laboratory
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Publication
34919799 | J:335935
First Author: Joyce MG
Year: 2021
Journal: Cell Rep
Title: SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity.
Volume: 37
Issue: 12
Pages: 110143
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Publication
- | J:308726
     
First Author: Joyce MGl Chen WH
Year: 2021
Journal: bioRxiv
Title: SARS-CoV-2 ferritin nonoparticle vaccines elicit broad SARS coronavirus immunogenicity.
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Publication
32365944 | J:291870
 
First Author: Chang YS
Year: 2020
Journal: Int J Mol Sci
Title: SARS Unique Domain (SUD) of Severe Acute Respiratory Syndrome Coronavirus Induces NLRP3 Inflammasome-Dependent CXCL10-Mediated Pulmonary Inflammation.
Volume: 21
Issue: 9
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Publication
21253575 | J:187558
First Author: Huang IC
Year: 2011
Journal: PLoS Pathog
Title: Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus.
Volume: 7
Issue: 1
Pages: e1001258
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Publication
16007097 | J:286299
First Author: Kuba K
Year: 2005
Journal: Nat Med
Title: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Volume: 11
Issue: 8
Pages: 875-9
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Publication
17974127 | J:141460
First Author: Yang XH
Year: 2007
Journal: Comp Med
Title: Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Volume: 57
Issue: 5
Pages: 450-9
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Publication
27173006 | J:291621
 
First Author: Li SW
Year: 2016
Journal: Sci Rep
Title: SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-β1 via ROS/p38 MAPK/STAT3 pathway.
Volume: 6
Pages: 25754
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Publication
27349522 | J:291625
 
First Author: Shen ZT
Year: 2016
Journal: Sci Rep
Title: SARS Coronavirus Fusion Peptide-Derived Sequence Suppresses Collagen-Induced Arthritis in DBA/1J Mice.
Volume: 6
Pages: 28672
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Publication
- | J:303470
     
First Author: Sanchez S
Year: 2021
Journal: bioRxiv
Title: Limiting the priming dose of a SARS CoV-2 vaccine improves virus-specific immunity.
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Publication
16048439 | J:287050
First Author: Yang Y
Year: 2005
Journal: Biochem J
Title: Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors.
Volume: 392
Issue: Pt 1
Pages: 135-43
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Publication
24355931 | J:302246
First Author: Chen WH
Year: 2014
Journal: Hum Vaccin Immunother
Title: Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate.
Volume: 10
Issue: 3
Pages: 648-58
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Publication
- | J:324937
     
First Author: Agarwal S
Year: 2022
Journal: bioRxiv
Title: Dietary alphaKG inhibits SARS CoV-2 infection and rescues inflamed lungs to restore normal O2 saturation in animals.
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Publication
27663205 | J:288523
First Author: McDermott JE
Year: 2016
Journal: BMC Syst Biol
Title: The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus.
Volume: 10
Issue: 1
Pages: 93
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Publication
- | J:299308
     
First Author: Tscherne A
Year: 2021
Journal: bioRxiv
Title: Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination.
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Publication
16228284 | -
First Author: Chang CK
Year: 2006
Journal: J Biomed Sci
Title: Modular organization of SARS coronavirus nucleocapsid protein.
Volume: 13
Issue: 1
Pages: 59-72
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Publication
- | J:299104
     
First Author: Liu R
Year: 2021
Journal: bioRxiv
Title: MVA vector vaccines inhibits SARS CoV-2 replication in upper and lower respiratory tracts of transgenic mice and prevent lethal disease.
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Publication
- | J:295383
     
First Author: Baray JC
Year: 2020
Journal: bioRxiv
Title: BANCOVID, the first D614G variant mRNA-based vaccine candidate against SARS CoV-2 elicits neutralizing antibody and balanced cellular immune response.
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Publication
- | J:325038
     
First Author: Shamseldin MM
Year: 2022
Journal: bioRxiv
Title: Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology.
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Allele
Hrsq10<PWK/PhJ> | MGI:6404144
 
