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Search results 1 to 100 out of 127 for Scai

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
286205 | SCAI
Type: gene
Organism: human
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Gene
100493243 | scai
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR022709 | SCAI
Type: Family
Description: SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [].
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Gene
690538 | Scai
Type: gene
Organism: rat
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Gene
612887 | SCAI
Type: gene
Organism: dog, domestic
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Gene
473107 | SCAI
Type: gene
Organism: chimpanzee
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Gene
521431 | SCAI
Type: gene
Organism: cattle
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Gene
427751 | SCAI
Type: gene
Organism: chicken
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Gene
556383 | scai
Type: gene
Organism: zebrafish
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Gene
712803 | SCAI
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2443716 | Scai
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19350017 | J:150313
First Author: Brandt DT
Year: 2009
Journal: Nat Cell Biol
Title: SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin.
Volume: 11
Issue: 5
Pages: 557-68
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Protein
A0A0N4SUW0
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Protein
A0A0N4SVJ6
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q8C8N2
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: false
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Protein
Q8C4E7
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: true
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Protein
Q3TQB4
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Publication
27820601 | J:240463
First Author: Hansen RK
Year: 2016
Journal: Nat Cell Biol
Title: SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Volume: 18
Issue: 12
Pages: 1357-1366
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Publication
23178076 | J:192312
First Author: Fintha A
Year: 2013
Journal: Am J Pathol
Title: Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition.
Volume: 182
Issue: 2
Pages: 388-400
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Protein Coding Gene
MGP_CAROLIEiJ_G0023534 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025711 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025688 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025683 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443716 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025423 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025555 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025642 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025548 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026187 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024986 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024454 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_09
Specimen Label: euxassay_011348_09
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_10
Specimen Label: euxassay_011348_10
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_11
Specimen Label: euxassay_011348_11
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_12
Specimen Label: euxassay_011348_12
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_13
Specimen Label: euxassay_011348_13
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_15
Specimen Label: euxassay_011348_15
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_16
Specimen Label: euxassay_011348_16
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4424456
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1760623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827884
Age: embryonic day 14.5
Image: euxassay_011348_17
Specimen Label: euxassay_011348_17
Detected: true
Specimen Num: 8
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Publication
39361422 | J:358836
 
First Author: Ghotbi E
Year: 2024
Journal: J Clin Invest
Title: Transcription factor KROX20 marks epithelial stem cell ancestors for hair follicle formation.
Volume: 134
Issue: 23
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Protein SCAI
Type: chain
End: 606
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Protein
Q8C8N2-2
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Protein
D6RHQ0
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: false
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Protein
B0R0E3
Organism: Mus musculus/domesticus
Length: 27  
Fragment?: true
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Protein Domain
IPR019069 | Restrct_endonuc_II_ScaI
Type: Family
Description: There are four classes of restriction endonucleases: types I, II,III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit composition, cleavage position, and cofactor requirements [, ], as summarised below:Type I enzymes () cleave at sites remote from recognition site; require both ATP and S-adenosyl-L-methionine to function; multifunctional protein with both restriction and methylase () activities.Type II enzymes () cleave within or at short specific distances from recognition site; most require magnesium; single function (restriction) enzymes independent of methylase.Type III enzymes () cleave at sites a short distance from recognition site; require ATP (but doesn't hydrolyse it); S-adenosyl-L-methionine stimulates reaction but is not required; exists as part of a complex with a modification methylase methylase ().Type IV enzymes target methylated DNA.Type II restriction endonucleases () are components of prokaryotic DNA restriction-modification mechanisms that protect the organism against invading foreign DNA. These site-specific deoxyribonucleases catalyse the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. Of the 3000 restriction endonucleases that have been characterised, most are homodimeric or tetrameric enzymes that cleave target DNA at sequence-specific sites close to the recognition site. For homodimeric enzymes, the recognition site is usually a palindromic sequence 4-8 bp in length. Most enzymes require magnesium ions as a cofactor for catalysis. Although they can vary in their mode of recognition, many restriction endonucleases share a similar structural core comprising four β-strands and one α-helix, as well as a similar mechanism of cleavage, suggesting a common ancestral origin []. However, there is still considerable diversity amongst restriction endonucleases [, ]. The target site recognition process triggers large conformational changes of the enzyme and the target DNA, leading to the activation of the catalytic centres. Like other DNA binding proteins, restriction enzymes are capable of non-specific DNA binding as well, which is the prerequisite for efficient target site location by facilitated diffusion. Non-specific binding usually does not involve interactions with the bases but only with the DNA backbone []. This entry represents the restriction endonuclease ScaI, which recognises and cleaves the double-stranded sequence AGT^ACT.
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Allele
Lmo1<tm1Thr> | MGI:3035822
Name: LIM domain only 1; targeted mutation 1, Terence H Rabbitts
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Lmo1/Lmo1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Protein Domain
IPR016607 | SCAI_metazoan/Viridiplantae
Type: Family
Description: This entry represents protein SCAI from metazoans and plants. SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [].
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Allele
Lmo1<tm2Thr> | MGI:3035823
Name: LIM domain only 1; targeted mutation 2, Terence H Rabbitts
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Del(14)3Mom | MGI:3714752
Name: deletion, Chr 14, Peter Mombaerts 3
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:3716055 | B6;129P2-Del(14)3Mom/MomJ
Attribute String: chromosome aberration, deletion, mutant stock, targeted mutation
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Publication
17662950 | J:122925
First Author: Fuss SH
Year: 2007
Journal: Cell
Title: Local and cis effects of the H element on expression of odorant receptor genes in mouse.
Volume: 130
Issue: 2
Pages: 373-84
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Allele
Antxr1<em1Bstc> | MGI:7310435
 
Name: anthrax toxin receptor 1; endonuclease-mediated mutation 1, Brad St. Croix
Allele Type: Endonuclease-mediated
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Genotype
Genotype
Symbol: Lmo1/Lmo1 Lmo3/Lmo3
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lmo1/Lmo1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(14)3Mom/+
Background: (C57BL/6J x 129P2/OlaHsd)F1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(14)3Mom/Del(14)3Mom
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
28194446 | J:280180
First Author: Roszko KL
Year: 2017
Journal: JCI Insight
Title: Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.
Volume: 2
Issue: 3
Pages: e91079
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Allele
Gna11<em1Mman> | MGI:6376284
 
Name: guanine nucleotide binding protein, alpha 11; endonuclease-mediated mutation 1, Michael Mannstadt
Allele Type: Endonuclease-mediated
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Strain
MGI:6423270 | C57BL/6N-Gna11<em1Mman>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6423284 | C57BL/6-Gna11<em1Mman>
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
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Strain
MGI:7310436 | B6.Cg-Antxr1<em1Bstc>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Lmo1/Lmo1 Lmo3/Lmo3
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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