|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 120 for Scap

<< First    < Previous  |  Next >    Last >>
0.048s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Sterol regulatory element-binding protein cleavage-activating protein (SCAP) is a escort protein required for cholesterol and lipid homeostasis []. It is an endoplasmic reticulum protein with eight transmembrane helices that serves as a cholesterol sensor []. In cholesterol-depleted cells, SCAP transports sterol regulatory element-binding proteins (SREBPs) to the Golgi, where the active fragment of SREBP is liberated by proteases so that it can activate genes for cholesterol synthesis [].A homologue of SCAP exists in Schizosaccharomyces pombe, named Scp1, which together with Sre1 (homologue to SREBP), may mediate a hypoxic response by monitoring oxygen-dependent sterol synthesis []..
Publication
First Author: Matsuda M
Year: 2001
Journal: Genes Dev
Title: SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.
Volume: 15
Issue: 10
Pages: 1206-16
Protein
Organism: Mus musculus
Length: 1276  
Fragment?: false
Publication
First Author: Motamed M
Year: 2011
Journal: J Biol Chem
Title: Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis.
Volume: 286
Issue: 20
Pages: 18002-12
Publication
First Author: Verheijen MH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: SCAP is required for timely and proper myelin membrane synthesis.
Volume: 106
Issue: 50
Pages: 21383-8
Publication
First Author: McFarlane MR
Year: 2015
Journal: J Lipid Res
Title: Scap is required for sterol synthesis and crypt growth in intestinal mucosa.
Volume: 56
Issue: 8
Pages: 1560-71
Publication
First Author: Kuriyama H
Year: 2005
Journal: Cell Metab
Title: Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver.
Volume: 1
Issue: 1
Pages: 41-51
Publication
First Author: Chen W
Year: 2016
Journal: PLoS Pathog
Title: ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs.
Volume: 12
Issue: 2
Pages: e1005462
Publication
First Author: Besnard V
Year: 2009
Journal: J Biol Chem
Title: Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
Volume: 284
Issue: 6
Pages: 4018-30
Publication
First Author: Suzuki R
Year: 2013
Journal: PLoS Biol
Title: Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Volume: 11
Issue: 4
Pages: e1001532
Publication  
First Author: Tsushima H
Year: 2018
Journal: Development
Title: Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis.
Volume: 145
Issue: 13
Publication
First Author: Yabe D
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.
Volume: 99
Issue: 20
Pages: 12753-8
Protein
Organism: Mus musculus
Length: 123  
Fragment?: true
Protein
Organism: Mus musculus
Length: 153  
Fragment?: true
Publication
First Author: Radhakrishnan A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.
Volume: 104
Issue: 16
Pages: 6511-8
Publication
First Author: Hughes AL
Year: 2005
Journal: Cell
Title: SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.
Volume: 120
Issue: 6
Pages: 831-42
Publication
First Author: Camargo N
Year: 2012
Journal: FASEB J
Title: High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism.
Volume: 26
Issue: 10
Pages: 4302-15
Publication    
First Author: Zhang L
Year: 2017
Journal: Elife
Title: Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
Volume: 6
Publication
First Author: Moon YA
Year: 2012
Journal: Cell Metab
Title: The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals.
Volume: 15
Issue: 2
Pages: 240-6
Publication
First Author: Papazyan R
Year: 2016
Journal: Cell Metab
Title: Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP.
Volume: 24
Issue: 6
Pages: 863-874
Publication
First Author: Bridges JP
Year: 2014
Journal: PLoS One
Title: Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturation.
Volume: 9
Issue: 5
Pages: e91376
Publication
First Author: Shimizu-Albergine M
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP.
Volume: 113
Issue: 38
Pages: E5685-93
Publication
First Author: Rudolph MC
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium.
Volume: 299
Issue: 6
Pages: E918-27
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:6111794
Assay Type: RT-PCR
Annotation Date: 2018-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6111878
Age: postnatal
Image: 5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6111794
Assay Type: RT-PCR
Annotation Date: 2018-01-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6111878
Age: postnatal
Image: 5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1654315
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1638815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Note: Staining is present in the maxillary process.
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4845275
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1653615
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848909
Age: embryonic day 9.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3609776
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3610156
Age: embryonic day 16.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3609776
Assay Type: RNA in situ
Annotation Date: 2006-01-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3610156
Age: embryonic day 14.5
Detected: true
Specimen Num: 1
Publication
First Author: York AG
Year: 2015
Journal: Cell
Title: Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling.
Volume: 163
Issue: 7
Pages: 1716-29
Publication
First Author: Li J
Year: 2007
Journal: Physiol Genomics
Title: Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Volume: 31
Issue: 2
Pages: 273-80
Publication
First Author: Tang JJ
Year: 2011
Journal: Cell Metab
Title: Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques.
Volume: 13
Issue: 1
Pages: 44-56
Publication
First Author: Horton JD
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
Volume: 100
Issue: 21
Pages: 12027-32
Publication
First Author: Tarling EJ
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.
Volume: 35
Issue: 4
Pages: 787-95
Publication
First Author: Verdier V
Year: 2012
Journal: Glia
Title: Aging of myelinating glial cells predominantly affects lipid metabolism and immune response pathways.
Volume: 60
Issue: 5
Pages: 751-60
Publication
First Author: Kidani Y
Year: 2013
Journal: Nat Immunol
Title: Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Volume: 14
Issue: 5
Pages: 489-99
Publication      
First Author: Zhang Y
Year: 2017
Journal: Genes Dev
Title: The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ.
Publication
First Author: Adlanmerini M
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold.
Volume: 116
Issue: 37
Pages: 18691-18699
Publication
First Author: Rong X
Year: 2017
Journal: J Clin Invest
Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.
Volume: 127
Issue: 10
Pages: 3640-3651
Publication
First Author: Sallam T
Year: 2016
Journal: Nature
Title: Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis.
Volume: 534
Issue: 7605
Pages: 124-8
Publication
First Author: Guan D
Year: 2018
Journal: Cell
Title: Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes.
Volume: 174
Issue: 4
Pages: 831-842.e12
Publication
First Author: Camargo N
Year: 2017
Journal: PLoS Biol
Title: Oligodendroglial myelination requires astrocyte-derived lipids.
Volume: 15
Issue: 5
Pages: e1002605
Publication    
First Author: Rong S
Year: 2017
Journal: Elife
Title: Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice.
Volume: 6
Publication
First Author: Wittenburg H
Year: 2002
Journal: Physiol Genomics
Title: Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice.
Volume: 8
Issue: 1
Pages: 67-77
Publication
First Author: Karmaus PWF
Year: 2017
Journal: J Exp Med
Title: Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.
Volume: 214
Issue: 9
Pages: 2629-2647
Publication
First Author: Korstanje R
Year: 2004
Journal: Arterioscler Thromb Vasc Biol
Title: Quantitative trait locus mapping of genes that regulate phospholipid transfer activity in SM/J and NZB/BlNJ inbred mice.
Volume: 24
Issue: 1
Pages: 155-60
Publication
First Author: Beigneux AP
Year: 2004
Journal: J Biol Chem
Title: ATP-citrate lyase deficiency in the mouse.
Volume: 279
Issue: 10
Pages: 9557-64
Publication
First Author: Guo M
Year: 2019
Journal: Nat Commun
Title: Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth.
Volume: 10
Issue: 1
Pages: 37
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Download
Title: MGI cDNA Clone Load
Publication      
First Author: Overbeek PA
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission for Overbeek Lentiviral Transgenic Lines
Publication
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
Publication
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).