Name: host response to SARS QTL 10, D4% weight; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq10<C57BL/6J> | MGI:6404145
 
Name: host response to SARS QTL 10, D4% weight; C57BL/6J
Allele Type: QTL
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Allele
Hrsq7<C57BL/6J> | MGI:6404178
 
Name: host response to SARS QTL 7, log titer; C57BL/6J
Allele Type: QTL
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Allele
Hrsq7<129S1/SvImJ> | MGI:6404180
 
Name: host response to SARS QTL 7, log titer; 129S1/SvImJ
Allele Type: QTL
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Allele
Hrsq7<PWK/PhJ> | MGI:6404177
 
Name: host response to SARS QTL 7, log titer; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq7<WSB/EiJ> | MGI:6404182
 
Name: host response to SARS QTL 7, log titer; WSB/EiJ
Allele Type: QTL
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Allele
Hrsq3<A/J> | MGI:6403778
 
Name: host response to SARS QTL 3, eosinophilia; A/J
Allele Type: QTL
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Allele
Hrsq11<C57BL/6J> | MGI:6404147
 
Name: host response to SARS QTL 11, log titer; C57BL/6J
Allele Type: QTL
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Allele
Hrsq12<PWK/PhJ> | MGI:6404148
 
Name: host response to SARS QTL 12, hemorrhage; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq12<C57BL/6J> | MGI:6404149
 
Name: host response to SARS QTL 12, hemorrhage; C57BL/6J
Allele Type: QTL
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Allele
Hrsq11<PWK/PhJ> | MGI:6404146
 
Name: host response to SARS QTL 11, log titer; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq1<WSB/EiJ> | MGI:6403776
 
Name: host response to SARS QTL 1, vascular cuffing; WSB/EiJ
Allele Type: QTL
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Allele
Hrsq1<C57BL/6J> | MGI:6403775
 
Name: host response to SARS QTL 1, vascular cuffing; C57BL/6J
Allele Type: QTL
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Allele
Hrsq2<PWK/PhJ> | MGI:6403777
 
Name: host response to SARS QTL 2, titer; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq6<WSB/EiJ> | MGI:6404176
 
Name: host response to SARS QTL 6, D3% weight; WSB/EiJ
Allele Type: QTL
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Allele
Hrsq6<C57BL/6J> | MGI:6404175
 
Name: host response to SARS QTL 6, D3% weight; C57BL/6J
Allele Type: QTL
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Allele
Hrsq9<NZO/HlLtJ> | MGI:6404190
 
Name: host response to SARS QTL 9, hemorrhage; NZO/HlLtJ
Allele Type: QTL
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Allele
Hrsq9<CAST/EiJ> | MGI:6404195
 
Name: host response to SARS QTL 9, hemorrhage; CAST/EiJ
Allele Type: QTL
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Allele
Hrsq9<129S1/SvImJ> | MGI:6404194
 
Name: host response to SARS QTL 9, hemorrhage; 129S1/SvImJ
Allele Type: QTL
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Allele
Hrsq9<PWK/PhJ> | MGI:6404189
 
Name: host response to SARS QTL 9, hemorrhage; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq9<NOD/ShiLtJ> | MGI:6404192
 
Name: host response to SARS QTL 9, hemorrhage; NOD/ShiLtJ
Allele Type: QTL
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Allele
Hrsq5<PWK/PhJ> | MGI:6404142
 
Name: host response to SARS QTL 5, D3% weight; PWK/PhJ
Allele Type: QTL
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Allele
Hrsq5<C57BL/6J> | MGI:6404143
 
Name: host response to SARS QTL 5, D3% weight; C57BL/6J
Allele Type: QTL
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Allele
Hrsq4<CAST/EiJ> | MGI:6403779
 
Name: host response to SARS QTL 4, vascular cuffing; CAST/EiJ
Allele Type: QTL
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom